Details for: SIDT2

Gene ID: 51092

Symbol: SIDT2

Ensembl ID: ENSG00000149577

Description: SID1 transmembrane family member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 112.1217
    Cell Significance Index: -17.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.1809
    Cell Significance Index: -17.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.2947
    Cell Significance Index: -16.3700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.3118
    Cell Significance Index: -18.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 34.4878
    Cell Significance Index: -17.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.1460
    Cell Significance Index: -16.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.3963
    Cell Significance Index: -17.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5392
    Cell Significance Index: -17.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.5326
    Cell Significance Index: -9.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5286
    Cell Significance Index: -17.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2268
    Cell Significance Index: 1107.7400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.1567
    Cell Significance Index: 19.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1358
    Cell Significance Index: 30.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0917
    Cell Significance Index: 127.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0166
    Cell Significance Index: 193.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8415
    Cell Significance Index: 91.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7167
    Cell Significance Index: 116.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5170
    Cell Significance Index: 11.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5135
    Cell Significance Index: 14.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4794
    Cell Significance Index: 33.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4477
    Cell Significance Index: 61.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4419
    Cell Significance Index: 87.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3839
    Cell Significance Index: 10.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3622
    Cell Significance Index: 72.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3264
    Cell Significance Index: 225.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2619
    Cell Significance Index: 4.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2200
    Cell Significance Index: 37.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2159
    Cell Significance Index: 77.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2153
    Cell Significance Index: 9.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2017
    Cell Significance Index: 13.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1944
    Cell Significance Index: 35.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1939
    Cell Significance Index: 9.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1030
    Cell Significance Index: 2.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1028
    Cell Significance Index: 45.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0988
    Cell Significance Index: 7.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0952
    Cell Significance Index: 2.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0879
    Cell Significance Index: 10.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0858
    Cell Significance Index: 2.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0718
    Cell Significance Index: 7.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0675
    Cell Significance Index: 36.8400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0528
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0463
    Cell Significance Index: 87.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0410
    Cell Significance Index: 4.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0384
    Cell Significance Index: 24.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0272
    Cell Significance Index: 50.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0251
    Cell Significance Index: 38.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0222
    Cell Significance Index: 10.0600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0199
    Cell Significance Index: 0.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0197
    Cell Significance Index: 0.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0139
    Cell Significance Index: 1.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0051
    Cell Significance Index: 6.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0038
    Cell Significance Index: 0.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0161
    Cell Significance Index: -12.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0164
    Cell Significance Index: -0.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0174
    Cell Significance Index: -12.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0187
    Cell Significance Index: -13.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0253
    Cell Significance Index: -2.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0307
    Cell Significance Index: -17.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0338
    Cell Significance Index: -21.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0415
    Cell Significance Index: -2.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0487
    Cell Significance Index: -6.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0516
    Cell Significance Index: -14.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0733
    Cell Significance Index: -10.6600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0954
    Cell Significance Index: -1.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0959
    Cell Significance Index: -7.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0977
    Cell Significance Index: -4.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0982
    Cell Significance Index: -20.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0984
    Cell Significance Index: -5.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1096
    Cell Significance Index: -6.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1144
    Cell Significance Index: -5.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1152
    Cell Significance Index: -11.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1212
    Cell Significance Index: -2.5900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1249
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1260
    Cell Significance Index: -14.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1302
    Cell Significance Index: -8.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1321
    Cell Significance Index: -6.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1406
    Cell Significance Index: -5.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1478
    Cell Significance Index: -1.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1670
    Cell Significance Index: -4.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1736
    Cell Significance Index: -5.5600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1738
    Cell Significance Index: -1.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1783
    Cell Significance Index: -10.9300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1919
    Cell Significance Index: -1.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2048
    Cell Significance Index: -3.5100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2094
    Cell Significance Index: -1.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2098
    Cell Significance Index: -7.2900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2126
    Cell Significance Index: -2.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2137
    Cell Significance Index: -4.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2151
    Cell Significance Index: -12.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2164
    Cell Significance Index: -17.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2223
    Cell Significance Index: -3.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2639
    Cell Significance Index: -7.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2647
    Cell Significance Index: -7.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2868
    Cell Significance Index: -14.9400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2881
    Cell Significance Index: -4.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3002
    Cell Significance Index: -10.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3152
    Cell Significance Index: -4.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3280
    Cell Significance Index: -8.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3759
    Cell Significance Index: -11.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3782
    Cell Significance Index: -12.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SIDT2 is a transmembrane protein belonging to the SID1 family, which is characterized by its ability to bind to Ap-1 and Ap-2 adaptor complexes. This interaction is crucial for regulating various cellular processes, including cell morphology, gene expression, and RNA transport. SIDT2 is highly expressed in hematopoietic cells, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and peripheral blood mononuclear cells. Its expression is also observed in other cell types, such as mucosal type mast cells, smooth muscle fibers of the ileum, and ciliated cells of the bronchus. **Pathways and Functions:** SIDT2 is involved in several signaling pathways, including Ap-1 and Ap-2 adaptor complex binding, cell morphology, and glucose homeostasis. It plays a crucial role in regulating insulin secretion in response to glucose stimuli, which is essential for maintaining glucose homeostasis. SIDT2 also participates in RNA catabolic processes, RNA transport, and nucleic acid transmembrane transporter activity. Its involvement in these pathways highlights its potential role in modulating gene expression and cellular responses to glucose stimuli. **Clinical Significance:** SIDT2's expression in immune cells, such as CD8-alpha-beta-positive, alpha-beta intraepithelial T cells, and epidermal Langerhans cells, suggests its involvement in immune regulation and response. Its role in regulating insulin secretion and glucose homeostasis also makes it a potential target for the treatment of diabetes and metabolic disorders. Furthermore, SIDT2's expression in hematopoietic cells implies its involvement in hematopoiesis and blood cell development, which could have implications for the treatment of hematological disorders. In conclusion, SIDT2 is a multifunctional protein involved in various cellular processes, including immune regulation, glucose homeostasis, and RNA transport. Its expression in immune cells and hematopoietic cells highlights its potential role in modulating immune responses and blood cell development. Further research is necessary to fully elucidate the clinical significance and therapeutic potential of SIDT2 in immune-related disorders.

