Details for: TRAPPC12

Gene ID: 51112

Symbol: TRAPPC12

Ensembl ID: ENSG00000171853

Description: trafficking protein particle complex subunit 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 276.7684
    Cell Significance Index: -43.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 167.4004
    Cell Significance Index: -42.4600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 98.7747
    Cell Significance Index: -40.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 94.9753
    Cell Significance Index: -44.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.2876
    Cell Significance Index: -36.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.6910
    Cell Significance Index: -36.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.0110
    Cell Significance Index: -44.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.6484
    Cell Significance Index: -41.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.3138
    Cell Significance Index: -44.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3622
    Cell Significance Index: -20.4900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.6575
    Cell Significance Index: 60.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9690
    Cell Significance Index: 136.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8638
    Cell Significance Index: 373.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7888
    Cell Significance Index: 354.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3758
    Cell Significance Index: 493.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1152
    Cell Significance Index: 49.3300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1014
    Cell Significance Index: 17.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0837
    Cell Significance Index: 41.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9457
    Cell Significance Index: 72.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9356
    Cell Significance Index: 101.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9227
    Cell Significance Index: 150.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8126
    Cell Significance Index: 22.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7583
    Cell Significance Index: 42.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7483
    Cell Significance Index: 10.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6717
    Cell Significance Index: 606.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6178
    Cell Significance Index: 41.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4960
    Cell Significance Index: 343.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4911
    Cell Significance Index: 14.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4293
    Cell Significance Index: 9.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4222
    Cell Significance Index: 21.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3804
    Cell Significance Index: 9.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3410
    Cell Significance Index: 186.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3345
    Cell Significance Index: 15.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3138
    Cell Significance Index: 56.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3043
    Cell Significance Index: 41.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2704
    Cell Significance Index: 119.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2298
    Cell Significance Index: 28.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2166
    Cell Significance Index: 6.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2040
    Cell Significance Index: 12.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1961
    Cell Significance Index: 301.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1537
    Cell Significance Index: 3.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1513
    Cell Significance Index: 3.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1463
    Cell Significance Index: 7.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1222
    Cell Significance Index: 7.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1119
    Cell Significance Index: 5.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1099
    Cell Significance Index: 2.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1085
    Cell Significance Index: 200.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1060
    Cell Significance Index: 199.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0642
    Cell Significance Index: 2.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0550
    Cell Significance Index: 34.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0450
    Cell Significance Index: 8.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0357
    Cell Significance Index: 16.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0314
    Cell Significance Index: 42.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0088
    Cell Significance Index: 0.1500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0028
    Cell Significance Index: 0.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0272
    Cell Significance Index: -19.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0338
    Cell Significance Index: -4.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0459
    Cell Significance Index: -34.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0469
    Cell Significance Index: -34.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0758
    Cell Significance Index: -42.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0795
    Cell Significance Index: -49.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0811
    Cell Significance Index: -13.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0910
    Cell Significance Index: -2.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1056
    Cell Significance Index: -2.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1058
    Cell Significance Index: -1.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1058
    Cell Significance Index: -12.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1061
    Cell Significance Index: -10.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1123
    Cell Significance Index: -14.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1292
    Cell Significance Index: -9.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1302
    Cell Significance Index: -37.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1446
    Cell Significance Index: -21.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1478
    Cell Significance Index: -17.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1646
    Cell Significance Index: -7.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1877
    Cell Significance Index: -4.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2055
    Cell Significance Index: -2.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2272
    Cell Significance Index: -47.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2610
    Cell Significance Index: -25.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2622
    Cell Significance Index: -5.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2675
    Cell Significance Index: -19.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2857
    Cell Significance Index: -32.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3093
    Cell Significance Index: -16.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3251
    Cell Significance Index: -16.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3405
    Cell Significance Index: -35.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3595
    Cell Significance Index: -5.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4591
    Cell Significance Index: -36.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4702
    Cell Significance Index: -12.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5377
    Cell Significance Index: -7.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5591
    Cell Significance Index: -19.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5818
    Cell Significance Index: -18.5300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5957
    Cell Significance Index: -8.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6003
    Cell Significance Index: -11.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6065
    Cell Significance Index: -19.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6154
    Cell Significance Index: -37.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6283
    Cell Significance Index: -20.5700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6391
    Cell Significance Index: -10.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6487
    Cell Significance Index: -9.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6773
    Cell Significance Index: -11.7100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7476
    Cell Significance Index: -15.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7616
    Cell Significance Index: -20.0300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7635
    Cell Significance Index: -9.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAPPC12 belongs to the TRAPP complex, a multi-subunit protein complex involved in regulating membrane trafficking, vesicle-mediated transport, and protein localization. The TRAPP complex is composed of 11 subunits, with TRAPPC12 being one of the key regulatory subunits. This gene is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. **Pathways and Functions:** TRAPPC12 is involved in various cellular pathways, including: 1. **Membrane Trafficking:** TRAPPC12 regulates the formation and movement of vesicles, facilitating the transport of proteins and lipids between the endoplasmic reticulum (ER) and the Golgi apparatus. 2. **Protein Localization:** TRAPPC12 ensures the correct localization of proteins to specific cellular compartments, such as the kinetochore, nucleus, and cytoplasm. 3. **Kinetochore Assembly:** TRAPPC12 is involved in the regulation of kinetochore assembly, a critical process for proper chromosome segregation during cell division. 4. **Vesicle Tethering:** TRAPPC12 regulates the tethering of vesicles to the plasma membrane, modulating the dynamics of membrane trafficking. **Clinical Significance:** Dysregulation of TRAPPC12 has been implicated in various human diseases, including: 1. **Immunodeficiency:** Alterations in TRAPPC12 expression have been linked to immunodeficiency disorders, such as thymic hypoplasia and T-cell immunodeficiency. 2. **Cancer:** TRAPPC12 mutations have been identified in certain types of cancer, including leukemia and lymphoma, suggesting its role in tumorigenesis and cancer progression. 3. **Neurological Disorders:** TRAPPC12 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, highlighting its potential role in neuronal function and degeneration. In conclusion, TRAPPC12 is a multifunctional gene involved in various cellular processes, including membrane trafficking, protein localization, and kinetochore assembly. Its dysregulation has been linked to various human diseases, underscoring its importance in maintaining cellular homeostasis and overall health. Further research is necessary to fully elucidate the functions and significance of TRAPPC12, with potential implications for the development of novel therapeutic strategies for human diseases.

