Details for: NIN

Gene ID: 51199

Symbol: NIN

Ensembl ID: ENSG00000100503

Description: ninein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 323.3143
    Cell Significance Index: -50.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 180.8445
    Cell Significance Index: -45.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 114.2500
    Cell Significance Index: -53.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.6904
    Cell Significance Index: -43.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 96.7757
    Cell Significance Index: -49.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.1381
    Cell Significance Index: -44.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.1369
    Cell Significance Index: -50.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.8718
    Cell Significance Index: -50.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.9003
    Cell Significance Index: -54.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.9319
    Cell Significance Index: -51.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.3955
    Cell Significance Index: -24.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.7658
    Cell Significance Index: 166.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.6549
    Cell Significance Index: 138.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.2674
    Cell Significance Index: 93.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.1038
    Cell Significance Index: 208.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.9444
    Cell Significance Index: 590.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.6512
    Cell Significance Index: 148.7700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.6822
    Cell Significance Index: 27.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6380
    Cell Significance Index: 125.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2997
    Cell Significance Index: 898.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2126
    Cell Significance Index: 63.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1902
    Cell Significance Index: 236.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9606
    Cell Significance Index: 113.2800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.9558
    Cell Significance Index: 12.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8280
    Cell Significance Index: 81.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8103
    Cell Significance Index: 290.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6087
    Cell Significance Index: 549.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5850
    Cell Significance Index: 105.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5820
    Cell Significance Index: 12.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4960
    Cell Significance Index: 9.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4899
    Cell Significance Index: 13.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4242
    Cell Significance Index: 68.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4047
    Cell Significance Index: 49.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2865
    Cell Significance Index: 156.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2359
    Cell Significance Index: 25.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1809
    Cell Significance Index: 3.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1793
    Cell Significance Index: 22.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1440
    Cell Significance Index: 19.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1351
    Cell Significance Index: 85.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1201
    Cell Significance Index: 53.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1028
    Cell Significance Index: 6.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0926
    Cell Significance Index: 17.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0280
    Cell Significance Index: 52.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0123
    Cell Significance Index: 0.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0076
    Cell Significance Index: 0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0052
    Cell Significance Index: 9.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0024
    Cell Significance Index: 3.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0151
    Cell Significance Index: -20.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0241
    Cell Significance Index: -15.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0271
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0349
    Cell Significance Index: -25.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0368
    Cell Significance Index: -20.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0379
    Cell Significance Index: -1.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0438
    Cell Significance Index: -32.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0440
    Cell Significance Index: -2.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0506
    Cell Significance Index: -7.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0575
    Cell Significance Index: -26.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0694
    Cell Significance Index: -52.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0729
    Cell Significance Index: -1.5800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0858
    Cell Significance Index: -1.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1012
    Cell Significance Index: -2.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1035
    Cell Significance Index: -7.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1113
    Cell Significance Index: -19.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1511
    Cell Significance Index: -31.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1539
    Cell Significance Index: -44.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1959
    Cell Significance Index: -5.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2149
    Cell Significance Index: -9.7400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2294
    Cell Significance Index: -2.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2694
    Cell Significance Index: -31.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2838
    Cell Significance Index: -28.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3075
    Cell Significance Index: -4.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3205
    Cell Significance Index: -41.4000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3234
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3323
    Cell Significance Index: -38.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3659
    Cell Significance Index: -23.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3667
    Cell Significance Index: -17.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3723
    Cell Significance Index: -19.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3902
    Cell Significance Index: -44.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4028
    Cell Significance Index: -12.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4062
    Cell Significance Index: -13.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4186
    Cell Significance Index: -10.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4320
    Cell Significance Index: -44.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4803
    Cell Significance Index: -12.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4914
    Cell Significance Index: -13.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4952
    Cell Significance Index: -12.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5451
    Cell Significance Index: -38.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5619
    Cell Significance Index: -41.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5756
    Cell Significance Index: -45.5900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5934
    Cell Significance Index: -7.4900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.6021
    Cell Significance Index: -8.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6487
    Cell Significance Index: -39.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6813
    Cell Significance Index: -21.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6981
    Cell Significance Index: -42.9100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7021
    Cell Significance Index: -17.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7090
    Cell Significance Index: -14.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7091
    Cell Significance Index: -14.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7477
    Cell Significance Index: -34.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7586
    Cell Significance Index: -16.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7676
    Cell Significance Index: -9.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Ninein is a highly conserved gene, with its human counterpart (NIN_HUMAN) exhibiting high sequence similarity to its orthologs in other species. The gene is characterized by its presence in the centrosome and pericentriolar material, where it interacts with microtubules and other cytoskeletal components. Ninein's expression is widespread, with significant levels observed in hematopoietic cells, smooth muscle cells, and epithelial cells. The gene's protein product, Ninein, is a GTP-binding protein that regulates axonogenesis, microtubule organization, and cell division. **Pathways and Functions:** Ninein's involvement in cellular processes is mediated through its interactions with various signaling pathways, including: 1. **Microtubule organization**: Ninein regulates microtubule dynamics, promoting the formation of stable microtubule networks essential for cell division, axonogenesis, and cytoskeletal organization. 2. **Centrosome function**: Ninein interacts with centrosomes, regulating centriole formation, centriole-centriole cohesion, and centrosome localization. 3. **Axonogenesis**: Ninein promotes axon outgrowth and guidance, essential for neuronal development and regeneration. 4. **Cell division**: Ninein regulates the formation of the mitotic spindle, ensuring accurate chromosome segregation during cell division. **Clinical Significance:** Ninein's dysregulation has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in the NIN gene have been associated with neurodegenerative diseases, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: Aberrant expression of Ninein has been observed in various types of cancer, including breast, lung, and colon cancer. 3. **Immune dysfunction**: Ninein's role in regulating axonogenesis and microtubule organization may contribute to immune dysfunction in diseases such as multiple sclerosis and autoimmune disorders. 4. **Neurodevelopmental disorders**: Ninein's involvement in axonogenesis and cell division may contribute to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, the ninein gene is a critical regulator of cellular processes, with implications in immune function and disease. Further research is necessary to fully elucidate the mechanisms by which Ninein regulates cellular processes and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 1469146612

