Details for: ZNF571

Gene ID: 51276

Symbol: ZNF571

Ensembl ID: ENSG00000180479

Description: zinc finger protein 571

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 72.8406
    Cell Significance Index: -11.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.6440
    Cell Significance Index: -11.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 25.9361
    Cell Significance Index: -12.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.7595
    Cell Significance Index: -10.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.9768
    Cell Significance Index: -10.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.3272
    Cell Significance Index: -11.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3862
    Cell Significance Index: -11.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9270
    Cell Significance Index: -11.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.3377
    Cell Significance Index: -7.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6769
    Cell Significance Index: -3.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1344
    Cell Significance Index: 215.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6761
    Cell Significance Index: 66.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6203
    Cell Significance Index: 13.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5804
    Cell Significance Index: 13.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5752
    Cell Significance Index: 519.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5604
    Cell Significance Index: 34.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4937
    Cell Significance Index: 341.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4247
    Cell Significance Index: 26.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4216
    Cell Significance Index: 267.7700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4140
    Cell Significance Index: 5.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4135
    Cell Significance Index: 82.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4020
    Cell Significance Index: 43.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3838
    Cell Significance Index: 23.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3828
    Cell Significance Index: 76.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3645
    Cell Significance Index: 59.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3087
    Cell Significance Index: 11.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2888
    Cell Significance Index: 12.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2736
    Cell Significance Index: 5.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2661
    Cell Significance Index: 7.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2454
    Cell Significance Index: 2.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2349
    Cell Significance Index: 84.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2217
    Cell Significance Index: 12.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2155
    Cell Significance Index: 16.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1975
    Cell Significance Index: 13.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1503
    Cell Significance Index: 17.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1088
    Cell Significance Index: 1.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0972
    Cell Significance Index: 2.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0898
    Cell Significance Index: 169.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0889
    Cell Significance Index: 16.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0840
    Cell Significance Index: 1.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0811
    Cell Significance Index: 5.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0613
    Cell Significance Index: 27.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0607
    Cell Significance Index: 1.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0506
    Cell Significance Index: 77.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0379
    Cell Significance Index: 1.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0357
    Cell Significance Index: 65.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0308
    Cell Significance Index: 0.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0292
    Cell Significance Index: 39.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0286
    Cell Significance Index: 0.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0285
    Cell Significance Index: 15.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0280
    Cell Significance Index: 0.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0241
    Cell Significance Index: 1.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0201
    Cell Significance Index: 2.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0175
    Cell Significance Index: 7.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0145
    Cell Significance Index: 0.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0055
    Cell Significance Index: 0.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0061
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0096
    Cell Significance Index: -7.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0119
    Cell Significance Index: -8.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0126
    Cell Significance Index: -1.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0157
    Cell Significance Index: -11.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0176
    Cell Significance Index: -9.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0213
    Cell Significance Index: -13.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0340
    Cell Significance Index: -9.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0364
    Cell Significance Index: -5.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0486
    Cell Significance Index: -8.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0531
    Cell Significance Index: -5.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0543
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0588
    Cell Significance Index: -12.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0659
    Cell Significance Index: -7.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0775
    Cell Significance Index: -2.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0797
    Cell Significance Index: -9.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0799
    Cell Significance Index: -1.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0803
    Cell Significance Index: -10.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0809
    Cell Significance Index: -5.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0872
    Cell Significance Index: -9.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1068
    Cell Significance Index: -5.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1070
    Cell Significance Index: -6.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1111
    Cell Significance Index: -2.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1151
    Cell Significance Index: -8.5800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1161
    Cell Significance Index: -1.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1167
    Cell Significance Index: -5.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1336
    Cell Significance Index: -10.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1409
    Cell Significance Index: -2.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1610
    Cell Significance Index: -9.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1672
    Cell Significance Index: -4.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1687
    Cell Significance Index: -3.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1851
    Cell Significance Index: -6.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1934
    Cell Significance Index: -6.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2019
    Cell Significance Index: -5.3100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2123
    Cell Significance Index: -1.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2154
    Cell Significance Index: -3.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2207
    Cell Significance Index: -7.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2213
    Cell Significance Index: -4.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2293
    Cell Significance Index: -4.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2378
    Cell Significance Index: -8.3300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2384
    Cell Significance Index: -5.1500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2387
    Cell Significance Index: -3.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2437
    Cell Significance Index: -8.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2437
    Cell Significance Index: -6.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Zinc Finger Domain**: ZNF571 contains a highly conserved zinc finger domain, which is responsible for its DNA-binding activity. This domain consists of a Cys2His2 type zinc finger motif that recognizes and binds to specific DNA sequences. 2. **RNA Polymerase II Specificity**: ZNF571 demonstrates specificity for RNA polymerase II, a key enzyme involved in transcriptional regulation. This specificity is crucial for its function in regulating gene expression. 3. **Transcriptional Regulation**: ZNF571 acts as a transcriptional regulator by binding to specific DNA sequences and modulating the transcriptional activity of RNA polymerase II. This results in the up- or down-regulation of target genes involved in various cellular processes. 4. **Cell-Specific Expression**: The expression of ZNF571 is observed in various cell types, including hematopoietic cells, smooth muscle cells, and immune cells. This cell-specific expression suggests that ZNF571 plays a role in maintaining cellular homeostasis and responding to specific environmental cues. **Pathways and Functions** 1. **Gene Expression Regulation**: ZNF571 regulates gene expression by binding to specific DNA sequences and influencing the transcriptional activity of RNA polymerase II. This process involves the recognition of cis-regulatory elements, such as enhancers and promoters, and the recruitment of co-activators and co-repressors. 2. **Cell Proliferation and Differentiation**: ZNF571 is involved in the regulation of cell proliferation and differentiation, particularly in hematopoietic cells. Its expression is required for the proper development and function of these cells. 3. **Immune Response**: ZNF571 is expressed in immune cells, such as T cells and mast cells, and plays a role in regulating their function and response to pathogens. 4. **Tissue Development and Maintenance**: ZNF571 is also involved in the development and maintenance of various tissues, including the smooth muscle of the ileum and the epithelial cells of the bronchus. **Clinical Significance** 1. **Cancer Association**: ZNF571 has been implicated in various types of cancer, including leukemia, lymphoma, and solid tumors. Its dysregulation is thought to contribute to tumorigenesis and cancer progression. 2. **Autoimmune Diseases**: ZNF571 is also involved in the regulation of immune responses and has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Infectious Diseases**: ZNF571 plays a role in the regulation of immune responses to pathogens and has been implicated in the development of infectious diseases, such as tuberculosis and HIV. 4. **Regenerative Medicine**: ZNF571 has potential therapeutic applications in regenerative medicine, particularly in the development of cell-based therapies for tissue repair and regeneration. In conclusion, ZNF571 is a transcription factor that plays a crucial role in regulating gene expression and cellular processes. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and infectious diseases. Further research is necessary to fully understand the mechanisms of ZNF571 and its potential therapeutic applications.

