Details for: OR1D2

Gene ID: 4991

Symbol: OR1D2

Ensembl ID: ENSG00000184166

Description: olfactory receptor family 1 subfamily D member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 5.4302
    Cell Significance Index: 112.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.0453
    Cell Significance Index: 43.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1879
    Cell Significance Index: 25.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1070
    Cell Significance Index: 26.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9615
    Cell Significance Index: 30.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.7996
    Cell Significance Index: 12.0500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.6389
    Cell Significance Index: 7.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1916
    Cell Significance Index: 11.5000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1045
    Cell Significance Index: 0.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0914
    Cell Significance Index: 1.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0580
    Cell Significance Index: 9.4300
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.0543
    Cell Significance Index: 0.5700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0185
    Cell Significance Index: 0.2000
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0147
    Cell Significance Index: 0.0800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0041
    Cell Significance Index: 0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0006
    Cell Significance Index: 0.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0003
    Cell Significance Index: -0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0003
    Cell Significance Index: -0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0018
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0018
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0027
    Cell Significance Index: -0.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0029
    Cell Significance Index: -0.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0033
    Cell Significance Index: -0.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0041
    Cell Significance Index: -0.1800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0043
    Cell Significance Index: -0.0300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0052
    Cell Significance Index: -0.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0054
    Cell Significance Index: -0.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0059
    Cell Significance Index: -0.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0071
    Cell Significance Index: -0.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0077
    Cell Significance Index: -1.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0079
    Cell Significance Index: -0.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0086
    Cell Significance Index: -0.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0087
    Cell Significance Index: -0.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0106
    Cell Significance Index: -0.6500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0111
    Cell Significance Index: -0.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0113
    Cell Significance Index: -0.5100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0126
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0127
    Cell Significance Index: -0.5200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0128
    Cell Significance Index: -0.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0134
    Cell Significance Index: -0.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0138
    Cell Significance Index: -0.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0145
    Cell Significance Index: -0.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0146
    Cell Significance Index: -0.3700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0148
    Cell Significance Index: -0.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0153
    Cell Significance Index: -0.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0153
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0156
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0160
    Cell Significance Index: -0.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0162
    Cell Significance Index: -0.5300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0174
    Cell Significance Index: -0.2200
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0189
    Cell Significance Index: -0.1900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0199
    Cell Significance Index: -0.2600
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0199
    Cell Significance Index: -0.2200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0203
    Cell Significance Index: -0.2500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0207
    Cell Significance Index: -0.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0207
    Cell Significance Index: -0.4400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0213
    Cell Significance Index: -0.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0213
    Cell Significance Index: -0.4600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0218
    Cell Significance Index: -0.2900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0220
    Cell Significance Index: -0.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0224
    Cell Significance Index: -0.6400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0225
    Cell Significance Index: -0.4700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0225
    Cell Significance Index: -0.3100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0260
    Cell Significance Index: -0.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0268
    Cell Significance Index: -0.5300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0268
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0275
    Cell Significance Index: -0.2900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0276
    Cell Significance Index: -0.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0280
    Cell Significance Index: -0.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0290
    Cell Significance Index: -0.8300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0296
    Cell Significance Index: -0.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0304
    Cell Significance Index: -0.6100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0306
    Cell Significance Index: -0.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0307
    Cell Significance Index: -0.8200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0309
    Cell Significance Index: -0.2900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0314
    Cell Significance Index: -0.8000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0323
    Cell Significance Index: -0.2000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0335
    Cell Significance Index: -0.6600
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0345
    Cell Significance Index: -0.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0350
    Cell Significance Index: -0.8400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0404
    Cell Significance Index: -0.5100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0404
    Cell Significance Index: -0.4700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0433
    Cell Significance Index: -0.5400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0438
    Cell Significance Index: -0.6000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0446
    Cell Significance Index: -0.8900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0450
    Cell Significance Index: -0.4900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0451
    Cell Significance Index: -0.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0454
    Cell Significance Index: -0.7600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0455
    Cell Significance Index: -0.5500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0456
    Cell Significance Index: -0.5700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0464
    Cell Significance Index: -0.4400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0469
    Cell Significance Index: -0.4900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0476
    Cell Significance Index: -0.9300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0479
    Cell Significance Index: -0.5700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0488
    Cell Significance Index: -0.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** OR1D2 is located on chromosome 11q13.3 and is significantly expressed in a wide range of cell types, including B cells, CD8-positive T cells, and epithelial cells of the large and small intestines. 2. **Olfactory Receptor Function:** OR1D2 is a member of the olfactory receptor family, which plays a vital role in detecting chemical stimuli involved in sensory perception of smell. This receptor is activated by binding to specific odorant molecules, triggering a signaling cascade that ultimately leads to the perception of a particular smell. 3. **G Protein-Coupled Receptor Activity:** OR1D2 belongs to the G protein-coupled receptor (GPCR) family, which is characterized by its ability to bind to ligands and activate a G protein-mediated signaling pathway. This pathway involves the activation of adenylate cyclase, leading to the production of cAMP and subsequent cellular responses. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR1D2 plays a crucial role in detecting chemical stimuli involved in sensory perception of smell. The receptor is activated by binding to specific odorant molecules, triggering a signaling cascade that ultimately leads to the perception of a particular smell. 2. **G Protein-Coupled Receptor Signaling Pathway:** OR1D2 activates a G protein-coupled receptor signaling pathway, which involves the activation of adenylate cyclase, leading to the production of cAMP and subsequent cellular responses. 3. **Immune System Regulation:** OR1D2 is significantly expressed in B cells and T cells, suggesting its involvement in immune system regulation. The receptor may play a role in modulating immune responses to odorant molecules, which could have implications for our understanding of immune system function. 4. **Intestinal Epithelial Cell Function:** OR1D2 is also expressed in epithelial cells of the large and small intestines, where it may play a role in maintaining the integrity of the epithelial barrier and regulating intestinal homeostasis. **Clinical Significance:** 1. **Olfactory Dysfunction:** Mutations in the OR1D2 gene have been associated with olfactory dysfunction, which can have significant impacts on quality of life. 2. **Immune System Disorders:** OR1D2 may play a role in modulating immune responses to odorant molecules, which could have implications for our understanding of immune system disorders such as allergies and autoimmune diseases. 3. **Gastrointestinal Disorders:** The expression of OR1D2 in epithelial cells of the large and small intestines suggests its potential role in maintaining the integrity of the epithelial barrier and regulating intestinal homeostasis. Dysregulation of OR1D2 may contribute to gastrointestinal disorders such as inflammatory bowel disease. 4. **Cancer Research:** OR1D2 has been identified as a potential biomarker for cancer diagnosis and prognosis. The receptor's expression in various tissues and its role in immune system regulation make it an attractive target for cancer research. In conclusion, OR1D2 is a multifaceted gene that plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell, as well as immune system regulation and epithelial cell function. Further research is needed to fully elucidate the functions and clinical significance of OR1D2, but its importance in our understanding of the human olfactory system and immune system is undeniable.

