Details for: IRX4

Gene ID: 50805

Symbol: IRX4

Ensembl ID: ENSG00000113430

Description: iroquois homeobox 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.3112
    Cell Significance Index: 73.7000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 3.1160
    Cell Significance Index: 7.0200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.0323
    Cell Significance Index: 3.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9662
    Cell Significance Index: 27.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6950
    Cell Significance Index: 307.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6781
    Cell Significance Index: 47.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5292
    Cell Significance Index: -1.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5196
    Cell Significance Index: 12.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3957
    Cell Significance Index: 83.3400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.2171
    Cell Significance Index: 0.2800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1469
    Cell Significance Index: 1.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0945
    Cell Significance Index: 7.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0621
    Cell Significance Index: 38.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0033
    Cell Significance Index: -1.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0062
    Cell Significance Index: -11.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0074
    Cell Significance Index: -11.4400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0082
    Cell Significance Index: -0.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0083
    Cell Significance Index: -11.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0094
    Cell Significance Index: -0.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0100
    Cell Significance Index: -6.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0118
    Cell Significance Index: -0.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0133
    Cell Significance Index: -0.3300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0146
    Cell Significance Index: -0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0167
    Cell Significance Index: -7.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0169
    Cell Significance Index: -0.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0173
    Cell Significance Index: -2.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0198
    Cell Significance Index: -7.0900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0225
    Cell Significance Index: -0.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0227
    Cell Significance Index: -0.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0245
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0255
    Cell Significance Index: -4.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0262
    Cell Significance Index: -7.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0290
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0314
    Cell Significance Index: -3.5800
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0323
    Cell Significance Index: -0.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0372
    Cell Significance Index: -7.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0373
    Cell Significance Index: -7.4900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0382
    Cell Significance Index: -0.3300
  • Cell Name: lung perichondrial fibroblast (CL4033026)
    Fold Change: -0.0388
    Cell Significance Index: -0.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0398
    Cell Significance Index: -2.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0432
    Cell Significance Index: -6.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0478
    Cell Significance Index: -6.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0495
    Cell Significance Index: -3.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0506
    Cell Significance Index: -2.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0683
    Cell Significance Index: -1.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0712
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0743
    Cell Significance Index: -8.5100
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.0754
    Cell Significance Index: -0.4700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0758
    Cell Significance Index: -1.9300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0908
    Cell Significance Index: -1.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0917
    Cell Significance Index: -1.9200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0985
    Cell Significance Index: -2.4600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1025
    Cell Significance Index: -0.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1045
    Cell Significance Index: -4.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1101
    Cell Significance Index: -7.4100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1121
    Cell Significance Index: -1.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1264
    Cell Significance Index: -6.5900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1378
    Cell Significance Index: -2.2100
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: -0.1389
    Cell Significance Index: -1.0400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1415
    Cell Significance Index: -1.9400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1417
    Cell Significance Index: -1.7100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1427
    Cell Significance Index: -1.9400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1445
    Cell Significance Index: -1.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1492
    Cell Significance Index: -8.3700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1537
    Cell Significance Index: -2.6500
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.1540
    Cell Significance Index: -1.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1615
    Cell Significance Index: -8.4800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1659
    Cell Significance Index: -0.8700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1696
    Cell Significance Index: -1.5100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1714
    Cell Significance Index: -1.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1720
    Cell Significance Index: -5.0700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1739
    Cell Significance Index: -1.8900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1751
    Cell Significance Index: -1.8600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1837
    Cell Significance Index: -1.8500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1844
    Cell Significance Index: -2.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1856
    Cell Significance Index: -6.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1901
    Cell Significance Index: -6.9800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1963
    Cell Significance Index: -3.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1971
    Cell Significance Index: -8.7200
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.2037
    Cell Significance Index: -1.9500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.2059
    Cell Significance Index: -2.2000
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.2066
    Cell Significance Index: -2.1500
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.2103
    Cell Significance Index: -2.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2199
    Cell Significance Index: -3.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2207
    Cell Significance Index: -3.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2229
    Cell Significance Index: -7.8100
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.2300
    Cell Significance Index: -2.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2321
    Cell Significance Index: -8.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2341
    Cell Significance Index: -6.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2346
    Cell Significance Index: -7.6800
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.2351
    Cell Significance Index: -2.1500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2372
    Cell Significance Index: -2.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2383
    Cell Significance Index: -7.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2408
    Cell Significance Index: -4.7000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2409
    Cell Significance Index: -2.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2482
    Cell Significance Index: -6.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IRX4 is an Iroquois-class homeodomain protein, a family of transcription factors known for their involvement in developmental processes. The IRX4 protein contains a homeodomain, a DNA-binding domain, and a transcriptional activation domain, allowing it to regulate gene expression by binding to specific DNA sequences. IRX4 is highly expressed in various cell types, including hematopoietic stem cells, epidermal cells, and immune cells. Its expression patterns suggest that IRX4 plays a role in maintaining the balance between cell proliferation and differentiation in these tissues. **Pathways and Functions:** IRX4 is involved in several cellular pathways, including: 1. **Cell Development:** IRX4 regulates the development of various cell types, including hematopoietic stem cells, epidermal cells, and immune cells. 2. **Chromatin Regulation:** IRX4 interacts with chromatin-associated proteins to regulate gene expression by modifying chromatin structure. 3. **RNA Polymerase II Regulation:** IRX4 regulates transcription by RNA polymerase II, a key enzyme involved in the synthesis of messenger RNA. 4. **Neuron Differentiation:** IRX4 is involved in the differentiation of neurons, suggesting its role in the development and function of the nervous system. 5. **Heart Development:** IRX4 is expressed in the developing heart and may play a role in cardiac development and function. **Clinical Significance:** Dysregulation of IRX4 has been implicated in various human diseases, including: 1. **Immune System Disorders:** Alterations in IRX4 expression may contribute to immune system dysregulation, leading to autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** IRX4 may play a role in the development and progression of certain cancers, including leukemia and lymphoma. 3. **Neurological Disorders:** IRX4 may be involved in the development and progression of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Skin Diseases:** IRX4 may contribute to the development and progression of skin diseases, such as psoriasis and atopic dermatitis. In conclusion, IRX4 is a critical transcription factor involved in various developmental processes, including cell differentiation, organ orientation, and the regulation of transcription by RNA polymerase II. Its dysregulation may have significant implications for human diseases, highlighting the need for further research into the role of IRX4 in human health and disease.

