Details for: NF2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 154.5531
Cell Significance Index: -24.0400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 98.5636
Cell Significance Index: -25.0000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 56.5955
Cell Significance Index: -26.7200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 54.7929
Cell Significance Index: -22.2600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 48.8933
Cell Significance Index: -25.1500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 23.3885
Cell Significance Index: -22.3300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 21.5012
Cell Significance Index: -26.5100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.4704
Cell Significance Index: -25.3700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.7891
Cell Significance Index: -26.7900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.5835
Cell Significance Index: -12.2200 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 3.2072
Cell Significance Index: 52.8500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.2313
Cell Significance Index: 16.8000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1649
Cell Significance Index: 1051.7900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0833
Cell Significance Index: 217.3000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8196
Cell Significance Index: 162.6600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6929
Cell Significance Index: 479.2100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6852
Cell Significance Index: 111.4500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.6169
Cell Significance Index: 71.8900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6169
Cell Significance Index: 221.2600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5118
Cell Significance Index: 50.6300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4688
Cell Significance Index: 13.1000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4235
Cell Significance Index: 32.5000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.4143
Cell Significance Index: 11.1000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3464
Cell Significance Index: 62.4500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3348
Cell Significance Index: 8.3700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3087
Cell Significance Index: 17.3200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.3059
Cell Significance Index: 13.5300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2944
Cell Significance Index: 36.2100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.2793
Cell Significance Index: 7.9700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2726
Cell Significance Index: 148.8500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2519
Cell Significance Index: 9.5400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2497
Cell Significance Index: 47.5200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2360
Cell Significance Index: 5.0500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2336
Cell Significance Index: 6.7300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2145
Cell Significance Index: 14.8400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1606
Cell Significance Index: 22.0600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1598
Cell Significance Index: 3.5000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1521
Cell Significance Index: 7.0900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1505
Cell Significance Index: 3.2600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1285
Cell Significance Index: 56.8300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1111
Cell Significance Index: 5.2200 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0801
Cell Significance Index: 10.3500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0706
Cell Significance Index: 1.2100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0527
Cell Significance Index: 2.3900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0471
Cell Significance Index: 3.1700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0376
Cell Significance Index: 70.8500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0362
Cell Significance Index: 1.8800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0258
Cell Significance Index: 3.3100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0225
Cell Significance Index: 1.3800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0202
Cell Significance Index: 31.1600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0144
Cell Significance Index: 0.9100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0109
Cell Significance Index: 20.0800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0093
Cell Significance Index: 4.2200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0084
Cell Significance Index: 5.3400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0048
Cell Significance Index: 0.1700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0047
Cell Significance Index: -6.3900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0139
Cell Significance Index: -10.1700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0161
Cell Significance Index: -2.7500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0173
Cell Significance Index: -0.9000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0184
Cell Significance Index: -1.3700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0223
Cell Significance Index: -16.8600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0256
Cell Significance Index: -18.9500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0301
Cell Significance Index: -4.3700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0305
Cell Significance Index: -1.9700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0431
Cell Significance Index: -24.3000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0471
Cell Significance Index: -5.5600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0480
Cell Significance Index: -2.5200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0490
Cell Significance Index: -30.5900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0793
Cell Significance Index: -22.8200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0801
Cell Significance Index: -2.1800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0826
Cell Significance Index: -8.4400 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1035
Cell Significance Index: -2.0200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1112
Cell Significance Index: -2.9700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1131
Cell Significance Index: -12.9600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1175
Cell Significance Index: -3.0200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1193
Cell Significance Index: -8.4400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1383
Cell Significance Index: -29.1300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1983
Cell Significance Index: -6.3500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2113
Cell Significance Index: -4.5000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2259
Cell Significance Index: -3.7800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2360
Cell Significance Index: -24.5700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2596
Cell Significance Index: -20.5600 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.3041
Cell Significance Index: -4.4900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3342
Cell Significance Index: -20.4900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3427
Cell Significance Index: -8.2200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3553
Cell Significance Index: -7.5400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3677
Cell Significance Index: -10.5400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.3741
Cell Significance Index: -4.6400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3742
Cell Significance Index: -10.9900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4127
Cell Significance Index: -14.3400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4228
Cell Significance Index: -5.0400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.4371
Cell Significance Index: -6.2600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.4496
Cell Significance Index: -4.1400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4681
Cell Significance Index: -14.9100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4746
Cell Significance Index: -15.5400 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4770
Cell Significance Index: -10.3100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5387
Cell Significance Index: -18.8700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.5836
Cell Significance Index: -11.5400 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.5853
Cell Significance Index: -11.7500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5883
Cell Significance Index: -15.0300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2106077742
Symbol: MERL_HUMAN
Name: Merlin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8453669
Title: A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.
PubMed ID: 8453669
PubMed ID: 8379998
Title: Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2.
PubMed ID: 8379998
DOI: 10.1038/363515a0
PubMed ID: 9817927
PubMed ID: 10401006
Title: Novel alternatively spliced isoforms of the neurofibromatosis type 2 tumor suppressor are targeted to the nucleus and cytoplasmic granules.
