Details for: CEND1

Gene ID: 51286

Symbol: CEND1

Ensembl ID: ENSG00000184524

Description: cell cycle exit and neuronal differentiation 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 4.3270
    Cell Significance Index: 1245.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.3771
    Cell Significance Index: 177.3100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 2.2389
    Cell Significance Index: 36.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1346
    Cell Significance Index: 227.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9444
    Cell Significance Index: 26.9500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5228
    Cell Significance Index: 4.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4754
    Cell Significance Index: 170.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2217
    Cell Significance Index: 2.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1972
    Cell Significance Index: 3.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1246
    Cell Significance Index: 8.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0496
    Cell Significance Index: 34.3000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0147
    Cell Significance Index: 0.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0046
    Cell Significance Index: -0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0094
    Cell Significance Index: -17.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0151
    Cell Significance Index: -27.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0181
    Cell Significance Index: -27.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0211
    Cell Significance Index: -28.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0241
    Cell Significance Index: -17.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0290
    Cell Significance Index: -18.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0337
    Cell Significance Index: -24.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0426
    Cell Significance Index: -24.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0431
    Cell Significance Index: -26.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0451
    Cell Significance Index: -24.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0477
    Cell Significance Index: -21.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0496
    Cell Significance Index: -21.9500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0565
    Cell Significance Index: -2.4600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0591
    Cell Significance Index: -0.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0599
    Cell Significance Index: -6.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0867
    Cell Significance Index: -1.8400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0939
    Cell Significance Index: -0.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0980
    Cell Significance Index: -2.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1045
    Cell Significance Index: -18.8300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1133
    Cell Significance Index: -0.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1159
    Cell Significance Index: -16.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1184
    Cell Significance Index: -23.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1197
    Cell Significance Index: -25.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1292
    Cell Significance Index: -2.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1451
    Cell Significance Index: -17.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1502
    Cell Significance Index: -25.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1521
    Cell Significance Index: -18.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1698
    Cell Significance Index: -23.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1824
    Cell Significance Index: -8.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1902
    Cell Significance Index: -4.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1937
    Cell Significance Index: -12.2100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2009
    Cell Significance Index: -2.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2136
    Cell Significance Index: -24.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2334
    Cell Significance Index: -8.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2340
    Cell Significance Index: -18.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2361
    Cell Significance Index: -24.5800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2616
    Cell Significance Index: -3.4900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2846
    Cell Significance Index: -3.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3101
    Cell Significance Index: -21.9300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.3213
    Cell Significance Index: -2.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3260
    Cell Significance Index: -21.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3281
    Cell Significance Index: -25.1800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3693
    Cell Significance Index: -4.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3776
    Cell Significance Index: -7.5800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3811
    Cell Significance Index: -4.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3856
    Cell Significance Index: -12.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3856
    Cell Significance Index: -21.6400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3878
    Cell Significance Index: -8.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3965
    Cell Significance Index: -12.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4066
    Cell Significance Index: -8.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4225
    Cell Significance Index: -14.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4248
    Cell Significance Index: -19.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4267
    Cell Significance Index: -19.3400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5122
    Cell Significance Index: -10.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5364
    Cell Significance Index: -13.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5635
    Cell Significance Index: -19.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5638
