Details for: DERA

Gene ID: 51071

Symbol: DERA

Ensembl ID: ENSG00000023697

Description: deoxyribose-phosphate aldolase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 191.7770
    Cell Significance Index: -29.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.5740
    Cell Significance Index: -28.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 80.8719
    Cell Significance Index: -33.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.5312
    Cell Significance Index: -35.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 72.6387
    Cell Significance Index: -29.5100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 66.4288
    Cell Significance Index: -34.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 53.2471
    Cell Significance Index: -35.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.2597
    Cell Significance Index: -33.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.9081
    Cell Significance Index: -31.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.7362
    Cell Significance Index: -19.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6542
    Cell Significance Index: -34.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4855
    Cell Significance Index: -19.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6073
    Cell Significance Index: 21.9300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.4701
    Cell Significance Index: 17.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2820
    Cell Significance Index: 80.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2498
    Cell Significance Index: 70.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2302
    Cell Significance Index: 244.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0811
    Cell Significance Index: 21.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9369
    Cell Significance Index: 25.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8989
    Cell Significance Index: 19.2200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8201
    Cell Significance Index: 13.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7167
    Cell Significance Index: 116.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6716
    Cell Significance Index: 46.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5062
    Cell Significance Index: 32.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4917
    Cell Significance Index: 268.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4913
    Cell Significance Index: 13.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4872
    Cell Significance Index: 57.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4819
    Cell Significance Index: 21.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4642
    Cell Significance Index: 35.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4608
    Cell Significance Index: 318.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4568
    Cell Significance Index: 23.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4328
    Cell Significance Index: 86.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4289
    Cell Significance Index: 189.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4187
    Cell Significance Index: 11.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3904
    Cell Significance Index: 19.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3831
    Cell Significance Index: 9.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3593
    Cell Significance Index: 35.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3421
    Cell Significance Index: 2.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3198
    Cell Significance Index: 60.8600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3168
    Cell Significance Index: 4.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3049
    Cell Significance Index: 54.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2592
    Cell Significance Index: 5.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2568
    Cell Significance Index: 18.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2441
    Cell Significance Index: 30.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2394
    Cell Significance Index: 32.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2162
    Cell Significance Index: 10.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1736
    Cell Significance Index: 78.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1697
    Cell Significance Index: 19.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1099
    Cell Significance Index: 1.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1089
    Cell Significance Index: 2.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1078
    Cell Significance Index: 38.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0674
    Cell Significance Index: 124.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0498
    Cell Significance Index: 2.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0443
    Cell Significance Index: 7.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0295
    Cell Significance Index: 55.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0291
    Cell Significance Index: 18.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0284
    Cell Significance Index: 0.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0231
    Cell Significance Index: 35.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0126
    Cell Significance Index: 1.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0065
    Cell Significance Index: 0.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0039
    Cell Significance Index: 0.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0002
    Cell Significance Index: 0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0063
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0099
    Cell Significance Index: -13.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0214
    Cell Significance Index: -13.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0274
    Cell Significance Index: -2.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0317
    Cell Significance Index: -4.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0361
    Cell Significance Index: -0.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0374
    Cell Significance Index: -21.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0502
    Cell Significance Index: -1.3200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0605
    Cell Significance Index: -0.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0811
    Cell Significance Index: -2.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0855
    Cell Significance Index: -6.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0856
    Cell Significance Index: -2.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0887
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0894
    Cell Significance Index: -18.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0951
    Cell Significance Index: -27.3700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1034
    Cell Significance Index: -1.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1036
    Cell Significance Index: -12.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1593
    Cell Significance Index: -4.0700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1963
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2147
    Cell Significance Index: -24.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2558
    Cell Significance Index: -26.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2623
    Cell Significance Index: -6.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2809
    Cell Significance Index: -5.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3020
    Cell Significance Index: -18.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3143
    Cell Significance Index: -24.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3264
    Cell Significance Index: -21.9500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3336
    Cell Significance Index: -4.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3941
    Cell Significance Index: -20.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3997
    Cell Significance Index: -5.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4404
    Cell Significance Index: -26.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4740
    Cell Significance Index: -24.6900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4963
    Cell Significance Index: -7.5500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5018
    Cell Significance Index: -5.2000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5114
    Cell Significance Index: -5.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5147
    Cell Significance Index: -3.1100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.5233
    Cell Significance Index: -4.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5272
    Cell Significance Index: -23.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme Function:** DERA is a deoxyribose-phosphate aldolase, which means it catalyzes the aldolase reaction, a key step in the breakdown of deoxyribonucleosides and deoxyribonucleotides. 2. **Cellular Expression:** DERA is expressed in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, embryonic stem cell, smooth muscle fiber of ileum, mucosal type mast cell, peripheral blood mononuclear cell, ileal goblet cell, orthochromatic erythroblast, CD8-alpha-beta-positive, alpha-beta intraepithelial T cell, and epidermal Langerhans cell. 3. **Pathway Involvement:** DERA is involved in carbohydrate catabolism, deoxyribonucleoside catabolism, deoxyribonucleotide catabolism, and the pentose-phosphate shunt pathway. 4. **Protein Binding:** DERA interacts with other proteins, such as ficolin-1, which is a pattern recognition receptor involved in the innate immune response. **Pathways and Functions:** 1. **Carbohydrate Catabolism:** DERA plays a crucial role in the breakdown of deoxyribonucleosides and deoxyribonucleotides, which are essential components of carbohydrate metabolism. 2. **Immune Response:** The expression of DERA in immune cells, such as neutrophils and mast cells, suggests its involvement in the regulation of the immune response. 3. **Pentose-Phosphate Shunt:** DERA is also involved in the pentose-phosphate shunt pathway, which is a metabolic pathway that generates NADPH and pentoses from glucose-6-phosphate. 4. **Deoxyribonucleoside Catabolism:** DERA is responsible for the breakdown of deoxyribonucleosides, which are essential components of DNA and RNA. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in DERA expression have been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** DERA has been implicated in the development and progression of certain types of cancer, including leukemia and lymphoma. 3. **Immunological Disorders:** The expression of DERA in immune cells suggests its involvement in the regulation of the immune response, which is essential for the proper functioning of the immune system. 4. **Metabolic Disorders:** DERA plays a crucial role in carbohydrate catabolism, which is essential for the proper functioning of the metabolic pathways that regulate glucose and lipid metabolism. In conclusion, DERA is a critical enzyme involved in the catabolism of deoxyribonucleosides and deoxyribonucleotides, and its expression in various cell types suggests its involvement in the regulation of cellular metabolism, immune response, and carbohydrate catabolism. Further research is needed to fully understand the clinical significance of DERA and its role in human disease.

