Details for: TBC1D25

Gene ID: 4943

Symbol: TBC1D25

Ensembl ID: ENSG00000068354

Description: TBC1 domain family member 25

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 78.8838
    Cell Significance Index: -12.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.4575
    Cell Significance Index: -11.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.2980
    Cell Significance Index: -11.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.7597
    Cell Significance Index: -11.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9598
    Cell Significance Index: -12.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8263
    Cell Significance Index: -10.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1576
    Cell Significance Index: -12.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6564
    Cell Significance Index: 64.9400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6126
    Cell Significance Index: 10.1000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5974
    Cell Significance Index: 9.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5632
    Cell Significance Index: 508.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5296
    Cell Significance Index: 61.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5277
    Cell Significance Index: 7.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4234
    Cell Significance Index: 84.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3842
    Cell Significance Index: 41.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3481
    Cell Significance Index: 20.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3452
    Cell Significance Index: 56.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3172
    Cell Significance Index: 19.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2915
    Cell Significance Index: 52.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2909
    Cell Significance Index: 8.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2759
    Cell Significance Index: 7.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2510
    Cell Significance Index: 90.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2464
    Cell Significance Index: 46.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2277
    Cell Significance Index: 45.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1964
    Cell Significance Index: 13.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1929
    Cell Significance Index: 23.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1865
    Cell Significance Index: 14.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1827
    Cell Significance Index: 9.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1604
    Cell Significance Index: 4.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1566
    Cell Significance Index: 3.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1280
    Cell Significance Index: 5.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0891
    Cell Significance Index: 1.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0864
    Cell Significance Index: 47.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0827
    Cell Significance Index: 57.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0796
    Cell Significance Index: 5.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0757
    Cell Significance Index: 9.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0749
    Cell Significance Index: 33.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0726
    Cell Significance Index: 5.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0716
    Cell Significance Index: 1.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0584
    Cell Significance Index: 3.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0501
    Cell Significance Index: 6.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0400
    Cell Significance Index: 2.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0333
    Cell Significance Index: 1.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0268
    Cell Significance Index: 1.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0087
    Cell Significance Index: 16.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0047
    Cell Significance Index: 0.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0041
    Cell Significance Index: 0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0019
    Cell Significance Index: 2.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0006
    Cell Significance Index: 1.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0007
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0018
    Cell Significance Index: -0.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0048
    Cell Significance Index: -3.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0086
    Cell Significance Index: -0.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0107
    Cell Significance Index: -8.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0113
    Cell Significance Index: -8.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0114
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0125
    Cell Significance Index: -9.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0132
    Cell Significance Index: -5.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0147
    Cell Significance Index: -1.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0161
    Cell Significance Index: -1.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0174
    Cell Significance Index: -2.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0195
    Cell Significance Index: -11.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0219
    Cell Significance Index: -13.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0224
    Cell Significance Index: -2.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0230
    Cell Significance Index: -0.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0235
    Cell Significance Index: -1.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0285
    Cell Significance Index: -1.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0396
    Cell Significance Index: -1.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0413
    Cell Significance Index: -0.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0437
    Cell Significance Index: -12.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0456
    Cell Significance Index: -2.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0493
    Cell Significance Index: -2.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0554
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0640
    Cell Significance Index: -13.4800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0889
    Cell Significance Index: -1.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1056
    Cell Significance Index: -2.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1113
    Cell Significance Index: -11.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1122
    Cell Significance Index: -2.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1199
    Cell Significance Index: -2.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1205
    Cell Significance Index: -3.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1321
    Cell Significance Index: -3.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1352
    Cell Significance Index: -2.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1365
    Cell Significance Index: -8.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1367
    Cell Significance Index: -3.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1382
    Cell Significance Index: -2.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1452
    Cell Significance Index: -11.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1479
    Cell Significance Index: -4.2400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1659
    Cell Significance Index: -2.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1739
    Cell Significance Index: -3.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1865
    Cell Significance Index: -6.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1883
    Cell Significance Index: -4.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1947
    Cell Significance Index: -3.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2054
    Cell Significance Index: -5.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2138
    Cell Significance Index: -6.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2236
    Cell Significance Index: -7.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2249
    Cell Significance Index: -4.8600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2338
    Cell Significance Index: -3.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2348
    Cell Significance Index: -3.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2417
    Cell Significance Index: -5.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TBC1D25 is a member of the TBC1 domain family, which is characterized by the presence of a TBC1 domain. This domain is responsible for the activation of GTPase activity, which is essential for various cellular processes. The protein products of TBC1D25 have been shown to interact with multiple partners, including Rab GTPases, which play a crucial role in regulating vesicle trafficking and membrane trafficking. The expression of TBC1D25 is widespread, with significant levels detected in the cerebral cortex, cardiac muscle, and intestinal epithelial cells. **Pathways and Functions:** The TBC1D25 gene is involved in several key cellular pathways, including: 1. **Activation of GTPase activity:** The TBC1 domain of TBC1D25 is responsible for the activation of GTPase activity, which is essential for various cellular processes, including autophagy and vesicle trafficking. 2. **Autophagosome regulation:** TBC1D25 has been shown to regulate autophagosome maturation, which is critical for the degradation of damaged or dysfunctional cellular components. 3. **Rab regulation of trafficking:** TBC1D25 interacts with Rab GTPases, which play a crucial role in regulating vesicle trafficking and membrane trafficking. 4. **Cytoplasmic vesicle regulation:** TBC1D25 has been implicated in the regulation of cytoplasmic vesicle formation and trafficking. 5. **Membrane trafficking regulation:** TBC1D25 regulates membrane trafficking, which is essential for the transport of cellular components across the cell membrane. **Clinical Significance:** Dysregulation of TBC1D25 has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** TBC1D25 has been shown to play a critical role in regulating autophagy, which is essential for the degradation of damaged or dysfunctional cellular components. Dysregulation of TBC1D25 may contribute to neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** TBC1D25 has been implicated in cancer, with dysregulation contributing to tumor progression and metastasis. 3. **Cardiovascular disease:** TBC1D25 has been shown to regulate membrane trafficking, which is essential for the transport of cellular components across the cell membrane. Dysregulation of TBC1D25 may contribute to cardiovascular disease. In conclusion, TBC1D25 is a gene that plays a critical role in regulating various cellular processes, including autophagy, vesicle trafficking, and membrane trafficking. Dysregulation of TBC1D25 has been implicated in various diseases, including neurodegenerative disorders, cancer, and cardiovascular disease. Further research is needed to fully elucidate the mechanisms by which TBC1D25 regulates cellular homeostasis and to explore its potential as a therapeutic target for these diseases.

