Details for: NPR1

Gene ID: 4881

Symbol: NPR1

Ensembl ID: ENSG00000169418

Description: natriuretic peptide receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.7780
    Cell Significance Index: -9.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.0970
    Cell Significance Index: -9.6400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 4.6626
    Cell Significance Index: 74.8100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.9556
    Cell Significance Index: 17.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.6021
    Cell Significance Index: 135.5400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 1.6904
    Cell Significance Index: 6.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0910
    Cell Significance Index: 25.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5840
    Cell Significance Index: 10.3200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3194
    Cell Significance Index: 2.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3120
    Cell Significance Index: 9.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2910
    Cell Significance Index: 5.6800
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: 0.2526
    Cell Significance Index: 2.8300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2217
    Cell Significance Index: 3.4300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.2077
    Cell Significance Index: 1.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1241
    Cell Significance Index: 6.2700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1196
    Cell Significance Index: 1.7200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1157
    Cell Significance Index: 1.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1141
    Cell Significance Index: 15.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1028
    Cell Significance Index: 6.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0921
    Cell Significance Index: 50.3200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0764
    Cell Significance Index: 1.8500
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.0561
    Cell Significance Index: 0.1900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0253
    Cell Significance Index: 0.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0034
    Cell Significance Index: -2.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0052
    Cell Significance Index: -9.7000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0106
    Cell Significance Index: -19.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0118
    Cell Significance Index: -5.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0120
    Cell Significance Index: -4.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0127
    Cell Significance Index: -19.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0128
    Cell Significance Index: -9.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0145
    Cell Significance Index: -19.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0147
    Cell Significance Index: -9.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0185
    Cell Significance Index: -13.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0193
    Cell Significance Index: -3.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0248
    Cell Significance Index: -13.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0258
    Cell Significance Index: -11.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0291
    Cell Significance Index: -5.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0319
    Cell Significance Index: -19.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0390
    Cell Significance Index: -11.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0415
    Cell Significance Index: -5.3200
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: -0.0484
    Cell Significance Index: -0.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0580
    Cell Significance Index: -11.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0617
    Cell Significance Index: -8.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0632
    Cell Significance Index: -13.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0633
    Cell Significance Index: -6.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0695
    Cell Significance Index: -8.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0769
    Cell Significance Index: -8.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0804
    Cell Significance Index: -13.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0827
    Cell Significance Index: -10.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0921
    Cell Significance Index: -10.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1136
    Cell Significance Index: -1.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1144
    Cell Significance Index: -11.9100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1172
    Cell Significance Index: -1.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1197
    Cell Significance Index: -3.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1218
    Cell Significance Index: -9.6500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1318
    Cell Significance Index: -5.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1327
    Cell Significance Index: -4.6100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.1497
    Cell Significance Index: -1.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1514
    Cell Significance Index: -11.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1709
    Cell Significance Index: -4.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1741
    Cell Significance Index: -13.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1800
    Cell Significance Index: -12.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1838
    Cell Significance Index: -8.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1840
    Cell Significance Index: -11.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2024
    Cell Significance Index: -12.4400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2106
    Cell Significance Index: -3.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2116
    Cell Significance Index: -4.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2144
    Cell Significance Index: -5.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2459
    Cell Significance Index: -13.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2657
    Cell Significance Index: -7.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2810
    Cell Significance Index: -13.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2865
    Cell Significance Index: -15.0400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2876
    Cell Significance Index: -4.5600
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.3025
    Cell Significance Index: -2.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3079
    Cell Significance Index: -13.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3206
    Cell Significance Index: -11.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3392
    Cell Significance Index: -17.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3511
    Cell Significance Index: -12.3000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3607
    Cell Significance Index: -5.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3618
    Cell Significance Index: -13.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3772
    Cell Significance Index: -12.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3786
    Cell Significance Index: -8.2900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3815
    Cell Significance Index: -4.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3824
    Cell Significance Index: -12.1800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3860
    Cell Significance Index: -5.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3864
    Cell Significance Index: -8.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3878
    Cell Significance Index: -10.3600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4153
    Cell Significance Index: -3.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4213
    Cell Significance Index: -11.2700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4241
    Cell Significance Index: -4.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4245
    Cell Significance Index: -12.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4317
    Cell Significance Index: -10.7700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.4463
    Cell Significance Index: -5.6200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4491
    Cell Significance Index: -5.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4533
    Cell Significance Index: -11.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4583
    Cell Significance Index: -12.0500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4595
    Cell Significance Index: -6.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4661
    Cell Significance Index: -7.8000
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.4661
    Cell Significance Index: -4.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NPR1 is a G protein-coupled receptor that binds to natriuretic peptides, such as atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Upon binding, NPR1 activates guanylyl cyclase, leading to the production of cyclic guanosine monophosphate (cGMP), a key second messenger involved in various cellular processes. NPR1's expression is widespread, with significant presence in endothelial cells, smooth muscle cells, and renal epithelial cells. Its unique expression pattern highlights the receptor's role in regulating cardiovascular and renal function. **Pathways and Functions:** NPR1's signaling pathway is intricately linked with various physiological processes, including: 1. **Cardiac Conduction:** NPR1 regulates cardiac conduction by modulating the expression of ion channels and pumps, thereby influencing heart rate and contractility. 2. **Blood Pressure Regulation:** NPR1 plays a critical role in regulating blood pressure by modulating vascular tone and renal sodium excretion. 3. **Renal Sodium Excretion:** NPR1 is involved in regulating renal sodium excretion, which is essential for maintaining electrolyte balance and blood pressure. 4. **Vascular Permeability:** NPR1 modulates vascular permeability by regulating the expression of adhesion molecules and ion channels. 5. **Angiogenesis:** NPR1 negatively regulates angiogenesis, a process essential for tumor growth and metastasis. **Clinical Significance:** Dysregulation of NPR1 has been implicated in various cardiovascular and renal disorders, including: 1. **Heart Failure:** NPR1's dysfunction has been linked to heart failure, as it impairs cardiac conduction and contractility. 2. **Hypertension:** NPR1's dysregulation contributes to hypertension, as it alters vascular tone and renal sodium excretion. 3. **Kidney Disease:** NPR1's dysfunction has been implicated in kidney disease, as it impairs renal sodium excretion and blood pressure regulation. 4. **Cancer:** NPR1's negative regulation of angiogenesis makes it a potential target for cancer therapy. In conclusion, NPR1 is a critical regulator of cardiovascular and renal homeostasis, and its dysregulation has significant implications for human health. Further research into NPR1's function and its role in various diseases will provide valuable insights into the development of novel therapeutic strategies.

