Details for: NFE2

Gene ID: 4778

Symbol: NFE2

Ensembl ID: ENSG00000123405

Description: nuclear factor, erythroid 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 23.8468
    Cell Significance Index: 10.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 4.4519
    Cell Significance Index: -2.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.3318
    Cell Significance Index: 59.5700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.8312
    Cell Significance Index: 30.8000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.3707
    Cell Significance Index: 8.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0520
    Cell Significance Index: 28.1400
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.6705
    Cell Significance Index: 4.8200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5055
    Cell Significance Index: 8.3300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.4914
    Cell Significance Index: 3.2600
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 0.3118
    Cell Significance Index: 1.6400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.2345
    Cell Significance Index: 2.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1270
    Cell Significance Index: 8.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1250
    Cell Significance Index: 2.3100
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.0880
    Cell Significance Index: 0.7500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0732
    Cell Significance Index: 1.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0634
    Cell Significance Index: 12.5800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0613
    Cell Significance Index: 0.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0435
    Cell Significance Index: 5.0700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0251
    Cell Significance Index: 0.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0145
    Cell Significance Index: 2.6100
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.0078
    Cell Significance Index: 0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0058
    Cell Significance Index: 3.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0011
    Cell Significance Index: -0.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0030
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0040
    Cell Significance Index: -0.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0046
    Cell Significance Index: -2.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0056
    Cell Significance Index: -1.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0062
    Cell Significance Index: -2.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0081
    Cell Significance Index: -0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0082
    Cell Significance Index: -1.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0106
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0107
    Cell Significance Index: -0.1900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0113
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0121
    Cell Significance Index: -2.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0127
    Cell Significance Index: -1.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0128
    Cell Significance Index: -1.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0136
    Cell Significance Index: -1.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0141
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0181
    Cell Significance Index: -2.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0184
    Cell Significance Index: -1.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0185
    Cell Significance Index: -1.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0203
    Cell Significance Index: -0.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0206
    Cell Significance Index: -0.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0217
    Cell Significance Index: -0.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0249
    Cell Significance Index: -1.9100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0255
    Cell Significance Index: -1.0500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0276
    Cell Significance Index: -0.5400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0276
    Cell Significance Index: -0.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0283
    Cell Significance Index: -1.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0303
    Cell Significance Index: -1.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0337
    Cell Significance Index: -1.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0349
    Cell Significance Index: -1.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0352
    Cell Significance Index: -2.3700
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0375
    Cell Significance Index: -0.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0391
    Cell Significance Index: -1.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0396
    Cell Significance Index: -1.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0420
    Cell Significance Index: -1.9800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0442
    Cell Significance Index: -1.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0446
    Cell Significance Index: -1.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0451
    Cell Significance Index: -1.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0465
    Cell Significance Index: -1.1600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0477
    Cell Significance Index: -0.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0485
    Cell Significance Index: -1.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0499
    Cell Significance Index: -2.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0516
    Cell Significance Index: -1.0800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0521
    Cell Significance Index: -0.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0526
    Cell Significance Index: -1.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0531
    Cell Significance Index: -2.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0547
    Cell Significance Index: -1.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0569
    Cell Significance Index: -1.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0571
    Cell Significance Index: -1.8700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0574
    Cell Significance Index: -0.6100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0575
    Cell Significance Index: -0.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0579
    Cell Significance Index: -1.1300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0580
    Cell Significance Index: -0.7500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0580
    Cell Significance Index: -0.9300
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0593
    Cell Significance Index: -0.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0593
    Cell Significance Index: -1.8900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0607
    Cell Significance Index: -1.9200
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.0614
    Cell Significance Index: -0.5500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0619
    Cell Significance Index: -0.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0625
    Cell Significance Index: -1.8000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0627
    Cell Significance Index: -0.9100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0634
    Cell Significance Index: -0.8700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0656
    Cell Significance Index: -0.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0656
    Cell Significance Index: -1.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0669
    Cell Significance Index: -1.9700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0671
    Cell Significance Index: -0.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0688
    Cell Significance Index: -0.7800
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0698
    Cell Significance Index: -0.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0722
    Cell Significance Index: -2.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0729
    Cell Significance Index: -1.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** NFE2 is significantly expressed in hematopoietic cells, including thymocytes, early and late promyelocytes, erythroid progenitor cells, and hematopoietic stem cells. 2. **Transcriptional Regulation:** NFE2 acts as a transcription factor that regulates the expression of target genes by binding to specific DNA sequences. 3. **Hematopoietic Lineage-Specific:** NFE2's expression is restricted to cells of the hematopoietic lineage, suggesting its specific role in hematopoiesis. 4. **Interactions with Other Proteins:** NFE2 interacts with Runx1, a transcription factor involved in megakaryocyte differentiation and platelet production. **Pathways and Functions:** 1. **Hematopoiesis:** NFE2 regulates the expression of genes involved in megakaryocyte differentiation and platelet production, highlighting its critical role in hematopoiesis. 2. **Integrated Stress Response Signaling:** NFE2 is involved in the integrated stress response signaling pathway, which is essential for cell survival and adaptation to stress. 3. **Regulation of Transcription by RNA Polymerase II:** NFE2 regulates transcription by RNA polymerase II, a key enzyme involved in the transcription of protein-coding genes. 4. **Interaction with Runx1:** NFE2 interacts with Runx1, a transcription factor involved in megakaryocyte differentiation and platelet production, suggesting a cooperative regulatory mechanism. **Clinical Significance:** 1. **Hematological Disorders:** NFE2's involvement in hematopoiesis suggests its potential role in the pathogenesis of hematological disorders, such as anemia and thrombocytopenia. 2. **Cancer:** NFE2's role in the integrated stress response signaling pathway may contribute to cancer development and progression, particularly in hematological malignancies. 3. **Therapeutic Implications:** Targeting NFE2's activity may provide a novel therapeutic strategy for the treatment of hematological disorders and cancer. In conclusion, NFE2 is a critical transcription factor that plays a pivotal role in regulating gene expression in hematopoiesis and beyond. Its involvement in hematopoiesis, integrated stress response signaling, and regulation of transcription by RNA polymerase II highlights the complexity of its functions. Further research is necessary to fully elucidate NFE2's role in disease and to explore its therapeutic potential.

