Details for: RNFT1

Gene ID: 51136

Symbol: RNFT1

Ensembl ID: ENSG00000189050

Description: ring finger protein, transmembrane 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 104.5998
    Cell Significance Index: -16.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.5287
    Cell Significance Index: -15.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.6485
    Cell Significance Index: -16.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 36.3346
    Cell Significance Index: -18.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.7692
    Cell Significance Index: -16.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.6072
    Cell Significance Index: -18.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9092
    Cell Significance Index: -15.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6604
    Cell Significance Index: -18.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0202
    Cell Significance Index: -6.6100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.4741
    Cell Significance Index: 23.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0525
    Cell Significance Index: 114.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9747
    Cell Significance Index: 158.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5989
    Cell Significance Index: 69.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5655
    Cell Significance Index: 36.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5287
    Cell Significance Index: 13.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5284
    Cell Significance Index: 105.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4999
    Cell Significance Index: 13.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4196
    Cell Significance Index: 83.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4032
    Cell Significance Index: 27.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3832
    Cell Significance Index: 346.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3767
    Cell Significance Index: 260.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3672
    Cell Significance Index: 5.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3174
    Cell Significance Index: 12.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3157
    Cell Significance Index: 37.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3081
    Cell Significance Index: 13.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2966
    Cell Significance Index: 15.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2920
    Cell Significance Index: 22.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2749
    Cell Significance Index: 7.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2382
    Cell Significance Index: 5.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2269
    Cell Significance Index: 22.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2201
    Cell Significance Index: 39.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2190
    Cell Significance Index: 78.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1946
    Cell Significance Index: 106.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1939
    Cell Significance Index: 85.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1319
    Cell Significance Index: 16.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1299
    Cell Significance Index: 16.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1162
    Cell Significance Index: 5.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1128
    Cell Significance Index: 5.1200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1128
    Cell Significance Index: 0.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1086
    Cell Significance Index: 7.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1084
    Cell Significance Index: 20.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1070
    Cell Significance Index: 14.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1055
    Cell Significance Index: 1.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1020
    Cell Significance Index: 2.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0893
    Cell Significance Index: 2.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0654
    Cell Significance Index: 4.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0586
    Cell Significance Index: 0.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0476
    Cell Significance Index: 3.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0433
    Cell Significance Index: 0.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0399
    Cell Significance Index: 2.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0262
    Cell Significance Index: 4.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0205
    Cell Significance Index: 0.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0145
    Cell Significance Index: 0.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0103
    Cell Significance Index: 15.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0099
    Cell Significance Index: 18.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0037
    Cell Significance Index: 6.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0011
    Cell Significance Index: -0.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0044
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0048
    Cell Significance Index: -6.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0049
    Cell Significance Index: -0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0090
    Cell Significance Index: -4.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0141
    Cell Significance Index: -10.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0183
    Cell Significance Index: -0.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0192
    Cell Significance Index: -14.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0218
    Cell Significance Index: -16.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0254
    Cell Significance Index: -1.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0290
    Cell Significance Index: -3.7500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0292
    Cell Significance Index: -0.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0295
    Cell Significance Index: -16.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0332
    Cell Significance Index: -20.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0364
    Cell Significance Index: -1.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0509
    Cell Significance Index: -5.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0533
    Cell Significance Index: -15.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0698
    Cell Significance Index: -10.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0759
    Cell Significance Index: -2.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0862
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0936
    Cell Significance Index: -10.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0968
    Cell Significance Index: -20.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0993
    Cell Significance Index: -2.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1080
    Cell Significance Index: -2.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1313
    Cell Significance Index: -2.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1381
    Cell Significance Index: -2.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1421
    Cell Significance Index: -7.4600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1490
    Cell Significance Index: -2.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1522
    Cell Significance Index: -4.0700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1552
    Cell Significance Index: -1.9300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1644
    Cell Significance Index: -1.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1679
    Cell Significance Index: -17.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1777
    Cell Significance Index: -6.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1835
    Cell Significance Index: -2.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2231
    Cell Significance Index: -17.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2253
    Cell Significance Index: -6.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2295
    Cell Significance Index: -6.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2423
    Cell Significance Index: -12.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2428
    Cell Significance Index: -3.5900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2456
    Cell Significance Index: -1.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2681
    Cell Significance Index: -16.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2698
    Cell Significance Index: -13.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RNFT1 is a member of the ring finger protein family, characterized by its unique structure and function. The protein contains a transmembrane domain, which allows it to interact with the endoplasmic reticulum and other cellular components. Its expression is highly specific to hematopoietic cells, suggesting a critical role in the development and function of these cells. RNFT1 is also involved in the regulation of protein ubiquitination, a process that plays a key role in protein degradation and cellular homeostasis. **Pathways and Functions** RNFT1 is implicated in several cellular pathways, including: 1. **Endoplasmic Reticulum (ER)**: RNFT1 interacts with the ER, influencing protein folding, transport, and degradation. 2. **Metal Ion Binding**: RNFT1 binds to metal ions, which is essential for its function and stability. 3. **Positive Regulation of the erad pathway**: RNFT1 regulates the erad pathway, a process involved in the degradation of misfolded proteins. 4. **Protein Autoubiquitination**: RNFT1 is involved in the autoubiquitination of itself, which regulates its activity and stability. 5. **Ubiquitin Binding**: RNFT1 interacts with ubiquitin, a protein involved in protein degradation and cellular homeostasis. **Clinical Significance** RNFT1 has been identified in various cell types, including hematopoietic cells, which suggests its potential role in hematological disorders. The involvement of RNFT1 in protein degradation pathways and cellular homeostasis makes it an important protein in the context of immune responses and disease. Further research is needed to fully understand the clinical significance of RNFT1 and its potential application in the diagnosis and treatment of diseases. In conclusion, RNFT1 is a unique protein that plays a critical role in cellular homeostasis and immune responses. Its involvement in protein degradation pathways, metal ion binding, and the regulation of the erad pathway highlights its significance in various cellular processes. Further research is needed to fully understand the clinical significance of RNFT1 and its potential application in the diagnosis and treatment of diseases.

