Details for: CLEC1A

Gene ID: 51267

Symbol: CLEC1A

Ensembl ID: ENSG00000150048

Description: C-type lectin domain family 1 member A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 10.6499
    Cell Significance Index: 64.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2082
    Cell Significance Index: -9.2100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 3.8233
    Cell Significance Index: 31.6200
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 1.5619
    Cell Significance Index: 12.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4479
    Cell Significance Index: 38.6600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.3082
    Cell Significance Index: 13.5500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1142
    Cell Significance Index: 19.6900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.1013
    Cell Significance Index: 15.8400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.7630
    Cell Significance Index: 5.4800
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.6276
    Cell Significance Index: 3.9300
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.4588
    Cell Significance Index: 1.7100
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.4042
    Cell Significance Index: 3.4200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.4022
    Cell Significance Index: 3.1800
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.3789
    Cell Significance Index: 2.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2262
    Cell Significance Index: 11.7800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.2074
    Cell Significance Index: 2.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1479
    Cell Significance Index: 1.6800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1127
    Cell Significance Index: 0.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0279
    Cell Significance Index: 0.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0172
    Cell Significance Index: 0.1400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.0131
    Cell Significance Index: 0.1800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0120
    Cell Significance Index: 0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0029
    Cell Significance Index: -5.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0036
    Cell Significance Index: -5.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0044
    Cell Significance Index: -3.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0066
    Cell Significance Index: -4.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0093
    Cell Significance Index: -5.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0095
    Cell Significance Index: -4.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0103
    Cell Significance Index: -1.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0123
    Cell Significance Index: -4.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0146
    Cell Significance Index: -4.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0170
    Cell Significance Index: -3.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0228
    Cell Significance Index: -4.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0246
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0250
    Cell Significance Index: -5.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0262
    Cell Significance Index: -3.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0269
    Cell Significance Index: -4.5900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0274
    Cell Significance Index: -0.2600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0284
    Cell Significance Index: -0.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0318
    Cell Significance Index: -3.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0328
    Cell Significance Index: -4.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0365
    Cell Significance Index: -4.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0397
    Cell Significance Index: -5.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0402
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0414
    Cell Significance Index: -4.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0496
    Cell Significance Index: -5.1600
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.0518
    Cell Significance Index: -0.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0552
    Cell Significance Index: -4.3700
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.0553
    Cell Significance Index: -0.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0564
    Cell Significance Index: -4.3300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0655
    Cell Significance Index: -0.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0659
    Cell Significance Index: -4.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0740
    Cell Significance Index: -3.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0763
    Cell Significance Index: -5.1300
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0819
    Cell Significance Index: -0.8900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0830
    Cell Significance Index: -1.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0832
    Cell Significance Index: -5.1200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0937
    Cell Significance Index: -1.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1037
    Cell Significance Index: -5.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1099
    Cell Significance Index: -5.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1128
    Cell Significance Index: -5.2600
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: -0.1163
    Cell Significance Index: -0.5000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1257
    Cell Significance Index: -1.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1273
    Cell Significance Index: -5.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1476
    Cell Significance Index: -5.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1484
    Cell Significance Index: -4.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1493
    Cell Significance Index: -5.2300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1520
    Cell Significance Index: -3.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1538
    Cell Significance Index: -4.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1545
    Cell Significance Index: -4.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1572
    Cell Significance Index: -2.3200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1576
    Cell Significance Index: -1.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1600
    Cell Significance Index: -8.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1602
    Cell Significance Index: -2.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1602
    Cell Significance Index: -5.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1606
    Cell Significance Index: -2.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1607
    Cell Significance Index: -5.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1629
    Cell Significance Index: -3.4100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1660
    Cell Significance Index: -2.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1661
    Cell Significance Index: -5.2900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1680
    Cell Significance Index: -4.1900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1758
    Cell Significance Index: -2.1800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1769
    Cell Significance Index: -3.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1833
    Cell Significance Index: -5.2300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1900
    Cell Significance Index: -6.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1922
    Cell Significance Index: -4.9400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1941
    Cell Significance Index: -2.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1950
    Cell Significance Index: -3.2900
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.1983
    Cell Significance Index: -0.6900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2053
    Cell Significance Index: -5.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2057
    Cell Significance Index: -5.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2076
    Cell Significance Index: -5.6500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2119
    Cell Significance Index: -5.2900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2122
    Cell Significance Index: -5.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2124
    Cell Significance Index: -3.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLEC1A is a transmembrane receptor that interacts with carbohydrate ligands, triggering a signaling cascade that regulates various cellular processes. The receptor's structure consists of a C-type lectin domain, which binds to specific carbohydrate motifs, and a cytoplasmic tail that interacts with downstream signaling molecules. CLEC1A's expression is highly regulated, with its levels varying depending on the tissue and cell type. **Pathways and Functions:** CLEC1A plays a crucial role in several signaling pathways, including: 1. **Carbohydrate binding**: CLEC1A binds to carbohydrate ligands, which triggers a signaling cascade that regulates immune responses and vascular function. 2. **Cell surface receptor signaling pathway**: CLEC1A interacts with downstream signaling molecules, such as Janus kinase (JAK) and spleen tyrosine kinase (Syk), to regulate cellular processes. 3. **Signal transduction**: CLEC1A's signaling pathway involves the activation of various kinases, including JAK and Syk, which regulate immune responses and cell survival. 4. **Transmembrane signaling receptor activity**: CLEC1A's transmembrane domain enables it to interact with ligands on the cell surface, initiating a signaling cascade that regulates cellular processes. **Clinical Significance:** CLEC1A's involvement in immune responses and vascular function makes it an important gene for understanding various diseases, including: 1. **Autoimmune disorders**: Abnormal CLEC1A expression or function may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Inflammatory disorders**: CLEC1A's role in regulating immune responses makes it a potential target for treating inflammatory disorders, such as asthma and allergies. 3. **Cancer**: CLEC1A's expression in cancer cells may contribute to tumor progression and metastasis. 4. **Pregnancy complications**: Abnormal CLEC1A expression in placental endothelial cells may contribute to pregnancy complications, such as preeclampsia. In conclusion, CLEC1A is a critical component of immune cell signaling and endothelial function, playing a significant role in regulating immune responses and vascular homeostasis. Further research is needed to fully elucidate the mechanisms by which CLEC1A regulates cellular processes and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 368247043

