Details for: DRICH1

Gene ID: 51233

Symbol: DRICH1

Ensembl ID: ENSG00000189269

Description: aspartate rich 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2323
    Cell Significance Index: 14.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2242
    Cell Significance Index: 44.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1458
    Cell Significance Index: 4.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1181
    Cell Significance Index: 23.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1095
    Cell Significance Index: 39.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1067
    Cell Significance Index: 20.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0905
    Cell Significance Index: 26.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0879
    Cell Significance Index: 3.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0780
    Cell Significance Index: 3.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0440
    Cell Significance Index: 4.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0425
    Cell Significance Index: 2.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0411
    Cell Significance Index: 37.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0402
    Cell Significance Index: 0.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0314
    Cell Significance Index: 2.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0303
    Cell Significance Index: 1.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0282
    Cell Significance Index: 0.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0260
    Cell Significance Index: 1.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0224
    Cell Significance Index: 3.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0205
    Cell Significance Index: 1.1500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0194
    Cell Significance Index: 0.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0186
    Cell Significance Index: 2.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0186
    Cell Significance Index: 3.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0175
    Cell Significance Index: 0.5000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0169
    Cell Significance Index: 0.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0112
    Cell Significance Index: 0.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0064
    Cell Significance Index: 1.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0044
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0044
    Cell Significance Index: 8.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0037
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0028
    Cell Significance Index: 4.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0014
    Cell Significance Index: 2.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0010
    Cell Significance Index: 0.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0001
    Cell Significance Index: -0.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0038
    Cell Significance Index: -2.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0044
    Cell Significance Index: -1.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0044
    Cell Significance Index: -3.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0044
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0045
    Cell Significance Index: -2.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0059
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0074
    Cell Significance Index: -1.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0081
    Cell Significance Index: -0.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0120
    Cell Significance Index: -0.2600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0125
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0125
    Cell Significance Index: -2.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0137
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0137
    Cell Significance Index: -1.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0166
    Cell Significance Index: -0.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0175
    Cell Significance Index: -0.2500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0185
    Cell Significance Index: -0.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0191
    Cell Significance Index: -2.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0236
    Cell Significance Index: -2.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0243
    Cell Significance Index: -3.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0249
    Cell Significance Index: -2.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0269
    Cell Significance Index: -0.8600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0273
    Cell Significance Index: -0.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0278
    Cell Significance Index: -2.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0285
    Cell Significance Index: -3.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0299
    Cell Significance Index: -0.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0310
    Cell Significance Index: -2.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0312
    Cell Significance Index: -0.5400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0316
    Cell Significance Index: -0.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0316
    Cell Significance Index: -1.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0318
    Cell Significance Index: -0.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0333
    Cell Significance Index: -1.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0365
    Cell Significance Index: -1.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0385
    Cell Significance Index: -1.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0421
    Cell Significance Index: -1.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0425
    Cell Significance Index: -0.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0432
    Cell Significance Index: -3.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0436
    Cell Significance Index: -2.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0437
    Cell Significance Index: -1.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0438