PubMed ID: 10401006
DOI: 10.1093/hmg/8.8.1561
PubMed ID: 11827459
Title: Multiple transcription initiation sites, alternative splicing, and differential polyadenylation contribute to the complexity of human neurofibromatosis 2 transcripts.
PubMed ID: 11827459
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9430655
Title: NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins.
PubMed ID: 9430655
PubMed ID: 10861283
Title: The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate.
PubMed ID: 10861283
PubMed ID: 10669747
Title: Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins.
PubMed ID: 10669747
PubMed ID: 12136076
Title: Neurofibromatosis 2 and malignant mesothelioma.
PubMed ID: 12136076
DOI: 10.1212/wnl.59.2.290
PubMed ID: 15541357
Title: MAP, a protein interacting with a tumor suppressor, merlin, through the run domain.
PubMed ID: 15541357
PubMed ID: 15598747
Title: Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L.
PubMed ID: 15598747
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18332868
Title: VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.
PubMed ID: 18332868
DOI: 10.1038/onc.2008.44
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19144871
Title: Identification of erythrocyte p55/MPP1 as a binding partner of NF2 tumor suppressor protein/Merlin.
PubMed ID: 19144871
DOI: 10.3181/0809-rm-275
PubMed ID: 20178741
Title: Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.
PubMed ID: 20178741
PubMed ID: 20159598
Title: Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded.
PubMed ID: 20159598
PubMed ID: 20159599
Title: Kibra Is a regulator of the Salvador/Warts/Hippo signaling network.
PubMed ID: 20159599
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21167305
Title: Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus.
PubMed ID: 21167305
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 11856822
Title: The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product.
PubMed ID: 11856822
PubMed ID: 8230593
Title: DNA diagnosis of neurofibromatosis 2. Altered coding sequence of the merlin tumor suppressor in an extended pedigree.
PubMed ID: 8230593
PubMed ID: 7913580
Title: Mutational analysis of patients with neurofibromatosis 2.
PubMed ID: 7913580
PubMed ID: 8004107
Title: Somatic NF2 gene mutations in familial and non-familial vestibular schwannoma.
PubMed ID: 8004107
DOI: 10.1093/hmg/3.2.347
PubMed ID: 8012353
Title: Exon scanning for mutation of the NF2 gene in schwannomas.
PubMed ID: 8012353
DOI: 10.1093/hmg/3.3.413
PubMed ID: 8081368
Title: Germline mutations in the neurofibromatosis type 2 tumour suppressor gene.
PubMed ID: 8081368
DOI: 10.1093/hmg/3.5.813
PubMed ID: 7951231
Title: Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas.
PubMed ID: 7951231
DOI: 10.1093/hmg/3.6.885
PubMed ID: 8162073
Title: Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types.
PubMed ID: 8162073
DOI: 10.1038/ng0294-185
PubMed ID: 7759081
Title: Eleven novel mutations in the NF2 tumour suppressor gene.
PubMed ID: 7759081
DOI: 10.1007/bf00223872
PubMed ID: 7666400
Title: Diagnostic issues in a family with late onset type 2 neurofibromatosis.
PubMed ID: 7666400
DOI: 10.1136/jmg.32.6.470
PubMed ID: 8566958
Title: A missense mutation in the NF2 gene results in moderate and mild clinical phenotypes of neurofibromatosis type 2.
PubMed ID: 8566958
DOI: 10.1007/bf02265270
PubMed ID: 8655144
Title: Screening for mutations in the neurofibromatosis type 2 (NF2) gene in sporadic meningiomas.
PubMed ID: 8655144
DOI: 10.1007/bf02281874
PubMed ID: 8698340
Title: Mutational spectrum in the neurofibromatosis type 2 gene in sporadic and familial schwannomas.
PubMed ID: 8698340
PubMed ID: 9643284
Title: Genotype/phenotype correlations in type 2 neurofibromatosis (NF2): evidence for more severe disease associated with truncating mutations.
PubMed ID: 9643284
DOI: 10.1136/jmg.35.6.450
PubMed ID: 10090912
Title: Germ-line NF2 mutations and disease severity in neurofibromatosis type 2 patients with retinal abnormalities.
PubMed ID: 10090912
DOI: 10.1086/302338
PubMed ID: 10790209
Title: Detection of novel NF2 mutations by an RNA mismatch cleavage method.
PubMed ID: 10790209
DOI: 10.1002/(sici)1098-1004(200005)15:5<474::aid-humu9>3.0.co;2-7
PubMed ID: 12709270
Title: Preimplantation diagnosis for neurofibromatosis.
PubMed ID: 12709270
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 20445339
Title: Molecular characterization of the NF2 gene in Korean patients with neurofibromatosis type 2: a report of four novel mutations.
PubMed ID: 20445339
Sequence Information:
- Length: 595
- Mass: 69690
- Checksum: B1A1BF2BD5DA561C
- Sequence:
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT YPPMNPIPAP LPPDIPSFNL IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN ELKTEIEALK LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.