Details for: NEK1

Gene ID: 4750

Symbol: NEK1

Ensembl ID: ENSG00000137601

Description: NIMA related kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 320.3570
    Cell Significance Index: -49.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 202.8833
    Cell Significance Index: -51.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 114.1017
    Cell Significance Index: -53.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 99.5429
    Cell Significance Index: -40.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.1321
    Cell Significance Index: -53.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.2417
    Cell Significance Index: -40.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.7692
    Cell Significance Index: -50.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.6643
    Cell Significance Index: -53.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.3739
    Cell Significance Index: -29.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1717
    Cell Significance Index: 435.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0920
    Cell Significance Index: 750.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9702
    Cell Significance Index: 151.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.9698
    Cell Significance Index: 38.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7772
    Cell Significance Index: 78.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.7471
    Cell Significance Index: 66.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5303
    Cell Significance Index: 85.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.4324
    Cell Significance Index: 990.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3284
    Cell Significance Index: 81.6500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2876
    Cell Significance Index: 15.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1683
    Cell Significance Index: 28.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9718
    Cell Significance Index: 21.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.8870
    Cell Significance Index: 22.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8623
    Cell Significance Index: 85.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8473
    Cell Significance Index: 168.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8032
    Cell Significance Index: 725.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6111
    Cell Significance Index: 1150.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5914
    Cell Significance Index: 17.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5793
    Cell Significance Index: 38.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5705
    Cell Significance Index: 14.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5178
    Cell Significance Index: 84.2100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4546
    Cell Significance Index: 9.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4526
    Cell Significance Index: 12.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4462
    Cell Significance Index: 283.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3786
    Cell Significance Index: 17.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3669
    Cell Significance Index: 45.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3592
    Cell Significance Index: 39.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2554
    Cell Significance Index: 46.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2220
    Cell Significance Index: 409.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2069
    Cell Significance Index: 318.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1953
    Cell Significance Index: 106.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1705
    Cell Significance Index: 23.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1668
    Cell Significance Index: 4.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1631
    Cell Significance Index: 31.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1546
    Cell Significance Index: 70.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1435
    Cell Significance Index: 2.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1056
    Cell Significance Index: 6.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0999
    Cell Significance Index: 12.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0608
    Cell Significance Index: 82.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0533
    Cell Significance Index: 1.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0313
    Cell Significance Index: 1.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0099
    Cell Significance Index: 0.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0042
    Cell Significance Index: -1.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0241
    Cell Significance Index: -3.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0295
    Cell Significance Index: -21.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0319
    Cell Significance Index: -23.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0352
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0401
    Cell Significance Index: -25.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0527
    Cell Significance Index: -2.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0552
    Cell Significance Index: -31.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0711
    Cell Significance Index: -53.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0738
    Cell Significance Index: -1.9700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1049
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1220
    Cell Significance Index: -20.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1426
    Cell Significance Index: -30.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1489
    Cell Significance Index: -17.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1570
    Cell Significance Index: -45.1800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1818
    Cell Significance Index: -2.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2225
    Cell Significance Index: -22.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2250
    Cell Significance Index: -11.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2301
    Cell Significance Index: -10.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2443
    Cell Significance Index: -25.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2630
    Cell Significance Index: -33.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3089
    Cell Significance Index: -4.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3284
    Cell Significance Index: -20.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3652
    Cell Significance Index: -17.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4058
    Cell Significance Index: -46.4900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4065
    Cell Significance Index: -5.1300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.4382
    Cell Significance Index: -4.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4424
    Cell Significance Index: -9.3900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4455
    Cell Significance Index: -6.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4499
    Cell Significance Index: -23.6200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4513
    Cell Significance Index: -7.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4575
    Cell Significance Index: -29.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4891
    Cell Significance Index: -8.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4925
    Cell Significance Index: -56.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5126
    Cell Significance Index: -6.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5366
    Cell Significance Index: -42.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5537
    Cell Significance Index: -41.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5678
    Cell Significance Index: -15.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5996
    Cell Significance Index: -11.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6286
    Cell Significance Index: -44.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6417
    Cell Significance Index: -39.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6931
    Cell Significance Index: -14.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7282
    Cell Significance Index: -14.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7374
    Cell Significance Index: -25.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7721
    Cell Significance Index: -24.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7941
    Cell Significance Index: -26.0000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8135
    Cell Significance Index: -11.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8694
    Cell Significance Index: -27.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Kinase Activity:** NEK1 is a serine/threonine-protein kinase, possessing a conserved kinase domain that enables it to phosphorylate and modulate the activity of downstream targets. 2. **Cell Cycle Regulation:** NEK1 is involved in regulating the cell cycle, particularly in the G2/M phase, where it influences the progression of cells from the G2 phase to mitosis. 3. **Centrosome Organization:** NEK1 is essential for maintaining centrosome structure and function, ensuring proper spindle formation and chromosome segregation during cell division. 4. **Protein Phosphorylation:** NEK1's kinase activity is responsible for phosphorylating and regulating the activity of numerous proteins, including those involved in cell cycle progression, centrosome organization, and protein degradation. **Pathways and Functions:** 1. **14-3-3 Protein Binding:** NEK1 interacts with 14-3-3 proteins, which modulate its kinase activity and regulate its localization to the centrosome. 2. **ATP Binding:** NEK1's kinase activity is dependent on ATP binding, which provides the energy required for phosphorylation reactions. 3. **Cell Division:** NEK1 plays a critical role in regulating the cell division process, ensuring proper spindle formation and chromosome segregation. 4. **Centriolar Satellite Assembly:** NEK1 is involved in the assembly of centriolar satellites, which are critical for the formation of the centrosome and spindle apparatus. **Clinical Significance:** 1. **Cancer Research:** NEK1 has been implicated in various types of cancer, including breast, lung, and colon cancer, where its overexpression is associated with tumor progression and poor prognosis. 2. **Neurological Disorders:** NEK1 has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where its dysregulation is thought to contribute to disease pathogenesis. 3. **Neurodevelopmental Disorders:** NEK1 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder, where its dysregulation is thought to contribute to abnormal brain development and function. In conclusion, NEK1 is a multifunctional kinase that plays a critical role in regulating various cellular processes, including cell cycle progression, centrosome organization, and protein phosphorylation. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and neurodevelopmental disorders. Further research is needed to fully elucidate the mechanisms by which NEK1 regulates cellular processes and to explore its therapeutic potential in disease prevention and treatment.

