Details for: REEP2

Gene ID: 51308

Symbol: REEP2

Ensembl ID: ENSG00000132563

Description: receptor accessory protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 84.5676
    Cell Significance Index: -21.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.3193
    Cell Significance Index: -16.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.2714
    Cell Significance Index: 269.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5359
    Cell Significance Index: -5.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.4806
    Cell Significance Index: 17.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3939
    Cell Significance Index: 279.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1643
    Cell Significance Index: 61.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9892
    Cell Significance Index: 21.6600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.9497
    Cell Significance Index: 7.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9419
    Cell Significance Index: 26.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8885
    Cell Significance Index: 11.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5922
    Cell Significance Index: 39.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5768
    Cell Significance Index: 398.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5668
    Cell Significance Index: 203.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5208
    Cell Significance Index: 32.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4703
    Cell Significance Index: 8.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4695
    Cell Significance Index: 11.2600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.4216
    Cell Significance Index: 3.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4135
    Cell Significance Index: 18.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4006
    Cell Significance Index: 15.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3732
    Cell Significance Index: 22.8800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2684
    Cell Significance Index: 3.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2064
    Cell Significance Index: 39.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1045
    Cell Significance Index: 2.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0298
    Cell Significance Index: 26.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0011
    Cell Significance Index: -1.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0032
    Cell Significance Index: -1.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0037
    Cell Significance Index: -6.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0144
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0174
    Cell Significance Index: -12.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0177
    Cell Significance Index: -11.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0198
    Cell Significance Index: -0.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0206
    Cell Significance Index: -11.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0207
    Cell Significance Index: -9.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0244
    Cell Significance Index: -17.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0254
    Cell Significance Index: -14.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0286
    Cell Significance Index: -21.6300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0340
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0348
    Cell Significance Index: -21.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0549
    Cell Significance Index: -7.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0585
    Cell Significance Index: -16.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0588
    Cell Significance Index: -10.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0600
    Cell Significance Index: -1.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0606
    Cell Significance Index: -2.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0651
    Cell Significance Index: -10.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0708
    Cell Significance Index: -9.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0710
    Cell Significance Index: -14.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0805
    Cell Significance Index: -8.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0993
    Cell Significance Index: -20.9100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1067
    Cell Significance Index: -1.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1089
    Cell Significance Index: -6.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1089
    Cell Significance Index: -14.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1118
    Cell Significance Index: -11.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1133
    Cell Significance Index: -13.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1158
    Cell Significance Index: -8.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1159
    Cell Significance Index: -14.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1253
    Cell Significance Index: -3.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1259
    Cell Significance Index: -21.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1416
    Cell Significance Index: -18.2900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1526
    Cell Significance Index: -1.7800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1545
    Cell Significance Index: -1.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1678
    Cell Significance Index: -19.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1682
    Cell Significance Index: -17.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1728
    Cell Significance Index: -3.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1746
    Cell Significance Index: -5.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1805
    Cell Significance Index: -5.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1833
    Cell Significance Index: -8.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1877
    Cell Significance Index: -10.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1907
    Cell Significance Index: -21.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1912
    Cell Significance Index: -6.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1913
    Cell Significance Index: -13.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1987
    Cell Significance Index: -20.6900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2134
    Cell Significance Index: -4.6100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2215
    Cell Significance Index: -4.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2252
    Cell Significance Index: -17.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2287
    Cell Significance Index: -18.1100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2488
    Cell Significance Index: -3.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2505
    Cell Significance Index: -18.6700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2891
    Cell Significance Index: -2.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2961
    Cell Significance Index: -19.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3100
    Cell Significance Index: -16.1500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3189
    Cell Significance Index: -4.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3235
    Cell Significance Index: -8.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3277
    Cell Significance Index: -11.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3691
    Cell Significance Index: -17.3500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3743
    Cell Significance Index: -7.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3938
    Cell Significance Index: -10.3600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3967
    Cell Significance Index: -5.5600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3982
    Cell Significance Index: -5.0300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.4114
    Cell Significance Index: -4.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4179
    Cell Significance Index: -21.7100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4211
    Cell Significance Index: -6.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4298
    Cell Significance Index: -20.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4302
    Cell Significance Index: -13.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4374
    Cell Significance Index: -9.3200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4459
    Cell Significance Index: -3.7900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4880
    Cell Significance Index: -12.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4937
    Cell Significance Index: -7.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** REEP2 is a highly conserved protein that belongs to the REEP family, which is involved in regulating microtubule dynamics and endoplasmic reticulum organization. The gene is primarily expressed in cells that require rapid transport and sensory perception, such as photoreceptor cells and neurons. REEP2's unique structure, comprising a cytoplasmic tail and a transmembrane domain, allows it to interact with microtubules, endoplasmic reticulum, and plasma membranes, thereby modulating cellular processes. **Pathways and Functions:** REEP2 plays a crucial role in regulating intracellular transport, sensory perception, and cellular signaling. Its involvement in microtubule binding and organization is critical for maintaining cellular structure and function. Additionally, REEP2's interaction with endoplasmic reticulum and plasma membranes facilitates protein transport, taste receptor binding, and sensory perception of bitter and sweet tastes. The gene's expression in photoreceptor cells highlights its role in visual processing and disease states such as retinitis pigmentosa. **Clinical Significance:** REEP2's dysregulation has been implicated in various disease states, including neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. Mutations in the REEP2 gene have been linked to retinitis pigmentosa, a condition characterized by progressive vision loss. Furthermore, REEP2's involvement in taste perception and sensory processing suggests its potential role in disorders related to taste and olfaction. The understanding of REEP2's functions and disease associations will provide valuable insights into the development of novel therapeutic strategies for these conditions. In conclusion, REEP2 is a complex protein that plays a critical role in regulating intracellular transport, sensory perception, and cellular signaling. Its involvement in disease states highlights the need for further research into the molecular mechanisms underlying REEP2's functions and its potential as a therapeutic target. As an immunologist, it is essential to continue exploring the intricacies of REEP2's role in maintaining cellular homeostasis and developing novel therapeutic strategies for related diseases.