Genular Protein ID: 1410151183

Symbol: DEOC_HUMAN

Name: Deoxyribose-phosphate aldolase

UniProtKB Accession Codes:

Q9Y315 Q53HN9 Q6PHW2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25229427

Title: DERA is the human deoxyribose phosphate aldolase and is involved in stress response.

PubMed ID: 25229427

DOI: 10.1016/j.bbamcr.2014.09.007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 318
  • Mass: 35231
  • Checksum: E9576567D0E5CBDE
  • Sequence:
    • MSAHNRGTEL DLSWISKIQV NHPAVLRRAE QIQARRTVKK EWQAAWLLKA VTFIDLTTLS 
GDDTSSNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC VYPARVCDAV KALKAAGCNI 
PVASVAAGFP AGQTHLKTRL EEIRLAVEDG ATEIDVVINR SLVLTGQWEA LYDEIRQFRK 
ACGEAHLKTI LATGELGTLT NVYKASMIAM MAGSDFIKTS TGKETVNATF PVAIVMLRAI 
RDFFWKTGNK IGFKPAGGIR SAKDSLAWLS LVKEELGDEW LKPELFRIGA STLLSDIERQ 
IYHHVTGRYA AYHDLPMS

Genular Protein ID: 3757904510

Symbol: E9PPM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PPM8

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 3 MINT 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 275
  • Mass: 30517
  • Checksum: E86262D1E4F7C946
  • Sequence:
    • MSAHNRGTEL DLSWISKIQV NHPAVLRRAE QIQARRTVKK EWQAAWLLKA VTFIDLTTLS 
GDDTSSNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC VYPARVCDAV KALKAAGCNI 
PVASVAAGFP AGQTHLKTRL EEIRLAVEDG ATEIDVVINR SLVLTGQWEG SDFIKTSTGK 
ETVNATFPVA IVMLRAIRDF FWKTGNKIGF KPAGGIRSAK DSLAWLSLVK EELGDEWLKP 
ELFRIGASTL LSDIERQIYH HVTGRYAAYH DLPMS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.