Genular Protein ID: 1569804595

Symbol: NEK1_HUMAN

Name: Serine/threonine-protein kinase Nek1

UniProtKB Accession Codes:

Q96PY6 G5E9Z3 Q05DG5 Q14CB7 Q5H9T1 Q6PIB8 Q96SS2 Q9H6P7 Q9Y594

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 12 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11572484

Title: Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.

PubMed ID: 11572484

DOI: 10.1093/dnares/8.4.179

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 15604234

Title: NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response.

PubMed ID: 15604234

DOI: 10.1158/0008-5472.can-04-2243

PubMed ID: 18843199

Title: Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control.

PubMed ID: 18843199

DOI: 10.4161/cc.7.20.6815

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20230784

Title: Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1.

PubMed ID: 20230784

DOI: 10.1016/j.bbrc.2010.03.077

PubMed ID: 21211617

Title: NEK1 mutations cause short-rib polydactyly syndrome type majewski.

PubMed ID: 21211617

DOI: 10.1016/j.ajhg.2010.12.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26167768

Title: An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.

PubMed ID: 26167768

DOI: 10.1038/ncb3201

PubMed ID: 27530628

Title: Compound heterozygous NEK1 variants in two siblings with oral-facial-digital syndrome type II (Mohr syndrome).

PubMed ID: 27530628

DOI: 10.1038/ejhg.2016.103

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 22499340

Title: NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases.

PubMed ID: 22499340

DOI: 10.1136/jmedgenet-2011-100717

PubMed ID: 26945885

Title: NEK1 mutations in familial amyotrophic lateral sclerosis.