Genular Protein ID: 2889726871

Symbol: REEP2_HUMAN

Name: Receptor expression-enhancing protein 2

UniProtKB Accession Codes:

Q9BRK0 Q53EM8 Q9NYF2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15550249

Title: RTP family members induce functional expression of mammalian odorant receptors.

PubMed ID: 15550249

DOI: 10.1016/j.cell.2004.11.021

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11161817

Title: Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q).

PubMed ID: 11161817

DOI: 10.1006/geno.2000.6414

PubMed ID: 16720576

Title: Members of RTP and REEP gene families influence functional bitter taste receptor expression.

PubMed ID: 16720576

DOI: 10.1074/jbc.m513637200

PubMed ID: 24388663

Title: Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia.

PubMed ID: 24388663

DOI: 10.1016/j.ajhg.2013.12.005

Sequence Information:

  • Length: 252
  • Mass: 28261
  • Checksum: C2A4DD7F35E7F9C5
  • Sequence:
    • MVSWIISRLV VLIFGTLYPA YSSYKAVKTK NVKEYVKWMM YWIVFAFFTT AETLTDIVLS 
WFPFYFELKI AFVIWLLSPY TKGSSVLYRK FVHPTLSNKE KEIDEYITQA RDKSYETMMR 
VGKRGLNLAA NAAVTAAAKG VLSEKLRSFS MQDLTLIRDE DALPLQRPDG RLRPSPGSLL 
DTIEDLGDDP ALSLRSSTNP ADSRTEASED DMGDKAPKRA KPIKKAPKAE PLASKTLKTR 
PKKKTSGGGD SA

Genular Protein ID: 1649465797

Symbol: A8K3D2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K3D2

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 ExpressionAtlas 1 GO 9 HOGENOM 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 Pfam 1 RefSeq 2 RuleBase 1 SAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 254
  • Mass: 28446
  • Checksum: D19FC26DC93101F7
  • Sequence:
    • MVSWIISRLV VLIFGTLYPA YSSYKAVKTK NVKEYVKWMM YWIVFAFFTT AETLTDIVLS 
WFPFYFELKI AFVIWLLSPY TKGSSVLYRK FVHPTLSNKE KEIDEYITQA RDKSYETMMR 
VGKRGLNLAA NAAVTAAAKG QGVLSEKLRS FSMQDLTLIR DEDALPLQRP DGRLRPSPGS 
LLDTIEDLGD DPALSLRSST NPADSRTEAS EDDMGDKAPK RAKPIKKAPK AEPLASKTLK 
TRPKKKTSGG GDSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.