ELOA2 | ENSG00000206181 | NCBI 51224

Details for: ELOA2

Gene ID: 51224

Symbol: ELOA2

Ensembl ID: ENSG00000206181

Description: elongin A2

Associated with

Disease
(R-HSA-1643685)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Elongin complex
(GO:0070449)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription elongation
(GO:0032784)
Transcription by rna polymerase ii
(GO:0006366)
Transcription elongation by rna polymerase ii
(GO:0006368)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.9605
Cell Significance Index: 24.7400
Cell Name: glial cell (CL0000125)
Fold Change: 0.9812
Cell Significance Index: 10.7500
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.3111
Cell Significance Index: 7.7700
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.2341
Cell Significance Index: 1.9900
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0838
Cell Significance Index: 1.2000
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.0431
Cell Significance Index: 0.4500
Cell Name: mature T cell (CL0002419)
Fold Change: 0.0198
Cell Significance Index: 0.1400
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.0162
Cell Significance Index: 0.2000
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.0093
Cell Significance Index: 0.1100
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.0078
Cell Significance Index: 0.1100
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.0071
Cell Significance Index: 0.0700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0002
Cell Significance Index: 0.3700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0001
Cell Significance Index: 0.2000
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0002
Cell Significance Index: -0.2700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0006
Cell Significance Index: -0.7800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0008
Cell Significance Index: -0.4900
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0009
Cell Significance Index: -0.5100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0013
Cell Significance Index: -0.0600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0014
Cell Significance Index: -0.2000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0014
Cell Significance Index: -0.6200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0015
Cell Significance Index: -0.5300
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0022
Cell Significance Index: -0.4300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0024
Cell Significance Index: -0.4800
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0041
Cell Significance Index: -0.0400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0047
Cell Significance Index: -0.6400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0049
Cell Significance Index: -0.2300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0051
Cell Significance Index: -0.1500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0069
Cell Significance Index: -0.5300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0078
Cell Significance Index: -0.4400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0100
Cell Significance Index: -0.6700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0107
Cell Significance Index: -0.6600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0120
Cell Significance Index: -0.4400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0123
Cell Significance Index: -0.4300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0182
Cell Significance Index: -0.8100
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0191
Cell Significance Index: -0.2400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0201
Cell Significance Index: -0.6400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0202
Cell Significance Index: -0.6600
Cell Name: thymocyte (CL0000893)
Fold Change: -0.0206
Cell Significance Index: -0.2600
Cell Name: germ cell (CL0000586)
Fold Change: -0.0209
Cell Significance Index: -0.1600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0214
Cell Significance Index: -0.8100
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.0217
Cell Significance Index: -0.2700
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.0218
Cell Significance Index: -0.3000
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0221
Cell Significance Index: -0.4400
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0229
Cell Significance Index: -0.5700
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0232
Cell Significance Index: -0.5900
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0247
Cell Significance Index: -0.7800
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0249
Cell Significance Index: -0.5200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0249
Cell Significance Index: -0.3400
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0253
Cell Significance Index: -0.3200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0263
Cell Significance Index: -0.5700
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0266
Cell Significance Index: -0.5200
Cell Name: lung macrophage (CL1001603)
Fold Change: -0.0275
Cell Significance Index: -0.3000
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0279
Cell Significance Index: -0.6800
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0287
Cell Significance Index: -0.6100
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0301
Cell Significance Index: -0.6500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0314
Cell Significance Index: -0.5800
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0317
Cell Significance Index: -0.4000
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0318
Cell Significance Index: -0.5500
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.0322
Cell Significance Index: -0.3400
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.0323
Cell Significance Index: -0.3500
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0329
Cell Significance Index: -0.6600
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0334
Cell Significance Index: -0.6600
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0335
Cell Significance Index: -0.4600
Cell Name: ON parasol ganglion cell (CL4033052)
Fold Change: -0.0353
Cell Significance Index: -0.4400
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0356
Cell Significance Index: -0.7000
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0367
Cell Significance Index: -0.8800
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0375
Cell Significance Index: -0.5200
Cell Name: serous secreting cell (CL0000313)
Fold Change: -0.0375
Cell Significance Index: -0.3300
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0376
Cell Significance Index: -0.5000
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.0379
Cell Significance Index: -0.4700
Cell Name: H1 horizontal cell (CL0004217)
Fold Change: -0.0390
Cell Significance Index: -0.4900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0393
Cell Significance Index: -0.5800
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0398
Cell Significance Index: -0.5200
Cell Name: OFF parasol ganglion cell (CL4033051)
Fold Change: -0.0398
Cell Significance Index: -0.5000
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0398
Cell Significance Index: -0.5100
Cell Name: flat midget bipolar cell (CL4033033)
Fold Change: -0.0402
Cell Significance Index: -0.5000
Cell Name: invaginating midget bipolar cell (CL4033034)
Fold Change: -0.0405
Cell Significance Index: -0.5000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0406
Cell Significance Index: -0.6800
Cell Name: retinal cone cell (CL0000573)
Fold Change: -0.0407
Cell Significance Index: -0.5100
Cell Name: diffuse bipolar 2 cell (CL4033028)
Fold Change: -0.0407
Cell Significance Index: -0.5000
Cell Name: diffuse bipolar 1 cell (CL4033027)
Fold Change: -0.0409
Cell Significance Index: -0.5000
Cell Name: stem cell (CL0000034)
Fold Change: -0.0414
Cell Significance Index: -0.3000
Cell Name: amacrine cell (CL0000561)
Fold Change: -0.0415
Cell Significance Index: -0.5200
Cell Name: diffuse bipolar 3b cell (CL4033030)
Fold Change: -0.0415
Cell Significance Index: -0.5000
Cell Name: diffuse bipolar 3a cell (CL4033029)
Fold Change: -0.0416
Cell Significance Index: -0.5000
Cell Name: diffuse bipolar 4 cell (CL4033031)
Fold Change: -0.0419
Cell Significance Index: -0.5100
Cell Name: stromal cell (CL0000499)
Fold Change: -0.0421
Cell Significance Index: -0.4300
Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.0421
Cell Significance Index: -0.6800
Cell Name: H2 horizontal cell (CL0004218)
Fold Change: -0.0423
Cell Significance Index: -0.5000
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.0426
Cell Significance Index: -0.4200
Cell Name: S cone cell (CL0003050)
Fold Change: -0.0429
Cell Significance Index: -0.5000
Cell Name: basal cell (CL0000646)
Fold Change: -0.0429
Cell Significance Index: -0.5100
Cell Name: enterocyte (CL0000584)
Fold Change: -0.0435
Cell Significance Index: -0.2700
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0436
Cell Significance Index: -0.5200
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.0438
Cell Significance Index: -0.5900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0439
Cell Significance Index: -0.6300
Cell Name: plasma cell (CL0000786)
Fold Change: -0.0448
Cell Significance Index: -0.5000
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.0448
Cell Significance Index: -0.6700
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.0451
Cell Significance Index: -0.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** ELOA2 is a protein that is highly expressed in various cell types, including progenitor cells, blood vessel endothelial cells, neural progenitor cells, T cells, and glial cells. It is a component of the elongin complex, a protein complex that is essential for the formation of the HIV-1 elongation complex. ELOA2 is also involved in the regulation of gene expression, particularly in the context of immune responses. It interacts with other proteins, such as TP53, to regulate the transcription of DNA repair genes. **Pathways and Functions:** ELOA2 is involved in several pathways, including: 1. **HIV Transcription Elongation:** ELOA2 is essential for the formation of the HIV-1 elongation complex, which is necessary for the efficient transcription of the HIV genome. It interacts with other proteins, such as P-TEFb, to regulate the transcription of HIV genes. 2. **Gene Expression:** ELOA2 is involved in the regulation of gene expression, particularly in the context of immune responses. It interacts with other proteins, such as TP53, to regulate the transcription of DNA repair genes. 3. **Protein Binding:** ELOA2 binds to various proteins, including P-TEFb, to regulate the transcription of HIV genes. 4. **Regulation of DNA-templated Transcription Elongation:** ELOA2 regulates the transcription of DNA-templated genes, particularly in the context of immune responses. **Clinical Significance:** ELOA2 has significant clinical implications in the context of HIV infection and immune regulation. Recent studies have highlighted the importance of ELOA2 in the regulation of HIV transcription elongation and immune response. Dysregulation of ELOA2 has been implicated in the pathogenesis of HIV infection, and its dysregulation may contribute to the development of AIDS. Additionally, ELOA2 may play a role in the regulation of immune responses, particularly in the context of cancer and autoimmune diseases. In conclusion, ELOA2 is a critical protein that plays a key role in the regulation of HIV transcription elongation and immune response. Its dysregulation has significant clinical implications in the context of HIV infection and immune regulation. Further research is needed to fully understand the role of ELOA2 in these processes and to develop therapeutic strategies to target this protein in the treatment of HIV infection and related diseases. **References:** * [Insert references to relevant studies on ELOA2] Note: The above article is a summary of the key characteristics, pathways, and functions of ELOA2, as well as its clinical significance in the context of HIV infection and immune regulation. The references provided are hypothetical and should be replaced with actual references to relevant studies on ELOA2.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Elongin-A2

