Details for: NGF

Gene ID: 4803

Symbol: NGF

Ensembl ID: ENSG00000134259

Description: nerve growth factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.1988
    Cell Significance Index: 17.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.1655
    Cell Significance Index: 9.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1313
    Cell Significance Index: 23.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0181
    Cell Significance Index: 24.6600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5019
    Cell Significance Index: 8.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4575
    Cell Significance Index: 58.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4166
    Cell Significance Index: 8.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1572
    Cell Significance Index: 22.8500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1429
    Cell Significance Index: 0.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1214
    Cell Significance Index: 43.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0815
    Cell Significance Index: 6.2600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0686
    Cell Significance Index: 0.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0586
    Cell Significance Index: 11.6200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0572
    Cell Significance Index: 0.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0407
    Cell Significance Index: 76.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0405
    Cell Significance Index: 27.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0241
    Cell Significance Index: 1.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0025
    Cell Significance Index: -3.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0034
    Cell Significance Index: -6.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0073
    Cell Significance Index: -9.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0088
    Cell Significance Index: -5.6000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0095
    Cell Significance Index: -0.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0111
    Cell Significance Index: -3.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0152
    Cell Significance Index: -11.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0159
    Cell Significance Index: -12.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0188
    Cell Significance Index: -2.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0193
    Cell Significance Index: -3.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0194
    Cell Significance Index: -12.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0201
    Cell Significance Index: -11.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0205
    Cell Significance Index: -11.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0210
    Cell Significance Index: -9.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0353
    Cell Significance Index: -0.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0424
    Cell Significance Index: -7.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0545
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0574
    Cell Significance Index: -12.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0615
    Cell Significance Index: -10.5000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0682
    Cell Significance Index: -0.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0688
    Cell Significance Index: -8.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0824
    Cell Significance Index: -1.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0844
    Cell Significance Index: -5.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0849
    Cell Significance Index: -10.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0882
    Cell Significance Index: -10.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0889
    Cell Significance Index: -2.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0930
    Cell Significance Index: -2.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1003
    Cell Significance Index: -10.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1137
    Cell Significance Index: -11.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1202
    Cell Significance Index: -6.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1483
    Cell Significance Index: -11.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1626
    Cell Significance Index: -3.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1664
    Cell Significance Index: -11.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1822
    Cell Significance Index: -10.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1892
    Cell Significance Index: -8.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1925
    Cell Significance Index: -4.1200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1963
    Cell Significance Index: -3.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1990
    Cell Significance Index: -10.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2065
    Cell Significance Index: -5.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2306
    Cell Significance Index: -10.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2415
    Cell Significance Index: -6.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2469
    Cell Significance Index: -7.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2554
    Cell Significance Index: -4.2800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2597
    Cell Significance Index: -5.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2662
    Cell Significance Index: -3.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2672
    Cell Significance Index: -11.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2712
    Cell Significance Index: -7.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2896
    Cell Significance Index: -10.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2943
    Cell Significance Index: -8.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2945
    Cell Significance Index: -10.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3026
    Cell Significance Index: -10.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3062
    Cell Significance Index: -10.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3117
    Cell Significance Index: -11.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3152
    Cell Significance Index: -10.3200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3414
    Cell Significance Index: -6.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3474
    Cell Significance Index: -10.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3485
    Cell Significance Index: -10.2700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3658
    Cell Significance Index: -5.6600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3672
    Cell Significance Index: -11.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3858
    Cell Significance Index: -11.0100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3878
    Cell Significance Index: -9.6700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3922
    Cell Significance Index: -4.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3961
    Cell Significance Index: -7.0000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.3983
    Cell Significance Index: -3.8400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4033
    Cell Significance Index: -6.4700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4082
    Cell Significance Index: -9.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4127
    Cell Significance Index: -11.0400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4231
    Cell Significance Index: -10.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4240
    Cell Significance Index: -10.6000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4261
    Cell Significance Index: -10.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4269
    Cell Significance Index: -11.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4292
    Cell Significance Index: -10.7200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4381
    Cell Significance Index: -8.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4404
    Cell Significance Index: -5.6400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4418
    Cell Significance Index: -5.6700
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.4422
    Cell Significance Index: -4.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4485
    Cell Significance Index: -9.8200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4603
    Cell Significance Index: -6.6200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.4705
    Cell Significance Index: -4.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4719
    Cell Significance Index: -9.7900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4779
    Cell Significance Index: -9.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4846
    Cell Significance Index: -8.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4927
    Cell Significance Index: -4.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NGF is a disulfide-linked homodimeric protein, consisting of two identical subunits. It is primarily produced in the brain and spinal cord, but also in peripheral tissues, such as the pancreas and adrenal glands. NGF is a potent mitogen for neurons, stimulating their growth, differentiation, and survival. It is also involved in the regulation of synaptic plasticity, a critical mechanism underlying learning and memory. **Pathways and Functions** NGF signaling pathways are complex and involve multiple downstream effectors. The primary pathways activated by NGF include: 1. **Activation of TrkA receptors**: NGF binding to TrkA receptors triggers the activation of several tyrosine kinases, including RET, FGFR, and PI3K, which in turn regulate various cellular processes, including cell survival, growth, and differentiation. 2. **Arms-mediated activation**: NGF binding to TrkA receptors also activates the arms region, a domain that recruits signaling complexes and regulates the activation of downstream effectors. 3. **Axon growth stimulation**: NGF promotes the growth and regeneration of axons, a critical process for neural repair and recovery. 4. **Cell death signaling**: NGF binding to its receptors can also trigger cell death signaling pathways, including the activation of death receptors and the activation of caspases. **Clinical Significance** NGF has been implicated in various neurological and psychiatric disorders, including: 1. **Neurodegenerative diseases**: NGF has been shown to play a role in the progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Mental health disorders**: NGF has been implicated in the pathophysiology of mental health disorders, including depression and anxiety. 3. **Neurological injuries**: NGF has been shown to promote neural repair and recovery after traumatic brain injury and stroke. 4. **Cancer**: NGF has been implicated in the development and progression of certain types of cancer, including breast cancer and prostate cancer. **Significantly Expressed Cells** NGF is expressed in various cell types, including: 1. **Contractile cells**: NGF is expressed in contractile cells, such as smooth muscle cells and cardiomyocytes. 2. **Conventional dendritic cells**: NGF is expressed in conventional dendritic cells, which play a critical role in immune responses. 3. **Mural cells**: NGF is expressed in mural cells, which are involved in the development and maintenance of blood vessels. 4. **Granulocyte monocyte progenitor cells**: NGF is expressed in granulocyte monocyte progenitor cells, which are involved in the development of immune cells. 5. **Fat cells**: NGF is expressed in fat cells, which play a critical role in energy metabolism. 6. **Neoplastic cells**: NGF is expressed in neoplastic cells, which are involved in the development and progression of cancer. 7. **Abnormal cells**: NGF is expressed in abnormal cells, which are involved in various neurological and psychiatric disorders. **Proteins** NGF is encoded by the NGF gene, which is located on chromosome 22. The NGF protein is a disulfide-linked homodimeric protein, consisting of two identical subunits. The NGF protein has a molecular weight of approximately 14.5 kDa and is composed of 126 amino acids. In conclusion, NGF is a critical regulator of nervous system development and function. Its signaling pathways are complex and involve multiple downstream effectors, and its dysregulation has been implicated in various neurological and psychiatric disorders. Further research is needed to fully understand the mechanisms of NGF signaling and its clinical significance.