Symbol: CLC1A_HUMAN

Name: C-type lectin domain family 1 member A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10671229

Title: Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells.

PubMed ID: 10671229

DOI: 10.1002/1521-4141(200002)30:2<697::aid-immu697>3.0.co;2-m

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 280
  • Mass: 31952
  • Checksum: 138235ED47553F4B
  • Sequence:
  • MQAKYSSTRD MLDDDGDTTM SLHSQGSATT RHPEPRRTEH RAPSSTWRPV ALTLLTLCLV 
    LLIGLAALGL LFFQYYQLSN TGQDTISQME ERLGNTSQEL QSLQVQNIKL AGSLQHVAEK 
    LCRELYNKAG AHRCSPCTEQ WKWHGDNCYQ FYKDSKSWED CKYFCLSENS TMLKINKQED 
    LEFAASQSYS EFFYSYWTGL LRPDSGKAWL WMDGTPFTSE LFHIIIDVTS PRSRDCVAIL 
    NGMIFSKDCK ELKRCVCERR AGMVKPESLH VPPETLGEGD

Genular Protein ID: 660367467

Symbol: B4DV89_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 188
  • Mass: 21739
  • Checksum: B04C4E8517544941
  • Sequence:
  • MQAKYSSTRD MLDDDGDTTM SLHSQASATT RHPEPRRTAH RCSPCTEQWK WHGDNCYQFY 
    KDSKSWEDCK YFCLSENSTM LKINKQEDLE FAASQSYSEF FYSYWTGLLR PDSGKAWLWM 
    DGTPFTSELF HIIIDVTSPR SRDCVAILNG MIFSKDCKEL KRCVCERRAG MVKPESLHVP 
    PETLGEGD

Genular Protein ID: 555697878

Symbol: E9PFB4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 247
  • Mass: 28410
  • Checksum: B4CAD1B8B86420A8
  • Sequence:
  • MQAKYSSTRD MLDDDGDTTM SLHSQGSATT RHPEPRRTVF QYYQLSNTGQ DTISQMEERL 
    GNTSQELQSL QVQNIKLAGS LQHVAEKLCR ELYNKAGAHR CSPCTEQWKW HGDNCYQFYK 
    DSKSWEDCKY FCLSENSTML KINKQEDLEF AASQSYSEFF YSYWTGLLRP DSGKAWLWMD 
    GTPFTSELFH IIIDVTSPRS RDCVAILNGM IFSKDCKELK RCVCERRAGM VKPESLHVPP 
    ETLGEGD

Genular Protein ID: 1564531986

Symbol: E7ESV9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 188
  • Mass: 21725
  • Checksum: B7ABD2E6D37016E1
  • Sequence:
  • MQAKYSSTRD MLDDDGDTTM SLHSQGSATT RHPEPRRTAH RCSPCTEQWK WHGDNCYQFY 
    KDSKSWEDCK YFCLSENSTM LKINKQEDLE FAASQSYSEF FYSYWTGLLR PDSGKAWLWM 
    DGTPFTSELF HIIIDVTSPR SRDCVAILNG MIFSKDCKEL KRCVCERRAG MVKPESLHVP 
    PETLGEGD

Genular Protein ID: 3885159901

Symbol: B3KRP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 247
  • Mass: 28424
  • Checksum: CF4E89FD3C3DE352
  • Sequence:
  • MQAKYSSTRD MLDDDGDTTM SLHSQASATT RHPEPRRTVF QYYQLSNTGQ DTISQMEERL 
    GNTSQELQSL QVQNIKLAGS LQHVAEKLCR ELYNKAGAHR CSPCTEQWKW HGDNCYQFYK 
    DSKSWEDCKY FCLSENSTML KINKQEDLEF AASQSYSEFF YSYWTGLLRP DSGKAWLWMD 
    GTPFTSELFH IIIDVTSPRS RDCVAILNGM IFSKDCKELK RCVCERRAGM VKPESLHVPP 
    ETLGEGD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.