    Cell Significance Index: -1.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0441
    Cell Significance Index: -2.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0454
    Cell Significance Index: -3.2100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0461
    Cell Significance Index: -0.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0477
    Cell Significance Index: -3.0800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0491
    Cell Significance Index: -0.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0500
    Cell Significance Index: -2.3300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0501
    Cell Significance Index: -0.6500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0534
    Cell Significance Index: -0.8800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0549
    Cell Significance Index: -0.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0554
    Cell Significance Index: -0.6600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0555
    Cell Significance Index: -0.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0574
    Cell Significance Index: -2.9900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0706
    Cell Significance Index: -0.5400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0753
    Cell Significance Index: -0.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0795
    Cell Significance Index: -2.9200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0804
    Cell Significance Index: -3.3000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0816
    Cell Significance Index: -1.1700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0850
    Cell Significance Index: -1.0600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0854
    Cell Significance Index: -1.6800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0903
    Cell Significance Index: -1.1400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0926
    Cell Significance Index: -2.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0930
    Cell Significance Index: -3.2300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0933
    Cell Significance Index: -2.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular expression:** DRICH1 is expressed in a diverse range of cell types, including amacrine cells, ON-bipolar cells, retinal ganglion cells, OFF-bipolar cells, retinal bipolar neurons, retinal cone cells, colon goblet cells, erythrocytes, and intestinal crypt stem cells of the small intestine. This widespread expression suggests a multifaceted role in maintaining cellular homeostasis. 2. **Protein binding:** DRICH1's involvement in protein binding pathways indicates its potential to modulate cellular interactions and signaling. This property may enable the gene to regulate various cellular processes, including cell-cell communication, migration, and differentiation. 3. **Conserved sequence:** The gene's conserved sequence across different species suggests that DRICH1 may have evolved to play a fundamental role in cellular biology, with its functions potentially being conserved across species. **Pathways and Functions:** 1. **Protein binding:** DRICH1's ability to bind proteins may be involved in regulating cellular signaling pathways, such as those mediated by G-proteins, kinases, or transcription factors. This binding capacity could enable the gene to modulate cellular responses to external stimuli, influencing processes like cell growth, differentiation, and survival. 2. **Cell-cell interactions:** DRICH1's expression in retinal cells and intestinal cells suggests its involvement in cell-cell interactions, which are crucial for maintaining tissue homeostasis and function. The gene may regulate adhesion molecules, junctional proteins, or other molecules essential for cell-cell communication. 3. **Regulation of cellular processes:** DRICH1's protein binding properties and widespread expression may enable it to regulate various cellular processes, including cell migration, proliferation, and differentiation. This regulatory capacity could be crucial for maintaining tissue homeostasis and responding to developmental cues. **Clinical Significance:** 1. **Retinal disorders:** DRICH1's expression in retinal cells raises the possibility that alterations in this gene may contribute to retinal disorders, such as retinitis pigmentosa or macular degeneration. Understanding the gene's function and its role in retinal biology may lead to the development of novel therapeutic strategies for these conditions. 2. **Intestinal diseases:** DRICH1's expression in intestinal cells suggests that alterations in this gene may contribute to intestinal diseases, such as inflammatory bowel disease (IBD) or colorectal cancer. Further investigation into the gene's function and its role in intestinal biology may provide insights into the development of new therapeutic approaches for these conditions. 3. **Cancer research:** DRICH1's protein binding properties and widespread expression in stem cells and cancer cells raise the possibility that this gene may play a role in cancer development and progression. Further research into the gene's function and its involvement in cancer biology may lead to the identification of novel therapeutic targets. In conclusion, DRICH1 is a gene with a complex expression profile and functional significance. Its involvement in protein binding pathways, cell-cell interactions, and regulation of cellular processes suggests a multifaceted role in maintaining cellular homeostasis. Further investigation into the gene's function and its role in various diseases may provide valuable insights into its clinical significance and potential therapeutic applications.

Genular Protein ID: 4068942635

Symbol: DRIC1_HUMAN

Name: Aspartate-rich protein 1

UniProtKB Accession Codes:

Q6PGQ1 Q6ICJ8 Q6P4I3 Q9NU31

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 4 Ensembl 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 229
  • Mass: 25064
  • Checksum: BB7B6F201690A1F2
  • Sequence:
    • MGNILTCCIN SHCGWPRGKD APCYESDTDI YETVAAATSE STTVEPGKLD VGATEGQDLQ 
HISNQKMPTG PPEDRLSLKF LPSSEEDNDD AKILPSPVQG SSEDNLSLVC LPRSEDDDCD 
DDDDDDAQIL PSRVQGGCYR FDSSSCSSED NLSLVCLPRS EDDDCDDDDD DAQILPSPVQ 
ACSEDSLFLR CSLRHKDEEE EDDDDIHITA RIESDLTLES LSDEEIHPG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.