Details for: MXI1

Gene ID: 4601

Symbol: MXI1

Ensembl ID: ENSG00000119950

Description: MAX interactor 1, dimerization protein

Associated with

  • Chromatin
    (GO:0000785)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleolus
    (GO:0005730)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 395.8977
    Cell Significance Index: -61.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 273.0211
    Cell Significance Index: -69.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 131.2962
    Cell Significance Index: -53.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 121.0766
    Cell Significance Index: -62.2800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.8999
    Cell Significance Index: -53.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.3214
    Cell Significance Index: -64.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.2529
    Cell Significance Index: -64.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.9724
    Cell Significance Index: -70.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.4840
    Cell Significance Index: -50.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.5143
    Cell Significance Index: -25.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6954
    Cell Significance Index: 104.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5869
    Cell Significance Index: 569.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5057
    Cell Significance Index: 302.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4112
    Cell Significance Index: 79.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3755
    Cell Significance Index: 1241.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2553
    Cell Significance Index: 204.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1268
    Cell Significance Index: 86.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9244
    Cell Significance Index: 22.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7711
    Cell Significance Index: 83.8800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.7590
    Cell Significance Index: 5.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7264
    Cell Significance Index: 138.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7080
    Cell Significance Index: 42.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6909
    Cell Significance Index: 477.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6306
    Cell Significance Index: 29.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5821
    Cell Significance Index: 74.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5556
    Cell Significance Index: 29.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5377
    Cell Significance Index: 1012.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4630
    Cell Significance Index: 204.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4106
    Cell Significance Index: 56.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4044
    Cell Significance Index: 6.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3819
    Cell Significance Index: 17.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3722
    Cell Significance Index: 203.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3557
    Cell Significance Index: 70.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3141
    Cell Significance Index: 21.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2980
    Cell Significance Index: 189.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2801
    Cell Significance Index: 47.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2468
    Cell Significance Index: 31.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2445
    Cell Significance Index: 44.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2005
    Cell Significance Index: 272.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1763
    Cell Significance Index: 4.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1530
    Cell Significance Index: 18.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1423
    Cell Significance Index: 14.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1386
    Cell Significance Index: 62.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1295
    Cell Significance Index: 5.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1073
    Cell Significance Index: 165.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0932
    Cell Significance Index: 4.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0790
    Cell Significance Index: 145.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0739
    Cell Significance Index: 5.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0155
    Cell Significance Index: 0.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0117
    Cell Significance Index: -0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0313
    Cell Significance Index: -22.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0413
    Cell Significance Index: -30.6100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0500
    Cell Significance Index: -0.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0654
    Cell Significance Index: -36.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0658
    Cell Significance Index: -41.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0846
    Cell Significance Index: -64.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0948
    Cell Significance Index: -3.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1258
    Cell Significance Index: -8.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1331
    Cell Significance Index: -2.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1751
    Cell Significance Index: -20.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1791
    Cell Significance Index: -18.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2004
    Cell Significance Index: -57.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2208
    Cell Significance Index: -6.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2291
    Cell Significance Index: -33.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2470
    Cell Significance Index: -15.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2510
    Cell Significance Index: -52.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2690
    Cell Significance Index: -18.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2899
    Cell Significance Index: -4.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3717
    Cell Significance Index: -9.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4096
    Cell Significance Index: -46.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4409
    Cell Significance Index: -45.9100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4844
    Cell Significance Index: -6.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5296
    Cell Significance Index: -62.4600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.5646
    Cell Significance Index: -7.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5937
    Cell Significance Index: -47.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6237
    Cell Significance Index: -32.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6287
    Cell Significance Index: -71.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7007
    Cell Significance Index: -9.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7536
    Cell Significance Index: -39.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8134
    Cell Significance Index: -52.4800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.8140
    Cell Significance Index: -13.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8347
    Cell Significance Index: -9.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8361
    Cell Significance Index: -24.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8517
    Cell Significance Index: -29.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9360
    Cell Significance Index: -26.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9535
    Cell Significance Index: -24.5100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.9718
    Cell Significance Index: -14.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0037
    Cell Significance Index: -25.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1243
    Cell Significance Index: -68.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2660
    Cell Significance Index: -26.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.2691
    Cell Significance Index: -33.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2701
    Cell Significance Index: -40.6800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.3730
    Cell Significance Index: -23.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4105
    Cell Significance Index: -46.1800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.4202
    Cell Significance Index: -17.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4227
    Cell Significance Index: -45.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.4533
    Cell Significance Index: -53.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.4646
    Cell Significance Index: -28.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.4711
    Cell Significance Index: -24.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5292
    Cell Significance Index: -53.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dimerization Protein:** MXI1 is a dimerization protein, meaning it can form dimers with other proteins to regulate transcriptional processes. 2. **Transcriptional Regulation:** MXI1 interacts with RNA polymerase II to modulate the activity of this enzyme, which is essential for gene expression. 3. **Cell Type-Specific Expression:** MXI1 is expressed in various cell types, including astrocytes, vascular leptomeningeal cells, and skeletal muscle satellite stem cells. 4. **Transcriptional Repression:** MXI1 has been shown to repress transcriptional activity in certain contexts, highlighting its role in regulating gene expression. **Pathways and Functions:** 1. **Chromatin Remodeling:** MXI1 interacts with chromatin-modifying enzymes to regulate chromatin structure and facilitate transcriptional activation or repression. 2. **RNA Polymerase II Cis-Regulatory Region Sequence-Specific DNA Binding:** MXI1 binds to specific DNA sequences near the promoter region of target genes, influencing the recruitment of RNA polymerase II and other transcriptional regulators. 3. **Regulation of Transcription by RNA Polymerase II:** MXI1 modulates the activity of RNA polymerase II, which is essential for transcribing DNA into RNA. 4. **Negative Regulation of Transcription:** MXI1 has been shown to repress transcriptional activity in certain contexts, highlighting its role in regulating gene expression. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in MXI1 expression have been linked to neurological disorders, such as autism spectrum disorder and schizophrenia, suggesting its potential involvement in brain development and function. 2. **Cancer:** MXI1 has been implicated in cancer development and progression, particularly in the context of gene expression regulation and epigenetic modifications. 3. **Muscle Development and Maintenance:** MXI1 expression in skeletal muscle satellite stem cells highlights its potential role in muscle development and maintenance. 4. **Gene Expression Regulation:** Understanding the mechanisms of MXI1 in regulating transcriptional processes can provide insights into the development and treatment of various diseases, including those related to gene expression dysregulation. In conclusion, MXI1 is a dimerization protein that plays a crucial role in regulating transcriptional processes, particularly in the context of gene expression and cellular differentiation. Further research is needed to elucidate the molecular mechanisms underlying MXI1 function and its clinical significance in various diseases.

