Details for: CNTN3

Gene ID: 5067

Symbol: CNTN3

Ensembl ID: ENSG00000113805

Description: contactin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.8070
    Cell Significance Index: 108.6400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.1055
    Cell Significance Index: 51.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0421
    Cell Significance Index: 610.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.5609
    Cell Significance Index: 56.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.4289
    Cell Significance Index: 163.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6056
    Cell Significance Index: 575.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4403
    Cell Significance Index: 54.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3601
    Cell Significance Index: 76.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2742
    Cell Significance Index: 881.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0247
    Cell Significance Index: 195.0200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.9683
    Cell Significance Index: 14.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8042
    Cell Significance Index: 9.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7922
    Cell Significance Index: 35.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7566
    Cell Significance Index: 74.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6974
    Cell Significance Index: 31.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5682
    Cell Significance Index: 513.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5104
    Cell Significance Index: 231.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3805
    Cell Significance Index: 61.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3333
    Cell Significance Index: 7.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2930
    Cell Significance Index: 15.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2220
    Cell Significance Index: 5.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2115
    Cell Significance Index: 23.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1811
    Cell Significance Index: 32.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1444
    Cell Significance Index: 1.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1435
    Cell Significance Index: 11.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1313
    Cell Significance Index: 247.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0961
    Cell Significance Index: 61.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0436
    Cell Significance Index: 5.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0323
    Cell Significance Index: 3.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0267
    Cell Significance Index: 41.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0253
    Cell Significance Index: 0.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0074
    Cell Significance Index: 0.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0035
    Cell Significance Index: 0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0104
    Cell Significance Index: -0.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0190
    Cell Significance Index: -1.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0208
    Cell Significance Index: -3.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0254
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0272
    Cell Significance Index: -20.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0337
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0430
    Cell Significance Index: -31.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0480
    Cell Significance Index: -36.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0567
    Cell Significance Index: -30.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0576
    Cell Significance Index: -35.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0580
    Cell Significance Index: -32.7100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0622
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0924
    Cell Significance Index: -15.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0995
    Cell Significance Index: -28.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1116
    Cell Significance Index: -2.2400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1230
    Cell Significance Index: -1.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1247
    Cell Significance Index: -2.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1293
    Cell Significance Index: -13.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1371
    Cell Significance Index: -27.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1496
    Cell Significance Index: -1.6300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1564
    Cell Significance Index: -2.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1597
    Cell Significance Index: -33.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1651
    Cell Significance Index: -21.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1891
    Cell Significance Index: -6.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2075
    Cell Significance Index: -23.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2112
    Cell Significance Index: -29.0000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2144
    Cell Significance Index: -2.8600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2459
    Cell Significance Index: -10.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2507
    Cell Significance Index: -29.2200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2568
    Cell Significance Index: -3.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2633
    Cell Significance Index: -34.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2637
    Cell Significance Index: -5.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3875
    Cell Significance Index: -5.8400
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.4133
    Cell Significance Index: -3.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4384
    Cell Significance Index: -34.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4469
    Cell Significance Index: -15.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4520
    Cell Significance Index: -33.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4923
    Cell Significance Index: -15.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5000
    Cell Significance Index: -23.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5019
    Cell Significance Index: -10.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5030
    Cell Significance Index: -26.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5058
    Cell Significance Index: -23.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5179
    Cell Significance Index: -32.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5377
    Cell Significance Index: -10.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5495
    Cell Significance Index: -17.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5651
    Cell Significance Index: -15.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5996
    Cell Significance Index: -31.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6402
    Cell Significance Index: -14.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6417
    Cell Significance Index: -10.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6663
    Cell Significance Index: -16.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6765
    Cell Significance Index: -17.3900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6890
    Cell Significance Index: -13.5600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7564
    Cell Significance Index: -7.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7568
    Cell Significance Index: -21.1500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.7683
    Cell Significance Index: -18.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7998
    Cell Significance Index: -29.3600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8093
    Cell Significance Index: -16.8900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.8623
    Cell Significance Index: -10.0600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.8831
    Cell Significance Index: -14.0100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.9161
    Cell Significance Index: -6.6600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.9232
    Cell Significance Index: -11.6500
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.9367
    Cell Significance Index: -9.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9517
    Cell Significance Index: -14.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.0050
    Cell Significance Index: -20.0400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.0068
    Cell Significance Index: -13.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CNTN3 is a transmembrane protein that belongs to the contactin family, which is characterized by its ability to bind to other proteins and lipids, facilitating cell adhesion and signaling. Its GPI-anchor attachment allows it to be anchored to the plasma membrane, where it can interact with other proteins and lipids to regulate various cellular processes. CNTN3 is expressed in a wide range of cell types, including neurons, muscle cells, and immune cells. Its expression is highly dynamic, with changes in expression levels observed in various developmental and pathological conditions. **Pathways and Functions:** CNTN3 is involved in several key pathways, including: 1. **Cell adhesion:** CNTN3 interacts with other contactin family members and with proteins like L1CAM and N-CAM to regulate cell adhesion and migration. 2. **Neuronal development:** CNTN3 plays a crucial role in the development and maturation of neurons, particularly in the cerebral cortex. 3. **Synaptic plasticity:** CNTN3 has been shown to regulate synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). 4. **Post-translational modification:** CNTN3 is involved in the synthesis of GPI-anchored proteins and has been shown to regulate the activity of enzymes involved in glycosylation and lipidation. **Clinical Significance:** CNTN3 has been implicated in various neurological and immunological disorders, including: 1. **Neurological disorders:** CNTN3 has been linked to conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Immune-related disorders:** CNTN3 has been shown to play a role in regulating immune cell function and has been implicated in conditions such as rheumatoid arthritis and lupus. 3. **Cancer:** CNTN3 has been shown to regulate cell adhesion and migration in cancer cells, making it a potential target for cancer therapy. In conclusion, CNTN3 is a complex protein with multiple roles in cell adhesion, neuronal development, and synaptic plasticity. Its expression is widespread in the nervous system and immune cells, and its dysregulation has been implicated in various neurological and immunological disorders. Further research is needed to fully elucidate the mechanisms by which CNTN3 regulates cellular processes and to explore its potential as a therapeutic target. **Recommendations for Future Research:** 1. **Investigate the mechanisms by which CNTN3 regulates cell adhesion and migration in different cell types.** 2. **Explore the role of CNTN3 in regulating synaptic plasticity and neuronal development.** 3. **Investigate the potential of CNTN3 as a therapeutic target for neurological and immunological disorders.** 4. **Characterize the expression patterns of CNTN3 in different tissues and cell types to better understand its role in disease.** By continuing to investigate the complexities of CNTN3, we can gain a deeper understanding of its role in cellular processes and its potential as a therapeutic target for various diseases.

