Details for: NTN3

Gene ID: 4917

Symbol: NTN3

Ensembl ID: ENSG00000162068

Description: netrin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1620
    Cell Significance Index: 2.0500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0855
    Cell Significance Index: 1.2000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.0543
    Cell Significance Index: 0.6500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0485
    Cell Significance Index: 0.5700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0141
    Cell Significance Index: 0.1700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0057
    Cell Significance Index: 0.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0045
    Cell Significance Index: 0.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0035
    Cell Significance Index: 0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0006
    Cell Significance Index: -0.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0006
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0008
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0010
    Cell Significance Index: -0.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0018
    Cell Significance Index: -0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0022
    Cell Significance Index: -0.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0025
    Cell Significance Index: -0.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0028
    Cell Significance Index: -0.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0029
    Cell Significance Index: -0.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0032
    Cell Significance Index: -0.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0044
    Cell Significance Index: -0.6400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0059
    Cell Significance Index: -0.1000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0084
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0096
    Cell Significance Index: -0.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0098
    Cell Significance Index: -0.2800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0103
    Cell Significance Index: -0.1300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0103
    Cell Significance Index: -0.1500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0118
    Cell Significance Index: -0.1200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0121
    Cell Significance Index: -0.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0138
    Cell Significance Index: -0.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0144
    Cell Significance Index: -0.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0153
    Cell Significance Index: -0.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0154
    Cell Significance Index: -0.6800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0160
    Cell Significance Index: -0.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0171
    Cell Significance Index: -0.4500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0173
    Cell Significance Index: -0.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0178
    Cell Significance Index: -0.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0179
    Cell Significance Index: -0.5700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0181
    Cell Significance Index: -0.2800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0187
    Cell Significance Index: -0.7100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0188
    Cell Significance Index: -0.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0191
    Cell Significance Index: -0.3200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0191
    Cell Significance Index: -0.2900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0196
    Cell Significance Index: -0.5000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0198
    Cell Significance Index: -0.4000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0198
    Cell Significance Index: -0.2300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0202
    Cell Significance Index: -0.2600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0204
    Cell Significance Index: -0.2800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0205
    Cell Significance Index: -0.2700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0207
    Cell Significance Index: -0.2900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0216
    Cell Significance Index: -0.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0224
    Cell Significance Index: -0.3300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0225
    Cell Significance Index: -0.3200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0226
    Cell Significance Index: -0.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0227
    Cell Significance Index: -0.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0231
    Cell Significance Index: -0.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0233
    Cell Significance Index: -0.6900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0241
    Cell Significance Index: -0.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0241
    Cell Significance Index: -0.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0243
    Cell Significance Index: -0.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0243
    Cell Significance Index: -0.4800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0248
    Cell Significance Index: -0.3100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0254
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0259
    Cell Significance Index: -0.4300
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0261
    Cell Significance Index: -0.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0269
    Cell Significance Index: -0.5400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0270
    Cell Significance Index: -0.3500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0272
    Cell Significance Index: -0.6600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0272
    Cell Significance Index: -0.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0273
    Cell Significance Index: -0.3300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0274
    Cell Significance Index: -0.5400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0275
    Cell Significance Index: -0.2900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0281
    Cell Significance Index: -0.3500
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0281
    Cell Significance Index: -0.3500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0284
    Cell Significance Index: -0.3600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0286
    Cell Significance Index: -0.3300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0287
    Cell Significance Index: -0.3200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0290
    Cell Significance Index: -0.3600
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0290
    Cell Significance Index: -0.3600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0292
    Cell Significance Index: -0.3600
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0294
    Cell Significance Index: -0.3700
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0294
    Cell Significance Index: -0.3600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0296
    Cell Significance Index: -0.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0298
    Cell Significance Index: -0.5200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0300
    Cell Significance Index: -0.3500
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.0301
    Cell Significance Index: -0.3700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0306
    Cell Significance Index: -0.3600
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.0307
    Cell Significance Index: -0.3700
  • Cell Name: diffuse bipolar 3a cell (CL4033029)
    Fold Change: -0.0308
    Cell Significance Index: -0.3700
  • Cell Name: H2 horizontal cell (CL0004218)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0315
    Cell Significance Index: -0.3200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0322
    Cell Significance Index: -0.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** Netrin 3 is expressed in a diverse range of cell types, including progenitor cells, microglial cells, T cells, plasma cells, and epithelial cells. 2. **Multifunctionality:** Netrin 3 is involved in various biological processes, including axon guidance, myogenesis, and immune regulation. 3. **Transcriptional Regulation:** Netrin 3 binds to RNA polymerase II, suggesting its potential role in transcriptional control. 4. **Signaling Pathways:** Netrin 3 interacts with multiple signaling pathways, including those involved in axon guidance, myogenesis, and immune response. 5. **Extracellular and Intracellular Localization:** Netrin 3 is found in both extracellular and intracellular compartments, indicating its involvement in both cell-cell and cell-matrix interactions. **Pathways and Functions:** 1. **Axon Guidance:** Netrin 3 plays a crucial role in the regulation of axon growth and guidance during neural development. 2. **Myogenesis:** Netrin 3 is involved in the regulation of muscle cell differentiation and fusion. 3. **Immune Regulation:** Netrin 3 modulates immune responses, including the regulation of T cell and plasma cell development. 4. **Transcriptional Regulation:** Netrin 3 binds to RNA polymerase II, influencing the transcriptional activity of target genes. 5. **Cellular Differentiation:** Netrin 3 participates in the regulation of cellular differentiation in various cell types, including progenitor cells and epithelial cells. **Clinical Significance:** 1. **Neurological Disorders:** Abnormalities in Netrin 3 expression have been linked to neurological disorders, such as autism and schizophrenia. 2. **Immune-Related Diseases:** Dysregulation of Netrin 3 has been implicated in immune-related diseases, including multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** Netrin 3's involvement in cell proliferation and differentiation suggests its potential role in cancer development and progression. 4. **Neurodevelopmental Disorders:** Netrin 3's expression in the cerebral cortex and its involvement in axon guidance suggest its potential role in neurodevelopmental disorders, such as cerebral palsy. In conclusion, Netrin 3 is a multifunctional gene that plays a critical role in various biological processes, including axon guidance, myogenesis, and immune regulation. Its complex interplay with multiple signaling pathways and its presence in distinct cellular compartments underscore its intricate functions in development, immune response, and tissue homeostasis. Further research is needed to fully elucidate the clinical significance of Netrin 3 and its potential applications in the treatment of neurological and immune-related disorders.

