NCBP1 | ENSG00000136937 | NCBI 4686

Details for: NCBP1

Gene ID: 4686

Symbol: NCBP1

Ensembl ID: ENSG00000136937

Description: nuclear cap binding protein subunit 1

Associated with

Abortive elongation of hiv-1 transcript in the absence of tat
(R-HSA-167242)
Axon guidance
(R-HSA-422475)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Fgfr2 alternative splicing
(R-HSA-6803529)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gene expression (transcription)
(R-HSA-74160)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of non-coding rna
(R-HSA-194441)
Metabolism of rna
(R-HSA-8953854)
Mrna capping
(R-HSA-72086)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Processing of capped intronless pre-mrna
(R-HSA-75067)
Processing of intronless pre-mrnas
(R-HSA-77595)
Regulation of expression of slits and robos
(R-HSA-9010553)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription termination
(R-HSA-73856)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by robo receptors
(R-HSA-376176)
Signal transduction
(R-HSA-162582)
Slbp dependent processing of replication-dependent histone pre-mrnas
(R-HSA-77588)
Slbp independent processing of histone pre-mrnas
(R-HSA-111367)
Snrnp assembly
(R-HSA-191859)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Transcription of the hiv genome
(R-HSA-167172)
Transport of mature mrna derived from an intron-containing transcript
(R-HSA-159236)
Transport of mature mrna derived from an intronless transcript
(R-HSA-159231)
Transport of mature mrnas derived from intronless transcripts
(R-HSA-159234)
Transport of mature transcript to cytoplasm
(R-HSA-72202)
Transport of the slbp dependant mature mrna
(R-HSA-159230)
Transport of the slbp independent mature mrna
(R-HSA-159227)
Viral infection pathways
(R-HSA-9824446)
7-methylguanosine mrna capping
(GO:0006370)
Alternative mrna splicing, via spliceosome
(GO:0000380)
Cap-dependent translational initiation
(GO:0002191)
Cytoplasm
(GO:0005737)
Defense response to virus
(GO:0051607)
Histone mrna metabolic process
(GO:0008334)
Mirna-mediated post-transcriptional gene silencing
(GO:0035195)
Molecular adaptor activity
(GO:0060090)
Mrna 3'-end processing
(GO:0031124)
Mrna binding
(GO:0003729)
Mrna export from nucleus
(GO:0006406)
Mrna metabolic process
(GO:0016071)
Mrna splicing, via spliceosome
(GO:0000398)
Mrna transcription by rna polymerase ii
(GO:0042789)
Nuclear-transcribed mrna catabolic process, nonsense-mediated decay
(GO:0000184)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of mrna 3'-end processing
(GO:0031442)
Positive regulation of mrna splicing, via spliceosome
(GO:0048026)
Positive regulation of rna binding
(GO:1905216)
Positive regulation of transcription elongation by rna polymerase ii
(GO:0032968)
Primary mirna processing
(GO:0031053)
Protein binding
(GO:0005515)
Regulation of mrna processing
(GO:0050684)
Regulation of translational initiation
(GO:0006446)
Regulatory ncrna-mediated post-transcriptional gene silencing
(GO:0035194)
Rna 7-methylguanosine cap binding
(GO:0000340)
Rna binding
(GO:0003723)
Rna cap binding
(GO:0000339)
Rna catabolic process
(GO:0006401)
Rna splicing
(GO:0008380)
Snrna export from nucleus
(GO:0006408)
Spliceosomal complex assembly
(GO:0000245)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 128.5157
Cell Significance Index: -19.9900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 81.8472
Cell Significance Index: -20.7600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 49.6269
Cell Significance Index: -23.4300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 48.5161
Cell Significance Index: -19.7100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 34.9020
Cell Significance Index: -23.4200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 20.6757
Cell Significance Index: -19.7400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 17.6811
Cell Significance Index: -21.8000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.2684
Cell Significance Index: -22.1500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.8979
Cell Significance Index: -18.1200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.6132
Cell Significance Index: -22.1500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.9706
Cell Significance Index: -8.6900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1809
Cell Significance Index: 1066.2500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9817
Cell Significance Index: 196.9200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9663
Cell Significance Index: 105.1000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9091
Cell Significance Index: 54.5800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8784
Cell Significance Index: 142.8600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.8028
Cell Significance Index: 45.0500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7996
Cell Significance Index: 10.9100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.7446
Cell Significance Index: 19.1400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7270
Cell Significance Index: 144.2700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.5917
Cell Significance Index: 14.7900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5507
Cell Significance Index: 380.9100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.5015
Cell Significance Index: 58.4400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4344
Cell Significance Index: 155.8100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4186
Cell Significance Index: 18.5200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4152
Cell Significance Index: 31.8600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.3929
Cell Significance Index: 14.8800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3618
Cell Significance Index: 22.8000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3331
Cell Significance Index: 63.4000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3258
Cell Significance Index: 8.7000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3251
Cell Significance Index: 19.9800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3250
Cell Significance Index: 9.3700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3185
Cell Significance Index: 8.9000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3102
Cell Significance Index: 6.7200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2844
Cell Significance Index: 19.6700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2839
Cell Significance Index: 51.1900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2482
Cell Significance Index: 11.2500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2455
Cell Significance Index: 30.1900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2344
Cell Significance Index: 27.6400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2150
Cell Significance Index: 11.1700
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1988
Cell Significance Index: 3.8800
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1889
Cell Significance Index: 103.1500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1850
Cell Significance Index: 25.4000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1474
Cell Significance Index: 9.9100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1440
Cell Significance Index: 5.0600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1314
Cell Significance Index: 6.8500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1024
Cell Significance Index: 157.6400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0938
Cell Significance Index: 41.4700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0773
