Details for: MTNR1A

Gene ID: 4543

Symbol: MTNR1A

Ensembl ID: ENSG00000168412

Description: melatonin receptor 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.1081
    Cell Significance Index: 15.2000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7860
    Cell Significance Index: 10.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6789
    Cell Significance Index: 16.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.6227
    Cell Significance Index: 38.1800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.5364
    Cell Significance Index: 9.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2377
    Cell Significance Index: 45.2400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1971
    Cell Significance Index: 2.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1833
    Cell Significance Index: 18.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1827
    Cell Significance Index: 3.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1190
    Cell Significance Index: 6.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1124
    Cell Significance Index: 101.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1044
    Cell Significance Index: 4.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0968
    Cell Significance Index: 1.4500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0955
    Cell Significance Index: 1.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0916
    Cell Significance Index: 5.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0907
    Cell Significance Index: 9.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0889
    Cell Significance Index: 14.4700
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.0690
    Cell Significance Index: 0.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0372
    Cell Significance Index: 2.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0302
    Cell Significance Index: 0.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0165
    Cell Significance Index: 0.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0141
    Cell Significance Index: 2.8400
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.0127
    Cell Significance Index: 0.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0098
    Cell Significance Index: 1.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0098
    Cell Significance Index: 0.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0072
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0018
    Cell Significance Index: 0.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0009
    Cell Significance Index: 0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0019
    Cell Significance Index: -0.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0025
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0029
    Cell Significance Index: -2.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0029
    Cell Significance Index: -1.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0038
    Cell Significance Index: -1.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0040
    Cell Significance Index: -2.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0042
    Cell Significance Index: -0.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0050
    Cell Significance Index: -0.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0052
    Cell Significance Index: -3.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0053
    Cell Significance Index: -0.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0073
    Cell Significance Index: -2.0900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0094
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0117
    Cell Significance Index: -2.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0122
    Cell Significance Index: -0.5700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0129
    Cell Significance Index: -0.1500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0129
    Cell Significance Index: -0.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0134
    Cell Significance Index: -1.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0138
    Cell Significance Index: -1.9000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0148
    Cell Significance Index: -0.2400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0152
    Cell Significance Index: -0.3100
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0169
    Cell Significance Index: -0.1800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0171
    Cell Significance Index: -0.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0172
    Cell Significance Index: -0.6500
  • Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
    Fold Change: -0.0189
    Cell Significance Index: -0.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0192
    Cell Significance Index: -1.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0264
    Cell Significance Index: -0.3600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0354
    Cell Significance Index: -0.3500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0365
    Cell Significance Index: -0.4300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0366
    Cell Significance Index: -0.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0368
    Cell Significance Index: -0.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0380
    Cell Significance Index: -1.2100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0380
    Cell Significance Index: -0.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0410
    Cell Significance Index: -1.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0417
    Cell Significance Index: -1.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0445
    Cell Significance Index: -1.2800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0480
    Cell Significance Index: -0.6300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0489
    Cell Significance Index: -0.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0495
    Cell Significance Index: -1.2400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0529
    Cell Significance Index: -1.3200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0542
    Cell Significance Index: -0.7900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0546
    Cell Significance Index: -0.8300
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0546
    Cell Significance Index: -0.6500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0584
    Cell Significance Index: -0.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0593
    Cell Significance Index: -1.9400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0601
    Cell Significance Index: -1.9000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0605
    Cell Significance Index: -0.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0610
    Cell Significance Index: -1.4100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0616
    Cell Significance Index: -0.8300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0621
    Cell Significance Index: -1.0500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0633
    Cell Significance Index: -0.9000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0635
    Cell Significance Index: -0.6900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0636
    Cell Significance Index: -0.6100
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.0650
    Cell Significance Index: -0.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0668
    Cell Significance Index: -3.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0670
    Cell Significance Index: -1.6700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0677
    Cell Significance Index: -0.7500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0678
    Cell Significance Index: -1.0900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0679
    Cell Significance Index: -0.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0694
    Cell Significance Index: -1.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0713
    Cell Significance Index: -1.7100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0716
    Cell Significance Index: -0.9900
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0732
    Cell Significance Index: -0.7100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0734
    Cell Significance Index: -1.5900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0735
    Cell Significance Index: -0.7400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0743
    Cell Significance Index: -1.4700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0756
    Cell Significance Index: -1.0600
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0757
    Cell Significance Index: -0.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0760
    Cell Significance Index: -0.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** The melatonin receptor 1A is a G protein-coupled receptor that is activated by melatonin, leading to the activation of downstream signaling pathways. 2. **Expression Pattern:** MTNR1A is widely expressed in various tissues, including immune cells, such as erythrocytes, megakaryocytes, and thymocytes. 3. **Signaling Pathways:** The melatonin receptor 1A is involved in several signaling pathways, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and G alpha (i) signaling events. 4. **Clinical Significance:** Dysregulation of MTNR1A has been implicated in several diseases, including autoimmune disorders, neurodegenerative diseases, and cancer. **Pathways and Functions:** 1. **Circadian Rhythm Regulation:** Melatonin receptor 1A plays a crucial role in regulating the circadian rhythm, which is essential for maintaining the homeostasis of various physiological processes. 2. **Immune Response:** MTNR1A is involved in regulating the immune response, including the activation of immune cells and the production of cytokines. 3. **Neuroprotection:** Melatonin receptor 1A has been shown to have neuroprotective effects, including the protection against oxidative stress and neuroinflammation. 4. **Cancer:** Dysregulation of MTNR1A has been implicated in several types of cancer, including breast cancer, prostate cancer, and colon cancer. **Clinical Significance:** 1. **Autoimmune Disorders:** Dysregulation of MTNR1A has been implicated in several autoimmune disorders, including multiple sclerosis, rheumatoid arthritis, and lupus. 2. **Neurodegenerative Diseases:** Melatonin receptor 1A has been shown to have neuroprotective effects in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Cancer:** Dysregulation of MTNR1A has been implicated in several types of cancer, including breast cancer, prostate cancer, and colon cancer. 4. **Therapeutic Potential:** Targeting MTNR1A has been proposed as a potential therapeutic strategy for treating various diseases, including autoimmune disorders, neurodegenerative diseases, and cancer. In conclusion, the melatonin receptor 1A gene (MTNR1A) plays a crucial role in regulating various physiological processes, including the immune response, circadian rhythm, and neuroprotection. Dysregulation of MTNR1A has been implicated in several diseases, including autoimmune disorders, neurodegenerative diseases, and cancer. Further research is needed to fully understand the role of MTNR1A in human health and disease, and to explore its therapeutic potential.