Genular Protein ID: 418346320

Symbol: NET3_HUMAN

Name: Netrin-3

UniProtKB Accession Codes:

O00634

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8828041

Title: Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3.

PubMed ID: 8828041

DOI: 10.1101/gr.6.6.525

PubMed ID: 9143507

Title: The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3.

PubMed ID: 9143507

DOI: 10.1006/geno.1997.4659

Sequence Information:

  • Length: 580
  • Mass: 61466
  • Checksum: 15F99643E74C644C
  • Sequence:
    • MPGWPWGLLL TAGTLFAALS PGPPAPADPC HDEGGAPRGC VPGLVNAALG REVLASSTCG 
RPATRACDAS DPRRAHSPAL LTSPGGTASP LCWRSESLPR APLNVTLTVP LGKAFELVFV 
SLRFCSAPPA SVALLKSQDH GRSWAPLGFF SSHCDLDYGR LPAPANGPAG PGPEALCFPA 
PLAQPDGSGL LAFSMQDSSP PGLDLDSSPV LQDWVTATDV RVVLTRPSTA GDPRDMEAVV 
PYSYAATDLQ VGGRCKCNGH ASRCLLDTQG HLICDCRHGT EGPDCGRCKP FYCDRPWQRA 
TARESHACLA CSCNGHARRC RFNMELYRLS GRRSGGVCLN CRHNTAGRHC HYCREGFYRD 
PGRALSDRRA CRACDCHPVG AAGKTCNQTT GQCPCKDGVT GLTCNRCAPG FQQSRSPVAP 
CVKTPIPGPT EDSSPVQPQD CDSHCKPARG SYRISLKKFC KKDYAVQVAV GARGEARGAW 
TRFPVAVLAV FRSGEERARR GSSALWVPAG DAACGCPRLL PGRRYLLLGG GPGAAAGGAG 
GRGPGLIAAR GSLVLPWRDA WTRRLRRLQR RERRGRCSAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.