Cell Significance Index: 105.1200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0688
Cell Significance Index: 6.8100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0677
Cell Significance Index: 1.1600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0631
Cell Significance Index: 116.2900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0547
Cell Significance Index: 2.5500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0537
Cell Significance Index: 101.0200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0505
Cell Significance Index: 3.2600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0366
Cell Significance Index: 0.9800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0324
Cell Significance Index: 20.5500
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0223
Cell Significance Index: 0.5400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0126
Cell Significance Index: 5.7100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0189
Cell Significance Index: -13.8300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0213
Cell Significance Index: -15.7600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0217
Cell Significance Index: -3.1600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0222
Cell Significance Index: -16.7700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0343
Cell Significance Index: -0.7300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0347
Cell Significance Index: -19.5900
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0365
Cell Significance Index: -0.8000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0383
Cell Significance Index: -4.9100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0394
Cell Significance Index: -2.7900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0403
Cell Significance Index: -25.1900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0460
Cell Significance Index: -7.8600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0468
Cell Significance Index: -2.2000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0632
Cell Significance Index: -6.4600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0656
Cell Significance Index: -18.8700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1043
Cell Significance Index: -11.9500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1097
Cell Significance Index: -2.9900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1106
Cell Significance Index: -23.3100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1149
Cell Significance Index: -14.8400
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1235
Cell Significance Index: -2.6400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1339
Cell Significance Index: -4.2900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1511
Cell Significance Index: -2.1700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1612
Cell Significance Index: -4.6000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1718
Cell Significance Index: -17.8900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1978
Cell Significance Index: -14.7400
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1985
Cell Significance Index: -2.9300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2574
Cell Significance Index: -7.5600
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.2615
Cell Significance Index: -6.3800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2649
Cell Significance Index: -13.9100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2653
Cell Significance Index: -21.0100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2657
Cell Significance Index: -16.2900
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2841
Cell Significance Index: -4.7900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2958
Cell Significance Index: -10.2800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3016
Cell Significance Index: -7.9300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3274
Cell Significance Index: -5.4800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3362
Cell Significance Index: -8.5900
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3389
Cell Significance Index: -4.0400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3430
Cell Significance Index: -11.2300
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3699
Cell Significance Index: -11.7800
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3708
Cell Significance Index: -7.8700
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4055
Cell Significance Index: -8.1400
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.4371
Cell Significance Index: -6.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** NCBP1 is a highly conserved gene that is expressed in a wide range of cell types, including germ cells, lens epithelial cells, and neurons. It is a member of the cap-binding protein family and is characterized by its ability to bind to the 5' cap of mRNA, which is essential for its translation. NCBP1 is also involved in the regulation of alternative splicing, which is a critical process in the generation of diverse protein isoforms. **Pathways and Functions** NCBP1 is involved in several key pathways, including: 1. **mRNA capping**: NCBP1 plays a crucial role in the capping of mRNA, which is essential for its translation. The cap-binding complex, which includes NCBP1, recognizes the 5' cap of mRNA and recruits other factors to facilitate translation. 2. **Alternative splicing**: NCBP1 is involved in the regulation of alternative splicing, which is a critical process in the generation of diverse protein isoforms. The NCBC complex, which includes NCBP1, recognizes specific sequences in the pre-mRNA and recruits splicing factors to facilitate the splicing of introns. 3. **Translation initiation**: NCBP1 is involved in the regulation of translation initiation, which is the process by which mRNA is translated into protein. The NCBC complex, which includes NCBP1, recognizes the 5' cap of mRNA and recruits ribosomes to facilitate translation. 4. **mRNA export**: NCBP1 is involved in the regulation of mRNA export, which is the process by which mRNA is exported from the nucleus to the cytoplasm. The NCBC complex, which includes NCBP1, recognizes specific sequences in the pre-mRNA and recruits export factors to facilitate the export of mRNA. **Clinical Significance** Dysregulation of NCBP1 has been implicated in various diseases, including: 1. **Cancer**: NCBP1 has been shown to be overexpressed in several types of cancer, including breast cancer and lung cancer. Its dysregulation is thought to contribute to the development and progression of cancer. 2. **Neurological disorders**: NCBP1 has been shown to be involved in the regulation of alternative splicing, which is a critical process in the generation of diverse protein isoforms. Dysregulation of NCBP1 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: NCBP1 has been shown to be involved in the regulation of mRNA capping, which is essential for the translation of viral mRNAs. Dysregulation of NCBP1 has been implicated in the development of viral infections, including HIV and influenza. In conclusion, NCBP1 is a critical component of the nuclear cap binding complex, which plays a pivotal role in regulating mRNA processing and translation. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and infectious diseases. Further research is needed to fully understand the role of NCBP1 in these diseases and to develop effective therapeutic strategies to target its dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Nuclear cap-binding protein subunit 1