Genular Protein ID: 2529621740

Symbol: RNFT1_HUMAN

Name: Protein PTD016

UniProtKB Accession Codes:

Q5M7Z0 Q8N7D0 Q96IZ9 Q9Y686

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EC 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17074343

Title: Identification of ten novel genes involved in human spermatogenesis by microarray analysis of testicular tissue.

PubMed ID: 17074343

DOI: 10.1016/j.fertnstert.2006.04.039

PubMed ID: 27485036

Title: Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation.

PubMed ID: 27485036

DOI: 10.1038/srep30955

Sequence Information:

  • Length: 435
  • Mass: 49710
  • Checksum: 60773323485B08A8
  • Sequence:
    • MPLFLLSLPT PPSASGHERR QRPEAKTSGS EKKYLRAMQA NRSQLHSPPG TGSSEDASTP 
QCVHTRLTGE GSCPHSGDVH IQINSIPKEC AENASSRNIR SGVHSCAHGC VHSRLRGHSH 
SEARLTDDTA AESGDHGSSS FSEFRYLFKW LQKSLPYILI LSVKLVMQHI TGISLGIGLL 
TTFMYANKSI VNQVFLRERS SKIQCAWLLV FLAGSSVLLY YTFHSQSLYY SLIFLNPTLD 
HLSFWEVFWI VGITDFILKF FFMGLKCLIL LVPSFIMPFK SKGYWYMLLE ELCQYYRTFV 
PIPVWFRYLI SYGEFGNVTR WSLGILLALL YLILKLLEFF GHLRTFRQVL RIFFTQPSYG 
VAASKRQCSD VDDICSICQA EFQKPILLIC QHIFCEECMT LWFNREKTCP LCRTVISDHI 
NKWKDGATSS HLQIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.