Details for: CUZD1

Gene ID: 50624

Symbol: CUZD1

Ensembl ID: ENSG00000138161

Description: CUB and zona pellucida like domains 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 229.6841
    Cell Significance Index: 115.3500
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 18.9655
    Cell Significance Index: -2.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.6699
    Cell Significance Index: -2.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.4007
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.7413
    Cell Significance Index: 297.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3824
    Cell Significance Index: 29.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.3814
    Cell Significance Index: 84.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6269
    Cell Significance Index: 28.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5520
    Cell Significance Index: 17.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4860
    Cell Significance Index: 92.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.4330
    Cell Significance Index: -1.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3907
    Cell Significance Index: 8.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3847
    Cell Significance Index: 38.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3562
    Cell Significance Index: 7.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2480
    Cell Significance Index: 223.9500
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.2357
    Cell Significance Index: 1.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2059
    Cell Significance Index: 22.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2027
    Cell Significance Index: 12.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1851
    Cell Significance Index: 30.1000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1418
    Cell Significance Index: 2.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1416
    Cell Significance Index: 3.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1224
    Cell Significance Index: 4.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0954
    Cell Significance Index: 6.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0939
    Cell Significance Index: 18.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0893
    Cell Significance Index: 25.7100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0854
    Cell Significance Index: 1.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0488
    Cell Significance Index: 17.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0381
    Cell Significance Index: 0.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0326
    Cell Significance Index: 0.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0321
    Cell Significance Index: 1.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0293
    Cell Significance Index: 1.1100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0252
    Cell Significance Index: 0.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0250
    Cell Significance Index: 0.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0210
    Cell Significance Index: 0.4100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0204
    Cell Significance Index: 0.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0128
    Cell Significance Index: 0.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0112
    Cell Significance Index: 0.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0104
    Cell Significance Index: 2.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0039
    Cell Significance Index: 0.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0021
    Cell Significance Index: 0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0011
    Cell Significance Index: -0.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0029
    Cell Significance Index: -2.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0029
    Cell Significance Index: -1.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0036
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0038
    Cell Significance Index: -0.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0038
    Cell Significance Index: -2.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0039
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0045
    Cell Significance Index: -2.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0048
    Cell Significance Index: -0.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0066
    Cell Significance Index: -0.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0096
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0123
    Cell Significance Index: -2.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0136
    Cell Significance Index: -1.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0200
    Cell Significance Index: -2.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0211
    Cell Significance Index: -2.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0216
    Cell Significance Index: -1.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0221
    Cell Significance Index: -1.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0234
    Cell Significance Index: -0.3400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0271
    Cell Significance Index: -0.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0279
    Cell Significance Index: -1.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0301
    Cell Significance Index: -1.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0357
    Cell Significance Index: -2.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0401
    Cell Significance Index: -3.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0402
    Cell Significance Index: -2.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0411
    Cell Significance Index: -1.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0450
    Cell Significance Index: -1.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0463
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0476
    Cell Significance Index: -0.6000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0485
    Cell Significance Index: -0.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0513
    Cell Significance Index: -1.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0533
    Cell Significance Index: -1.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0552
    Cell Significance Index: -1.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0569
    Cell Significance Index: -1.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0586
    Cell Significance Index: -0.4000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0592
    Cell Significance Index: -0.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0597
    Cell Significance Index: -1.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0611
    Cell Significance Index: -2.1400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0617
    Cell Significance Index: -0.7800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0631
    Cell Significance Index: -0.5600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0632
    Cell Significance Index: -0.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0633
    Cell Significance Index: -2.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0639
    Cell Significance Index: -3.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0644
    Cell Significance Index: -2.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0648
    Cell Significance Index: -2.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0679
    Cell Significance Index: -1.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0700
    Cell Significance Index: -1.2100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0712
    Cell Significance Index: -0.9500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0713
    Cell Significance Index: -1.5400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0752
    Cell Significance Index: -1.5300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0760
    Cell Significance Index: -1.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0767
    Cell Significance Index: -2.2600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0780
    Cell Significance Index: -1.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0782
    Cell Significance Index: -1.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0787
    Cell Significance Index: -2.3100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0792
    Cell Significance Index: -1.1100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0804
    Cell Significance Index: -0.9900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0807
    Cell Significance Index: -1.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0817
    Cell Significance Index: -1.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0834
    Cell Significance Index: -2.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transmembrane structure**: CUZD1 is a transmembrane protein, consisting of a transmembrane domain and extracellular and intracellular domains. 2. **CUB and zona pellucida-like domains**: The protein's extracellular domain is composed of CUB (Cysteine-rich Unstructured Box) and zona pellucida-like domains, which are known to interact with various ligands. 3. **Significant expression in epithelial cells**: CUZD1 is highly expressed in epithelial cells, which are the primary site of cell adhesion and barrier function in the body. **Pathways and Functions** 1. **Cell adhesion**: CUZD1 interacts with various ligands, including members of the immunoglobulin superfamily, to regulate cell adhesion and migration. 2. **Cell cycle regulation**: CUZD1 has been implicated in the regulation of the cell cycle, particularly in the G1 phase. 3. **Signaling pathways**: CUZD1 is involved in various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. 4. **Zymogen granule membrane**: CUZD1 is specifically expressed in pancreatic acinar cells, where it is involved in the regulation of zymogen granule membrane dynamics. **Clinical Significance** 1. **Pancreatic diseases**: Alterations in CUZD1 expression have been linked to pancreatic diseases, including pancreatitis and pancreatic cancer. 2. **Gastrointestinal disorders**: CUZD1's role in maintaining epithelial barrier function makes it a potential target for the treatment of gastrointestinal disorders, such as inflammatory bowel disease. 3. **Neurological disorders**: CUZD1's expression in retinal bipolar neurons suggests its potential involvement in neurological disorders, such as retinitis pigmentosa. In conclusion, CUZD1 is a complex transmembrane protein that plays a multifaceted role in regulating cell adhesion, cell cycle, and signaling pathways. Further studies on CUZD1's mechanisms of action and its clinical significance will provide valuable insights into the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 3509396342

