Details for: PDE11A

Gene ID: 50940

Symbol: PDE11A

Ensembl ID: ENSG00000128655

Description: phosphodiesterase 11A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.0456
    Cell Significance Index: -6.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.4688
    Cell Significance Index: -6.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 9.7317
    Cell Significance Index: 213.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5013
    Cell Significance Index: -12.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.5589
    Cell Significance Index: 26.2600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.4378
    Cell Significance Index: 8.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.1100
    Cell Significance Index: 319.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.9463
    Cell Significance Index: 14.2600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.7780
    Cell Significance Index: 4.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7664
    Cell Significance Index: 145.8500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5918
    Cell Significance Index: 12.6500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.4022
    Cell Significance Index: 3.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3745
    Cell Significance Index: 22.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3573
    Cell Significance Index: 7.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3561
    Cell Significance Index: 27.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3388
    Cell Significance Index: 33.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3345
    Cell Significance Index: 15.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3237
    Cell Significance Index: 292.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2784
    Cell Significance Index: 30.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2632
    Cell Significance Index: 6.5800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2546
    Cell Significance Index: 3.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2348
    Cell Significance Index: 84.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2173
    Cell Significance Index: 6.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1980
    Cell Significance Index: 32.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1463
    Cell Significance Index: 10.1200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1210
    Cell Significance Index: 1.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1064
    Cell Significance Index: 21.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0803
    Cell Significance Index: 2.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0729
    Cell Significance Index: 8.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0707
    Cell Significance Index: 3.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0649
    Cell Significance Index: 11.0800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0606
    Cell Significance Index: 0.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0586
    Cell Significance Index: 11.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0555
    Cell Significance Index: 35.2600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0533
    Cell Significance Index: 0.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0414
    Cell Significance Index: 1.1100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0348
    Cell Significance Index: 0.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0324
    Cell Significance Index: 1.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0056
    Cell Significance Index: -3.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0100
    Cell Significance Index: -1.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0102
    Cell Significance Index: -5.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0106
    Cell Significance Index: -6.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0114
    Cell Significance Index: -5.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0133
    Cell Significance Index: -6.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0138
    Cell Significance Index: -0.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0148
    Cell Significance Index: -0.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0168
    Cell Significance Index: -0.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0183
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0239
    Cell Significance Index: -5.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0244
    Cell Significance Index: -0.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0248
    Cell Significance Index: -2.5400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0300
    Cell Significance Index: -0.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0323
    Cell Significance Index: -1.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0345
    Cell Significance Index: -5.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0367
    Cell Significance Index: -4.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0384
    Cell Significance Index: -4.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0390
    Cell Significance Index: -2.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0394
    Cell Significance Index: -5.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0468
    Cell Significance Index: -2.9500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0512
    Cell Significance Index: -0.6400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0530
    Cell Significance Index: -2.3100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0533
    Cell Significance Index: -1.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0559
    Cell Significance Index: -0.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0623
    Cell Significance Index: -6.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0721
    Cell Significance Index: -3.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0749
    Cell Significance Index: -1.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0787
    Cell Significance Index: -1.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0792
    Cell Significance Index: -5.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0855
    Cell Significance Index: -0.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0882
    Cell Significance Index: -5.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0935
    Cell Significance Index: -3.5400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0946
    Cell Significance Index: -1.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0960
    Cell Significance Index: -5.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1001
    Cell Significance Index: -2.4000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1070
    Cell Significance Index: -1.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1108
    Cell Significance Index: -5.7700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1112
    Cell Significance Index: -2.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1229
    Cell Significance Index: -3.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1247
    Cell Significance Index: -4.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1287
    Cell Significance Index: -2.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1306
    Cell Significance Index: -4.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1355
    Cell Significance Index: -2.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1387
    Cell Significance Index: -3.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1395
    Cell Significance Index: -2.9600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1497
    Cell Significance Index: -1.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1555
    Cell Significance Index: -5.7100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1608
    Cell Significance Index: -2.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1614
    Cell Significance Index: -4.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1623
    Cell Significance Index: -5.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1640
    Cell Significance Index: -4.0900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1675
    Cell Significance Index: -2.0300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1683
    Cell Significance Index: -3.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1684
    Cell Significance Index: -4.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PDE11A is a dual-specific phosphodiesterase enzyme, meaning it has the ability to degrade both cAMP and cGMP. This unique characteristic allows it to regulate multiple signaling pathways, including those involved in immune response, platelet activation, and cellular homeostasis. PDE11A is also a calmodulin-activated enzyme, which means it is regulated by the binding of calmodulin, a calcium-binding protein. This regulation allows PDE11A to fine-tune its activity in response to changes in calcium levels within the cell. **Pathways and Functions:** PDE11A is involved in various signaling pathways, including: 1. **Immune Response:** PDE11A regulates the activity of immune cells, such as hematopoietic cells and Langerhans cells, by degrading cAMP and cGMP. This degradation of these cyclic nucleotides leads to the activation of immune cells and the regulation of immune responses. 2. **Platelet Homeostasis:** PDE11A is involved in the regulation of platelet activation and aggregation. By degrading cAMP and cGMP, PDE11A helps to regulate platelet function and maintain platelet homeostasis. 3. **Signaling Events:** PDE11A is also involved in the regulation of signaling events, including those mediated by G-protein coupled receptors (GPCRs). By degrading cAMP and cGMP, PDE11A helps to regulate the activity of GPCRs and maintain cellular homeostasis. 4. **Calmodulin-activated Signaling:** PDE11A is regulated by calmodulin, a calcium-binding protein. This regulation allows PDE11A to fine-tune its activity in response to changes in calcium levels within the cell. **Clinical Significance:** The dysregulation of PDE11A has been implicated in various diseases, including: 1. **Immune Disorders:** PDE11A dysregulation has been linked to immune disorders, such as autoimmune diseases and allergies. 2. **Cancer:** PDE11A dysregulation has been implicated in the development and progression of various cancers, including breast cancer and prostate cancer. 3. **Neurological Disorders:** PDE11A dysregulation has been linked to neurological disorders, such as Parkinson's disease and Alzheimer's disease. 4. **Cardiovascular Diseases:** PDE11A dysregulation has been implicated in cardiovascular diseases, including hypertension and atherosclerosis. In conclusion, PDE11A is a unique phosphodiesterase gene that plays a crucial role in various cellular processes, including immune response, signaling pathways, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of PDE11A in normal and diseased states.