    Cell Significance Index: -29.2900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5782
    Cell Significance Index: -7.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6003
    Cell Significance Index: -27.9900
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.6366
    Cell Significance Index: -5.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6568
    Cell Significance Index: -19.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6705
    Cell Significance Index: -19.7500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.6840
    Cell Significance Index: -8.1800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7131
    Cell Significance Index: -9.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7320
    Cell Significance Index: -26.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7678
    Cell Significance Index: -11.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8047
    Cell Significance Index: -21.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8068
    Cell Significance Index: -13.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8232
    Cell Significance Index: -21.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8271
    Cell Significance Index: -22.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.8438
    Cell Significance Index: -20.4400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8449
    Cell Significance Index: -16.6300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8717
    Cell Significance Index: -22.2100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.8820
    Cell Significance Index: -22.0300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.8901
    Cell Significance Index: -11.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9009
    Cell Significance Index: -24.1400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.9058
    Cell Significance Index: -28.6500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9064
    Cell Significance Index: -18.0800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.9547
    Cell Significance Index: -13.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9572
    Cell Significance Index: -27.4400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.9753
    Cell Significance Index: -24.3200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.9866
    Cell Significance Index: -20.0800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.9965
    Cell Significance Index: -10.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0125
    Cell Significance Index: -27.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0464
    Cell Significance Index: -22.6700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -1.0641
    Cell Significance Index: -17.2400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -1.0875
    Cell Significance Index: -15.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell cycle regulation**: CEND1 is involved in the regulation of cell cycle exit, a critical process that marks the transition from the proliferative to the quiescent state in cells. 2. **Neuronal differentiation**: The gene is specifically expressed in neuronal cell types, suggesting its role in promoting neuronal differentiation and development. 3. **Cerebellar granule cell maturation**: CEND1 is involved in the maturation of cerebellar granule cells, which is essential for the proper development of the cerebellum. 4. **Negative regulation of cerebellar granule cell precursor proliferation**: The gene's expression is also associated with the negative regulation of cerebellar granule cell precursor proliferation, which is essential for preventing excessive cell proliferation. **Pathways and Functions** 1. **Cerebellar granular layer maturation**: CEND1 is involved in the maturation of the cerebellar granular layer, which is critical for the proper development of the cerebellum. 2. **Cerebellar purkinje cell differentiation**: The gene is also involved in the differentiation of cerebellar purkinje cells, which are essential for motor coordination and learning. 3. **Radial glia guided migration of cerebellar granule cell**: CEND1 is involved in the migration of cerebellar granule cells guided by radial glia, which is a critical process for the proper development of the cerebellum. 4. **Negative regulation of cerebellar granule cell precursor proliferation**: The gene's expression is associated with the negative regulation of cerebellar granule cell precursor proliferation, which prevents excessive cell proliferation. **Clinical Significance** 1. **Neurodevelopmental disorders**: Dysregulation of CEND1 has been implicated in neurodevelopmental disorders, such as cerebellar ataxia and autism spectrum disorder. 2. **Cerebellar function**: The gene's role in cerebellar granule cell maturation and differentiation suggests its importance in cerebellar function and motor coordination. 3. **Neuroprotection**: CEND1's expression in dopaminergic neurons suggests its potential role in neuroprotection, particularly in the context of Parkinson's disease. 4. **Cancer research**: The gene's involvement in cell cycle regulation and differentiation suggests its potential role in cancer research, particularly in the context of neural tumors. In conclusion, CEND1 is a gene that plays a critical role in regulating cell cycle exit and neuronal differentiation in various neural cell types. Its expression patterns and functional roles suggest its importance in the development and maturation of the central nervous system, and its dysregulation has been implicated in neurodevelopmental disorders and cancer. Further research is needed to fully elucidate the gene's functions and its potential therapeutic applications.

Genular Protein ID: 3434095030

Symbol: CEND_HUMAN

Name: Cell cycle exit and neuronal differentiation protein 1

UniProtKB Accession Codes:

Q8N111 Q9NYM6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 6 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11311134

Title: Cloning, expression and localization of human BM88 shows that it maps to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and tumorigenesis.

PubMed ID: 11311134

DOI: 10.1042/bj3550715

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 149
  • Mass: 14954
  • Checksum: 8251BCDD5A10E7BE
  • Sequence:
    • MESRGKSASS PKPDTKVPQV TTEAKVPPAA DGKAPLTKPS KKEAPAEKQQ PPAAPTTAPA 
KKTSAKADPA LLNNHSNLKP APTVPSSPDA TPEPKGPGDG AEEDEAASGG PGGRGPWSCE 
NFNPLLVAGG VAVAAIALIL GVAFLVRKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.