Details for: OR3A2

Gene ID: 4995

Symbol: OR3A2

Ensembl ID: ENSG00000221882

Description: olfactory receptor family 3 subfamily A member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 20.8300
    Cell Significance Index: -3.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.7344
    Cell Significance Index: -3.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3244
    Cell Significance Index: 42.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7907
    Cell Significance Index: 17.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4194
    Cell Significance Index: 15.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3447
    Cell Significance Index: 15.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2846
    Cell Significance Index: 46.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2427
    Cell Significance Index: 14.5700
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.2335
    Cell Significance Index: 2.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2126
    Cell Significance Index: 21.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1789
    Cell Significance Index: 3.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1751
    Cell Significance Index: 3.0000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1682
    Cell Significance Index: 1.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1545
    Cell Significance Index: 29.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1349
    Cell Significance Index: 3.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1333
    Cell Significance Index: 8.4000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1140
    Cell Significance Index: 1.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0864
    Cell Significance Index: 9.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0730
    Cell Significance Index: 4.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0587
    Cell Significance Index: 11.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0473
    Cell Significance Index: 3.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0318
    Cell Significance Index: 1.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0298
    Cell Significance Index: 10.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0249
    Cell Significance Index: 1.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0217
    Cell Significance Index: 0.9900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0199
    Cell Significance Index: 0.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0130
    Cell Significance Index: 1.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0116
    Cell Significance Index: 0.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0088
    Cell Significance Index: 16.6600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0085
    Cell Significance Index: 0.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0066
    Cell Significance Index: 0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0058
    Cell Significance Index: 3.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0057
    Cell Significance Index: 10.4600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0054
    Cell Significance Index: 0.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0053
    Cell Significance Index: 0.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0052
    Cell Significance Index: 7.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0041
    Cell Significance Index: 6.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0037
    Cell Significance Index: 0.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0038
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0053
    Cell Significance Index: -2.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0061
    Cell Significance Index: -0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0064
    Cell Significance Index: -1.2800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0070
    Cell Significance Index: -0.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0090
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0095
    Cell Significance Index: -1.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0108
    Cell Significance Index: -1.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0118
    Cell Significance Index: -0.3400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0119
    Cell Significance Index: -0.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0127
    Cell Significance Index: -1.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0140
    Cell Significance Index: -0.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0145
    Cell Significance Index: -0.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0145
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0145
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0147
    Cell Significance Index: -1.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0148
    Cell Significance Index: -0.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0173
    Cell Significance Index: -1.0600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0207
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0222
    Cell Significance Index: -2.5900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0223
    Cell Significance Index: -0.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0247
    Cell Significance Index: -2.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0259
    Cell Significance Index: -3.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0275
    Cell Significance Index: -1.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0283
    Cell Significance Index: -2.9500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0310
    Cell Significance Index: -0.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0316
    Cell Significance Index: -0.8500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0318
    Cell Significance Index: -0.3600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0379
    Cell Significance Index: -0.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0384
    Cell Significance Index: -0.7500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0405
    Cell Significance Index: -0.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0442
    Cell Significance Index: -2.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0459
    Cell Significance Index: -3.4200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0475
    Cell Significance Index: -1.1600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0593
    Cell Significance Index: -0.8200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0601
    Cell Significance Index: -0.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0625
    Cell Significance Index: -1.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0628
    Cell Significance Index: -2.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0642
    Cell Significance Index: -1.5400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0656
    Cell Significance Index: -1.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0689
    Cell Significance Index: -2.2000
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0689
    Cell Significance Index: -0.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0709
    Cell Significance Index: -2.3200
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.0737
    Cell Significance Index: -0.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0759
    Cell Significance Index: -2.6600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0772
    Cell Significance Index: -1.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0790
    Cell Significance Index: -2.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0794
    Cell Significance Index: -2.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0818
    Cell Significance Index: -2.0400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0842
    Cell Significance Index: -1.0500
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0843
    Cell Significance Index: -0.5300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0856
    Cell Significance Index: -1.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0905
    Cell Significance Index: -2.3800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0914
    Cell Significance Index: -1.0800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0927
    Cell Significance Index: -1.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0945
    Cell Significance Index: -4.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0981
    Cell Significance Index: -1.1700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1003
    Cell Significance Index: -1.4400
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.1017
    Cell Significance Index: -1.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Family 3 Subfamily A Member 2**: OR3A2 belongs to the olfactory receptor family 3, which is responsible for detecting odorant molecules in the air. 2. **G Protein-Coupled Receptor Activity**: OR3A2 is a G protein-coupled receptor, which means it can interact with G proteins to transmit signals within cells. 3. **Expression in Multiple Tissues**: OR3A2 is expressed in various tissues, including the brain, colon, and small intestine, suggesting a broader role in sensory perception and beyond. **Pathways and Functions:** 1. **Detection of Chemical Stimulus**: OR3A2 is involved in detecting chemical stimuli involved in sensory perception of smell, which is essential for our ability to perceive odors. 2. **Expression and Translocation of Olfactory Receptors**: OR3A2 plays a role in the expression and translocation of olfactory receptors, ensuring that these receptors are properly localized and functional. 3. **G Protein-Coupled Receptor Signaling Pathway**: OR3A2 activates the G protein-coupled receptor signaling pathway, which is a critical signaling mechanism in cells. 4. **Olfactory Signaling Pathway**: OR3A2 is part of the olfactory signaling pathway, which is responsible for transmitting signals from olfactory receptors to the brain, where they are interpreted as specific odors. **Clinical Significance:** 1. **Olfactory Dysfunction**: Alterations in OR3A2 expression or function may contribute to olfactory dysfunction, such as anosmia or hyposmia, which can have significant impacts on quality of life. 2. **Neurodegenerative Diseases**: OR3A2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where olfactory dysfunction is a common feature. 3. **Gastrointestinal Disorders**: OR3A2 expression in the colon and small intestine suggests a potential role in gastrointestinal disorders, such as inflammatory bowel disease or irritable bowel syndrome. 4. **Cancer Research**: OR3A2 has been identified as a potential biomarker for certain types of cancer, such as colon cancer, where its expression is altered. In conclusion, OR3A2 is a complex gene with multiple roles in sensory perception, signaling, and disease. Further research is necessary to fully understand its functions and clinical significance, but its importance in olfactory perception and beyond is undeniable.

