Details for: NTN3

Gene ID: 4917

Symbol: NTN3

Ensembl ID: ENSG00000162068

Description: netrin 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.23
    Marker Score: 53002
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.74
    Marker Score: 6802.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.13
    Marker Score: 3153
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.41
    Marker Score: 4157
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.95
    Marker Score: 2176
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.46
    Marker Score: 855
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.24
    Marker Score: 1185.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.24
    Marker Score: 1312
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71758.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48004
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1783
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 498
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1344
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1194
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.69
    Marker Score: 666
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 525
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.66
    Marker Score: 10253.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.61
    Marker Score: 1263
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1196.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.54
    Marker Score: 215
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.52
    Marker Score: 615
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.5
    Marker Score: 262
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 284
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.47
    Marker Score: 521
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.47
    Marker Score: 2832
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.46
    Marker Score: 218
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.44
    Marker Score: 1703
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 380
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 219
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.35
    Marker Score: 266
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.34
    Marker Score: 223
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.31
    Marker Score: 318
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.29
    Marker Score: 127
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.28
    Marker Score: 508.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.25
    Marker Score: 73.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.25
    Marker Score: 163
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.23
    Marker Score: 82
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.22
    Marker Score: 270.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.22
    Marker Score: 75.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.21
    Marker Score: 555
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.2
    Marker Score: 76.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 66.5
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.17
    Marker Score: 76.5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.16
    Marker Score: 202
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.15
    Marker Score: 75.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 357
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.14
    Marker Score: 222
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.14
    Marker Score: 43.5
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.14
    Marker Score: 76.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.14
    Marker Score: 195
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.13
    Marker Score: 77.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.13
    Marker Score: 550
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.12
    Marker Score: 77.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 128
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 65.5
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.1
    Marker Score: 73.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.1
    Marker Score: 66.5
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.1
    Marker Score: 64.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.09
    Marker Score: 313
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.08
    Marker Score: 79
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.08
    Marker Score: 65
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.07
    Marker Score: 74.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.07
    Marker Score: 76.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.07
    Marker Score: 77.5
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 219
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.07
    Marker Score: 77.5
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.06
    Marker Score: 51.5
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.06
    Marker Score: 75.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.06
    Marker Score: 67.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.06
    Marker Score: 81
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.06
    Marker Score: 75.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.06
    Marker Score: 104
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.06
    Marker Score: 71
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.06
    Marker Score: 70.5
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.05
    Marker Score: 541
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.05
    Marker Score: 76.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.05
    Marker Score: 75.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.05
    Marker Score: 70
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.05
    Marker Score: 77.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.05
    Marker Score: 75.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.05
    Marker Score: 118
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.04
    Marker Score: 155
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.04
    Marker Score: 65
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.03
    Marker Score: 70
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.03
    Marker Score: 77.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.03
    Marker Score: 72

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Other Information

**Key characteristics** * NNT3 is a large protein with a molecular weight of approximately 140 kDa. * It is a transmembrane protein that is expressed in a variety of cell types. * It is a key component of the netrin family of cell adhesion molecules. * NNT3 is involved in the guidance of migrating cells. * It is expressed in a variety of cell types, including progenitor cells, microglial cells, blood vessel endothelial cells, T cells, plasma cells, pericytes, B cells, kidney distal convoluted tubule epithelial cells, goblet cells, and cerebral cortex GABAergic interneurons. **Pathways and functions** NTN3 is involved in a variety of cellular processes, including: * Cell migration * Cell adhesion * Cell signaling * Tissue development NTN3 is a key regulator of neuronal migration and axonal guidance. It is expressed in a variety of cell types that are involved in neural development, including progenitor cells, microglial cells, and blood vessel endothelial cells. NNT3 binds to a specific DNA sequence, called the Netrin-3 repeat (NRG), which is found in the 5' UTR of many neural genes. This binding event recruits NNT3 to the NRG-containing DNA, which then activates the transcription of these genes. **Clinical significance** Mutations in the NNT3 gene have been linked to a number of human diseases, including autism, schizophrenia, and developmental disorders. These findings suggest that NNT3 is a critical factor in human health. **Additional information** * NNT3 is a highly conserved protein, with similar sequences found in organisms from flies to humans. * It is a member of the immunoglobulin superfamily, which are characterized by their ability to bind to specific ligands and regulate cell function. * NNT3 is a known regulator of neuronal migration and axonal guidance. * It is a potential therapeutic target for a variety of neurological disorders.

Genular Protein ID: 418346320

Symbol: NET3_HUMAN

Name: Netrin-3

UniProtKB Accession Codes:

O00634

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8828041

Title: Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3.

PubMed ID: 8828041

DOI: 10.1101/gr.6.6.525

PubMed ID: 9143507

Title: The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3.

PubMed ID: 9143507

DOI: 10.1006/geno.1997.4659

Sequence Information:

  • Length: 580
  • Mass: 61466
  • Checksum: 15F99643E74C644C
  • Sequence:
    • MPGWPWGLLL TAGTLFAALS PGPPAPADPC HDEGGAPRGC VPGLVNAALG REVLASSTCG 
RPATRACDAS DPRRAHSPAL LTSPGGTASP LCWRSESLPR APLNVTLTVP LGKAFELVFV 
SLRFCSAPPA SVALLKSQDH GRSWAPLGFF SSHCDLDYGR LPAPANGPAG PGPEALCFPA 
PLAQPDGSGL LAFSMQDSSP PGLDLDSSPV LQDWVTATDV RVVLTRPSTA GDPRDMEAVV 
PYSYAATDLQ VGGRCKCNGH ASRCLLDTQG HLICDCRHGT EGPDCGRCKP FYCDRPWQRA 
TARESHACLA CSCNGHARRC RFNMELYRLS GRRSGGVCLN CRHNTAGRHC HYCREGFYRD 
PGRALSDRRA CRACDCHPVG AAGKTCNQTT GQCPCKDGVT GLTCNRCAPG FQQSRSPVAP 
CVKTPIPGPT EDSSPVQPQD CDSHCKPARG SYRISLKKFC KKDYAVQVAV GARGEARGAW 
TRFPVAVLAV FRSGEERARR GSSALWVPAG DAACGCPRLL PGRRYLLLGG GPGAAAGGAG 
GRGPGLIAAR GSLVLPWRDA WTRRLRRLQR RERRGRCSAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.