Details for: MTNR1A

Gene ID: 4543

Symbol: MTNR1A

Ensembl ID: ENSG00000168412

Description: melatonin receptor 1A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.86
    Marker Score: 2691
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.27
    Marker Score: 6771
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3173
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.03
    Marker Score: 1154
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.68
    Marker Score: 2321
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10754
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7546
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3647
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.21
    Marker Score: 706
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4816
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32717.5
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.04
    Marker Score: 2924
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.98
    Marker Score: 2308
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2388
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5297
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.84
    Marker Score: 442
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.83
    Marker Score: 347
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 735
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1225
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.43
    Marker Score: 818
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 248
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.36
    Marker Score: 722
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.33
    Marker Score: 194
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.32
    Marker Score: 323
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.31
    Marker Score: 4816
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.28
    Marker Score: 90
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.28
    Marker Score: 1700
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 133
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 141
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.21
    Marker Score: 242
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.2
    Marker Score: 783
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.19
    Marker Score: 341
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 50
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.15
    Marker Score: 531
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 64
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.09
    Marker Score: 5253
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 94
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 92
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.07
    Marker Score: 292
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 62
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 58
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.06
    Marker Score: 557
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.04
    Marker Score: 82
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.04
    Marker Score: 347
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.03
    Marker Score: 53.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.03
    Marker Score: 44

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Other Information

**Key characteristics:** - MTNR1A is a single-pass membrane protein with a molecular weight of approximately 140 kDa. - It is expressed in high levels in the retina of the eye and in peripheral tissues such as blood vessels, kidney, and colon. - It is a key regulator of the circadian rhythm, with its expression and activity changing in a cyclical pattern over a period of 24 hours. - It is also involved in the regulation of other physiological processes, including metabolism, stress response, and reproduction. **Pathways and functions:** - MTNR1A is a key regulator of the circadian rhythm. - It is expressed in the retina of the eye, where it is responsible for regulating the sleep-wake cycle. - It is also expressed in other tissues, where it helps to regulate a variety of physiological processes. - MTNR1A is a receptor for melatonin, a hormone that regulates the circadian rhythm. - Melatonin binding to MTNR1A inhibits the activity of the receptor, which leads to the suppression of the circadian rhythm. - MTNR1A is also a receptor for organic cyclic compounds, such as melatonin and cortisol. - These ligands can activate MTNR1A, which can then inhibit the activity of the receptor. **Clinical significance:** MTNR1A gene variants have been linked to a number of human diseases, including insomnia, depression, and metabolic disorders. - Mutations in MTNR1A have been shown to be associated with the development of seasonal affective disorder (SAD), a type of depression that is characterized by seasonal changes in mood and behavior. - MTNR1A is also a potential target for the treatment of obesity, as it is expressed in high levels in adipose tissue. - Drugs that target MTNR1A have been shown to be effective in treating SAD and obesity.

Genular Protein ID: 1025497217

Symbol: MTR1A_HUMAN

Name: Melatonin receptor type 1A

UniProtKB Accession Codes:

P48039 A0AVC5 B0M0L2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 ELM 1 EMBL 7 EMDB 3 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 7 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7946354

Title: Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses.

PubMed ID: 7946354

DOI: 10.1016/0896-6273(94)90055-8

PubMed ID: 10471411

Title: Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders.

PubMed ID: 10471411

DOI: 10.1006/bbrc.1999.1308

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 31019306

Title: Structural basis of ligand recognition at the human MT1 melatonin receptor.

PubMed ID: 31019306

DOI: 10.1038/s41586-019-1141-3

Sequence Information:

  • Length: 350
  • Mass: 39375
  • Checksum: DF7C67111D2386ED
  • Sequence:
    • MQGNGSALPN ASQPVLRGDG ARPSWLASAL ACVLIFTIVV DILGNLLVIL SVYRNKKLRN 
AGNIFVVSLA VADLVVAIYP YPLVLMSIFN NGWNLGYLHC QVSGFLMGLS VIGSIFNITG 
IAINRYCYIC HSLKYDKLYS SKNSLCYVLL IWLLTLAAVL PNLRAGTLQY DPRIYSCTFA 
QSVSSAYTIA VVVFHFLVPM IIVIFCYLRI WILVLQVRQR VKPDRKPKLK PQDFRNFVTM 
FVVFVLFAIC WAPLNFIGLA VASDPASMVP RIPEWLFVAS YYMAYFNSCL NAIIYGLLNQ 
NFRKEYRRII VSLCTARVFF VDSSNDVADR VKWKPSPLMT NNNVVKVDSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.