Details for: MVK

Gene ID: 4598

Symbol: MVK

Ensembl ID: ENSG00000110921

Description: mevalonate kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 88.3344
    Cell Significance Index: -13.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.7763
    Cell Significance Index: -13.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.4241
    Cell Significance Index: -12.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.9564
    Cell Significance Index: -12.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.4197
    Cell Significance Index: -14.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7147
    Cell Significance Index: -12.6300
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 4.0269
    Cell Significance Index: 5.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6315
    Cell Significance Index: -14.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.5848
    Cell Significance Index: 69.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2617
    Cell Significance Index: 147.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1153
    Cell Significance Index: 10.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8619
    Cell Significance Index: 11.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7255
    Cell Significance Index: 655.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6442
    Cell Significance Index: 127.8500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5641
    Cell Significance Index: 8.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5570
    Cell Significance Index: 33.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5552
    Cell Significance Index: 28.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5427
    Cell Significance Index: 88.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3901
    Cell Significance Index: 20.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3493
    Cell Significance Index: 62.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3292
    Cell Significance Index: 40.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2850
    Cell Significance Index: 8.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2737
    Cell Significance Index: 5.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2142
    Cell Significance Index: 42.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2121
    Cell Significance Index: 4.4400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1968
    Cell Significance Index: 2.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1960
    Cell Significance Index: 8.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1886
    Cell Significance Index: 5.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1826
    Cell Significance Index: 12.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1796
    Cell Significance Index: 276.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1756
    Cell Significance Index: 11.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1694
    Cell Significance Index: 7.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1552
    Cell Significance Index: 55.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1549
    Cell Significance Index: 19.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1467
    Cell Significance Index: 14.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1463
    Cell Significance Index: 18.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1424
    Cell Significance Index: 77.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1392
    Cell Significance Index: 26.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1356
    Cell Significance Index: 6.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1349
    Cell Significance Index: 93.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1212
    Cell Significance Index: 3.5600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1193
    Cell Significance Index: 1.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1112
    Cell Significance Index: 49.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1072
    Cell Significance Index: 197.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1019
    Cell Significance Index: 2.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0993
    Cell Significance Index: 2.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0784
    Cell Significance Index: 2.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0626
    Cell Significance Index: 4.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0592
    Cell Significance Index: 8.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0527
    Cell Significance Index: 3.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0470
    Cell Significance Index: 1.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0322
    Cell Significance Index: 43.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0173
    Cell Significance Index: 2.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0170
    Cell Significance Index: 12.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0028
    Cell Significance Index: -2.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0094
    Cell Significance Index: -5.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0164
    Cell Significance Index: -0.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0175
    Cell Significance Index: -1.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0200
    Cell Significance Index: -2.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0209
    Cell Significance Index: -1.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0221
    Cell Significance Index: -12.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0266
    Cell Significance Index: -4.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0270
    Cell Significance Index: -16.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0323
    Cell Significance Index: -9.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0437
    Cell Significance Index: -1.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0457
    Cell Significance Index: -6.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0544
    Cell Significance Index: -0.9100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0708
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0717
    Cell Significance Index: -15.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0755
    Cell Significance Index: -8.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0811
    Cell Significance Index: -5.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0909
    Cell Significance Index: -3.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0966
    Cell Significance Index: -2.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1116
    Cell Significance Index: -6.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1117
    Cell Significance Index: -3.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1167
    Cell Significance Index: -6.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1315
    Cell Significance Index: -1.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1345
    Cell Significance Index: -14.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1379
    Cell Significance Index: -10.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1396
    Cell Significance Index: -3.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1460
    Cell Significance Index: -1.7400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1560
    Cell Significance Index: -2.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1683
    Cell Significance Index: -4.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1746
    Cell Significance Index: -7.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1791
    Cell Significance Index: -12.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1830
    Cell Significance Index: -11.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1987
    Cell Significance Index: -4.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2002
    Cell Significance Index: -7.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2088
    Cell Significance Index: -2.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2174
    Cell Significance Index: -2.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2264
    Cell Significance Index: -5.8200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2859
    Cell Significance Index: -4.0100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2883
    Cell Significance Index: -4.0000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2943
    Cell Significance Index: -3.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2974
    Cell Significance Index: -7.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3069
    Cell Significance Index: -10.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3093
    Cell Significance Index: -9.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MVK is a member of the kinase family of enzymes, which are characterized by their ability to transfer phosphate groups to specific substrates. The mevalonate kinase activity of MVK is critical for the regulation of cholesterol biosynthesis and is influenced by the transcription factor SREBP (sterol regulatory element-binding protein). SREBP is a master regulator of cholesterol synthesis, and its activation leads to the increased expression of MVK, resulting in enhanced cholesterol production. MVK's activity is also modulated by other regulatory mechanisms, including phosphorylation and protein binding, which can either activate or inhibit its function. **Pathways and Functions** MVK is involved in several key pathways, including: 1. **Cholesterol biosynthesis**: MVK is a critical enzyme in the mevalonate pathway, which is responsible for the synthesis of cholesterol from acetyl-CoA. The reaction catalyzed by MVK is a rate-limiting step in this pathway, and its dysregulation can lead to impaired cholesterol synthesis. 2. **Isoprenoid biosynthesis**: MVK is also involved in the biosynthesis of isoprenoids, which are essential for the synthesis of cholesterol and other biomolecules. Isoprenoids play a critical role in various cellular processes, including cell signaling, membrane structure, and immune response modulation. 3. **Regulation of inflammatory response**: MVK has been shown to negatively regulate the inflammatory response by inhibiting the activation of NF-κB, a transcription factor involved in the regulation of inflammatory genes. 4. **Regulation of SREBP activity**: MVK is a key regulator of SREBP activity, and its dysregulation can lead to impaired cholesterol synthesis and other metabolic disorders. **Clinical Significance** Dysregulation of MVK has been implicated in various diseases, including: 1. **Hypercholesterolemia**: Impaired MVK activity can lead to reduced cholesterol synthesis, resulting in hypercholesterolemia, a condition characterized by elevated levels of cholesterol in the blood. 2. **Atherosclerosis**: MVK's role in cholesterol biosynthesis makes it a potential target for the treatment of atherosclerosis, a condition characterized by the buildup of cholesterol-rich plaques in the arteries. 3. **Inflammatory disorders**: MVK's negative regulation of the inflammatory response makes it a potential therapeutic target for the treatment of inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. 4. **Neurological disorders**: MVK's expression in the brain and its role in cholesterol biosynthesis make it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, MVK is a critical enzyme involved in the biosynthesis of cholesterol and isoprenoids, and its dysregulation can lead to various metabolic disorders. Further research is needed to fully understand the role of MVK in human health and disease, and to explore its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 1808933397