Genular Protein ID: 1567431944

Symbol: CNTN3_HUMAN

Name: Contactin-3

UniProtKB Accession Codes:

Q9P232 B9EK50 Q9H039

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11013081

Title: Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.

PubMed ID: 11013081

DOI: 10.1006/geno.2000.6310

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 20133774

Title: The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules.

PubMed ID: 20133774

DOI: 10.1073/pnas.0911235107

Sequence Information:

  • Length: 1028
  • Mass: 112883
  • Checksum: 575945CD75D21844
  • Sequence:
    • MMFPWKQLIL LSFIGCLGGE LLLQGPVFIK EPSNSIFPVG SEDKKITLHC EARGNPSPHY 
RWQLNGSDID MSMEHRYKLN GGNLVVINPN RNWDTGTYQC FATNSLGTIV SREAKLQFAY 
LENFKTKMRS TVSVREGQGV VLLCGPPPHS GELSYAWIFN EYPSFVEEDS RRFVSQETGH 
LYISKVEPSD VGNYTCVVTS MVTNARVLGS PTPLVLRSDG VMGEYEPKIE VQFPETLPAA 
KGSTVKLECF ALGNPIPQIN WRRSDGLPFS SKIKLRKFSG VLEIPNFQQE DAGSYECIAE 
NSRGKNVARG RLTYYAKPHW VQLIKDVEIA VEDSLYWECR ASGKPKPSYR WLKNGAALVL 
EERTQIENGA LTISNLSVTD SGMFQCIAEN KHGLVYSSAE LKVVASAPDF SKNPMKKLVQ 
VQVGSLVSLD CKPRASPRAL SSWKKGDVSV QEHERISLLN DGGLKIANVT KADAGTYTCM 
AENQFGKANG TTHLVVTEPT RITLAPSNMD VSVGESVILP CQVQHDPLLD IIFTWYFNGA 
LADFKKDGSH FEKVGGSSSG DLMIRNIQLK HSGKYVCMVQ TGVDSVSSAA DLIVRGSPGP 
PENVKVDEIT DTTAQLSWKE GKDNHSPVIS YSIQARTPFS VGWQTVTTVP EVIDGKTHTA 
TVVELNPWVE YEFRVVASNK IGGGEPSLPS EKVRTEEAVP EVPPSEVNGG GGSRSELVIT 
WDPVPEELQN GEGFGYVVAF RPLGVTTWIQ TVVTSPDTPR YVFRNESIVP YSPYEVKVGV 
YNNKGEGPFS PVTTVFSAEE EPTVAPSQVS ANSLSSSEIE VSWNTIPWKL SNGHLLGYEV 
RYWNGGGKEE SSSKMKVAGN ETSARLRGLK SNLAYYTAVR AYNSAGAGPF SATVNVTTKK 
TPPSQPPGNV VWNATDTKVL LNWEQVKAME NESEVTGYKV FYRTSSQNNV QVLNTNKTSA 
ELVLPIKEDY IIEVKATTDG GDGTSSEQIR IPRITSMDAR GSTSAISNVH PMSSYMPIVL 
FLIVYVLW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.