Details for: COL5A3

Gene ID: 50509

Symbol: COL5A3

Ensembl ID: ENSG00000080573

Description: collagen type V alpha 3 chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 5.6510
    Cell Significance Index: 79.0200
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.3193
    Cell Significance Index: 14.6600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.9138
    Cell Significance Index: 15.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6686
    Cell Significance Index: 13.0500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5056
    Cell Significance Index: 7.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4486
    Cell Significance Index: 57.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3464
    Cell Significance Index: 9.9300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.3285
    Cell Significance Index: 1.4300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2671
    Cell Significance Index: 6.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2191
    Cell Significance Index: 43.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1817
    Cell Significance Index: 11.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1728
    Cell Significance Index: 2.0600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1414
    Cell Significance Index: 1.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0703
    Cell Significance Index: 48.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0528
    Cell Significance Index: 32.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0501
    Cell Significance Index: 22.1300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0500
    Cell Significance Index: 0.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0199
    Cell Significance Index: 7.1300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0061
    Cell Significance Index: -11.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0089
    Cell Significance Index: -6.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0132
    Cell Significance Index: -7.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0137
    Cell Significance Index: -25.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0168
    Cell Significance Index: -25.9200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0206
    Cell Significance Index: -0.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0206
    Cell Significance Index: -28.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0212
    Cell Significance Index: -15.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0230
    Cell Significance Index: -14.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0242
    Cell Significance Index: -3.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0307
    Cell Significance Index: -23.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0384
    Cell Significance Index: -17.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0403
    Cell Significance Index: -21.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0408
    Cell Significance Index: -4.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0423
    Cell Significance Index: -8.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0552
    Cell Significance Index: -9.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0571
    Cell Significance Index: -16.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0676
    Cell Significance Index: -12.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0852
    Cell Significance Index: -12.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0896
    Cell Significance Index: -17.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1178
    Cell Significance Index: -14.4800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1256
    Cell Significance Index: -0.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1338
    Cell Significance Index: -6.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1524
    Cell Significance Index: -19.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1698
    Cell Significance Index: -17.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1755
    Cell Significance Index: -20.7000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1807
    Cell Significance Index: -2.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1913
    Cell Significance Index: -22.2900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2001
    Cell Significance Index: -2.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2050
    Cell Significance Index: -15.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2129
    Cell Significance Index: -15.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2151
    Cell Significance Index: -22.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2215
    Cell Significance Index: -25.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2631
    Cell Significance Index: -19.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2644
    Cell Significance Index: -17.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2724
    Cell Significance Index: -16.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3196
    Cell Significance Index: -16.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3458
    Cell Significance Index: -16.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3523
    Cell Significance Index: -21.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3862
    Cell Significance Index: -21.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4087
    Cell Significance Index: -21.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4254
    Cell Significance Index: -6.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4272
    Cell Significance Index: -22.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4513
    Cell Significance Index: -19.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4561
    Cell Significance Index: -9.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4570
    Cell Significance Index: -11.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4742
    Cell Significance Index: -6.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4768
