Details for: P2RX7
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 143.5595
Cell Significance Index: -22.3300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 85.3166
Cell Significance Index: -21.6400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 42.8278
Cell Significance Index: -22.0300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.1677
Cell Significance Index: -22.4000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.6943
Cell Significance Index: -22.4700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.8113
Cell Significance Index: -10.5300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 1.6494
Cell Significance Index: 101.1200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.5770
Cell Significance Index: 316.3400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.3502
Cell Significance Index: 20.8900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6176
Cell Significance Index: 221.5300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.4231
Cell Significance Index: 7.8200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4033
Cell Significance Index: 278.9600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4015
Cell Significance Index: 76.4100 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.3126
Cell Significance Index: 4.1700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2912
Cell Significance Index: 262.9800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.2604
Cell Significance Index: 7.4300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2587
Cell Significance Index: 25.6000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2140
Cell Significance Index: 42.4600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1597
Cell Significance Index: 10.7400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0945
Cell Significance Index: 5.8100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0833
Cell Significance Index: 13.5500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0270
Cell Significance Index: 49.7900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0199
Cell Significance Index: 8.8200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0101
Cell Significance Index: 19.0800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0069
Cell Significance Index: 10.6500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0042
Cell Significance Index: 0.1400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0083
Cell Significance Index: -11.2900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0099
Cell Significance Index: -0.1700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0239
Cell Significance Index: -0.8400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0248
Cell Significance Index: -15.7400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0278
Cell Significance Index: -20.3700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0295
Cell Significance Index: -22.3500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0360
Cell Significance Index: -16.3500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0387
Cell Significance Index: -28.6700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0394
Cell Significance Index: -21.4900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0423
Cell Significance Index: -26.4200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0428
Cell Significance Index: -2.2300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0499
Cell Significance Index: -5.4300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0508
Cell Significance Index: -28.6400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0637
Cell Significance Index: -2.9700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0689
Cell Significance Index: -19.8400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0692
Cell Significance Index: -12.4800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0779
Cell Significance Index: -3.5300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0871
Cell Significance Index: -2.5100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0893
Cell Significance Index: -12.2700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0952
Cell Significance Index: -9.7200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1035
Cell Significance Index: -15.0500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1092
Cell Significance Index: -2.7300 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1112
Cell Significance Index: -14.2500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1382
Cell Significance Index: -29.1100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1390
Cell Significance Index: -23.7400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1428
Cell Significance Index: -17.5600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1430
Cell Significance Index: -10.9800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1612
Cell Significance Index: -20.8300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1820
Cell Significance Index: -11.7400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1859
Cell Significance Index: -21.3000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1899
Cell Significance Index: -22.4000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1906
Cell Significance Index: -19.8500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2123
Cell Significance Index: -14.6800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2136
Cell Significance Index: -5.9700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2143
Cell Significance Index: -24.9800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2342
Cell Significance Index: -10.3600 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.2462
Cell Significance Index: -2.6400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2578
Cell Significance Index: -20.4200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2672
Cell Significance Index: -14.0300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2735
Cell Significance Index: -8.7100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2882
Cell Significance Index: -21.4800 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2925
Cell Significance Index: -6.3200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2926
Cell Significance Index: -13.7500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3024
Cell Significance Index: -21.3900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3296
Cell Significance Index: -10.7900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.3458
Cell Significance Index: -20.7600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3488
Cell Significance Index: -13.2100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3618
Cell Significance Index: -20.3000 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.3668
Cell Significance Index: -4.8900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3704
Cell Significance Index: -9.7400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3882
Cell Significance Index: -9.3100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3894
Cell Significance Index: -8.5300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3918
Cell Significance Index: -10.4800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4109
Cell Significance Index: -25.9000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4177
Cell Significance Index: -21.7000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4327
Cell Significance Index: -15.1600 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.4402
Cell Significance Index: -5.4600 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4420
Cell Significance Index: -9.3800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.4445
Cell Significance Index: -9.6300 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.5041
Cell Significance Index: -10.1200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.5473
Cell Significance Index: -27.6600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.5684
Cell Significance Index: -11.7900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.5883
Cell Significance Index: -11.6300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.5948
Cell Significance Index: -17.4700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5963
Cell Significance Index: -20.7200 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5981
Cell Significance Index: -14.9200 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.5984
Cell Significance Index: -26.0200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.6165
Cell Significance Index: -15.7500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6235
Cell Significance Index: -22.8900 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.6278
Cell Significance Index: -6.8400 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.6362
Cell Significance Index: -11.0000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.6442
Cell Significance Index: -17.2000 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.6523
Cell Significance Index: -13.6200 - Cell Name: neural cell (CL0002319)
Fold Change: -0.6583
Cell Significance Index: -7.6800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 271551531
Symbol: P2RX7_HUMAN
Name: P2X purinoceptor 7
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9038151
Title: The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA.