Genular Protein ID: 2104252369

Symbol: OR1D2_HUMAN

Name: Olfactory receptor 1D2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8097991

Title: The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism.

PubMed ID: 8097991

DOI: 10.1159/000133534

PubMed ID: 10673334

Title: Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

PubMed ID: 10673334

DOI: 10.1006/geno.1999.6030

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 8004088

Title: Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

PubMed ID: 8004088

DOI: 10.1093/hmg/3.2.229

PubMed ID: 12663925

Title: Identification of a testicular odorant receptor mediating human sperm chemotaxis.

PubMed ID: 12663925

DOI: 10.1126/science.1080376

PubMed ID: 15458659

Title: Dual capacity of a human olfactory receptor.

PubMed ID: 15458659

DOI: 10.1016/j.cub.2004.09.034

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

PubMed ID: 16820410

Title: Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.

PubMed ID: 16820410

DOI: 10.1242/jcs.03046

Sequence Information:

  • Length: 312
  • Mass: 35240
  • Checksum: 71B05367C0AA135B
  • Sequence:
  • MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS SDSRLHTPVY 
    FFLANLSFTD LFFVTNTIPK MLVNLQSHNK AISYAGCLTQ LYFLVSLVAL DNLILAVMAY 
    DRYVAICCPL HYTTAMSPKL CILLLSLCWV LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE 
    MYVLLRMACS NIQINHTVLI ATGCFIFLIP FGFVIISYVL IIRAILRIPS VSKKYKAFST 
    CASHLGAVSL FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL 
    GRLLDKHFKR LT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.