Symbol: KIME_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q03426

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 12 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1377680

Title: Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.

PubMed ID: 1377680

DOI: 10.1016/s0021-9258(18)42199-0

PubMed ID: 8302606

Title: Insertional activation of mevalonate kinase by hepatitis B virus DNA in a human hepatoma cell line.

PubMed ID: 8302606

PubMed ID: 11313768

Title: Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome.

PubMed ID: 11313768

DOI: 10.1038/sj.ejhg.5200595

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9325256

Title: Identification of catalytic residues in human mevalonate kinase.

PubMed ID: 9325256

DOI: 10.1074/jbc.272.41.25449

PubMed ID: 9392419

Title: Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.

PubMed ID: 9392419

PubMed ID: 11278915

Title: Investigation of invariant serine/threonine residues in mevalonate kinase. Tests of the functional significance of a proposed substrate binding motif and a site implicated in human inherited disease.

PubMed ID: 11278915

DOI: 10.1074/jbc.m011478200

PubMed ID: 14730012

Title: Mevalonate kinase is a cytosolic enzyme in humans.

PubMed ID: 14730012

DOI: 10.1242/jcs.00910

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22983302

Title: Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis.

PubMed ID: 22983302

DOI: 10.1038/ng.2409

PubMed ID: 24781643

Title: Splicing mutation in MVK is a cause of porokeratosis of Mibelli.

PubMed ID: 24781643

DOI: 10.1007/s00403-014-1465-7

PubMed ID: 18302342

Title: Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism.

PubMed ID: 18302342

DOI: 10.1021/bi7024386

PubMed ID: 10417275

Title: Identification of a mutation cluster in mevalonate kinase deficiency, including a new mutation in a patient of Mennonite ancestry.

PubMed ID: 10417275

DOI: 10.1086/302489

PubMed ID: 10401001

Title: Identification and characterization of three novel missense mutations in mevalonate kinase cDNA causing mevalonic aciduria, a disorder of isoprene biosynthesis.

