Details for: P2RX7

Gene ID: 5027

Symbol: P2RX7

Ensembl ID: ENSG00000089041

Description: purinergic receptor P2X 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.5595
    Cell Significance Index: -22.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.3166
    Cell Significance Index: -21.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.8278
    Cell Significance Index: -22.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1677
    Cell Significance Index: -22.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6943
    Cell Significance Index: -22.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8113
    Cell Significance Index: -10.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6494
    Cell Significance Index: 101.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5770
    Cell Significance Index: 316.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.3502
    Cell Significance Index: 20.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6176
    Cell Significance Index: 221.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4231
    Cell Significance Index: 7.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4033
    Cell Significance Index: 278.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4015
    Cell Significance Index: 76.4100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.3126
    Cell Significance Index: 4.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2912
    Cell Significance Index: 262.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2604
    Cell Significance Index: 7.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2587
    Cell Significance Index: 25.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2140
    Cell Significance Index: 42.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1597
    Cell Significance Index: 10.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0945
    Cell Significance Index: 5.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0833
    Cell Significance Index: 13.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0270
    Cell Significance Index: 49.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0199
    Cell Significance Index: 8.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0101
    Cell Significance Index: 19.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0069
    Cell Significance Index: 10.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0042
    Cell Significance Index: 0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0083
    Cell Significance Index: -11.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0099
    Cell Significance Index: -0.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0239
    Cell Significance Index: -0.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0248
    Cell Significance Index: -15.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0278
    Cell Significance Index: -20.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0295
    Cell Significance Index: -22.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0360
    Cell Significance Index: -16.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0387
    Cell Significance Index: -28.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0394
    Cell Significance Index: -21.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0423
    Cell Significance Index: -26.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0428
    Cell Significance Index: -2.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0499
    Cell Significance Index: -5.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0508
    Cell Significance Index: -28.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0637
    Cell Significance Index: -2.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0689
    Cell Significance Index: -19.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0692
    Cell Significance Index: -12.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0779
    Cell Significance Index: -3.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0871
    Cell Significance Index: -2.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0893
    Cell Significance Index: -12.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0952
    Cell Significance Index: -9.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1035
    Cell Significance Index: -15.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1092
    Cell Significance Index: -2.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1112
    Cell Significance Index: -14.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1382
    Cell Significance Index: -29.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1390
    Cell Significance Index: -23.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1428
    Cell Significance Index: -17.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1430
    Cell Significance Index: -10.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1612
    Cell Significance Index: -20.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1820
    Cell Significance Index: -11.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1859
    Cell Significance Index: -21.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1899
    Cell Significance Index: -22.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1906
    Cell Significance Index: -19.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2123
    Cell Significance Index: -14.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2136
    Cell Significance Index: -5.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2143
    Cell Significance Index: -24.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2342
    Cell Significance Index: -10.3600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2462
    Cell Significance Index: -2.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2578
    Cell Significance Index: -20.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2672
    Cell Significance Index: -14.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2735
    Cell Significance Index: -8.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2882
    Cell Significance Index: -21.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2925
    Cell Significance Index: -6.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2926
    Cell Significance Index: -13.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3024
    Cell Significance Index: -21.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3296
    Cell Significance Index: -10.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3458
    Cell Significance Index: -20.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3488
    Cell Significance Index: -13.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3618
    Cell Significance Index: -20.3000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3668
    Cell Significance Index: -4.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3704
    Cell Significance Index: -9.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3882
    Cell Significance Index: -9.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3894
    Cell Significance Index: -8.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3918
    Cell Significance Index: -10.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4109
    Cell Significance Index: -25.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4177
    Cell Significance Index: -21.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4327
    Cell Significance Index: -15.1600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4402
    Cell Significance Index: -5.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4420
    Cell Significance Index: -9.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4445
    Cell Significance Index: -9.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5041
    Cell Significance Index: -10.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5473
    Cell Significance Index: -27.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5684
    Cell Significance Index: -11.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5883
    Cell Significance Index: -11.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5948
    Cell Significance Index: -17.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5963
    Cell Significance Index: -20.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5981
    Cell Significance Index: -14.9200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5984
    Cell Significance Index: -26.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6165
    Cell Significance Index: -15.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6235
    Cell Significance Index: -22.8900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6278
    Cell Significance Index: -6.8400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6362
    Cell Significance Index: -11.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6442
    Cell Significance Index: -17.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6523
    Cell Significance Index: -13.6200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6583
    Cell Significance Index: -7.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Purinergic Receptor**: P2X 7 is a purinergic receptor, which responds to extracellular ATP (adenosine triphosphate) and other purine nucleotides. 2. **Ion Channel**: P2X 7 forms ion channels in the cell membrane, allowing the influx of ions, including calcium, potassium, and sodium. 3. **Pore Formation**: The receptor can form pores in the cell membrane, which is a unique feature among purinergic receptors. 4. **Inflammatory Signaling**: P2X 7 plays a key role in inflammatory signaling, particularly in the activation of immune cells and the production of pro-inflammatory cytokines. 5. **Cell Signaling**: The receptor is involved in various cell signaling pathways, including calcium-mediated signaling, MAPK cascades, and protein phosphorylation. **Pathways and Functions:** 1. **Apoptotic Signaling**: P2X 7 is involved in the regulation of apoptosis (programmed cell death) in immune cells and neurons. 2. **Inflammatory Response**: The receptor plays a crucial role in the initiation and maintenance of inflammatory responses, particularly in the activation of immune cells and the production of pro-inflammatory cytokines. 3. **Immune System**: P2X 7 is expressed on various immune cells, including macrophages, neutrophils, and T cells, and is involved in their activation and function. 4. **Neurotransmission**: The receptor is also expressed in neurons and is involved in neurotransmission, particularly in the regulation of excitatory postsynaptic potentials. 5. **Cell Proliferation**: P2X 7 is involved in the regulation of cell proliferation, particularly in the context of cancer. **Clinical Significance:** 1. **Inflammatory Diseases**: The P2X 7 receptor is a target for the treatment of inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. 2. **Autoimmune Diseases**: The receptor is involved in the pathogenesis of autoimmune diseases, including lupus and rheumatoid arthritis. 3. **Cancer**: P2X 7 is involved in the regulation of cell proliferation and survival in cancer cells, and is a potential target for cancer therapy. 4. **Neurological Disorders**: The receptor is involved in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 5. **Toxicity**: The P2X 7 receptor is also involved in the toxicity of certain compounds, including ATP and other purine nucleotides. In conclusion, the P2RX7 gene encodes for a critical component of the purinergic signaling system, which is involved in various physiological and pathological processes. The receptor's unique ability to form pores in the cell membrane and its involvement in inflammatory signaling make it a promising target for the treatment of inflammatory diseases and other conditions.