    Cell Significance Index: -16.5700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5121
    Cell Significance Index: -8.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5138
    Cell Significance Index: -16.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5140
    Cell Significance Index: -18.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5170
    Cell Significance Index: -8.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5292
    Cell Significance Index: -20.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5335
    Cell Significance Index: -18.6900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5469
    Cell Significance Index: -11.6900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.5487
    Cell Significance Index: -6.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5565
    Cell Significance Index: -16.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5580
    Cell Significance Index: -18.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5714
    Cell Significance Index: -26.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6065
    Cell Significance Index: -10.1500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6170
    Cell Significance Index: -15.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6213
    Cell Significance Index: -17.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6262
    Cell Significance Index: -17.5000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.6382
    Cell Significance Index: -7.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6384
    Cell Significance Index: -8.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6608
    Cell Significance Index: -23.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6779
    Cell Significance Index: -19.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6859
    Cell Significance Index: -17.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7172
    Cell Significance Index: -19.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7590
    Cell Significance Index: -16.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7699
    Cell Significance Index: -20.6300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7723
    Cell Significance Index: -11.0600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7809
    Cell Significance Index: -19.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7873
    Cell Significance Index: -21.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7922
    Cell Significance Index: -20.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7931
    Cell Significance Index: -22.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7954
    Cell Significance Index: -19.0800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.8065
    Cell Significance Index: -16.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8104
    Cell Significance Index: -17.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8229
    Cell Significance Index: -20.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8269
    Cell Significance Index: -8.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Collagen Type V Alpha 3 Chain:** COL5A3 encodes for a specific subunit of collagen type V, a non-fibrillar collagen that plays a vital role in the formation of collagen fibrils and other multimeric structures. 2. **Expression Pattern:** This gene is highly expressed in various cell types, including astrocytes, fibroblasts, and neurons, indicating its widespread involvement in different tissue types and developmental processes. 3. **Signaling Pathways:** COL5A3 interacts with multiple signaling pathways, including Met activating ptk2 signaling, Met promoting cell motility, and Ncam1 interactions, highlighting its role in regulating cellular behavior and response to environmental cues. **Pathways and Functions:** 1. **Collagen Biosynthesis and Modification:** COL5A3 is essential for the production of collagen type V, which participates in the formation of collagen fibrils and other multimeric structures, contributing to the structural integrity of tissues. 2. **Cell-Matrix Adhesion:** This gene plays a crucial role in cell-matrix adhesion, facilitating the interaction between cells and the extracellular matrix, which is essential for maintaining tissue architecture and function. 3. **Developmental Biology:** COL5A3 is involved in various developmental processes, including skin development, nervous system development, and embryonic morphogenesis, highlighting its importance in tissue formation and patterning. 4. **Extracellular Matrix Organization:** This gene contributes to the organization of the extracellular matrix, including the formation of collagen fibrils and other structural components, which is essential for maintaining tissue homeostasis. **Clinical Significance:** 1. **Skin Disorders:** Mutations in COL5A3 have been associated with skin disorders, such as vascular Ehlers-Danlos syndrome, which highlights the importance of this gene in maintaining skin integrity and function. 2. **Neurological Disorders:** Alterations in COL5A3 expression have been linked to neurological disorders, including Alzheimer's disease and amyotrophic lateral sclerosis, suggesting its role in neuronal function and survival. 3. **Cancer Metastasis:** COL5A3 has been implicated in cancer metastasis, as it can promote cell motility and invasion, highlighting its potential as a therapeutic target in cancer treatment. 4. **Regenerative Medicine:** Understanding the function and regulation of COL5A3 can provide insights into the development of novel therapeutic strategies for tissue repair and regeneration. In conclusion, COL5A3 is a vital gene that plays a critical role in various cellular processes, including collagen biosynthesis, cell-matrix adhesion, and development. Its clinical significance is underscored by its involvement in skin disorders, neurological disorders, cancer metastasis, and regenerative medicine. Further research is necessary to fully elucidate the mechanisms underlying COL5A3 function and to explore its therapeutic potential in different diseases.