PubMed ID: 10401001

DOI: 10.1093/hmg/8.8.1523

PubMed ID: 10369261

Title: Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome.

PubMed ID: 10369261

DOI: 10.1038/9691

PubMed ID: 10369262

Title: Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome.

PubMed ID: 10369262

DOI: 10.1038/9696

PubMed ID: 11313769

Title: Molecular analysis of MVK mutations and enzymatic activity in hyper-IgD and periodic fever syndrome.

PubMed ID: 11313769

DOI: 10.1038/sj.ejhg.5200614

PubMed ID: 15536479

Title: MVK mutations and associated clinical features in Italian patients affected with autoinflammatory disorders and recurrent fever.

PubMed ID: 15536479

DOI: 10.1038/sj.ejhg.5201323

Sequence Information:

  • Length: 396
  • Mass: 42451
  • Checksum: C8F6B629B58CD229
  • Sequence:
    • MLSEVLLVSA PGKVILHGEH AVVHGKVALA VSLNLRTFLR LQPHSNGKVD LSLPNIGIKR 
AWDVARLQSL DTSFLEQGDV TTPTSEQVEK LKEVAGLPDD CAVTERLAVL AFLYLYLSIC 
RKQRALPSLD IVVWSELPPG AGLGSSAAYS VCLAAALLTV CEEIPNPLKD GDCVNRWTKE 
DLELINKWAF QGERMIHGNP SGVDNAVSTW GGALRYHQGK ISSLKRSPAL QILLTNTKVP 
RNTRALVAGV RNRLLKFPEI VAPLLTSIDA ISLECERVLG EMGEAPAPEQ YLVLEELIDM 
NQHHLNALGV GHASLDQLCQ VTRARGLHSK LTGAGGGGCG ITLLKPGLEQ PEVEATKQAL 
TSCGFDCLET SIGAPGVSIH SATSLDSRVQ QALDGL

Genular Protein ID: 3521231837

Symbol: F5H8H2_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H8H2

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 5 Gene3D 2 GeneTree 1 HGNC 1 IntAct 1 InterPro 5 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 2 Rhea 1 RuleBase 1 SUPFAM 2 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 344
  • Mass: 37172
  • Checksum: 3B2DAB0F753F90AF
  • Sequence:
    • MLSEVLLVSA PGKVILHGEH AVVHGKVALA VSLNLRTFLR LQPHSNGKVD LSLPNIGIKR 
AWDVARLQSL DTSFLEQGDV TTPTSEQVEK LKEVAGLPDD CAVTERLAVL AFLYLYLSIC 
RKQRWTKEDL ELINKWAFQG ERMIHGNPSG VDNAVSTWGG ALRYHQGKIS SLKRSPALQI 
LLTNTKVPRN TRALVAGVRN RLLKFPEIVA PLLTSIDAIS LECERVLGEM GEAPAPEQYL 
VLEELIDMNQ HHLNALGVGH ASLDQLCQVT RARGLHSKLT GAGGGGCGIT LLKPGLEQPE 
VEATKQALTS CGFDCLETSI GAPGVSIHSA TSLDSRVQQA LDGL

Genular Protein ID: 2039624559

Symbol: B7Z301_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z301

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 5 Gene3D 2 InterPro 5 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 1 RuleBase 1 SUPFAM 2 UniPathway 1

Sequence Information:

  • Length: 344
  • Mass: 37157
  • Checksum: D1351214FF1C4D99
  • Sequence:
    • MLSEVLLVSA PGKVILHGEH AVVHGKVALA VSLNLRTFLR LQPHSNGKVD LSLPNIGIKR 
AWDVARLQSL DTSFLEQGDV TTPTSEQVEK LKEVAGLPDD CAVTERLAVL AFLYLYLSIC 
RKQRWTKEDL ELINKWAFQG ERMIHGNPSG VDNAVSTWGG ALRYHQGKIS SLKRSPALLI 
LLTNTKVPRN TRALVAGVRN RLLKFPEIVA PLLTSIDAIS LECERVLGEM GEAPAPEQYL 
VLEELIDMNQ HHLNALGVGH ASLDQLCQVT RARGLHSKLT GAGGGGCGIT LLKPGLEQPE 
VEATKQALTS CGFDCLETSI GAPGVSIHSA TSLDSRVQQA LDGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.