Details for: NFIL3

Gene ID: 4783

Symbol: NFIL3

Ensembl ID: ENSG00000165030

Description: nuclear factor, interleukin 3 regulated

Associated with

  • Circadian clock
    (R-HSA-400253)
  • Cellular response to interleukin-4
    (GO:0071353)
  • Chromatin
    (GO:0000785)
  • Circadian rhythm
    (GO:0007623)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Natural killer cell differentiation
    (GO:0001779)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Transcription by rna polymerase ii
    (GO:0006366)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 179.1119
    Cell Significance Index: -27.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 108.1242
    Cell Significance Index: -27.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.2482
    Cell Significance Index: -24.0700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.3086
    Cell Significance Index: -28.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.6042
    Cell Significance Index: -27.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.2992
    Cell Significance Index: -27.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0539
    Cell Significance Index: -27.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.0882
    Cell Significance Index: 117.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2487
    Cell Significance Index: -7.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.5286
    Cell Significance Index: 25.7500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1689
    Cell Significance Index: 9.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1245
    Cell Significance Index: 79.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9701
    Cell Significance Index: 428.9200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.9279
    Cell Significance Index: 22.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9171
    Cell Significance Index: 47.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7716
    Cell Significance Index: 105.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7055
    Cell Significance Index: 637.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6662
    Cell Significance Index: 9.0900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.6432
    Cell Significance Index: 2.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5407
    Cell Significance Index: 32.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5054
    Cell Significance Index: 54.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4593
    Cell Significance Index: 74.7000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4156
    Cell Significance Index: 7.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4132
    Cell Significance Index: 18.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4056
    Cell Significance Index: 80.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3857
    Cell Significance Index: 10.3000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3653
    Cell Significance Index: 2.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3608
    Cell Significance Index: 23.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3016
    Cell Significance Index: 16.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2608
    Cell Significance Index: 142.4300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.2325
    Cell Significance Index: 2.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2253
    Cell Significance Index: 4.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2112
    Cell Significance Index: 134.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2032
    Cell Significance Index: 24.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1926
    Cell Significance Index: 9.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1844
    Cell Significance Index: 5.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1834
    Cell Significance Index: 5.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1803
    Cell Significance Index: 17.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1679
    Cell Significance Index: 33.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1498
    Cell Significance Index: 28.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1458
    Cell Significance Index: 11.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1426
    Cell Significance Index: 2.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1259
    Cell Significance Index: 22.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1240
    Cell Significance Index: 3.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1175
    Cell Significance Index: 8.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0663
    Cell Significance Index: 3.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0649
    Cell Significance Index: 122.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0621
    Cell Significance Index: 22.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0481
    Cell Significance Index: 5.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0336
    Cell Significance Index: 1.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0241
    Cell Significance Index: 4.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0228
    Cell Significance Index: 2.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0225
    Cell Significance Index: 1.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0189
    Cell Significance Index: 13.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0118
    Cell Significance Index: 0.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0118
    Cell Significance Index: 1.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0071
    Cell Significance Index: 10.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0049
    Cell Significance Index: 0.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0007
    Cell Significance Index: 1.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0052
    Cell Significance Index: -7.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -6.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0102
    Cell Significance Index: -7.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0156
    Cell Significance Index: -7.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0219
    Cell Significance Index: -16.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0317
    Cell Significance Index: -17.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0370
    Cell Significance Index: -0.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0399
    Cell Significance Index: -4.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0609
    Cell Significance Index: -17.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0674
    Cell Significance Index: -14.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0684
    Cell Significance Index: -9.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0803
    Cell Significance Index: -9.3600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0833
    Cell Significance Index: -1.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0858
    Cell Significance Index: -2.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1011
    Cell Significance Index: -5.3100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1073
    Cell Significance Index: -1.1200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1611
    Cell Significance Index: -2.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1841
    Cell Significance Index: -3.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1882
    Cell Significance Index: -22.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1986
    Cell Significance Index: -5.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2081
    Cell Significance Index: -13.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2139
    Cell Significance Index: -2.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2206
    Cell Significance Index: -4.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2391
    Cell Significance Index: -15.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2471
    Cell Significance Index: -25.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2598
    Cell Significance Index: -8.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2667
    Cell Significance Index: -13.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2805
    Cell Significance Index: -6.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2852
    Cell Significance Index: -22.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2955
    Cell Significance Index: -7.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3185
    Cell Significance Index: -16.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3303
    Cell Significance Index: -8.4900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3494
    Cell Significance Index: -2.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3608
    Cell Significance Index: -22.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3710
    Cell Significance Index: -9.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4268
    Cell Significance Index: -9.0900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4348
    Cell Significance Index: -6.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4738
    Cell Significance Index: -3.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4964
    Cell Significance Index: -10.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5118
    Cell Significance Index: -20.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NFIL3 is a member of the NFIL family of transcription factors, which are known for their role in regulating gene expression in response to various stimuli, including cytokines and growth factors. NFIL3 is specifically regulated by interleukin-3 (IL-3), a cytokine involved in the differentiation and proliferation of hematopoietic cells. NFIL3 is predominantly expressed in cells of the immune system, including hematopoietic cells, natural killer cells, and fibroblasts. **Pathways and Functions:** NFIL3 is involved in various cellular processes, including: 1. **Immune Response:** NFIL3 regulates the transcription of genes involved in immune responses, such as those involved in the activation of natural killer cells and the differentiation of hematopoietic cells. 2. **Gene Expression:** NFIL3 binds to specific DNA sequences, influencing the transcription of genes involved in cell differentiation, proliferation, and survival. 3. **Circadian Rhythm:** NFIL3 is also involved in the regulation of the circadian clock, which is essential for maintaining the body's internal clock and regulating various physiological processes. 4. **Chromatin Remodeling:** NFIL3 interacts with chromatin remodeling complexes, influencing the structure and function of chromatin. **Functions:** NFIL3 has several functions, including: 1. **Transcriptional Regulation:** NFIL3 regulates the transcription of genes involved in immune responses, cell differentiation, and tissue development. 2. **Cell Differentiation:** NFIL3 is involved in the differentiation of hematopoietic cells, natural killer cells, and other immune cells. 3. **Apoptosis:** NFIL3 regulates the expression of genes involved in apoptosis, which is essential for maintaining tissue homeostasis. 4. **Circadian Rhythm Regulation:** NFIL3 regulates the expression of genes involved in the circadian clock, which is essential for maintaining the body's internal clock. **Clinical Significance:** NFIL3 has significant implications for various diseases, including: 1. **Immunodeficiency Disorders:** NFIL3 dysregulation has been implicated in immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer:** NFIL3 is involved in the regulation of gene expression in cancer cells, and dysregulation of NFIL3 has been implicated in various types of cancer. 3. **Autoimmune Diseases:** NFIL3 regulates the transcription of genes involved in immune responses, and dysregulation of NFIL3 has been implicated in autoimmune diseases, such as rheumatoid arthritis. 4. **Neurological Disorders:** NFIL3 is involved in the regulation of gene expression in the nervous system, and dysregulation of NFIL3 has been implicated in neurological disorders, such as Parkinson's disease. In conclusion, NFIL3 is a critical transcription factor that plays a central role in regulating immune responses, gene expression, and tissue development. Its dysregulation has significant implications for various diseases, including immunodeficiency disorders, cancer, autoimmune diseases, and neurological disorders. Further research is needed to fully understand the mechanisms of NFIL3 and its clinical significance.