Genular Protein ID: 2309883841

Symbol: MXI1_HUMAN

Name: Max-interacting protein 1

UniProtKB Accession Codes:

P50539 B1ANN7 D3DR25 D3DRA9 Q15887 Q6FHW2 Q96E53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 17 Ensembl 23 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8425219

Title: Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites.

PubMed ID: 8425219

DOI: 10.1016/0092-8674(93)90662-a

PubMed ID: 8838813

Title: Genomic organization of human MXI1, a putative tumor suppressor gene.

PubMed ID: 8838813

DOI: 10.1006/geno.1996.0144

PubMed ID: 8918230

Title: Expression, regulation and polymorphism of the mxi1 genes.

PubMed ID: 8918230

DOI: 10.1016/0378-1119(96)00206-5

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7789959

Title: Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas.

PubMed ID: 7789959

DOI: 10.1007/bf00209493

PubMed ID: 7773287

Title: Mutation of the MXI1 gene in prostate cancer.

PubMed ID: 7773287

DOI: 10.1038/ng0395-249

Sequence Information:

  • Length: 228
  • Mass: 26062
  • Checksum: 82F83F499B907DD3
  • Sequence:
    • MERVKMINVQ RLLEAAEFLE RRERECEHGY ASSFPSMPSP RLQHSKPPRR LSRAQKHSSG 
SSNTSTANRS THNELEKNRR AHLRLCLERL KVLIPLGPDC TRHTTLGLLN KAKAHIKKLE 
EAERKSQHQL ENLEREQRFL KWRLEQLQGP QEMERIRMDS IGSTISSDRS DSEREEIEVD 
VESTEFSHGE VDNISTTSIS DIDDHSSLPS IGSDEGYSSA SVKLSFTS

Genular Protein ID: 3748631225

Symbol: A0A0S2Z3X5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3X5

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 4 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 182
  • Mass: 20558
  • Checksum: C6A82E8A3F12A152
  • Sequence:
    • MPSPRLQHSK PPRRLSRAQK HSSGSSNTST ANRRAHLRLC LERLKVLIPL GPDCTRHTTL 
GLLNKAKAHI KKLEEAERKS QHQLENLERE QRFLKWRLEQ LQGPQEMERI RMDSIGSTIS 
SDRSDSEREE IEVDVESTEF SHGEVDNIST TSISDIDDHS SLPSIGSDEG YSSASVKLSF 
TS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.