Details for: MUC7

Gene ID: 4589

Symbol: MUC7

Ensembl ID: ENSG00000171195

Description: mucin 7, secreted

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 44.1425
    Cell Significance Index: 245.7000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 29.7926
    Cell Significance Index: 198.4000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 26.9811
    Cell Significance Index: 562.7100
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 2.4719
    Cell Significance Index: 30.7000
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.4972
    Cell Significance Index: 1.0700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.4192
    Cell Significance Index: 24.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1464
    Cell Significance Index: 53.4500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.9393
    Cell Significance Index: 9.4000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.8229
    Cell Significance Index: 11.2900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.7359
    Cell Significance Index: 6.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.5893
    Cell Significance Index: -1.8100
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.5596
    Cell Significance Index: 4.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5165
    Cell Significance Index: 12.5100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3895
    Cell Significance Index: 5.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3767
    Cell Significance Index: 5.1400
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.2040
    Cell Significance Index: 1.8700
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.1215
    Cell Significance Index: 1.2700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0844
    Cell Significance Index: 2.1100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0833
    Cell Significance Index: 2.6400
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.0410
    Cell Significance Index: 0.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0144
    Cell Significance Index: 1.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0026
    Cell Significance Index: 0.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -6.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0057
    Cell Significance Index: -3.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0068
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0080
    Cell Significance Index: -1.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0086
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0088
    Cell Significance Index: -5.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0091
    Cell Significance Index: -1.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0095
    Cell Significance Index: -5.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0095
    Cell Significance Index: -1.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0109
    Cell Significance Index: -3.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0115
    Cell Significance Index: -0.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0144
    Cell Significance Index: -6.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0158
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0219
    Cell Significance Index: -3.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0233
    Cell Significance Index: -4.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0260
    Cell Significance Index: -5.4700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0324
    Cell Significance Index: -0.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0334
    Cell Significance Index: -4.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0356
    Cell Significance Index: -0.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0411
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0440
    Cell Significance Index: -5.0400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0458
    Cell Significance Index: -0.6100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0547
    Cell Significance Index: -0.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0566
    Cell Significance Index: -5.8900
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0629
    Cell Significance Index: -0.5000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0630
    Cell Significance Index: -0.8300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0645
    Cell Significance Index: -2.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0671
    Cell Significance Index: -5.0000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0754
    Cell Significance Index: -0.7600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0759
    Cell Significance Index: -0.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0774
    Cell Significance Index: -2.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0788
    Cell Significance Index: -5.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0828
    Cell Significance Index: -0.9000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0892
    Cell Significance Index: -0.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0920
    Cell Significance Index: -4.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0951
    Cell Significance Index: -2.7400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0951
    Cell Significance Index: -0.8600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0959
    Cell Significance Index: -0.6500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0971
    Cell Significance Index: -1.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1004
    Cell Significance Index: -6.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1059
    Cell Significance Index: -8.1300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1067
    Cell Significance Index: -1.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1068
    Cell Significance Index: -5.0200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1097
    Cell Significance Index: -1.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1169
    Cell Significance Index: -5.3000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1302
    Cell Significance Index: -1.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1311
    Cell Significance Index: -2.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1321
    Cell Significance Index: -7.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1347
    Cell Significance Index: -1.5300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1348
    Cell Significance Index: -1.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1390
    Cell Significance Index: -7.0200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1392
    Cell Significance Index: -0.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1395
    Cell Significance Index: -5.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1418
    Cell Significance Index: -2.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1453
    Cell Significance Index: -5.0900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.1476
    Cell Significance Index: -0.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1536
    Cell Significance Index: -5.0300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1546
    Cell Significance Index: -6.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1557
    Cell Significance Index: -4.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1579
    Cell Significance Index: -4.2300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1579
    Cell Significance Index: -2.0000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1611
    Cell Significance Index: -2.6100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1633
    Cell Significance Index: -1.6900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1680
    Cell Significance Index: -4.2800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1788
    Cell Significance Index: -2.5400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1805
    Cell Significance Index: -2.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1827
    Cell Significance Index: -4.0000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1838
    Cell Significance Index: -3.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1852
    Cell Significance Index: -5.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1858
    Cell Significance Index: -8.2200
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1892
    Cell Significance Index: -1.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1952
    Cell Significance Index: -5.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MUC7 is a type of mucin protein, which is a large, heavily glycosylated glycoprotein. Its primary function is to form a protective mucous layer on epithelial surfaces, including the respiratory, gastrointestinal, and genitourinary tracts. MUC7 is significantly expressed in various cell types, including erythrocytes, serous secreting cells, duct epithelial cells, and goblet cells. Its expression is also observed in immune cells, such as double negative thymocytes and hematopoietic stem cells, highlighting its role in the immune system. **Pathways and Functions:** MUC7 interacts with various immune cells and molecules, including C-type lectin receptors (CLRs), Dectin-2 family, and antimicrobial peptides. These interactions facilitate the recognition and elimination of pathogens, thereby protecting epithelial surfaces against infection. MUC7 also modulates the immune response by influencing the activity of immune cells, such as macrophages and neutrophils. Additionally, MUC7 is involved in the regulation of protein metabolism and post-translational protein modification, which is essential for maintaining the integrity of epithelial surfaces. **Clinical Significance:** Dysregulation of MUC7 has been implicated in various diseases, including metabolic disorders, inflammatory conditions, and cancer. For instance, mutations in the MUC7 gene have been associated with an increased risk of colon cancer. Furthermore, alterations in MUC7 expression have been observed in inflammatory conditions, such as asthma and chronic obstructive pulmonary disease (COPD). The potential therapeutic applications of MUC7 are vast, and further research is necessary to fully elucidate its role in the immune system and its clinical significance. In conclusion, MUC7 is a critical mucin protein that plays a vital role in the innate immune system. Its unique glycosylation pattern and interactions with immune cells and molecules enable it to protect epithelial surfaces against pathogens and toxins. Further research is necessary to fully elucidate the clinical significance of MUC7 and its potential therapeutic applications in the prevention and treatment of various diseases.