Genular Protein ID: 271551531

Symbol: P2RX7_HUMAN

Name: P2X purinoceptor 7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9038151

Title: The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA.

PubMed ID: 9038151

DOI: 10.1074/jbc.272.9.5482

PubMed ID: 9826911

Title: Gene structure and chromosomal localization of the human P2X7 receptor.

PubMed ID: 9826911

PubMed ID: 15896293

Title: Identification and characterization of splice variants of the human P2X7 ATP channel.

PubMed ID: 15896293

DOI: 10.1016/j.bbrc.2005.04.087

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11707406

Title: Proteomic and functional evidence for a P2X7 receptor signalling complex.

PubMed ID: 11707406

DOI: 10.1093/emboj/20.22.6347

PubMed ID: 12107182

Title: Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus.

PubMed ID: 12107182

DOI: 10.1074/jbc.m205120200

PubMed ID: 18971257

Title: Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts.

PubMed ID: 18971257

DOI: 10.1096/fj.08-114637

PubMed ID: 20450227

Title: Mutation of putative N-linked glycosylation sites on the human nucleotide receptor P2X7 reveals a key residue important for receptor function.

PubMed ID: 20450227

DOI: 10.1021/bi902083n

PubMed ID: 21821797

Title: P2X(7) is a scavenger receptor for apoptotic cells in the absence of its ligand, extracellular ATP.

PubMed ID: 21821797

DOI: 10.4049/jimmunol.1101178

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11150303

Title: A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor.

PubMed ID: 11150303

DOI: 10.1074/jbc.m010353200

PubMed ID: 12586825

Title: An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor.

PubMed ID: 12586825

DOI: 10.1074/jbc.m212759200

PubMed ID: 15123679

Title: An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor.

PubMed ID: 15123679

DOI: 10.1074/jbc.m313902200

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23303206

Title: A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration.

PubMed ID: 23303206

DOI: 10.1096/fj.12-215368

PubMed ID: 28326637

Title: Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis.

PubMed ID: 28326637

DOI: 10.1002/humu.23218

Sequence Information:

  • Length: 595
  • Mass: 68585
  • Checksum: 584C17EF6D5EC899
  • Sequence:
  • MPACCSCSDV FQYETNKVTR IQSMNYGTIK WFFHVIIFSY VCFALVSDKL YQRKEPVISS 
    VHTKVKGIAE VKEEIVENGV KKLVHSVFDT ADYTFPLQGN SFFVMTNFLK TEGQEQRLCP 
    EYPTRRTLCS SDRGCKKGWM DPQSKGIQTG RCVVYEGNQK TCEVSAWCPI EAVEEAPRPA 
    LLNSAENFTV LIKNNIDFPG HNYTTRNILP GLNITCTFHK TQNPQCPIFR LGDIFRETGD 
    NFSDVAIQGG IMGIEIYWDC NLDRWFHHCR PKYSFRRLDD KTTNVSLYPG YNFRYAKYYK 
    ENNVEKRTLI KVFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLAAVF IDFLIDTYSS 
    NCCRSHIYPW CKCCQPCVVN EYYYRKKCES IVEPKPTLKY VSFVDESHIR MVNQQLLGRS 
    LQDVKGQEVP RPAMDFTDLS RLPLALHDTP PIPGQPEEIQ LLRKEATPRS RDSPVWCQCG 
    SCLPSQLPES HRCLEELCCR KKPGACITTS ELFRKLVLSR HVLQFLLLYQ EPLLALDVDS 
    TNSRLRHCAY RCYATWRFGS QDMADFAILP SCCRWRIRKE FPKSEGQYSG FKSPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.