Details for: ZNF219

Gene ID: 51222

Symbol: ZNF219

Ensembl ID: ENSG00000165804

Description: zinc finger protein 219

Associated with

  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Histamine receptor activity
    (GO:0004969)
  • Limb bud formation
    (GO:0060174)
  • Membrane
    (GO:0016020)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of chondrocyte differentiation
    (GO:0032332)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 99.3280
    Cell Significance Index: -15.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.7439
    Cell Significance Index: -14.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.4614
    Cell Significance Index: -16.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.3440
    Cell Significance Index: -13.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.8958
    Cell Significance Index: -15.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9466
    Cell Significance Index: -15.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0496
    Cell Significance Index: -15.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.6276
    Cell Significance Index: 35.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2846
    Cell Significance Index: -5.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2474
    Cell Significance Index: 74.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2116
    Cell Significance Index: 119.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9733
    Cell Significance Index: 44.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8454
    Cell Significance Index: 23.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8319
    Cell Significance Index: 52.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7443
    Cell Significance Index: 21.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7168
    Cell Significance Index: 19.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6898
    Cell Significance Index: 47.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6085
    Cell Significance Index: 31.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5051
    Cell Significance Index: 13.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4159
    Cell Significance Index: 9.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3696
    Cell Significance Index: 333.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3429
    Cell Significance Index: 42.1700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3327
    Cell Significance Index: 0.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3286
    Cell Significance Index: 38.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3191
    Cell Significance Index: 63.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2958
    Cell Significance Index: 53.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2692
    Cell Significance Index: 12.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2626
    Cell Significance Index: 3.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2470
    Cell Significance Index: 13.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2371
    Cell Significance Index: 45.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2325
    Cell Significance Index: 16.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2324
    Cell Significance Index: 102.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2295
    Cell Significance Index: 4.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2195
    Cell Significance Index: 5.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1978
    Cell Significance Index: 136.8400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1665
    Cell Significance Index: 2.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1636
    Cell Significance Index: 4.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1582
    Cell Significance Index: 3.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1195
    Cell Significance Index: 1.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1047
    Cell Significance Index: 21.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0936
    Cell Significance Index: 15.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0924
    Cell Significance Index: 3.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0799
    Cell Significance Index: 10.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0746
    Cell Significance Index: 2.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0606
    Cell Significance Index: 2.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0604
    Cell Significance Index: 32.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0366
    Cell Significance Index: 13.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0062
    Cell Significance Index: 0.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0053
    Cell Significance Index: 0.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0047
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0047
    Cell Significance Index: 8.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0028
    Cell Significance Index: 5.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0012
    Cell Significance Index: -0.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0039
    Cell Significance Index: -0.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0066
    Cell Significance Index: -0.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0083
    Cell Significance Index: -1.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0091
    Cell Significance Index: -6.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0098
    Cell Significance Index: -13.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0101
    Cell Significance Index: -1.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0130
    Cell Significance Index: -5.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0192
    Cell Significance Index: -14.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0292
    Cell Significance Index: -16.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0293
    Cell Significance Index: -18.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0310
    Cell Significance Index: -5.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0379
    Cell Significance Index: -3.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0422
    Cell Significance Index: -12.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0459
    Cell Significance Index: -3.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0552
    Cell Significance Index: -8.0200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0556
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0608
    Cell Significance Index: -6.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0815
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0881
    Cell Significance Index: -18.5700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0911
    Cell Significance Index: -1.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0935
    Cell Significance Index: -2.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1164
    Cell Significance Index: -6.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1297
    Cell Significance Index: -15.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1436
    Cell Significance Index: -14.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1610
    Cell Significance Index: -10.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1686
    Cell Significance Index: -13.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1729
    Cell Significance Index: -10.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1871
    Cell Significance Index: -12.5800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1959
    Cell Significance Index: -1.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2283
    Cell Significance Index: -3.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2448
    Cell Significance Index: -12.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2516
    Cell Significance Index: -7.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2548
    Cell Significance Index: -3.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2598
    Cell Significance Index: -4.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2754
    Cell Significance Index: -7.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2796
    Cell Significance Index: -3.0400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2906
    Cell Significance Index: -2.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2917
    Cell Significance Index: -6.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2950
    Cell Significance Index: -6.1800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3007
    Cell Significance Index: -4.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3080
    Cell Significance Index: -8.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3211
    Cell Significance Index: -7.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3374
    Cell Significance Index: -8.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3441
    Cell Significance Index: -15.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3520
    Cell Significance Index: -12.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF219 is a member of the zinc finger protein family, characterized by its ability to bind to DNA and regulate gene expression. Its expression is predominantly observed in hematopoietic cells, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and stromal cells of bone marrow. The protein's expression is also detected in smooth muscle fibers of the ileum, mucosal type mast cells, and conjunctival epithelial cells. **Pathways and Functions:** ZNF219 is involved in multiple signaling pathways, including: 1. **DNA-binding transcription factor activity**: ZNF219 regulates gene expression by binding to specific DNA sequences, thereby modulating the transcription of target genes. 2. **G protein-coupled receptor signaling pathway**: ZNF219 interacts with G protein-coupled receptors, influencing cell signaling and response to external stimuli. 3. **Histamine receptor activity**: ZNF219 can bind to histamine receptors, modulating immune responses and inflammatory processes. 4. **Regulation of DNA-templated transcription**: ZNF219 regulates the transcription of genes involved in cell growth, differentiation, and survival. ZNF219's functions can be divided into two main categories: 1. **Positive regulation**: ZNF219 promotes the expression of genes involved in cell differentiation, growth, and survival, such as chondrocyte differentiation and positive regulation of transcription by RNA polymerase II. 2. **Negative regulation**: ZNF219 suppresses the expression of genes involved in immune responses, inflammation, and cell proliferation, such as negative regulation of DNA-templated transcription and negative regulation of transcription by RNA polymerase II. **Clinical Significance:** Understanding the role of ZNF219 in immune regulation and cellular processes has significant implications for the diagnosis and treatment of various diseases, including: 1. **Immune disorders**: Dysregulation of ZNF219 expression may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: ZNF219's role in regulating cell growth and differentiation may impact cancer development and progression. 3. **Inflammatory diseases**: ZNF219's involvement in the regulation of immune responses and inflammation may influence the severity and treatment of inflammatory diseases, such as asthma and allergies. In conclusion, ZNF219 is a transcription factor that plays a critical role in regulating various cellular processes, including immune response, cell differentiation, and growth. Further research is needed to fully elucidate the mechanisms of ZNF219's functions and its implications in human disease.