Genular Protein ID: 3816286220

Symbol: MUC7_HUMAN

Name: Mucin-7

UniProtKB Accession Codes:

Q8TAX7 Q9UCD7 Q9UCD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7690757

Title: Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7).

PubMed ID: 7690757

DOI: 10.1016/s0021-9258(20)80762-5

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1445223

Title: Structural features of the low-molecular-mass human salivary mucin.

PubMed ID: 1445223

DOI: 10.1042/bj2870639

PubMed ID: 8104046

Title: Low-molecular-mass human salivary mucin, MG2: structure and binding of Pseudomonas aeruginosa.

PubMed ID: 8104046

DOI: 10.1177/10454411930040030901

PubMed ID: 11378823

Title: Genetic polymorphism of MUC7: allele frequencies and association with asthma.

PubMed ID: 11378823

DOI: 10.1038/sj.ejhg.5200642

PubMed ID: 12407114

Title: Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.

PubMed ID: 12407114

DOI: 10.1074/jbc.m203094200

Sequence Information:

  • Length: 377
  • Mass: 39159
  • Checksum: 1BF92D1855C13F4A
  • Sequence:
    • MKTLPLFVCI CALSACFSFS EGRERDHELR HRRHHHQSPK SHFELPHYPG LLAHQKPFIR 
KSYKCLHKRC RPKLPPSPNN PPKFPNPHQP PKHPDKNSSV VNPTLVATTQ IPSVTFPSAS 
TKITTLPNVT FLPQNATTIS SRENVNTSSS VATLAPVNSP APQDTTAAPP TPSATTPAPP 
SSSAPPETTA APPTPSATTQ APPSSSAPPE TTAAPPTPPA TTPAPPSSSA PPETTAAPPT 
PSATTPAPLS SSAPPETTAV PPTPSATTLD PSSASAPPET TAAPPTPSAT TPAPPSSPAP 
QETTAAPITT PNSSPTTLAP DTSETSAAPT HQTTTSVTTQ TTTTKQPTSA PGQNKISRFL 
LYMKNLLNRI IDDMVEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.