Genular Protein ID: 3293139256

Symbol: CO5A3_HUMAN

Name: Collagen alpha-3(V) chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10722718

Title: The pro-alpha3 (V) collagen chain. Complete primary structure, expression domains in adult and developing tissues, and comparison to the structures and expression domains of the other types V and XI procollagen chains.

PubMed ID: 10722718

DOI: 10.1074/jbc.275.12.8749

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 1571108

Title: Isolation of the alpha 3-chain of human type V collagen and characterization by partial sequencing.

PubMed ID: 1571108

DOI: 10.1515/bchm3.1992.373.1.69

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

Sequence Information:

  • Length: 1745
  • Mass: 172121
  • Checksum: 4F5644D2A919D864
  • Sequence:
  • MGNRRDLGQP RAGLCLLLAA LQLLPGTQAD PVDVLKALGV QGGQAGVPEG PGFCPQRTPE 
    GDRAFRIGQA STLGIPTWEL FPEGHFPENF SLLITLRGQP ANQSVLLSIY DERGARQLGL 
    ALGPALGLLG DPFRPLPQQV NLTDGRWHRV AVSIDGEMVT LVADCEAQPP VLGHGPRFIS 
    IAGLTVLGTQ DLGEKTFEGD IQELLISPDP QAAFQACERY LPDCDNLAPA ATVAPQGEPE 
    TPRPRRKGKG KGRKKGRGRK GKGRKKNKEI WTSSPPPDSA ENQTSTDIPK TETPAPNLPP 
    TPTPLVVTST VTTGLNATIL ERSLDPDSGT ELGTLETKAA REDEEGDDST MGPDFRAAEY 
    PSRTQFQIFP GAGEKGAKGE PAVIEKGQQF EGPPGAPGPQ GVVGPSGPPG PPGFPGDPGP 
    PGPAGLPGIP GIDGIRGPPG TVIMMPFQFA GGSFKGPPVS FQQAQAQAVL QQTQLSMKGP 
    PGPVGLTGRP GPVGLPGHPG LKGEEGAEGP QGPRGLQGPH GPPGRVGKMG RPGADGARGL 
    PGDTGPKGDR GFDGLPGLPG EKGQRGDFGH VGQPGPPGED GERGAEGPPG PTGQAGEPGP 
    RGLLGPRGSP GPTGRPGVTG IDGAPGAKGN VGPPGEPGPP GQQGNHGSQG LPGPQGLIGT 
    PGEKGPPGNP GIPGLPGSDG PLGHPGHEGP TGEKGAQGPP GSAGPPGYPG PRGVKGTSGN 
    RGLQGEKGEK GEDGFPGFKG DVGLKGDQGK PGAPGPRGED GPEGPKGQAG QAGEEGPPGS 
    AGEKGKLGVP GLPGYPGRPG PKGSIGFPGP LGPIGEKGKS GKTGQPGLEG ERGPPGSRGE 
    RGQPGATGQP GPKGDVGQDG APGIPGEKGL PGLQGPPGFP GPKGPPGHQG KDGRPGHPGQ 
    RGELGFQGQT GPPGPAGVLG PQGKTGEVGP LGERGPPGPP GPPGEQGLPG LEGREGAKGE 
    LGPPGPLGKE GPAGLRGFPG PKGGPGDPGP TGLKGDKGPP GPVGANGSPG ERGPLGPAGG 
    IGLPGQSGSE GPVGPAGKKG SRGERGPPGP TGKDGIPGPL GPLGPPGAAG PSGEEGDKGD 
    VGAPGHKGSK GDKGDAGPPG QPGIRGPAGH PGPPGADGAQ GRRGPPGLFG QKGDDGVRGF 
    VGVIGPPGLQ GLPGPPGEKG EVGDVGSMGP HGAPGPRGPQ GPTGSEGTPG LPGGVGQPGA 
    VGEKGERGDA GDPGPPGAPG IPGPKGDIGE KGDSGPSGAA GPPGKKGPPG EDGAKGSVGP 
    TGLPGDLGPP GDPGVSGIDG SPGEKGDPGD VGGPGPPGAS GEPGAPGPPG KRGPSGHMGR 
    EGREGEKGAK GEPGPDGPPG RTGPMGARGP PGRVGPEGLR GIPGPVGEPG LLGAPGQMGP 
    PGPLGPSGLP GLKGDTGPKG EKGHIGLIGL IGPPGEAGEK GDQGLPGVQG PPGPKGDPGP 
    PGPIGSLGHP GPPGVAGPLG QKGSKGSPGS MGPRGDTGPA GPPGPPGAPA ELHGLRRRRR 
    FVPVPLPVVE GGLEEVLASL TSLSLELEQL RRPPGTAERP GLVCHELHRN HPHLPDGEYW 
    IDPNQGCARD SFRVFCNFTA GGETCLYPDK KFEIVKLASW SKEKPGGWYS TFRRGKKFSY 
    VDADGSPVNV VQLNFLKLLS ATARQNFTYS CQNAAAWLDE ATGDYSHSAR FLGTNGEELS 
    FNQTTAATVS VPQDGCRLRK GQTKTLFEFS SSRAGFLPLW DVAATDFGQT NQKFGFELGP 
    VCFSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.