Details for: TONSL

Gene ID: 4796

Symbol: TONSL

Ensembl ID: ENSG00000160949

Description: tonsoku like, DNA repair protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 36.2596
    Cell Significance Index: -5.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.5477
    Cell Significance Index: -6.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.0151
    Cell Significance Index: -6.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.4101
    Cell Significance Index: -6.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.4828
    Cell Significance Index: -6.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.9490
    Cell Significance Index: -7.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.8208
    Cell Significance Index: 279.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7777
    Cell Significance Index: 51.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.7739
    Cell Significance Index: -7.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6732
    Cell Significance Index: 272.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3879
    Cell Significance Index: 62.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1284
    Cell Significance Index: 67.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0682
    Cell Significance Index: 116.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7795
    Cell Significance Index: 11.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.7128
    Cell Significance Index: -1.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6490
    Cell Significance Index: 128.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5538
    Cell Significance Index: 28.7700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.5212
    Cell Significance Index: 7.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4968
    Cell Significance Index: 34.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4599
    Cell Significance Index: 9.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3787
    Cell Significance Index: 341.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3623
    Cell Significance Index: 42.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3361
    Cell Significance Index: 5.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3106
    Cell Significance Index: 8.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2493
    Cell Significance Index: 3.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2111
    Cell Significance Index: 2.8800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2054
    Cell Significance Index: 2.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1514
    Cell Significance Index: 5.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1241
    Cell Significance Index: 24.9000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1049
    Cell Significance Index: 1.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0960
    Cell Significance Index: 2.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0957
    Cell Significance Index: 11.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0944
    Cell Significance Index: 17.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0863
    Cell Significance Index: 3.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0844
    Cell Significance Index: 9.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0832
    Cell Significance Index: 2.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0815
    Cell Significance Index: 56.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0777
    Cell Significance Index: 14.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0649
    Cell Significance Index: 2.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0639
    Cell Significance Index: 4.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0601
    Cell Significance Index: 32.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0511
    Cell Significance Index: 6.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0505
    Cell Significance Index: 1.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0437
    Cell Significance Index: 2.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0337
    Cell Significance Index: 14.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0333
    Cell Significance Index: 2.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0285
    Cell Significance Index: 0.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0281
    Cell Significance Index: 10.0700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0077
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0064
    Cell Significance Index: 12.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0042
    Cell Significance Index: 0.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0020
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0014
    Cell Significance Index: 0.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0010
    Cell Significance Index: 1.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0020
    Cell Significance Index: -1.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0035
    Cell Significance Index: -4.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0040
    Cell Significance Index: -2.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0074
    Cell Significance Index: -5.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0100
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0111
    Cell Significance Index: -2.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0120
    Cell Significance Index: -0.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0129
    Cell Significance Index: -1.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0131
    Cell Significance Index: -5.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0167
    Cell Significance Index: -1.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0216
    Cell Significance Index: -0.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0254
    Cell Significance Index: -0.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0255
    Cell Significance Index: -3.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0258
    Cell Significance Index: -7.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0309
    Cell Significance Index: -1.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0323
    Cell Significance Index: -3.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0341
    Cell Significance Index: -0.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0375
    Cell Significance Index: -2.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0406
    Cell Significance Index: -5.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0572
    Cell Significance Index: -1.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0630
    Cell Significance Index: -6.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0655
    Cell Significance Index: -1.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0685
    Cell Significance Index: -1.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0745
    Cell Significance Index: -5.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0761
    Cell Significance Index: -5.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0837
    Cell Significance Index: -6.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0840
    Cell Significance Index: -3.9500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0949
    Cell Significance Index: -1.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0975
    Cell Significance Index: -5.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1029
    Cell Significance Index: -5.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1031
    Cell Significance Index: -2.7100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1062
    Cell Significance Index: -0.6300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1071
    Cell Significance Index: -1.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1101
    Cell Significance Index: -2.8300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1392
    Cell Significance Index: -2.9800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1408
    Cell Significance Index: -3.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1423
    Cell Significance Index: -4.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1440
    Cell Significance Index: -6.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1473
    Cell Significance Index: -5.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1582
    Cell Significance Index: -5.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TONSL gene is a single-copy gene that is highly expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, mural cells, and neural progenitor cells. It encodes a protein that shares structural and functional similarities with the NF-kappa-B inhibitor, IκBα, suggesting a potential role in regulating transcription factors. The TONSL protein is characterized by its ability to bind to chromatin, interact with histones, and modulate DNA repair processes. **Pathways and Functions:** The TONSL gene is involved in several critical cellular pathways, including: 1. **DNA Repair**: TONSL plays a crucial role in the repair of double-strand breaks via homologous recombination, a process essential for maintaining genome stability. 2. **Chromatin Organization**: The TONSL protein interacts with histones, influencing chromatin structure and function, which is crucial for gene expression and cellular differentiation. 3. **Cell Cycle Regulation**: TONSL is involved in the regulation of the cell cycle, particularly during the G2/M phase, where it modulates the activity of the Mcm complex, a key regulator of DNA replication. 4. **Transcriptional Regulation**: The TONSL protein acts as a histone reader, modulating the activity of transcription factors and influencing gene expression. **Clinical Significance:** The TONSL gene has been implicated in various diseases, including: 1. **Cancer**: Altered expression of TONSL has been observed in several types of cancer, suggesting its potential role as a tumor suppressor or oncogene. 2. **Neurological Disorders**: TONSL has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where impaired DNA repair mechanisms contribute to disease progression. 3. **Cardiac Disease**: Abnormal expression of TONSL has been observed in cardiac myoblasts, suggesting its potential role in the development of cardiac disease. In conclusion, the TONSL gene is a critical regulator of DNA repair, chromatin organization, and cell cycle regulation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying TONSL function and its role in human disease.