PubMed ID: 26945885

DOI: 10.1093/brain/aww033

PubMed ID: 27455347

Title: NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

PubMed ID: 27455347

DOI: 10.1038/ng.3626

Sequence Information:

  • Length: 1258
  • Mass: 142828
  • Checksum: 339C4BFA56612530
  • Sequence:
    • MEKYVRLQKI GEGSFGKAIL VKSTEDGRQY VIKEINISRM SSKEREESRR EVAVLANMKH 
PNIVQYRESF EENGSLYIVM DYCEGGDLFK RINAQKGVLF QEDQILDWFV QICLALKHVH 
DRKILHRDIK SQNIFLTKDG TVQLGDFGIA RVLNSTVELA RTCIGTPYYL SPEICENKPY 
NNKSDIWALG CVLYELCTLK HAFEAGSMKN LVLKIISGSF PPVSLHYSYD LRSLVSQLFK 
RNPRDRPSVN SILEKGFIAK RIEKFLSPQL IAEEFCLKTF SKFGSQPIPA KRPASGQNSI 
SVMPAQKITK PAAKYGIPLA YKKYGDKKLH EKKPLQKHKQ AHQTPEKRVN TGEERRKISE 
EAARKRRLEF IEKEKKQKDQ IISLMKAEQM KRQEKERLER INRAREQGWR NVLSAGGSGE 
VKAPFLGSGG TIAPSSFSSR GQYEHYHAIF DQMQQQRAED NEAKWKREIY GRGLPERGIL 
PGVRPGFPYG AAGHHHFPDA DDIRKTLKRL KAVSKQANAN RQKGQLAVER AKQVEEFLQR 
KREAMQNKAR AEGHMVYLAR LRQIRLQNFN ERQQIKAKLR GEKKEANHSE GQEGSEEADM 
RRKKIESLKA HANARAAVLK EQLERKRKEA YEREKKVWEE HLVAKGVKSS DVSPPLGQHE 
TGGSPSKQQM RSVISVTSAL KEVGVDSSLT DTRETSEEMQ KTNNAISSKR EILRRLNENL 
KAQEDEKGKQ NLSDTFEINV HEDAKEHEKE KSVSSDRKKW EAGGQLVIPL DELTLDTSFS 
TTERHTVGEV IKLGPNGSPR RAWGKSPTDS VLKILGEAEL QLQTELLENT TIRSEISPEG 
EKYKPLITGE KKVQCISHEI NPSAIVDSPV ETKSPEFSEA SPQMSLKLEG NLEEPDDLET 
EILQEPSGTN KDESLPCTIT DVWISEEKET KETQSADRIT IQENEVSEDG VSSTVDQLSD 
IHIEPGTNDS QHSKCDVDKS VQPEPFFHKV VHSEHLNLVP QVQSVQCSPE ESFAFRSHSH 
LPPKNKNKNS LLIGLSTGLF DANNPKMLRT CSLPDLSKLF RTLMDVPTVG DVRQDNLEID 
EIEDENIKEG PSDSEDIVFE ETDTDLQELQ ASMEQLLREQ PGEEYSEEEE SVLKNSDVEP 
TANGTDVADE DDNPSSESAL NEEWHSDNSD GEIASECECD SVFNHLEELR LHLEQEMGFE 
KFFEVYEKIK AIHEDEDENI EICSKIVQNI LGNEHQHLYA KILHLVMADG AYQEDNDE

Genular Protein ID: 3422972183

Symbol: Q5JXL9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5JXL9

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 11 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 2 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 6 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 142
  • Mass: 16579
  • Checksum: AF3814256AE401EB
  • Sequence:
    • MEKYVRLQKI GEGSFGKAIL VKSTEDGRQY VIKEINISRM SSKEREESRR EVAVLANMKH 
PNIVQYRESF EENGSLYIVM DYCEGGDLFK RINAQKGVLF QEDQILDWFV QICLALKHVH 
DRKILHRDIK SQNIFLTKDG TV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.