PubMed ID: 9038151
PubMed ID: 9826911
Title: Gene structure and chromosomal localization of the human P2X7 receptor.
PubMed ID: 9826911
PubMed ID: 15896293
Title: Identification and characterization of splice variants of the human P2X7 ATP channel.
PubMed ID: 15896293
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11707406
Title: Proteomic and functional evidence for a P2X7 receptor signalling complex.
PubMed ID: 11707406
PubMed ID: 12107182
Title: Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus.
PubMed ID: 12107182
PubMed ID: 18971257
Title: Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts.
PubMed ID: 18971257
DOI: 10.1096/fj.08-114637
PubMed ID: 20450227
Title: Mutation of putative N-linked glycosylation sites on the human nucleotide receptor P2X7 reveals a key residue important for receptor function.
PubMed ID: 20450227
DOI: 10.1021/bi902083n
PubMed ID: 21821797
Title: P2X(7) is a scavenger receptor for apoptotic cells in the absence of its ligand, extracellular ATP.
PubMed ID: 21821797
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 11150303
Title: A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor.
PubMed ID: 11150303
PubMed ID: 12586825
Title: An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor.
PubMed ID: 12586825
PubMed ID: 15123679
Title: An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor.
PubMed ID: 15123679
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 23303206
Title: A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration.
PubMed ID: 23303206
DOI: 10.1096/fj.12-215368
PubMed ID: 28326637
Title: Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis.
PubMed ID: 28326637
DOI: 10.1002/humu.23218
Sequence Information:
- Length: 595
- Mass: 68585
- Checksum: 584C17EF6D5EC899
- Sequence:
MPACCSCSDV FQYETNKVTR IQSMNYGTIK WFFHVIIFSY VCFALVSDKL YQRKEPVISS VHTKVKGIAE VKEEIVENGV KKLVHSVFDT ADYTFPLQGN SFFVMTNFLK TEGQEQRLCP EYPTRRTLCS SDRGCKKGWM DPQSKGIQTG RCVVYEGNQK TCEVSAWCPI EAVEEAPRPA LLNSAENFTV LIKNNIDFPG HNYTTRNILP GLNITCTFHK TQNPQCPIFR LGDIFRETGD NFSDVAIQGG IMGIEIYWDC NLDRWFHHCR PKYSFRRLDD KTTNVSLYPG YNFRYAKYYK ENNVEKRTLI KVFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLAAVF IDFLIDTYSS NCCRSHIYPW CKCCQPCVVN EYYYRKKCES IVEPKPTLKY VSFVDESHIR MVNQQLLGRS LQDVKGQEVP RPAMDFTDLS RLPLALHDTP PIPGQPEEIQ LLRKEATPRS RDSPVWCQCG SCLPSQLPES HRCLEELCCR KKPGACITTS ELFRKLVLSR HVLQFLLLYQ EPLLALDVDS TNSRLRHCAY RCYATWRFGS QDMADFAILP SCCRWRIRKE FPKSEGQYSG FKSPY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.