Genular Protein ID: 3411565552

Symbol: TONSL_HUMAN

Name: NF-kappa-B inhibitor-like protein 2

UniProtKB Accession Codes:

Q96HA7 B5MDP0 C9JKB1 C9JNV8 Q13006 Q9UGJ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7738005

Title: Cloning of a differentially expressed I kappa B-related protein.

PubMed ID: 7738005

DOI: 10.1074/jbc.270.18.10680

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11246458

Title: Isolation, sequence, and chromosomal localisation of the human IkappaBR gene (NFKBIL2).

PubMed ID: 11246458

DOI: 10.1017/s0003480000007910

PubMed ID: 9242696

Title: Selective up-regulation of cytokine-induced RANTES gene expression in lung epithelial cells by overexpression of IkappaBR.

PubMed ID: 9242696

DOI: 10.1074/jbc.272.32.20191

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21113133

Title: RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.

PubMed ID: 21113133

DOI: 10.1038/emboj.2010.304

PubMed ID: 21055983

Title: The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.

PubMed ID: 21055983

DOI: 10.1016/j.molcel.2010.10.024

PubMed ID: 21055984

Title: Identification of the MMS22L-TONSL complex that promotes homologous recombination.

PubMed ID: 21055984

DOI: 10.1016/j.molcel.2010.10.023

PubMed ID: 21055985

Title: A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.

PubMed ID: 21055985

DOI: 10.1016/j.molcel.2010.10.022

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26527279

Title: Analysis of the histone H3.1 interactome: a suitable chaperone for the right event.

PubMed ID: 26527279

DOI: 10.1016/j.molcel.2015.08.005

PubMed ID: 27797818

Title: The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress.

PubMed ID: 27797818

DOI: 10.15252/embj.201593132

PubMed ID: 29478807

Title: The histone chaperones ASF1 and CAF-1 promote MMS22L-TONSL-mediated Rad51 loading onto ssDNA during homologous recombination in human cells.

PubMed ID: 29478807

DOI: 10.1016/j.molcel.2018.01.031

PubMed ID: 33857403

Title: DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.

PubMed ID: 33857403

DOI: 10.1016/j.molcel.2021.03.041

PubMed ID: 27338793

Title: H4K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex.

PubMed ID: 27338793

DOI: 10.1038/nature18312

PubMed ID: 30773277

Title: Bi-allelic variants in TONSL cause sponastrime dysplasia and a spectrum of skeletal dysplasia phenotypes.

