Details for: MRPL30

Gene ID: 51263

Symbol: MRPL30

Ensembl ID: ENSG00000185414

Description: mitochondrial ribosomal protein L30

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 38.9127
    Cell Significance Index: -16.0300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.1482
    Cell Significance Index: -15.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.3010
    Cell Significance Index: -12.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 29.0638
    Cell Significance Index: -14.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.1135
    Cell Significance Index: -12.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0046
    Cell Significance Index: -12.3000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.1482
    Cell Significance Index: 34.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4366
    Cell Significance Index: 233.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3431
    Cell Significance Index: 80.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0783
    Cell Significance Index: 117.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7886
    Cell Significance Index: 22.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6715
    Cell Significance Index: 7.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6470
    Cell Significance Index: 29.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5660
    Cell Significance Index: 29.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5628
    Cell Significance Index: 38.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4934
    Cell Significance Index: 67.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4923
    Cell Significance Index: 31.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4830
    Cell Significance Index: 10.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4592
    Cell Significance Index: 12.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3572
    Cell Significance Index: 43.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3453
    Cell Significance Index: 62.2400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3444
    Cell Significance Index: 2.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2764
    Cell Significance Index: 16.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2519
    Cell Significance Index: 32.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2481
    Cell Significance Index: 135.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2418
    Cell Significance Index: 48.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2402
    Cell Significance Index: 106.2000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2394
    Cell Significance Index: 1.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2179
    Cell Significance Index: 4.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2170
    Cell Significance Index: 15.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2157
    Cell Significance Index: 7.5000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1813
    Cell Significance Index: 1.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1662
    Cell Significance Index: 31.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1516
    Cell Significance Index: 7.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1485
    Cell Significance Index: 14.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1217
    Cell Significance Index: 6.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1181
    Cell Significance Index: 4.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1073
    Cell Significance Index: 12.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1056
    Cell Significance Index: 2.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1055
    Cell Significance Index: 13.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0952
    Cell Significance Index: 3.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0873
    Cell Significance Index: 31.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0801
    Cell Significance Index: 13.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0726
    Cell Significance Index: 1.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0714
    Cell Significance Index: 1.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0699
    Cell Significance Index: 8.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0595
    Cell Significance Index: 2.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0566
    Cell Significance Index: 3.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0483
    Cell Significance Index: 0.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0428
    Cell Significance Index: 2.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0388
    Cell Significance Index: 0.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0141
    Cell Significance Index: 1.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0104
    Cell Significance Index: 0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0001
    Cell Significance Index: -0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0057
    Cell Significance Index: -10.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0077
    Cell Significance Index: -14.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0091
    Cell Significance Index: -14.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0097
    Cell Significance Index: -0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0133
    Cell Significance Index: -18.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0150
    Cell Significance Index: -11.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0194
    Cell Significance Index: -12.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0199
    Cell Significance Index: -11.2400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0284
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0286
    Cell Significance Index: -17.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0307
    Cell Significance Index: -13.9200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0358
    Cell Significance Index: -0.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0500
    Cell Significance Index: -5.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0732
    Cell Significance Index: -1.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0760
    Cell Significance Index: -5.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0822
    Cell Significance Index: -17.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0862
    Cell Significance Index: -10.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0908
    Cell Significance Index: -1.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0947
    Cell Significance Index: -13.7700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1007
    Cell Significance Index: -1.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1022
    Cell Significance Index: -2.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1224
    Cell Significance Index: -6.8700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1312
    Cell Significance Index: -2.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1360
    Cell Significance Index: -10.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1400
    Cell Significance Index: -5.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1489
    Cell Significance Index: -15.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1504
    Cell Significance Index: -3.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1779
    Cell Significance Index: -4.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1864
    Cell Significance Index: -11.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2069
    Cell Significance Index: -5.9300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2169
    Cell Significance Index: -5.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2786
    Cell Significance Index: -5.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2804
    Cell Significance Index: -4.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2860
    Cell Significance Index: -9.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2935
    Cell Significance Index: -9.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2945
    Cell Significance Index: -10.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3113
    Cell Significance Index: -10.9100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3213
    Cell Significance Index: -6.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3221
    Cell Significance Index: -6.9600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3583
    Cell Significance Index: -5.4000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3723
    Cell Significance Index: -7.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3741
    Cell Significance Index: -11.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3756
    Cell Significance Index: -7.5400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3810
    Cell Significance Index: -5.4600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3845
    Cell Significance Index: -4.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: MRPL30 is a mitochondrial ribosomal protein, indicating its specific localization within the mitochondrial inner membrane. 2. **Ribosomal subunit composition**: As a component of the mitochondrial large ribosomal subunit, MRPL30 contributes to the assembly and function of the ribosome. 3. **High tissue specificity**: MRPL30 is significantly expressed in various cell types, including embryonic stem cells, immune cells, and epithelial cells, suggesting its role in specific cellular processes. 4. **Protein synthesis regulation**: MRPL30 is involved in the regulation of protein synthesis within the mitochondria, which is essential for energy metabolism and cellular homeostasis. **Pathways and Functions:** 1. **Mitochondrial translation**: MRPL30 plays a crucial role in the initiation, elongation, and termination of protein synthesis within the mitochondria. 2. **Metabolism of proteins**: As a component of the mitochondrial ribosome, MRPL30 contributes to the regulation of protein synthesis, which is essential for energy metabolism and cellular homeostasis. 3. **Mitochondrial inner membrane**: MRPL30 is localized within the mitochondrial inner membrane, where it participates in the regulation of mitochondrial function and biogenesis. 4. **Regulation of protein synthesis**: MRPL30 regulates protein synthesis within the mitochondria, which is essential for maintaining cellular homeostasis and responding to cellular stress. **Clinical Significance:** 1. **Mitochondrial diseases**: Dysregulation of MRPL30 has been implicated in various mitochondrial diseases, including neurodegenerative disorders and metabolic disorders. 2. **Cancer and immunology**: MRPL30 has been shown to be involved in the regulation of protein synthesis within immune cells, suggesting its potential role in cancer and immunological disorders. 3. **Neurodegenerative disorders**: MRPL30 has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 4. **Nutritional disorders**: MRPL30 has been linked to nutritional disorders, including fatty acid oxidation disorders and mitochondrial myopathies. In conclusion, MRPL30 is a crucial component of the mitochondrial ribosome, playing a vital role in protein synthesis within the mitochondria. Its dysregulation has been implicated in various diseases, highlighting its importance in maintaining mitochondrial function and overall human health. Further research is needed to elucidate the specific mechanisms by which MRPL30 regulates protein synthesis and its role in human disease.

Genular Protein ID: 1419005591

Symbol: RM30_HUMAN

Name: 39S ribosomal protein L28, mitochondrial

UniProtKB Accession Codes:

Q8TCC3 A6NIC6 D3DVI0 D3DVI3 Q0D2Q7 Q6ZTP4 Q96Q69 Q9P0N0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 EMBL 12 EMDB 57 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 60 PDBsum 60 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 3 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 161
  • Mass: 18546
  • Checksum: E818AD8B8AA7DD23
  • Sequence:
    • MAGILRLVVQ WPPGRLQTVT KGVESLICTD WIRHKFTRSR IPEKVFQASP EDHEKYGGDP 
QNPHKLHIVT RIKSTRRRPY WEKDIIKMLG LEKAHTPQVH KNIPSVNAKL KVVKHLIRIK 
PLKLPQGLPA EENMSNTCLK STGELVVQWH LKPVEQKAHE S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.