Symbol: CUZD1_HUMAN

Name: Transmembrane protein UO-44

UniProtKB Accession Codes:

Q86UP6 A8K080 B2RN93 D3DRE5 Q7Z660 Q7Z661 Q86SG1 Q86UP5 Q9HAR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15184879

Title: Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane-associated protein, UO-44.

PubMed ID: 15184879

DOI: 10.1038/sj.onc.1207754

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

Sequence Information:

  • Length: 607
  • Mass: 68153
  • Checksum: 098A365612251C5E
  • Sequence:
    • MELVRRLMPL TLLILSCLAE LTMAEAEGNA SCTVSLGGAN MAETHKAMIL QLNPSENCTW 
TIERPENKSI RIIFSYVQLD PDGSCESENI KVFDGTSSNG PLLGQVCSKN DYVPVFESSS 
STLTFQIVTD SARIQRTVFV FYYFFSPNIS IPNCGGYLDT LEGSFTSPNY PKPHPELAYC 
VWHIQVEKDY KIKLNFKEIF LEIDKQCKFD FLAIYDGPST NSGLIGQVCG RVTPTFESSS 
NSLTVVLSTD YANSYRGFSA SYTSIYAENI NTTSLTCSSD RMRVIISKSY LEAFNSNGNN 
LQLKDPTCRP KLSNVVEFSV PLNGCGTIRK VEDQSITYTN IITFSASSTS EVITRQKQLQ 
IIVKCEMGHN STVEIIYITE DDVIQSQNAL GKYNTSMALF ESNSFEKTIL ESPYYVDLNQ 
TLFVQVSLHT SDPNLVVFLD TCRASPTSDF ASPTYDLIKS GCSRDETCKV YPLFGHYGRF 
QFNAFKFLRS MSSVYLQCKV LICDSSDHQS RCNQGCVSRS KRDISSYKWK TDSIIGPIRL 
KRDRSASGNS GFQHETHAEE TPNQPFNSVH LFSFMVLALN VVTVATITVR HFVNQRADYK 
YQKLQNY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.