Genular Protein ID: 652527499

Symbol: NFIL3_HUMAN

Name: Nuclear factor interleukin-3-regulated protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1620116

Title: Transcriptional repression by a novel member of the bZIP family of transcription factors.

PubMed ID: 1620116

DOI: 10.1128/mcb.12.7.3070-3077.1992

PubMed ID: 7565758

Title: Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter.

PubMed ID: 7565758

DOI: 10.1128/mcb.15.11.6055

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8836190

Title: Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1.

PubMed ID: 8836190

DOI: 10.1093/nar/24.18.3607

PubMed ID: 10942106

Title: Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis.

PubMed ID: 10942106

DOI: 10.1007/s004390000306

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24062447

Title: Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1.

PubMed ID: 24062447

DOI: 10.1073/pnas.1308888110

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 462
  • Mass: 51472
  • Checksum: D19946AAC774C3E7
  • Sequence:
  • MQLRKMQTVK KEQASLDASS NVDKMMVLNS ALTEVSEDST TGEELLLSEG SVGKNKSSAC 
    RRKREFIPDE KKDAMYWEKR RKNNEAAKRS REKRRLNDLV LENKLIALGE ENATLKAELL 
    SLKLKFGLIS STAYAQEIQK LSNSTAVYFQ DYQTSKSNVS SFVDEHEPSM VSSSCISVIK 
    HSPQSSLSDV SEVSSVEHTQ ESSVQGSCRS PENKFQIIKQ EPMELESYTR EPRDDRGSYT 
    ASIYQNYMGN SFSGYSHSPP LLQVNRSSSN SPRTSETDDG VVGKSSDGED EQQVPKGPIH 
    SPVELKHVHA TVVKVPEVNS SALPHKLRIK AKAMQIKVEA FDNEFEATQK LSSPIDMTSK 
    RHFELEKHSA PSMVHSSLTP FSVQVTNIQD WSLKSEHWHQ KELSGKTQNS FKTGVVEMKD 
    SGYKVSDPEN LYLKQGIANL SAEVVSLKRL IATQPISASD SG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.