Genular Protein ID: 3379578670

Symbol: ZN571_HUMAN

Name: Zinc finger protein 571

UniProtKB Accession Codes:

Q7Z3V5 Q2HIY0 Q3ZCU3 Q9NZX7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 609
  • Mass: 70792
  • Checksum: 7DAA91B38A806EF1
  • Sequence:
    • MPHLLVTFRD VAIDFSQEEW ECLDPAQRDL YRDVMLENYS NLISLDLESS CVTKKLSPEK 
EIYEMESLQW ENMGKRINHH LQYNGLGDNM ECKGNLEGQE ASQEGLYMCV KITCEEKATE 
SHSTSSTFHR IIPTKEKLYK CKECRQGFSY LSCLIQHEEN HNIEKCSEVK KHRNTFSKKP 
SYIQHQRIQT GEKPYECMEC GKAFGRTSDL IQHQKIHTNE KPYQCNACGK AFIRGSQLTE 
HQRVHTGEKP YECKKCGKAF SYCSQYTLHQ RIHSGEKPYE CKDCGKAFIL GSQLTYHQRI 
HSGEKPYECK ECGKAFILGS HLTYHQRVHT GEKPYICKEC GKAFLCASQL NEHQRIHTGE 
KPYECKECGK TFFRGSQLTY HLRVHSGERP YKCKECGKAF ISNSNLIQHQ RIHTGEKPYK 
CKECGKAFIC GKQLSEHQRI HTGEKPFECK ECGKAFIRVA YLTQHEKIHG EKHYECKECG 
KTFVRATQLT YHQRIHTGEK PYKCKECDKA FIYGSQLSEH QRIHRGEKPY ECKQCGKAFI 
RGSHLTEHLR THTGEKPYEC KECGRAFSRG SELTLHQRIH TGEKPYTCVQ CGKDFRCPSQ 
LTQHTRLHN

Genular Protein ID: 2981154705

Symbol: A8K5U8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K5U8

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 609
  • Mass: 70786
  • Checksum: F939811DFC5A4A06
  • Sequence:
    • MPHLLVTFRD VAIDFSQEEW ECLDPAQRDL YRDVMLENYS NLISLDLESS CVTKKLSPEK 
EIYEMESLQW ENMGKRINHH LQYNGLGDNM ECKGNLEGQE ASQEGLYMCV KITCEEKATE 
SHSTSSTFHR IIPTKEKLYK CKECRQGFSY LSCLIQHEEN HNIEKCSEVK KHRNTFSKKP 
SYIQHQRIQT GEKPYECMEC GKAFGRTSDL IQHQKIHTNE KPYQCNACGK AFIRGSQLTE 
HQRVHTGEKP YDCKKCGKAF SYCSQYTLHQ RIHSGEKPFE CKDCGKAFIL GSQLTYHQRI 
HSGEKPYECK ECGKAFILGS HLTYHQRVHT GEKPYICKEC GKAFLCASQL NEHQRIHTGE 
KPYECKECGK TFFRGSQLTY HLRVHSGERP YKCKECGKAF ISNSNLIQHQ RIHTGEKPYK 
CKECGKAFIC GKQLSEHQRI HTGEKPFECK ECGKAFIRVA YLTQHEKIHG EKHYECKECG 
KTFVRATQLT YHQRIHTGEK PYKCKECDKA FIYGSQLSEH QRIHRGEKPY ECKQCGKAFI 
RGSHLTEHLR THTGEKPYEC KECGRAFSRG SEHTLHQRIH TGEKPYTCVQ CGKDFRCPSQ 
LTQHTRLHN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.