Genular Protein ID: 2645803182

Symbol: TPC12_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21525244

Title: C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.

PubMed ID: 21525244

DOI: 10.1091/mbc.e10-11-0873

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25918224

Title: TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment.

PubMed ID: 25918224

DOI: 10.1083/jcb.201501090

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 28777934

Title: Mutations in TRAPPC12 manifest in progressive childhood encephalopathy and Golgi dysfunction.

PubMed ID: 28777934

DOI: 10.1016/j.ajhg.2017.07.006

Sequence Information:

  • Length: 735
  • Mass: 79375
  • Checksum: B844FB3749866E3F
  • Sequence:
  • MEDAGGGEET PAPEAPHPPQ LAPPEEQGLL FQEETIDLGG DEFGSEENET ASEGSSPLAD 
    KLNEHMMESV LISDSPNSEG DAGDLGRVRD EAEPGGEGDP GPEPAGTPSP SGEADGDCAP 
    EDAAPSSGGA PRQDAAREVP GSEAARPEQE PPVAEPVPVC TIFSQRAPPA SGDGFEPQMV 
    KSPSFGGASE ASARTPPQVV QPSPSLSTFF GDTAASHSLA SDFFDSFTTS AFISVSNPGA 
    GSPAPASPPP LAVPGTEGRP EPVAMRGPQA AAPPASPEPF AHIQAVFAGS DDPFATALSM 
    SEMDRRNDAW LPGEATRGVL RAVATQQRGA VFVDKENLTM PGLRFDNIQG DAVKDLMLRF 
    LGEKAAAKRQ VLNADSVEQS FVGLKQLISC RNWRAAVDLC GRLLTAHGQG YGKSGLLTSH 
    TTDSLQLWFV RLALLVKLGL FQNAEMEFEP FGNLDQPDLY YEYYPHVYPG RRGSMVPFSM 
    RILHAELQQY LGNPQESLDR LHKVKTVCSK ILANLEQGLA EDGGMSSVTQ EGRQASIRLW 
    RSRLGRVMYS MANCLLLMKD YVLAVEAYHS VIKYYPEQEP QLLSGIGRIS LQIGDIKTAE 
    KYFQDVEKVT QKLDGLQGKI MVLMNSAFLH LGQNNFAEAH RFFTEILRMD PRNAVANNNA 
    AVCLLYLGKL KDSLRQLEAM VQQDPRHYLH ESVLFNLTTM YELESSRSMQ KKQALLEAVA 
    GKEGDSFNTQ CLKLA

Genular Protein ID: 622522258

Symbol: A0A0J9YXQ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 379
  • Mass: 42953
  • Checksum: D25E38D530060C00
  • Sequence:
  • MLRFLGEKAA AKRQVLNADS VEQSFVGLKQ LISCRNWRAA VDLCGRLLTA HGQGYGKSGL 
    LTSHTTDSLQ LWFVRLALLV KLGLFQNAEM EFEPFGNLDQ PDLYYEYYPH VYPGRRGSMV 
    PFSMRILHAE LQQYLGNPQE SLDRLHKVKT VCSKILANLE QGLAEDGGMS SVTQEGRQAS 
    IRLWRSRLGR VMYSMANCLL LMKDYVLAVE AYHSVIKYYP EQEPQLLSGI GRISLQIGDI 
    KTAEKYFQDV EKVTQKLDGL QGKIMVLMNS AFLHLGQNNF AEAHRFFTEI LRMDPRNAVA 
    NNNAAVCLLY LGKLKDSLRQ LEAMVQQDPR HYLHESVLFN LTTMYELESS RSMQKKQALL 
    EAVAGKEGDS FNTQCLKLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.