Details for: ORC5

Gene ID: 5001

Symbol: ORC5

Ensembl ID: ENSG00000164815

Description: origin recognition complex subunit 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 144.2024
    Cell Significance Index: -22.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 90.9742
    Cell Significance Index: -23.0800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 54.3152
    Cell Significance Index: -22.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.0416
    Cell Significance Index: -24.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.3807
    Cell Significance Index: -19.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.5115
    Cell Significance Index: -24.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.4005
    Cell Significance Index: -23.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.0697
    Cell Significance Index: -21.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3260
    Cell Significance Index: -19.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1276
    Cell Significance Index: -24.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.4419
    Cell Significance Index: -11.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.9968
    Cell Significance Index: 760.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5556
    Cell Significance Index: 312.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1027
    Cell Significance Index: 179.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0616
    Cell Significance Index: 59.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9299
    Cell Significance Index: 184.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8701
    Cell Significance Index: 32.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8236
    Cell Significance Index: 36.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7503
    Cell Significance Index: 677.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6913
    Cell Significance Index: 46.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6858
    Cell Significance Index: 245.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5733
    Cell Significance Index: 62.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5704
    Cell Significance Index: 15.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5272
    Cell Significance Index: 31.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4835
    Cell Significance Index: 8.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4632
    Cell Significance Index: 9.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4613
    Cell Significance Index: 319.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4272
    Cell Significance Index: 32.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4085
    Cell Significance Index: 8.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3206
    Cell Significance Index: 9.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3174
    Cell Significance Index: 8.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2562
    Cell Significance Index: 15.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2407
    Cell Significance Index: 16.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1700
    Cell Significance Index: 4.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1471
    Cell Significance Index: 26.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1418
    Cell Significance Index: 3.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1292
    Cell Significance Index: 8.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1117
    Cell Significance Index: 11.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1037
    Cell Significance Index: 12.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1035
    Cell Significance Index: 56.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1004
    Cell Significance Index: 44.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0901
    Cell Significance Index: 169.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0829
    Cell Significance Index: 11.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0814
    Cell Significance Index: 0.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0764
    Cell Significance Index: 34.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0608
    Cell Significance Index: 38.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0482
    Cell Significance Index: 2.1900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0460
    Cell Significance Index: 0.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0459
    Cell Significance Index: 84.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0458
    Cell Significance Index: 70.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0438
    Cell Significance Index: 5.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0389
    Cell Significance Index: 4.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0350
    Cell Significance Index: 0.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0060
    Cell Significance Index: 0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0022
    Cell Significance Index: 3.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0063
    Cell Significance Index: -1.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0097
    Cell Significance Index: -0.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0105
    Cell Significance Index: -0.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0191
    Cell Significance Index: -2.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0202
    Cell Significance Index: -2.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0245
    Cell Significance Index: -17.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0262
    Cell Significance Index: -19.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0295
    Cell Significance Index: -22.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0400
    Cell Significance Index: -22.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0454
    Cell Significance Index: -28.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0704
    Cell Significance Index: -1.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0706
    Cell Significance Index: -20.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0828
    Cell Significance Index: -8.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0880
    Cell Significance Index: -2.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0965
    Cell Significance Index: -5.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1038
    Cell Significance Index: -4.8400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1093
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1132
    Cell Significance Index: -12.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1263
    Cell Significance Index: -8.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1280
    Cell Significance Index: -26.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1345
    Cell Significance Index: -17.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1478
    Cell Significance Index: -6.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1510
    Cell Significance Index: -7.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1528
    Cell Significance Index: -15.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1855
    Cell Significance Index: -11.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2061
    Cell Significance Index: -6.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2204
    Cell Significance Index: -7.6600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2253
    Cell Significance Index: -3.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2305
    Cell Significance Index: -17.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2356
    Cell Significance Index: -12.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2429
    Cell Significance Index: -14.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2521
    Cell Significance Index: -5.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2544
    Cell Significance Index: -6.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2613
    Cell Significance Index: -5.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2737
    Cell Significance Index: -21.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3019
    Cell Significance Index: -5.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3097
    Cell Significance Index: -10.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3178
    Cell Significance Index: -10.1200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3292
    Cell Significance Index: -4.8600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3416
    Cell Significance Index: -4.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3507
    Cell Significance Index: -5.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3523
    Cell Significance Index: -7.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4209
    Cell Significance Index: -8.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4325
    Cell Significance Index: -11.0500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4469
    Cell Significance Index: -5.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ORC5 is a small protein with a molecular weight of approximately 35 kDa. It is a part of the ORC complex, which is composed of five subunits (ORC1-5). ORC5 is highly conserved across species, suggesting its essential role in DNA replication. The protein contains a unique C-terminal domain that is involved in the recognition of DNA sequences at the origin of replication. ORC5 is also known to interact with other proteins, including Cdc6, which is essential for the assembly of the pre-replicative complex. **Pathways and Functions** ORC5 is involved in several key pathways related to DNA replication and cell cycle progression. These include: 1. **Activation of the pre-replicative complex**: ORC5 recognizes specific DNA sequences at the origin of replication and recruits other proteins to assemble the pre-replicative complex. 2. **Assembly of the ORC complex at the origin of replication**: ORC5 binds to DNA sequences at the origin of replication, allowing the assembly of the ORC complex. 3. **Regulation of DNA replication**: ORC5 interacts with other proteins to regulate DNA replication, including the recruitment of helicases and primases. 4. **Cell cycle checkpoints**: ORC5 is involved in the regulation of cell cycle checkpoints, which ensure that DNA replication is accurate and complete. **Clinical Significance** ORC5 dysregulation has been implicated in various diseases, including: 1. **Cancer**: ORC5 mutations have been found in certain types of cancer, including breast and ovarian cancer. 2. **Neurodegenerative diseases**: ORC5 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Congenital disorders**: ORC5 mutations have been associated with congenital disorders, such as intellectual disability and autism spectrum disorder. In conclusion, ORC5 is a critical component of the ORC complex, essential for the initiation of DNA replication in eukaryotic cells. Its dysregulation has been implicated in various diseases, highlighting the importance of ORC5 in maintaining genome stability and cellular homeostasis. **Future Directions** Further research is needed to fully understand the role of ORC5 in DNA replication and its implications in human disease. This includes: 1. **Investigating ORC5 function in different cell types**: ORC5 expression and function vary across different cell types, highlighting the need for further research on its role in specific cell types. 2. **Developing therapeutic strategies**: ORC5 dysregulation has been implicated in various diseases, suggesting the potential for therapeutic intervention. 3. **Elucidating ORC5 interactions with other proteins**: ORC5 interacts with other proteins to regulate DNA replication, highlighting the need for further research on its interactions with other proteins.

