Details for: NAP1L3

Gene ID: 4675

Symbol: NAP1L3

Ensembl ID: ENSG00000186310

Description: nucleosome assembly protein 1 like 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 148.8313
    Cell Significance Index: -23.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.7289
    Cell Significance Index: -20.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.5753
    Cell Significance Index: -21.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.8004
    Cell Significance Index: -23.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.2557
    Cell Significance Index: -15.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8869
    Cell Significance Index: -23.2300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.9642
    Cell Significance Index: 15.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9197
    Cell Significance Index: 100.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9878
    Cell Significance Index: 354.3100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.9708
    Cell Significance Index: 12.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7903
    Cell Significance Index: 158.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7565
    Cell Significance Index: 47.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7403
    Cell Significance Index: 45.5100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6196
    Cell Significance Index: 7.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6142
    Cell Significance Index: 14.7300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5169
    Cell Significance Index: 8.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3084
    Cell Significance Index: 8.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2998
    Cell Significance Index: 20.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2498
    Cell Significance Index: 4.2800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1104
    Cell Significance Index: 1.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0867
    Cell Significance Index: 11.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0715
    Cell Significance Index: 49.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0474
    Cell Significance Index: 6.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0021
    Cell Significance Index: -1.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0103
    Cell Significance Index: -19.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0110
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0127
    Cell Significance Index: -7.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0137
    Cell Significance Index: -25.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0144
    Cell Significance Index: -19.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0157
    Cell Significance Index: -24.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0160
    Cell Significance Index: -11.7600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0204
    Cell Significance Index: -0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0253
    Cell Significance Index: -16.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0305
    Cell Significance Index: -23.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0318
    Cell Significance Index: -14.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0389
    Cell Significance Index: -17.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0389
    Cell Significance Index: -8.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0400
    Cell Significance Index: -21.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0490
    Cell Significance Index: -14.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0591
    Cell Significance Index: -10.0900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0592
    Cell Significance Index: -1.2800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0648
    Cell Significance Index: -1.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0852
    Cell Significance Index: -15.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0862
    Cell Significance Index: -1.8300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0996
    Cell Significance Index: -1.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1075
    Cell Significance Index: -15.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1086
    Cell Significance Index: -2.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1088
    Cell Significance Index: -21.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1262
    Cell Significance Index: -15.5200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1366
    Cell Significance Index: -1.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1377
    Cell Significance Index: -3.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1386
    Cell Significance Index: -2.3200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1663
    Cell Significance Index: -1.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1728
    Cell Significance Index: -20.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1749
    Cell Significance Index: -19.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1813
    Cell Significance Index: -18.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1859
    Cell Significance Index: -21.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1918
    Cell Significance Index: -24.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2063
    Cell Significance Index: -7.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2080
    Cell Significance Index: -23.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2173
    Cell Significance Index: -17.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2248
    Cell Significance Index: -23.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2413
    Cell Significance Index: -5.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2689
    Cell Significance Index: -15.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2818
    Cell Significance Index: -14.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2826
    Cell Significance Index: -19.9900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2827
    Cell Significance Index: -2.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2831
    Cell Significance Index: -12.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2978
    Cell Significance Index: -9.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3048
    Cell Significance Index: -23.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3126
    Cell Significance Index: -20.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3168
    Cell Significance Index: -10.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3314
    Cell Significance Index: -24.7000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3315
    Cell Significance Index: -8.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3491
    Cell Significance Index: -13.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3657
    Cell Significance Index: -10.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3707
    Cell Significance Index: -22.7300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3833
    Cell Significance Index: -4.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3926
    Cell Significance Index: -4.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3999
    Cell Significance Index: -18.8000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4280
    Cell Significance Index: -2.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4379
    Cell Significance Index: -15.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4406
    Cell Significance Index: -4.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4422
    Cell Significance Index: -22.9700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4432
    Cell Significance Index: -5.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4586
    Cell Significance Index: -11.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4815
    Cell Significance Index: -10.0500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4855
    Cell Significance Index: -6.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4940
    Cell Significance Index: -10.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5188
    Cell Significance Index: -7.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5363
    Cell Significance Index: -25.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5522
    Cell Significance Index: -24.0100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.5866
    Cell Significance Index: -7.1100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5985
    Cell Significance Index: -11.7800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.6006
    Cell Significance Index: -3.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6097
    Cell Significance Index: -16.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6193
    Cell Significance Index: -15.8200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6619
    Cell Significance Index: -10.2400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.6660
    Cell Significance Index: -13.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NAP1L3 exhibits a high degree of sequence homology to NAP1, a protein essential for the assembly of nucleosomes, the fundamental units of chromatin. The NAP1L3 protein shares a similar modular structure, comprising a nucleosome-binding domain and a histone-binding domain, suggesting a conserved mechanism of chromatin assembly. Notably, NAP1L3 is predominantly expressed in GABAergic neurons, glycinergic neurons, and caudal ganglionic eminence-derived cortical interneurons, highlighting its role in the development and function of these neuronal populations. **Pathways and Functions:** NAP1L3 is implicated in several key pathways, including chromatin assembly, histone binding, and protein binding. Its protein interactions with histones, chromatin-modifying enzymes, and other chromatin-associated proteins suggest a role in regulating chromatin structure and function. Furthermore, NAP1L3's localization to the nucleus and its association with nucleosome assembly complexes imply a direct involvement in the assembly of nucleosomes and the regulation of gene expression. Our data suggest that NAP1L3 plays a critical role in maintaining the integrity of chromatin and ensuring proper gene expression in neurons. **Clinical Significance:** The identification of NAP1L3 as a key regulator of chromatin assembly and neuronal function has significant implications for our understanding of neurological disorders. Mutations in NAP1L3 have been linked to autism spectrum disorder (ASD), a complex neurodevelopmental disorder characterized by impaired social interaction and communication. Further research is needed to elucidate the mechanisms by which NAP1L3 dysfunction contributes to ASD and to explore potential therapeutic strategies targeting this gene. Additionally, NAP1L3's role in regulating chromatin assembly may have broader implications for our understanding of other neurodevelopmental disorders, such as schizophrenia and intellectual disability. In conclusion, NAP1L3 is a gene that has been extensively studied and remains a subject of ongoing research. Its role in regulating chromatin assembly and neuronal function has significant implications for our understanding of neurological disorders, particularly ASD. Further investigation into the mechanisms by which NAP1L3 dysfunction contributes to ASD and its potential therapeutic targets will be essential for advancing our understanding of this complex disorder.

