Details for: NGF
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.1988
Cell Significance Index: 17.2200 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.1655
Cell Significance Index: 9.7900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.1313
Cell Significance Index: 23.6800 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.0181
Cell Significance Index: 24.6600 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.5019
Cell Significance Index: 8.2700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.4575
Cell Significance Index: 58.6500 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.4166
Cell Significance Index: 8.1300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.1572
Cell Significance Index: 22.8500 - Cell Name: perivascular cell (CL4033054)
Fold Change: 0.1429
Cell Significance Index: 0.6600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1214
Cell Significance Index: 43.5400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0815
Cell Significance Index: 6.2600 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.0686
Cell Significance Index: 0.8900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0586
Cell Significance Index: 11.6200 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.0572
Cell Significance Index: 0.7200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0407
Cell Significance Index: 76.7000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0405
Cell Significance Index: 27.9800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0241
Cell Significance Index: 1.2200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0025
Cell Significance Index: -3.8500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0034
Cell Significance Index: -6.2200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0073
Cell Significance Index: -9.9600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0088
Cell Significance Index: -5.6000 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.0095
Cell Significance Index: -0.1500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0111
Cell Significance Index: -3.1800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0152
Cell Significance Index: -11.2900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0159
Cell Significance Index: -12.0100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0188
Cell Significance Index: -2.5800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0193
Cell Significance Index: -3.8700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0194
Cell Significance Index: -12.1300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0201
Cell Significance Index: -11.3100 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0205
Cell Significance Index: -11.2100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0210
Cell Significance Index: -9.5400 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0353
Cell Significance Index: -0.7500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0424
Cell Significance Index: -7.6400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0545
Cell Significance Index: -0.7800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0574
Cell Significance Index: -12.0800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0615
Cell Significance Index: -10.5000 - Cell Name: mural cell (CL0008034)
Fold Change: -0.0682
Cell Significance Index: -0.8300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0688
Cell Significance Index: -8.4600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0824
Cell Significance Index: -1.6300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0844
Cell Significance Index: -5.1900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0849
Cell Significance Index: -10.9700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0882
Cell Significance Index: -10.1000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0889
Cell Significance Index: -2.3800 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0930
Cell Significance Index: -2.0100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1003
Cell Significance Index: -10.2500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1137
Cell Significance Index: -11.8400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1202
Cell Significance Index: -6.3100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1483
Cell Significance Index: -11.0500 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1626
Cell Significance Index: -3.9000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1664
Cell Significance Index: -11.1900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1822
Cell Significance Index: -10.2300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1892
Cell Significance Index: -8.8900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1925
Cell Significance Index: -4.1200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1963
Cell Significance Index: -3.9400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1990
Cell Significance Index: -10.3400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2065
Cell Significance Index: -5.9200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2306
Cell Significance Index: -10.7500 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2415
Cell Significance Index: -6.3500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2469
Cell Significance Index: -7.8700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2554
Cell Significance Index: -4.2800 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.2597
Cell Significance Index: -5.4200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2662
Cell Significance Index: -3.9300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2672
Cell Significance Index: -11.8200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2712
Cell Significance Index: -7.5800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2896
Cell Significance Index: -10.6300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2943
Cell Significance Index: -8.0100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2945
Cell Significance Index: -10.3500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3026
Cell Significance Index: -10.6000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3062
Cell Significance Index: -10.6400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3117
Cell Significance Index: -11.8000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3152
Cell Significance Index: -10.3200 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.3414
Cell Significance Index: -6.7200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.3474
Cell Significance Index: -10.0100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3485
Cell Significance Index: -10.2700 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.3658
Cell Significance Index: -5.6600 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.3672
Cell Significance Index: -11.6200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3858
Cell Significance Index: -11.0100 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.3878
Cell Significance Index: -9.6700 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.3922
Cell Significance Index: -4.6900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.3961
Cell Significance Index: -7.0000 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.3983
Cell Significance Index: -3.8400 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.4033
Cell Significance Index: -6.4700 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.4082
Cell Significance Index: -9.9600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4127
Cell Significance Index: -11.0400 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.4231
Cell Significance Index: -10.7800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4240
Cell Significance Index: -10.6000 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.4261
Cell Significance Index: -10.6300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4269
Cell Significance Index: -11.4400 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4292
Cell Significance Index: -10.7200 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.4381
Cell Significance Index: -8.5700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.4404
Cell Significance Index: -5.6400 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.4418
Cell Significance Index: -5.6700 - Cell Name: muscle cell (CL0000187)
Fold Change: -0.4422
Cell Significance Index: -4.2300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4485
Cell Significance Index: -9.8200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.4603
Cell Significance Index: -6.6200 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.4705
Cell Significance Index: -4.6600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4719
Cell Significance Index: -9.7900 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.4779
Cell Significance Index: -9.5300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4846
Cell Significance Index: -8.3100 - Cell Name: neuron (CL0000540)
Fold Change: -0.4927
Cell Significance Index: -4.6700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2997446187
Symbol: NGF_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6688123
Title: Human beta-nerve growth factor gene sequence highly homologous to that of mouse.