Genular Protein ID: 1754684343

Symbol: PDE11_HUMAN

Name: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

UniProtKB Accession Codes:

Q9HCR9 Q14CD1 Q53T16 Q96S76 Q9GZY7 Q9HB46 Q9NY45

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 15 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 4 Rhea 2 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10906126

Title: Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression.

PubMed ID: 10906126

DOI: 10.1074/jbc.m003041200

PubMed ID: 10725373

Title: Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A.

PubMed ID: 10725373

DOI: 10.1073/pnas.97.7.3702

PubMed ID: 11050148

Title: Cloning and characterisation of two splice variants of human phosphodiesterase 11A.

PubMed ID: 11050148

DOI: 10.1073/pnas.200355397

PubMed ID: 11121118

Title: Genomic organization of the human phosphodiesterase PDE11A gene: evolutionary relatedness with other PDEs containing GAF domains.

PubMed ID: 11121118

DOI: 10.1046/j.1432-1327.2001.01866.x

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15800651

Title: 3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues.

PubMed ID: 15800651

DOI: 10.1038/sj.ijir.3901317

PubMed ID: 16079899

Title: Phosphodiesterase 11 (PDE11): is it a player in human testicular function?

PubMed ID: 16079899

DOI: 10.1038/sj.ijir.3901377

PubMed ID: 16330539

Title: cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11.

PubMed ID: 16330539

DOI: 10.1074/jbc.m511468200

PubMed ID: 16767104

Title: A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia.

PubMed ID: 16767104

DOI: 10.1038/ng1809

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 933
  • Mass: 104752
  • Checksum: B725AE6963D6E799
  • Sequence:
    • MAASRLDFGE VETFLDRHPE LFEDYLMRKG KQEMVEKWLQ RHSQGQGALG PRPSLAGTSS 
LAHSTCRGGS SVGGGTGPNG SAHSQPLPGG GDCGGVPLSP SWAGGSRGDG NLQRRASQKE 
LRKSFARSKA IHVNRTYDEQ VTSRAQEPLS SVRRRALLRK ASSLPPTTAH ILSALLESRV 
NLPRYPPTAI DYKCHLKKHN ERQFFLELVK DISNDLDLTS LSYKILIFVC LMVDADRCSL 
FLVEGAAAGK KTLVSKFFDV HAGTPLLPCS STENSNEVQV PWGKGIIGYV GEHGETVNIP 
DAYQDRRFND EIDKLTGYKT KSLLCMPIRS SDGEIIGVAQ AINKIPEGAP FTEDDEKVMQ 
MYLPFCGIAI SNAQLFAASR KEYERSRALL EVVNDLFEEQ TDLEKIVKKI MHRAQTLLKC 
ERCSVLLLED IESPVVKFTK SFELMSPKCS ADAENSFKES MEKSSYSDWL INNSIAELVA 
STGLPVNISD AYQDPRFDAE ADQISGFHIR SVLCVPIWNS NHQIIGVAQV LNRLDGKPFD 
DADQRLFEAF VIFCGLGINN TIMYDQVKKS WAKQSVALDV LSYHATCSKA EVDKFKAANI 
PLVSELAIDD IHFDDFSLDV DAMITAALRM FMELGMVQKF KIDYETLCRW LLTVRKNYRM 
VLYHNWRHAF NVCQLMFAML TTAGFQDILT EVEILAVIVG CLCHDLDHRG TNNAFQAKSG 
SALAQLYGTS ATLEHHHFNH AVMILQSEGH NIFANLSSKE YSDLMQLLKQ SILATDLTLY 
FERRTEFFEL VSKGEYDWNI KNHRDIFRSM LMTACDLGAV TKPWEISRQV AELVTSEFFE 
QGDRERLELK LTPSAIFDRN RKDELPRLQL EWIDSICMPL YQALVKVNVK LKPMLDSVAT 
NRSKWEELHQ KRLLASTASS SPASVMVAKE DRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.