Genular Protein ID: 2671551030

Symbol: ZN219_HUMAN

Name: Zinc finger protein 219

UniProtKB Accession Codes:

Q9P2Y4 D3DS16 Q53Y57 Q8IYC1 Q9BW28

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 7 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10819330

Title: Isolation and characterization of a novel zinc finger gene, ZNF219, and mapping to the human chromosome 14q11 region.

PubMed ID: 10819330

DOI: 10.1093/dnares/7.2.137

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14621294

Title: Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor.

PubMed ID: 14621294

DOI: 10.1093/dnares/10.4.155

PubMed ID: 19549071

Title: Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219.

PubMed ID: 19549071

DOI: 10.1111/j.1471-4159.2009.06250.x

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 722
  • Mass: 76877
  • Checksum: AB2B6B37904FC14B
  • Sequence:
    • MEGSRPRAPS GHLAPSPPAF DGELDLQRYS NGPAVSAGSL GMGAVSWSES RAGERRFPCP 
VCGKRFRFNS ILALHLRAHP GAQAFQCPHC GHRAAQRALL RSHLRTHQPE RPRSPAARLL 
LELEERALLR EARLGRARSS GGMQATPATE GLARPQAPSS SAFRCPYCKG KFRTSAERER 
HLHILHRPWK CGLCSFGSSQ EEELLHHSLT AHGAPERPLA ATSAAPPPQP QPQPPPQPEP 
RSVPQPEPEP EPEREATPTP APAAPEEPPA PPEFRCQVCG QSFTQSWFLK GHMRKHKASF 
DHACPVCGRC FKEPWFLKNH MKVHASKLGP LRAPGPASGP ARAPQPPDLG LLAYEPLGPA 
LLLAPAPTPA ERREPPSLLG YLSLRAGEGR PNGEGAEPGP GRSFGGFRPL SSALPARARR 
HRAEEPEEEE EVVEAEEETW ARGRSLGSLA SLHPRPGEGP GHSASAAGAQ ARSTATQEEN 
GLLVGGTRPE GGRGATGKDC PFCGKSFRSA HHLKVHLRVH TGERPYKCPH CDYAGTQSGS 
LKYHLQRHHR EQRSGAGPGP PPEPPPPSQR GSAPQSGAKP SPQPATWVEG ASSPRPPSSG 
AGPGSRRKPA SPGRTLRNGR GGEAEPLDLS LRAGPGGEAG PGGALHRCLF CPFATGAPEL 
MALHLQVHHS RRARGRRPPQ ADASPPYARV PSGETPPSPS QEGEEGSGLS RPGEAGLGGQ 
ER

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.