Symbol: NIN_HUMAN

Name: Ninein

UniProtKB Accession Codes:

Q8N4C6 A6NDB8 B7WPA3 C9JSB6 C9JSG2 C9JXL2 Q5BKU3 Q6P0P6 Q9BWU6 Q9C012 Q9C013 Q9C014 Q9H5I6 Q9HAT7 Q9HBY5 Q9HCK7 Q9UH61

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 4 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11004522

Title: Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta.

PubMed ID: 11004522

DOI: 10.1016/s0167-4781(00)00127-5

PubMed ID: 11162463

Title: Genomic organization and molecular characterization of the human ninein gene.

PubMed ID: 11162463

DOI: 10.1006/bbrc.2000.4050

PubMed ID: 15190203

Title: Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation.

PubMed ID: 15190203

PubMed ID: 10997877

Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10997877

DOI: 10.1093/dnares/7.4.271

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11956314

Title: CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation.

PubMed ID: 11956314

DOI: 10.1242/jcs.115.9.1825

PubMed ID: 12403812

Title: Assembly of centrosomal proteins and microtubule organization depends on PCM-1.

PubMed ID: 12403812

DOI: 10.1083/jcb.200204023

PubMed ID: 12927815

Title: Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle.

PubMed ID: 12927815

DOI: 10.1016/s0006-291x(03)01510-9

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15147888

Title: A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors.

PubMed ID: 15147888

DOI: 10.1016/j.febslet.2004.04.024

PubMed ID: 9506584

Title: Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome.

PubMed ID: 9506584

DOI: 10.1002/1529-0131(199803)41:3<551::aid-art22>3.0.co;2-x

PubMed ID: 14503922

Title: Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia.

PubMed ID: 14503922

DOI: 10.1186/1471-2431-3-11

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20596670

Title: Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation.

PubMed ID: 20596670

DOI: 10.3892/ijo_00000691

PubMed ID: 23386061

Title: Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.

PubMed ID: 23386061

DOI: 10.1038/emboj.2013.3

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28422092

Title: Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68.

PubMed ID: 28422092

DOI: 10.1038/ncomms15057

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

PubMed ID: 22933543

Title: Novel microcephalic primordial dwarfism disorder associated with variants in the centrosomal protein ninein.