Genular Protein ID: 1593478250

Symbol: NFE2_HUMAN

Name: Transcription factor NF-E2 45 kDa subunit

UniProtKB Accession Codes:

Q16621 Q07720 Q6ICV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8248255

Title: Isolation of cDNA encoding the human NF-E2 protein.

PubMed ID: 8248255

DOI: 10.1073/pnas.90.23.11366

PubMed ID: 8355703

Title: Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner.

PubMed ID: 8355703

DOI: 10.1128/mcb.13.9.5604-5612.1993

PubMed ID: 7724591

Title: Isolation of a differentially regulated splicing isoform of human NF-E2.

PubMed ID: 7724591

DOI: 10.1073/pnas.92.8.3511

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11154691

Title: Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation.

PubMed ID: 11154691

DOI: 10.1074/jbc.m007846200

PubMed ID: 16287851

Title: Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus.

PubMed ID: 16287851

DOI: 10.1128/mcb.25.23.10365-10378.2005

PubMed ID: 18718448

Title: Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination.

PubMed ID: 18718448

DOI: 10.1016/j.bbrc.2008.07.164

Sequence Information:

  • Length: 373
  • Mass: 41473
  • Checksum: A9821170FB2ED67C
  • Sequence:
    • MSPCPPQQSR NRVIQLSTSE LGEMELTWQE IMSITELQGL NAPSEPSFEP QAPAPYLGPP 
PPTTYCPCSI HPDSGFPLPP PPYELPASTS HVPDPPYSYG NMAIPVSKPL SLSGLLSEPL 
QDPLALLDIG LPAGPPKPQE DPESDSGLSL NYSDAESLEL EGTEAGRRRS EYVEMYPVEY 
PYSLMPNSLA HSNYTLPAAE TPLALEPSSG PVRAKPTARG EAGSRDERRA LAMKIPFPTD 
KIVNLPVDDF NELLARYPLT ESQLALVRDI RRRGKNKVAA QNCRKRKLET IVQLERELER 
LTNERERLLR ARGEADRTLE VMRQQLTELY RDIFQHLRDE SGNSYSPEEY ALQQAADGTI 
FLVPRGTKME ATD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.