Genular Protein ID: 2997446187

Symbol: NGF_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 6688123

Title: Human beta-nerve growth factor gene sequence highly homologous to that of mouse.

PubMed ID: 6688123

DOI: 10.1038/303821a0

PubMed ID: 6327169

Title: Sequence homology of human and mouse beta-NGF subunit genes.

PubMed ID: 6327169

DOI: 10.1101/sqb.1983.048.01.048

PubMed ID: 2374737

Title: cDNA sequence of human beta-NGF.

PubMed ID: 2374737

DOI: 10.1093/nar/18.13.4020

PubMed ID: 10322959

Title: Cloning and sequencing of the gene for premature beta nerve growth factor.

PubMed ID: 10322959

PubMed ID: 15014171

Title: Human-specific amino acid changes found in 103 protein-coding genes.

PubMed ID: 15014171

DOI: 10.1093/molbev/msh100

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2025430

Title: Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.

PubMed ID: 2025430

DOI: 10.1016/0896-6273(91)90180-8

PubMed ID: 1849459

Title: The trk proto-oncogene encodes a receptor for nerve growth factor.

PubMed ID: 1849459

DOI: 10.1016/0092-8674(91)90419-y

PubMed ID: 20164177

Title: Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI.

PubMed ID: 20164177

DOI: 10.1074/jbc.m110.100479

PubMed ID: 10490030

Title: Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.

PubMed ID: 10490030

DOI: 10.1038/43705

PubMed ID: 15131306

Title: Structure of nerve growth factor complexed with the shared neurotrophin receptor p75.

PubMed ID: 15131306

DOI: 10.1126/science.1095190

PubMed ID: 17196528

Title: Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.

PubMed ID: 17196528

DOI: 10.1016/j.neuron.2006.09.034

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 14976160

Title: A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception.

PubMed ID: 14976160

DOI: 10.1093/hmg/ddh096

PubMed ID: 20978020

Title: A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy.

PubMed ID: 20978020

DOI: 10.1136/jmg.2010.081455

PubMed ID: 22302274

Title: Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort.

PubMed ID: 22302274

DOI: 10.1007/s00415-011-6397-y

Sequence Information:

  • Length: 241
  • Mass: 26959
  • Checksum: 619DFC65EB3BD671
  • Sequence:
  • MSMLFYTLIT AFLIGIQAEP HSESNVPAGH TIPQAHWTKL QHSLDTALRR ARSAPAAAIA 
    ARVAGQTRNI TVDPRLFKKR RLRSPRVLFS TQPPREAADT QDLDFEVGGA APFNRTHRSK 
    RSSSHPIFHR GEFSVCDSVS VWVGDKTTAT DIKGKEVMVL GEVNINNSVF KQYFFETKCR 
    DPNPVDSGCR GIDSKHWNSY CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKAVRR 
    A

Genular Protein ID: 3979274978

Symbol: A0A346FYQ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 296
  • Mass: 32523
  • Checksum: C0F5C7BEA20EE4C2
  • Sequence:
  • MASSNGHFNE VLASGRAVQG AGWHAGPKLS SASGPNNSFT KGAAFYPGHT EVHSVMSMLF 
    YTLITAFLIG IQAEPHSESN VPAGHTIPQA HWTKLQHSLD TALRRARSAP AAAIAARVAG 
    QTRNITVDPR LFKKRRLRSP RVLFSTQPPR EAADTQDLDF EVGGAAPFNR THRSKRSSSH 
    PIFHRGEFSV CDSVSVWVGD KTTATDIKGK EVMVLGEVNI NNSVFKQYFF ETKCRDPNPV 
    DSGCRGIDSK HWNSYCTTTH TFVKALTMDG KQAAWRFIRI DTACVCVLSR KAVRRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.