Details for: AADAT

Gene ID: 51166

Symbol: AADAT

Ensembl ID: ENSG00000109576

Description: aminoadipate aminotransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 96.2742
    Cell Significance Index: -14.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.7081
    Cell Significance Index: -14.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.8425
    Cell Significance Index: -14.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.7788
    Cell Significance Index: -14.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7981
    Cell Significance Index: -14.9900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0738
    Cell Significance Index: 26.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7111
    Cell Significance Index: 70.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5548
    Cell Significance Index: 111.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3898
    Cell Significance Index: 351.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3800
    Cell Significance Index: 8.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3746
    Cell Significance Index: 60.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3722
    Cell Significance Index: 22.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3688
    Cell Significance Index: 23.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3654
    Cell Significance Index: 39.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3270
    Cell Significance Index: 19.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3122
    Cell Significance Index: 215.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3038
    Cell Significance Index: 15.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2951
    Cell Significance Index: 16.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2343
    Cell Significance Index: 84.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1722
    Cell Significance Index: 32.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1480
    Cell Significance Index: 6.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1309
    Cell Significance Index: 25.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0936
    Cell Significance Index: 2.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0918
    Cell Significance Index: 6.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0640
    Cell Significance Index: 1.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0447
    Cell Significance Index: 5.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0344
    Cell Significance Index: 0.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0295
    Cell Significance Index: 0.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0290
    Cell Significance Index: 5.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0127
    Cell Significance Index: 6.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0093
    Cell Significance Index: 1.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0050
    Cell Significance Index: 9.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0048
    Cell Significance Index: 0.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0038
    Cell Significance Index: 0.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0014
    Cell Significance Index: -0.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0040
    Cell Significance Index: -6.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0051
    Cell Significance Index: -0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0076
    Cell Significance Index: -14.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0099
    Cell Significance Index: -1.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0112
    Cell Significance Index: -8.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0135
    Cell Significance Index: -18.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0143
    Cell Significance Index: -9.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0165
    Cell Significance Index: -2.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0214
    Cell Significance Index: -15.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0216
    Cell Significance Index: -15.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0217
    Cell Significance Index: -9.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0285
    Cell Significance Index: -16.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0356
    Cell Significance Index: -4.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0423
    Cell Significance Index: -12.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0437
    Cell Significance Index: -1.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0486
    Cell Significance Index: -3.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0585
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0674
    Cell Significance Index: -11.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0786
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0864
    Cell Significance Index: -18.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0878
    Cell Significance Index: -1.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1041
    Cell Significance Index: -13.4600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1119
    Cell Significance Index: -1.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1128
    Cell Significance Index: -11.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1185
    Cell Significance Index: -13.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1361
    Cell Significance Index: -4.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1368
    Cell Significance Index: -14.2400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1528
    Cell Significance Index: -2.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1598
    Cell Significance Index: -11.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1751
    Cell Significance Index: -9.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1987
    Cell Significance Index: -2.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1991
    Cell Significance Index: -15.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2061
    Cell Significance Index: -15.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2092
    Cell Significance Index: -4.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2107
    Cell Significance Index: -4.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2115
    Cell Significance Index: -14.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2153
    Cell Significance Index: -11.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2161
    Cell Significance Index: -13.9400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2175
    Cell Significance Index: -3.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2211
    Cell Significance Index: -10.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2402
    Cell Significance Index: -11.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2468
    Cell Significance Index: -6.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2747
    Cell Significance Index: -12.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3011
    Cell Significance Index: -7.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3044
    Cell Significance Index: -9.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3066
    Cell Significance Index: -5.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3163
    Cell Significance Index: -6.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3378
    Cell Significance Index: -7.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3400
    Cell Significance Index: -11.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3445
    Cell Significance Index: -12.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3464
    Cell Significance Index: -6.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3573
    Cell Significance Index: -13.5300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3577
    Cell Significance Index: -5.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3750
    Cell Significance Index: -4.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3759
    Cell Significance Index: -9.8900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3767
    Cell Significance Index: -3.9000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3833
    Cell Significance Index: -6.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3903
    Cell Significance Index: -9.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4089
    Cell Significance Index: -7.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4096
    Cell Significance Index: -12.0700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4190
    Cell Significance Index: -7.2500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4285
    Cell Significance Index: -6.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4333
    Cell Significance Index: -12.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4402
    Cell Significance Index: -16.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4424
    Cell Significance Index: -8.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AADAT is a member of the aminotransferase family, which is involved in the transfer of amino groups between amino acids. The enzyme exhibits specificity for 2-aminoadipate, a key intermediate in the catabolic pathway of lysine. AADAT's unique substrate specificity and high expression levels in various cell types make it an attractive candidate for studying immune regulation and metabolic disorders. **Pathways and Functions:** AADAT is involved in several metabolic and immune-related pathways, including: 1. **Amino acid metabolism:** AADAT is crucial for the catabolism of lysine, which is an essential amino acid. The enzyme's activity is essential for maintaining the balance of amino acids in the body. 2. **Neurodevelopment:** AADAT has been shown to play a role in the development and function of neurons, particularly in the brain. The enzyme's expression in L2/3-6 intratelencephalic projecting glutamatergic neurons suggests its involvement in neuronal development and synaptic plasticity. 3. **Immune regulation:** AADAT has been found to be expressed in various immune cells, including hematopoietic cells, mast cells, and monocytes. The enzyme's activity may contribute to the regulation of immune responses, including the modulation of cytokine production and the maintenance of immune cell homeostasis. 4. **Kynurenine metabolism:** AADAT is involved in the metabolism of kynurenine, a metabolite of tryptophan. The enzyme's activity is essential for the conversion of kynurenine to other metabolites, which play important roles in immune regulation and neurodevelopment. **Clinical Significance:** AADAT's involvement in metabolic and immune-related pathways makes it an attractive candidate for studying various diseases, including: 1. **Metabolic disorders:** Dysregulation of AADAT activity may contribute to metabolic disorders, such as lysinemia or amino acid disorders. 2. **Neurodegenerative diseases:** AADAT's role in neurodevelopment and synaptic plasticity suggests its involvement in neurodegenerative diseases, such as Alzheimer's or Parkinson's disease. 3. **Autoimmune disorders:** AADAT's expression in immune cells and its involvement in immune regulation may contribute to autoimmune disorders, such as multiple sclerosis or rheumatoid arthritis. In conclusion, AADAT is a multifunctional enzyme that plays a crucial role in amino acid metabolism, neurodevelopment, and immune regulation. Further studies are needed to fully elucidate the mechanisms by which AADAT contributes to various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 2176399874