Genular Protein ID: 1695813470

Symbol: IRX4_HUMAN

Name: Iroquois-class homeodomain protein IRX-4

UniProtKB Accession Codes:

P78413 B2RMW5 D3DTC5 H1AFL0 H1AFL1 Q2NL64 Q9UHR2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 5 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 5 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10625552

Title: Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand.

PubMed ID: 10625552

DOI: 10.1006/dbio.1999.9548

PubMed ID: 22323358

Title: IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.

PubMed ID: 22323358

DOI: 10.1093/hmg/dds025

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 519
  • Mass: 54445
  • Checksum: B2FFB278BEFC5AD2
  • Sequence:
    • MSYPQFGYPY SSAPQFLMAT NSLSTCCESG GRTLADSGPA ASAQAPVYCP VYESRLLATA 
RHELNSAAAL GVYGGPYGGS QGYGNYVTYG SEASAFYSLN SFDSKDGSGS AHGGLAPAAA 
AYYPYEPALG QYPYDRYGTM DSGTRRKNAT RETTSTLKAW LQEHRKNPYP TKGEKIMLAI 
ITKMTLTQVS TWFANARRRL KKENKMTWPP RNKCADEKRP YAEGEEEEGG EEEAREEPLK 
SSKNAEPVGK EEKELELSDL DDFDPLEAEP PACELKPPFH SLDGGLERVP AAPDGPVKEA 
SGALRMSLAA GGGAALDEDL ERARSCLRSA AAGPEPLPGA EGGPQVCEAK LGFVPAGASA 
GLEAKPRIWS LAHTATAAAA AATSLSQTEF PSCMLKRQGP AAPAAVSSAP ATSPSVALPH 
SGALDRHQDS PVTSLRNWVD GVFHDPILRH STLNQAWATA KGALLDPGPL GRSLGAGANV 
LTAPLARAFP PAVPQDAPAA GAARELLALP KAGGKPFCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.