PubMed ID: 30773277

DOI: 10.1016/j.ajhg.2019.01.007

PubMed ID: 30773278

Title: Hypomorphic mutations in TONSL cause sponastrime dysplasia.

PubMed ID: 30773278

DOI: 10.1016/j.ajhg.2019.01.009

PubMed ID: 32959051

Title: Novel TONSL variants cause SPONASTRIME dysplasia and associate with spontaneous chromosome breaks, defective cell proliferation and apoptosis.

PubMed ID: 32959051

DOI: 10.1093/hmg/ddaa195

Sequence Information:

  • Length: 1378
  • Mass: 150929
  • Checksum: 8E3013861864DCDE
  • Sequence:
    • MSLERELRQL SKAKAKAQRA GQRREEAALC HQLGELLAGH GRYAEALEQH WQELQLRERA 
DDPLGCAVAH RKIGERLAEM EDYPAALQHQ HQYLELAHSL RNHTELQRAW ATIGRTHLDI 
YDHCQSRDAL LQAQAAFEKS LAIVDEELEG TLAQGELNEM RTRLYLNLGL TFESLQQTAL 
CNDYFRKSIF LAEQNHLYED LFRARYNLGT IHWRAGQHSQ AMRCLEGARE CAHTMRKRFM 
ESECCVVIAQ VLQDLGDFLA AKRALKKAYR LGSQKPVQRA AICQNLQHVL AVVRLQQQLE 
EAEGRDPQGA MVICEQLGDL FSKAGDFPRA AEAYQKQLRF AELLDRPGAE RAIIHVSLAT 
TLGDMKDHHG AVRHYEEELR LRSGNVLEEA KTWLNIALSR EEAGDAYELL APCFQKALSC 
AQQAQRPQLQ RQVLQHLHTV QLRLQPQEAP ETETRLRELS VAEDEDEEEE AEEAAATAES 
EALEAGEVEL SEGEDDTDGL TPQLEEDEEL QGHLGRRKGS KWNRRNDMGE TLLHRACIEG 
QLRRVQDLVR QGHPLNPRDY CGWTPLHEAC NYGHLEIVRF LLDHGAAVDD PGGQGCEGIT 
PLHDALNCGH FEVAELLLER GASVTLRTRK GLSPLETLQQ WVKLYRRDLD LETRQKARAM 
EMLLQAAASG QDPHSSQAFH TPSSLLFDPE TSPPLSPCPE PPSNSTRLPE ASQAHVRVSP 
GQAAPAMARP RRSRHGPASS SSSSEGEDSA GPARPSQKRP RCSATAQRVA AWTPGPASNR 
EAATASTSRA AYQAAIRGVG SAQSRLGPGP PRGHSKALAP QAALIPEEEC LAGDWLELDM 
PLTRSRRPRP RGTGDNRRPS STSGSDSEES RPRARAKQVR LTCMQSCSAP VNAGPSSLAS 
EPPGSPSTPR VSEPSGDSSA AGQPLGPAPP PPIRVRVQVQ DHLFLIPVPH SSDTHSVAWL 
AEQAAQRYYQ TCGLLPRLTL RKEGALLAPQ DLIPDVLQSN DEVLAEVTSW DLPPLTDRYR 
RACQSLGQGE HQQVLQAVEL QGLGLSFSAC SLALDQAQLT PLLRALKLHT ALRELRLAGN 
RLGDKCVAEL VAALGTMPSL ALLDLSSNHL GPEGLRQLAM GLPGQATLQS LEELDLSMNP 
LGDGCGQSLA SLLHACPLLS TLRLQACGFG PSFFLSHQTA LGSAFQDAEH LKTLSLSYNA 
LGAPALARTL QSLPAGTLLH LELSSVAAGK GDSDLMEPVF RYLAKEGCAL AHLTLSANHL 
GDKAVRDLCR CLSLCPSLIS LDLSANPEIS CASLEELLST LQKRPQGLSF LGLSGCAVQG 
PLGLGLWDKI AAQLRELQLC SRRLCAEDRD ALRQLQPSRP GPGECTLDHG SKLFFRRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.