PubMed ID: 22933543

DOI: 10.1210/jc.2012-2150

Sequence Information:

  • Length: 2090
  • Mass: 243249
  • Checksum: 51D27CD38A369209
  • Sequence:
    • MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 
RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 
PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 
DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 
DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 
GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 
ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 
KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 
SRLENELLEN AEKLAEYENL TNKLQRNLEN VLAEKFGDLD PSSAEFFLQE ERLTQMRNEY 
ERQCRVLQDQ VDELQSELEE YRAQGRVLRL PLKNSPSEEV EANSGGIEPE HGLGSEECNP 
LNMSIEAELV IEQMKEQHHR DICCLRLELE DKVRHYEKQL DETVVSCKKA QENMKQRHEN 
ETHTLEKQIS DLKNEIAELQ GQAAVLKEAH HEATCRHEEE KKQLQVKLEE EKTHLQEKLR 
LQHEMELKAR LTQAQASFER EREGLQSSAW TEEKVRGLTQ ELEQFHQEQL TSLVEKHTLE 
KEELRKELLE KHQRELQEGR EKMETECNRR TSQIEAQFQS DCQKVTERCE SALQSLEGRY 
RQELKDLQEQ QREEKSQWEF EKDELTQECA EAQELLKETL KREKTTSLVL TQEREMLEKT 
YKEHLNSMVV ERQQLLQDLE DLRNVSETQQ SLLSDQILEL KSSHKRELRE REEVLCQAGA 
SEQLASQRLE RLEMEHDQER QEMMSKLLAM ENIHKATCET ADRERAEMST EISRLQSKIK 
EMQQATSPLS MLQSGCQVIG EEEVEGDGAL SLLQQGEQLL EENGDVLLSL QRAHEQAVKE 
NVKMATEISR LQQRLQKLEP GLVMSSCLDE PATEFFGNTA EQTEQFLQQN RTKQVEGVTR 
RHVLSDLEDD EVRDLGSTGT SSVQRQEVKI EESEASVEGF SELENSEETR TESWELKNQI 
SQLQEQLMML CADCDRASEK KQDLLFDVSV LKKKLKMLER IPEASPKYKL LYEDVSREND 
CLQEELRMME TRYDEALENN KELTAEVFRL QDELKKMEEV TETFLSLEKS YDEVKIENEG 
LNVLVLRLQG KIEKLQESVV QRCDCCLWEA SLENLEIEPD GNILQLNQTL EECVPRVRSV 
HHVIEECKQE NQYLEGNTQL LEKVKAHEIA WLHGTIQTHQ ERPRVQNQVI LEENTTLLGF 
QDKHFQHQAT IAELELEKTK LQELTRKLKE RVTILVKQKD VLSHGEKEEE LKAMMHDLQI 
TCSEMQQKVE LLRYESEKLQ QENSILRNEI TTLNEEDSIS NLKLGTLNGS QEEMWQKTET 
VKQENAAVQK MVENLKKQIS ELKIKNQQLD LENTELSQKN SQNQEKLQEL NQRLTEMLCQ 
KEKEPGNSAL EEREQEKFNL KEELERCKVQ SSTLVSSLEA ELSEVKIQTH IVQQENHLLK 
DELEKMKQLH RCPDLSDFQQ KISSVLSYNE KLLKEKEALS EELNSCVDKL AKSSLLEHRI 
ATMKQEQKSW EHQSASLKSQ LVASQEKVQN LEDTVQNVNL QMSRMKSDLR VTQQEKEALK 
QEVMSLHKQL QNAGGKSWAP EIATHPSGLH NQQKRLSWDK LDHLMNEEQQ LLWQENERLQ 
TMVQNTKAEL THSREKVRQL ESNLLPKHQK HLNPSGTMNP TEQEKLSLKR ECDQFQKEQS 
PANRKVSQMN SLEQELETIH LENEGLKKKQ VKLDEQLMEM QHLRSTATPS PSPHAWDLQL 
LQQQACPMVP REQFLQLQRQ LLQAERINQH LQEELENRTS ETNTPQGNQE QLVTVMEERM 
IEVEQKLKLV KRLLQEKVNQ LKEQVSLPGH LCSPTSHSSF NSSFTSLYCH

Genular Protein ID: 3044355404

Symbol: Q5XUU0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5XUU0

Database IDs:

ARBA 4 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 PharmGKB 1 RefSeq 2 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 1989
  • Mass: 231106
  • Checksum: E8B1DEA2ECDFD48C
  • Sequence:
    • MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 
RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 
PEVTVIEPLD EEARPSYIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 
DWIEEKLQEV CEDLGITRDG HLDRKKLVSI CEQYGLQNVD GEILEEVFHN LDPDGTMSVE 
DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVISCLDD 
GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 
ALASFKAEVR HLLERVDQVV REKEKLRSDL DKAEKLKSSM ASEVDDHHAA IERRNEYNLR 
KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 
SRLENELLEN AEKLAEYENL TNKLQRNLEN VLAEKFGDLD PSSAEFFLQE ERLTQMRNEY 
ERQCRVLQDQ VDELQSELEE YRAQGRVFRL PLKNSPSEEV EANSGGIEPE HGLGSEECNP 
LNMSIEAELV IEQMKEQHHR DICCLRLELE DKVRHYEKQL DETVVSCKKA QENMKQRHEN 
ETHTLEKQIS DLKNEIAELQ GQAAVLKEAH HEATCRHEEE KKQLQVKLEE EKTHLQEKLR 
LQHEMELKAR LTQAQASFER EREGLQSSAW TEEKVRGLTQ ELEQFHQEQL TSLVEKHTLE 
KEELRKELLE KHQRELQEGR EKMETECNRR TTQIEAQFQS DCQKVTERCE SALQSLEGRY 
RQELKDLQEQ QREEKSQWEF EKDELTQECA EAQELLKETL KREKTTSLVL TQEREMLEKT 
YKEHLNSMVV ERQQLLQDLE DLRNVSETQQ SLLSDQILEL KSSHIRELRE REEVLCQAGA 
SEQLASQRLE RLEMEHAQER QEMMSKLLAM ENIHKATCET ADRERAEMST EISRLQSKIK 
EMQQATSPLS MLQSGCQVIG EEEVEGDGAL SLLHQGEQLL EENGDVFLSL QRAHEQAVKE 
NVKMATEISR LQQRLQKLEP GLVMSSCLDE PATEFFGNTA EQTEPFLQQN RTKQVEGVTR 
RHVLSDLEDD EVRDLGSTGT SSVQRQEVKI EESEASVEGF SELENSEETR TESWELKNQI 
SQLQEQLMML CADCDRASEK KQDLLFDVSV LKKKLKMLER IPEASPKYKL LYEDVSREND 
CLQEELRMME TRYDEALENN KELTAEVFRL QDELKKMEEV TETFLSLEKS YDEVKIENEE 
LNVLVLRLQG KIEKLQESVV QRCDCCLWEA SLENLEIEPD GNILQLNQTL EECVPRVRSV 
HHVIEECKQE NQYLEGNTQL LEKVKAHEIA WLHGTIQTHQ ERPRVQNQVI LEENTTLLGF 
QDKHFQHQAT IAELELEKTK LQELTRKLKE RVTILVKQKD VLSHGEKEEE LKAMMHDLQI 
TCSEMQQKVE LLRYESEKLQ QENSILRNEI TTLNEEDSIS NLKLGTLNGS QEEMWQKTET 
VKQENAAVQK MVENLKKQIS ELKIKNQQLD LENTELSQKN SQNQEKLQEL NQRLTEMLCQ 
KEKEPGNSAL EEREQEKFNL KEELERCKVQ SSTLVSSLEA ELSEVKIQTH IVQQENHLLK 
DELEKMKQLH RCPDLSDFQQ KISSVLSYNE KLLKEKEALS EELNSCVDKL AKSSLLEHRI 
ATMKQEQKSW EHQSASLKSQ LVASQEKVQN LEDTVQNVNL QMSRMKSDLR VTQQEKEALK 
QEVMSLHKQL QNAGGKSWAP EIATHPSGLH NQQKRLSWDK LDHLMNEEQQ LLWQENERLQ 
TMVQNTKAEL THSREKVRQL ESNLLPKHQK HLNPSGTMNP TEQEKLSLKR ECDQFQKEQS 
PANRKVSQMN SLEQELETIH LENEGLKKKQ VKLDEQLMEN SVVGSSREGC SSLPEIVCED 
AAPEVHCDA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.