Genular Protein ID: 832192255

Symbol: TBC25_HUMAN

Name: TBC1 domain family member 25

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21383079

Title: OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.

PubMed ID: 21383079

DOI: 10.1083/jcb.201008107

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 688
  • Mass: 76327
  • Checksum: 5B070FE11D78D0A4
  • Sequence:
  • MATASGASDL SGSGAPPPGV GAQAAAAAEE EEREVVRVRV KKCESFLPPE FRSFAVDPQI 
    TSLDVLQHIL IRAFDLSGKK NFGISYLGRD RLGQEVYLSL LSDWDLSTAF ATASKPYLQL 
    RVDIRPSEDS PLLEDWDIIS PKDVIGSDVL LAEKRSSLTT AALPFTQSIL TQVGRTLSKV 
    QQVLSWSYGE DVKPFKPPLS DAEFHTYLNH EGQLSRPEEL RLRIYHGGVE PSLRKVVWRY 
    LLNVYPDGLT GRERMDYMKR KSREYEQLKS EWAQRANPED LEFIRSTVLK DVLRTDRAHP 
    YYAGPEDGPH LRALHDLLTT YAVTHPQVSY CQGMSDLASP ILAVMDHEGH AFVCFCGIMK 
    RLAANFHPDG RAMATKFAHL KLLLRHADPD FYQYLQEAGA DDLFFCYRWL LLELKREFAF 
    DDALRMLEVT WSSLPPDPPE HEVELVGPPS QVADAGFGGH RGWPVRQRHM LRPAGGGGST 
    FEDAVDHLAT ASQGPGGGGR LLRQASLDGL QQLRDNMGSR RDPLVQLPHP AALISSKSLS 
    EPLLNSPDPL LSSFSHPDSP SSSSPPSTQE ASPTGDMAVG SPLMQEVGSP KDPGKSLPPV 
    PPMGLPPPQE FGRGNPFMLF LCLAILLEHR DHIMRNGLDY NELAMHFDRL VRKHHLGRVL 
    RRARALFADY LQSEVWDSEE GAEATAAS

Genular Protein ID: 3644776379

Symbol: B4DF03_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 692
  • Mass: 76766
  • Checksum: 2978652FC7AEE7E9
  • Sequence:
  • MATASGASDL SGSGAPPPGV GAQAAAAAEE EEREVVRVRV KVRLAKCESF LPPEFRSFAV 
    DPQITSLDVL QHILIRAFDL SGKKNFGISY LGRDRLGQEV YLSLLSDWDL STAFATASKP 
    YLQLRVDIRP SEDSPLLEDW DIISPKDVIG SDVLLAEKRS SLTTAALPFT QSILTQVGRT 
    LSKVQQVLSW SYGEDVKPFK PPLSDAEFHT YLNHEGQLSR PEELRLRIYH GGVEPSLRKV 
    VWRYLLNVYP DGLTGRERMD YMKRKSREYE QLKSEWAQRA NPEDLEFIRS TVLKDVLRTD 
    RAHPYYAGPE DGPHLRALHD LLTTYAVTHP QVSYCQGMSD LASPILAVMD HEGHAFVCFC 
    GIMKRLAANF HPDGRAMATK FAHLKLLLRH ADPDFYQYLQ EAGADDLFFC YRWLLLELKR 
    EFAFDDALRM LEVTWSSLPP DPPEHEVELV GPPSQVADAG FGGHRGWPVR QRHMLRPAGG 
    GGSTFEDAVD HLATASQGPG GGGRLLRQAS LDGLQQLRDN MGSRRDPLVQ LPHPAALISS 
    KSLSEPLLNS PDPLLSSFSH PDSPSSSSPP STQEASPTGD MAVGSPLMQE VGSPKDPGKS 
    LPPVPPMGLP PPQEFGRGNP FMLFLCLAIL LEHRDHIMRN GLDYNELAMH FDRLVRKHHL 
    GRVLRRARAL FADYLQSEVW DSEEGAEATA AS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.