Genular Protein ID: 3252822763

Symbol: NCBP1_HUMAN

Name: Nuclear cap-binding protein subunit 1

UniProtKB Accession Codes:

Q09161 B2R718 Q59G76 Q5T1V0 Q5T7X2

Database IDs:

Citations:

PubMed ID: 8069914

Title: A nuclear cap binding protein complex involved in pre-mRNA splicing.

PubMed ID: 8069914

DOI: 10.1016/0092-8674(94)90530-4

PubMed ID: 7937105

Title: Cloning of a complementary DNA encoding an 80 kilodalton nuclear cap binding protein.

PubMed ID: 7937105

DOI: 10.1093/nar/22.19.3861

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7651522

Title: A cap-binding protein complex mediating U snRNA export.

PubMed ID: 7651522

DOI: 10.1038/376709a0

PubMed ID: 9111328

Title: Interaction between the human nuclear cap-binding protein complex and hnRNP F.

PubMed ID: 9111328

DOI: 10.1128/mcb.17.5.2587

PubMed ID: 10973943

Title: Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex.

PubMed ID: 10973943

DOI: 10.1074/jbc.c000482200

PubMed ID: 11551508

Title: Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20.

PubMed ID: 11551508

DOI: 10.1016/s0092-8674(01)00475-5

PubMed ID: 11340157

Title: Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m(7) guanosine cap.

PubMed ID: 11340157

DOI: 10.1128/mcb.21.11.3632-3641.2001

PubMed ID: 12093754

Title: The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.

PubMed ID: 12093754

DOI: 10.1093/emboj/cdf345

PubMed ID: 15059963

Title: The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex.

PubMed ID: 15059963

DOI: 10.1101/gad.1170204

PubMed ID: 15361857

Title: eIF4G is required for the pioneer round of translation in mammalian cells.

PubMed ID: 15361857

DOI: 10.1038/nsmb824

PubMed ID: 16186820

Title: CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells.

PubMed ID: 16186820

DOI: 10.1038/nsmb995

PubMed ID: 17190602

Title: Human mRNA export machinery recruited to the 5' end of mRNA.

PubMed ID: 17190602

DOI: 10.1016/j.cell.2006.10.044

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16317009

Title: Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC).

PubMed ID: 16317009

DOI: 10.1074/jbc.m508590200

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 17873884

Title: Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA.

PubMed ID: 17873884

DOI: 10.1038/nsmb1297

PubMed ID: 18423201

Title: SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.

PubMed ID: 18423201

DOI: 10.1016/j.cell.2008.02.031

PubMed ID: 18369367

Title: NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.

PubMed ID: 18369367

DOI: 10.1038/embor.2008.36

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19632182

Title: Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.

PubMed ID: 19632182

DOI: 10.1016/j.cell.2009.04.046

PubMed ID: 19648179

Title: A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation.

PubMed ID: 19648179

DOI: 10.1101/gad.1823409

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25220460

Title: The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.

PubMed ID: 25220460

DOI: 10.1016/j.celrep.2014.08.020

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26382858

Title: mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.

PubMed ID: 26382858

DOI: 10.1038/ncomms9192

PubMed ID: 27117702

Title: The m(6)A methyltransferase METTL3 promotes translation in human cancer cells.

PubMed ID: 27117702

DOI: 10.1016/j.molcel.2016.03.021

PubMed ID: 27871484

Title: Identification of a nuclear exosome decay pathway for processed transcripts.