Genular Protein ID: 3788550713

Symbol: ORC5_HUMAN

Name: Origin recognition complex subunit 5

UniProtKB Accession Codes:

O43913 A4D0P8 O60590 O95268

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 8 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9829972

Title: The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p.

PubMed ID: 9829972

DOI: 10.1074/jbc.273.49.32421

PubMed ID: 9417919

Title: Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22.

PubMed ID: 9417919

DOI: 10.1006/geno.1997.5003

PubMed ID: 9765232

Title: ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases.

PubMed ID: 9765232

DOI: 10.1074/jbc.273.42.27137

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12909626

Title: The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle.

PubMed ID: 12909626

DOI: 10.1074/jbc.m307535200

PubMed ID: 17716973

Title: ATP-dependent assembly of the human origin recognition complex.

PubMed ID: 17716973

DOI: 10.1074/jbc.m705905200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 31160578

Title: The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing.

PubMed ID: 31160578

DOI: 10.1038/s41467-019-10321-x

Sequence Information:

  • Length: 435
  • Mass: 50283
  • Checksum: 0FEB0E829C124745
  • Sequence:
    • MPHLENVVLC RESQVSILQS LFGERHHFSF PSIFIYGHTA SGKTYVTQTL LKTLELPHVF 
VNCVECFTLR LLLEQILNKL NHLSSSEDGC STEITCETFN DFVRLFKQVT TAENLKDQTV 
YIVLDKAEYL RDMEANLLPG FLRLQELADR NVTVLFLSEI VWEKFRPNTG CFEPFVLYFP 
DYSIGNLQKI LSHDHPPEYS ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV 
VKGEASERDT RKLWRNIEPH LKKAMQTVYL REISSSQWEK LQKDDTDPGQ LKGLSAHTHV 
ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTNF LKKHEKTSNH LLGPKPFPLD 
RLLAILYSIV DSRVAPTANI FSQITSLVTL QLLTLVGHDD QLDGPKYKCT VSLDFIRAIA 
RTVNFDIIKY LYDFL

Genular Protein ID: 2099098098

Symbol: Q53FC8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53FC8

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 6 RefSeq 2 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 435
  • Mass: 50284
  • Checksum: F99AC808529EAC3D
  • Sequence:
    • MPHLENVVLC RESQVSILQS LFGERHHFSF PSIFIYGHTA SGKTYVTQTL LKTLELPHVF 
VNCVECFTLR LLLEQILNKL DHLSSSEDGC STEITCETFN DFVRLFKQVT TAENLKDQTV 
YIVLDKAEYL RDMEANLLPG FLRLQELADR NVTVLFLSEI VWEKFRPNTG CFEPFVLYFP 
DYSIGNLQKI LSHDHPPEYS ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV 
VKGEASERDT RKLWRNIEPH LKKAMQTVYL REISSSQWEK LQKDDTDPGQ LKGLSAHTHV 
ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTNF LKKHEKTSNH LLGPKPFPLD 
RLLAILYSIV DSRVAPTANI FSQITSLVTL QLLTLVGHDD QLDGPKYKCT VSLDFIRAIA 
RTVNFDIIKY LYDFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.