PubMed ID: 6688123
DOI: 10.1038/303821a0
PubMed ID: 6327169
Title: Sequence homology of human and mouse beta-NGF subunit genes.
PubMed ID: 6327169
PubMed ID: 2374737
PubMed ID: 10322959
Title: Cloning and sequencing of the gene for premature beta nerve growth factor.
PubMed ID: 10322959
PubMed ID: 15014171
Title: Human-specific amino acid changes found in 103 protein-coding genes.
PubMed ID: 15014171
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2025430
Title: Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.
PubMed ID: 2025430
PubMed ID: 1849459
Title: The trk proto-oncogene encodes a receptor for nerve growth factor.
PubMed ID: 1849459
PubMed ID: 20164177
Title: Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI.
PubMed ID: 20164177
PubMed ID: 10490030
Title: Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.
PubMed ID: 10490030
DOI: 10.1038/43705
PubMed ID: 15131306
Title: Structure of nerve growth factor complexed with the shared neurotrophin receptor p75.
PubMed ID: 15131306
PubMed ID: 17196528
Title: Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.
PubMed ID: 17196528
PubMed ID: 10391209
Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.
PubMed ID: 10391209
DOI: 10.1038/10290
PubMed ID: 14976160
Title: A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception.
PubMed ID: 14976160
DOI: 10.1093/hmg/ddh096
PubMed ID: 20978020
Title: A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy.
PubMed ID: 20978020
PubMed ID: 22302274
Title: Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort.
PubMed ID: 22302274
Sequence Information:
- Length: 241
- Mass: 26959
- Checksum: 619DFC65EB3BD671
- Sequence:
MSMLFYTLIT AFLIGIQAEP HSESNVPAGH TIPQAHWTKL QHSLDTALRR ARSAPAAAIA ARVAGQTRNI TVDPRLFKKR RLRSPRVLFS TQPPREAADT QDLDFEVGGA APFNRTHRSK RSSSHPIFHR GEFSVCDSVS VWVGDKTTAT DIKGKEVMVL GEVNINNSVF KQYFFETKCR DPNPVDSGCR GIDSKHWNSY CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKAVRR A
Genular Protein ID: 3979274978
Symbol: A0A346FYQ1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 296
- Mass: 32523
- Checksum: C0F5C7BEA20EE4C2
- Sequence:
MASSNGHFNE VLASGRAVQG AGWHAGPKLS SASGPNNSFT KGAAFYPGHT EVHSVMSMLF YTLITAFLIG IQAEPHSESN VPAGHTIPQA HWTKLQHSLD TALRRARSAP AAAIAARVAG QTRNITVDPR LFKKRRLRSP RVLFSTQPPR EAADTQDLDF EVGGAAPFNR THRSKRSSSH PIFHRGEFSV CDSVSVWVGD KTTATDIKGK EVMVLGEVNI NNSVFKQYFF ETKCRDPNPV DSGCRGIDSK HWNSYCTTTH TFVKALTMDG KQAAWRFIRI DTACVCVLSR KAVRRA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.