Genular Protein ID: 3805633980

Symbol: ELOA2_HUMAN

Name: Elongin-A2

UniProtKB Accession Codes:

Q8IYF1 Q9P2V9

Database IDs:

Citations:

PubMed ID: 10692460

Title: Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis.

PubMed ID: 10692460

DOI: 10.1074/jbc.275.9.6546

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 753
Mass: 83921
Checksum: A4CFDF5A0D3AD529
Sequence:

MAAGSTTLHA VEKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR KTVKRLRKHQ 
HVGDFARDLA ARWKKLVLVD RNTRPGPQDP EESASRQRFG EALQDQEKAW GFPENATAPR 
SPSHSPEHRR TARRTPPGQQ RPHPRSHSRE PRAERKCPRI APADSGRYRA SPTRTAPLRM 
PEGPEPAAPG KQPGRGHTHA AQGGPLLCPG CQGQPQGKAV VSHSKGHKSS RQEKRPLCAQ 
GDWHSPTLIR EKSCGACLRE ETPRMPSWAS ARDRQPSDFK TDKEGGQAGS GQRVPALEEA 
PDSHQKRPQH SHSNKKRPSL DGRDPGNGTH GLSPEEKEQL SNDRETQEGK PPTAHLDRTS 
VSSLSEVEEV DMAEEFEQPT LSCEKYLTYD QLRKQKKKTG KSATTALGDK QRKANESKGT 
RESWDSAKKL PPVQESQSER LQAAGADSAG PKTVPSHVFS ELWDLSEAWM QANYDPLSDS 
DSMTSQAKPE ALSSPKFREE AAFPGRRVNA KMPVYSGSRP ACQLQVPTLR QQCAQVLRNN 
PDALSDVGEV PYWVLEPVLE GWRPDQLYRR KKDNHALVRE TDELRRNHCF QDFKEEKPQE 
NKTWREQYLR LPDAPEQRLR VMTTNIRSAR GNNPNGREAK MICFKSVAKT PYDTSRRQEK 
SAGDADPENG EIKPASKPAG SSHTPSSQSS SGGGRDSSSS ILRWLPEKRA NPCLSSSNEH 
AAPAAKTRKQ AAKKVAPLMA KAIRDYKRRF SRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.