PubMed ID: 27871484

DOI: 10.1016/j.molcel.2016.09.025

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30842217

Title: NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.

PubMed ID: 30842217

DOI: 10.1101/gad.322602.118

PubMed ID: 34564892

Title: Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia.

PubMed ID: 34564892

DOI: 10.1002/ana.26228

PubMed ID: 11545740

Title: Crystal structure of the human nuclear cap binding complex.

PubMed ID: 11545740

DOI: 10.1016/s1097-2765(01)00299-4

PubMed ID: 12374755

Title: Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex.

PubMed ID: 12374755

DOI: 10.1093/emboj/cdf538

PubMed ID: 12434151

Title: Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.

PubMed ID: 12434151

DOI: 10.1038/nsb874

Sequence Information:

Length: 790
Mass: 91839
Checksum: F10DE7B9D16FDA0B
Sequence:

MSRRRHSDEN DGGQPHKRRK TSDANETEDH LESLICKVGE KSACSLESNL EGLAGVLEAD 
LPNYKSKILR LLCTVARLLP EKLTIYTTLV GLLNARNYNF GGEFVEAMIR QLKESLKANN 
YNEAVYLVRF LSDLVNCHVI AAPSMVAMFE NFVSVTQEED VPQVRRDWYV YAFLSSLPWV 
GKELYEKKDA EMDRIFANTE SYLKRRQKTH VPMLQVWTAD KPHPQEEYLD CLWAQIQKLK 
KDRWQERHIL RPYLAFDSIL CEALQHNLPP FTPPPHTEDS VYPMPRVIFR MFDYTDDPEG 
PVMPGSHSVE RFVIEENLHC IIKSHWKERK TCAAQLVSYP GKNKIPLNYH IVEVIFAELF 
QLPAPPHIDV MYTTLLIELC KLQPGSLPQV LAQATEMLYM RLDTMNTTCV DRFINWFSHH 
LSNFQFRWSW EDWSDCLSQD PESPKPKFVR EVLEKCMRLS YHQRILDIVP PTFSALCPAN 
PTCIYKYGDE SSNSLPGHSV ALCLAVAFKS KATNDEIFSI LKDVPNPNQD DDDDEGFSFN 
PLKIEVFVQT LLHLAAKSFS HSFSALAKFH EVFKTLAESD EGKLHVLRVM FEVWRNHPQM 
IAVLVDKMIR TQIVDCAAVA NWIFSSELSR DFTRLFVWEI LHSTIRKMNK HVLKIQKELE 
EAKEKLARQH KRRSDDDDRS SDRKDGVLEE QIERLQEKVE SAQSEQKNLF LVIFQRFIMI 
LTEHLVRCET DGTSVLTPWY KNCIERLQQI FLQHHQIIQQ YMVTLENLLF TAELDPHILA 
VFQQFCALQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NCBP1

Associated with

Cells (max top 100)

Other Information

A nuclear cap binding protein complex involved in pre-mRNA splicing. PubMed ID: 8069914

Cloning of a complementary DNA encoding an 80 kilodalton nuclear cap binding protein. PubMed ID: 7937105

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A cap-binding protein complex mediating U snRNA export. PubMed ID: 7651522

Interaction between the human nuclear cap-binding protein complex and hnRNP F. PubMed ID: 9111328

Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex. PubMed ID: 10973943

Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. PubMed ID: 11551508

Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m(7) guanosine cap. PubMed ID: 11340157

The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. PubMed ID: 12093754

The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex. PubMed ID: 15059963

eIF4G is required for the pioneer round of translation in mammalian cells. PubMed ID: 15361857

CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. PubMed ID: 16186820

Human mRNA export machinery recruited to the 5' end of mRNA. PubMed ID: 17190602

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC). PubMed ID: 16317009

Molecular composition of IMP1 ribonucleoprotein granules. PubMed ID: 17289661

Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. PubMed ID: 17873884

SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. PubMed ID: 18423201

NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. PubMed ID: 18369367

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. PubMed ID: 19632182

A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation. PubMed ID: 19648179

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex. PubMed ID: 25220460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. PubMed ID: 26382858

The m(6)A methyltransferase METTL3 promotes translation in human cancer cells. PubMed ID: 27117702

Identification of a nuclear exosome decay pathway for processed transcripts. PubMed ID: 27871484

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction. PubMed ID: 30842217

Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia. PubMed ID: 34564892

Crystal structure of the human nuclear cap binding complex. PubMed ID: 11545740

Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex. PubMed ID: 12374755

Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. PubMed ID: 12434151