Genular Protein ID: 947572721

Symbol: NP1L3_HUMAN

Name: Nucleosome assembly protein 1-like 3

UniProtKB Accession Codes:

Q99457 B2RCM0 O60788

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8976385

Title: Cloning, expression pattern and mapping to Xq of NAP1L3, a gene encoding a peptide homologous to human and yeast nucleosome assembly proteins.

PubMed ID: 8976385

DOI: 10.1159/000134435

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 506
  • Mass: 57593
  • Checksum: A63672CBC2F98A87
  • Sequence:
    • MAEADFKMVS EPVAHGVAEE EMASSTSDSG EESDSSSSSS STSDSSSSSS TSGSSSGSGS 
SSSSSGSTSS RSRLYRKKRV PEPSRRARRA PLGTNFVDRL PQAVRNRVQA LRNIQDECDK 
VDTLFLKAIH DLERKYAELN KPLYDRRFQI INAEYEPTEE ECEWNSEDEE FSSDEEVQDN 
TPSEMPPLEG EEEENPKENP EVKAEEKEVP KEIPEVKDEE KEVPKEIPEV KAEEKADSKD 
CMEATPEVKE DPKEVPQVKA DDKEQPKATE AKARAAVRET HKRVPEERLQ DSVDLKRARK 
GKPKREDPKG IPDYWLIVLK NVDKLGPMIQ KYDEPILKFL SDVSLKFSKP GQPVSYTFEF 
HFLPNPYFRN EVLVKTYIIK AKPDHNDPFF SWGWEIEDCK GCKIDWRRGK DVTVTTTQSR 
TTATGEIEIQ PRVVPNASFF NFFSPPEIPM IGKLEPREDA ILDEDFEIGQ ILHDNVILKS 
IYYYTGEVNG TYYQFGKHYG NKKYRK

Genular Protein ID: 2903597308

Symbol: Q8IYV1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IYV1

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 506
  • Mass: 57571
  • Checksum: B3977473F97C804D
  • Sequence:
    • MAEADFKMVS EPVAHGVAEE EMASSTSDSG EESDSSSSSS STSDSSSSSS TSGSSSGSGS 
SSSSSGSTSS RSRLYRKKRV PEPSRRARRA PLGTNFVDRL PQAVRNRVQA LRNIQDECDK 
VDTLFLKAIH DLERKYAELN KPLYDRRFQI INAEYEPTEE ECEWNSEDEE FSSDEEVQDN 
TPSEMPPLEG EEEENPKENP EVKAEEKEVP KEIPEVKDEE KEVAKEITEV KAEEKADSKD 
CMEATPEVKE DPKEVPQVKA DDKEQPKATE AKARAAVRET HKRVPEERLQ DSVDLKRARK 
GKPKREDPKG IPDYWLIVLK NVDKLGPMIQ KYDEPILKFL SDVSLKFSKP GQPVSYTFEF 
HFLPNPYFRN EVLVKTYIIK AKPDHNDPFF SWGWEIEDCK GCKIDWRRGK DVTVTTTQSR 
TTATGEIEIQ PRVVPNASFF NFFSPPEIPM IGKLEPREDA ILDEDFEIGQ ILHDNVILKS 
IYYYTGEVNG TYYQFGKHYG NKKYRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.