Symbol: AADAT_HUMAN

Name: 2-aminoadipate aminotransferase

UniProtKB Accession Codes:

Q8N5Z0 B3KP84 Q9UL02

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 93 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 6 EMBL 4 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 33 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12126930

Title: Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).

PubMed ID: 12126930

DOI: 10.1016/s1096-7192(02)00037-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18620547

Title: Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II.

PubMed ID: 18620547

DOI: 10.1042/bsr20080085

PubMed ID: 18056995

Title: Crystal structure of human kynurenine aminotransferase II.

PubMed ID: 18056995

DOI: 10.1074/jbc.m708358200

PubMed ID: 18056996

Title: Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia.

PubMed ID: 18056996

DOI: 10.1074/jbc.m707925200

Sequence Information:

  • Length: 425
  • Mass: 47352
  • Checksum: 448CCAAB2173A7BA
  • Sequence:
    • MNYARFITAA SAARNPSPIR TMTDILSRGP KSMISLAGGL PNPNMFPFKT AVITVENGKT 
IQFGEEMMKR ALQYSPSAGI PELLSWLKQL QIKLHNPPTI HYPPSQGQMD LCVTSGSQQG 
LCKVFEMIIN PGDNVLLDEP AYSGTLQSLH PLGCNIINVA SDESGIVPDS LRDILSRWKP 
EDAKNPQKNT PKFLYTVPNG NNPTGNSLTS ERKKEIYELA RKYDFLIIED DPYYFLQFNK 
FRVPTFLSMD VDGRVIRADS FSKIISSGLR IGFLTGPKPL IERVILHIQV STLHPSTFNQ 
LMISQLLHEW GEEGFMAHVD RVIDFYSNQK DAILAAADKW LTGLAEWHVP AAGMFLWIKV 
KGINDVKELI EEKAVKMGVL MLPGNAFYVD SSAPSPYLRA SFSSASPEQM DVAFQVLAQL 
IKESL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.