Genular Protein ID: 1692740624

Symbol: SIDT2_HUMAN

Name: SID1 transmembrane family member 2

UniProtKB Accession Codes:

Q8NBJ9 Q8NBY7 Q9Y357

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 4 Ensembl 1 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 27046251

Title: Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes.

PubMed ID: 27046251

DOI: 10.1080/15548627.2016.1145325

PubMed ID: 27846365

Title: Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes.

PubMed ID: 27846365

DOI: 10.1080/15548627.2016.1248019

PubMed ID: 28277980

Title: SIDT2 mediates gymnosis, the uptake of naked single-stranded oligonucleotides into living cells.

PubMed ID: 28277980

DOI: 10.1080/15476286.2017.1302641

Sequence Information:

  • Length: 832
  • Mass: 94454
  • Checksum: 5DDA17E7DC5A33FD
  • Sequence:
    • MFALGLPFLV LLVASVESHL GVLGPKNVSQ KDAEFERTYV DEVNSELVNI YTFNHTVTRN 
RTEGVRVSVN VLNKQKGAPL LFVVRQKEAV VSFQVPLILR GMFQRKYLYQ KVERTLCQPP 
TKNESEIQFF YVDVSTLSPV NTTYQLRVSR MDDFVLRTGE QFSFNTTAAQ PQYFKYEFPE 
GVDSVIVKVT SNKAFPCSVI SIQDVLCPVY DLDNNVAFIG MYQTMTKKAA ITVQRKDFPS 
NSFYVVVVVK TEDQACGGSL PFYPFAEDEP VDQGHRQKTL SVLVSQAVTS EAYVSGMLFC 
LGIFLSFYLL TVLLACWENW RQKKKTLLVA IDRACPESGH PRVLADSFPG SSPYEGYNYG 
SFENVSGSTD GLVDSAGTGD LSYGYQGRSF EPVGTRPRVD SMSSVEEDDY DTLTDIDSDK 
NVIRTKQYLY VADLARKDKR VLRKKYQIYF WNIATIAVFY ALPVVQLVIT YQTVVNVTGN 
QDICYYNFLC AHPLGNLSAF NNILSNLGYI LLGLLFLLII LQREINHNRA LLRNDLCALE 
CGIPKHFGLF YAMGTALMME GLLSACYHVC PNYTNFQFDT SFMYMIAGLC MLKLYQKRHP 
DINASAYSAY ACLAIVIFFS VLGVVFGKGN TAFWIVFSII HIIATLLLST QLYYMGRWKL 
DSGIFRRILH VLYTDCIRQC SGPLYVDRMV LLVMGNVINW SLAAYGLIMR PNDFASYLLA 
IGICNLLLYF AFYIIMKLRS GERIKLIPLL CIVCTSVVWG FALFFFFQGL STWQKTPAES 
REHNRDCILL DFFDDHDIWH FLSSIAMFGS FLVLLTLDDD LDTVQRDKIY VF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.