Genular Protein ID: 972057719

Symbol: ANPRA_HUMAN

Name: Atrial natriuretic peptide receptor type A

UniProtKB Accession Codes:

P16066 B0ZBF0 Q5SR08 Q6P4Q3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 28 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2569967

Title: Human atrial natriuretic peptide receptor defines a new paradigm for second messenger signal transduction.

PubMed ID: 2569967

DOI: 10.1002/j.1460-2075.1989.tb03518.x

PubMed ID: 9618281

Title: Organization of the human natriuretic peptide receptor A gene.

PubMed ID: 9618281

DOI: 10.1006/bbrc.1998.8693

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7954658

Title: Expression of mRNA for atrial natriuretic peptide receptor guanylate cyclase (ANPRA) in human retina.

PubMed ID: 7954658

DOI: 10.1007/bf02088585

PubMed ID: 1660465

Title: Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera.

PubMed ID: 1660465

DOI: 10.1016/s0021-9258(18)54463-x

PubMed ID: 1672777

Title: Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP).

PubMed ID: 1672777

DOI: 10.1126/science.1672777

PubMed ID: 20977274

Title: Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B.

PubMed ID: 20977274

DOI: 10.1021/bi101700e

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1061
  • Mass: 118919
  • Checksum: E6B5BD0FCA32F70D
  • Sequence:
    • MPGPRRPAGS RLRLLLLLLL PPLLLLLRGS HAGNLTVAVV LPLANTSYPW SWARVGPAVE 
LALAQVKARP DLLPGWTVRT VLGSSENALG VCSDTAAPLA AVDLKWEHNP AVFLGPGCVY 
AAAPVGRFTA HWRVPLLTAG APALGFGVKD EYALTTRAGP SYAKLGDFVA ALHRRLGWER 
QALMLYAYRP GDEEHCFFLV EGLFMRVRDR LNITVDHLEF AEDDLSHYTR LLRTMPRKGR 
VIYICSSPDA FRTLMLLALE AGLCGEDYVF FHLDIFGQSL QGGQGPAPRR PWERGDGQDV 
SARQAFQAAK IITYKDPDNP EYLEFLKQLK HLAYEQFNFT MEDGLVNTIP ASFHDGLLLY 
IQAVTETLAH GGTVTDGENI TQRMWNRSFQ GVTGYLKIDS SGDRETDFSL WDMDPENGAF 
RVVLNYNGTS QELVAVSGRK LNWPLGYPPP DIPKCGFDNE DPACNQDHLS TLEVLALVGS 
LSLLGILIVS FFIYRKMQLE KELASELWRV RWEDVEPSSL ERHLRSAGSR LTLSGRGSNY 
GSLLTTEGQF QVFAKTAYYK GNLVAVKRVN RKRIELTRKV LFELKHMRDV QNEHLTRFVG 
ACTDPPNICI LTEYCPRGSL QDILENESIT LDWMFRYSLT NDIVKGMLFL HNGAICSHGN 
LKSSNCVVDG RFVLKITDYG LESFRDLDPE QGHTVYAKKL WTAPELLRMA SPPVRGSQAG 
DVYSFGIILQ EIALRSGVFH VEGLDLSPKE IIERVTRGEQ PPFRPSLALQ SHLEELGLLM 
QRCWAEDPQE RPPFQQIRLT LRKFNRENSS NILDNLLSRM EQYANNLEEL VEERTQAYLE 
EKRKAEALLY QILPHSVAEQ LKRGETVQAE AFDSVTIYFS DIVGFTALSA ESTPMQVVTL 
LNDLYTCFDA VIDNFDVYKV ETIGDAYMVV SGLPVRNGRL HACEVARMAL ALLDAVRSFR 
IRHRPQEQLR LRIGIHTGPV CAGVVGLKMP RYCLFGDTVN TASRMESNGE ALKIHLSSET 
KAVLEEFGGF ELELRGDVEM KGKGKVRTYW LLGERGSSTR G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.