Genular Protein ID: 3730786397

Symbol: OR3A2_HUMAN

Name: Olfactory receptor 3A2

UniProtKB Accession Codes:

P47893 Q6IFM3 Q9P1Q3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 GO 6 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10673334

Title: Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

PubMed ID: 10673334

DOI: 10.1006/geno.1999.6030

PubMed ID: 8004088

Title: Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

PubMed ID: 8004088

DOI: 10.1093/hmg/3.2.229

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 321
  • Mass: 35207
  • Checksum: 642FCD0CC1660F8A
  • Sequence:
    • MSLQKLMEPE AGTNRTAVAE FILLGLVQTE EMQPVVFVLL LFAYLVTTGG NLSILAAVLV 
EPKLHAPMYF FLGNLSVLDV GCITVTVPAM LGRLLSHKST ISYDACLSQL FFFHLLAGMD 
CFLLTAMAYD RLLAICQPLT YSTRMSQTVQ RMLVAASLAC AFTNALTHTV AMSTLNFCGP 
NEVNHFYCDL PQLFQLSCSS TQLNELLLFA VGFIMAGTPL VLIITAYSHV AAAVLRIRSV 
EGRKKAFSTC GSHLTVVCLF FGRGIFNYMR LGSEEASDKD KGVGVFNTVI NPMLNPLIYS 
LRNPDVQGAL WQIFLGRRSL T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.