Genular Protein ID: 1025497217

Symbol: MTR1A_HUMAN

Name: Melatonin receptor type 1A

UniProtKB Accession Codes:

P48039 A0AVC5 B0M0L2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 ELM 1 EMBL 7 EMDB 3 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7946354

Title: Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses.

PubMed ID: 7946354

DOI: 10.1016/0896-6273(94)90055-8

PubMed ID: 10471411

Title: Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders.

PubMed ID: 10471411

DOI: 10.1006/bbrc.1999.1308

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 31019306

Title: Structural basis of ligand recognition at the human MT1 melatonin receptor.

PubMed ID: 31019306

DOI: 10.1038/s41586-019-1141-3

Sequence Information:

  • Length: 350
  • Mass: 39375
  • Checksum: DF7C67111D2386ED
  • Sequence:
    • MQGNGSALPN ASQPVLRGDG ARPSWLASAL ACVLIFTIVV DILGNLLVIL SVYRNKKLRN 
AGNIFVVSLA VADLVVAIYP YPLVLMSIFN NGWNLGYLHC QVSGFLMGLS VIGSIFNITG 
IAINRYCYIC HSLKYDKLYS SKNSLCYVLL IWLLTLAAVL PNLRAGTLQY DPRIYSCTFA 
QSVSSAYTIA VVVFHFLVPM IIVIFCYLRI WILVLQVRQR VKPDRKPKLK PQDFRNFVTM 
FVVFVLFAIC WAPLNFIGLA VASDPASMVP RIPEWLFVAS YYMAYFNSCL NAIIYGLLNQ 
NFRKEYRRII VSLCTARVFF VDSSNDVADR VKWKPSPLMT NNNVVKVDSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.