Details for: ZNF771

Gene ID: 51333

Symbol: ZNF771

Ensembl ID: ENSG00000179965

Description: zinc finger protein 771

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.1346
    Cell Significance Index: -14.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.7619
    Cell Significance Index: -13.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.1970
    Cell Significance Index: -11.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.5657
    Cell Significance Index: -14.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.0731
    Cell Significance Index: -13.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6695
    Cell Significance Index: -14.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.1614
    Cell Significance Index: -9.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0744
    Cell Significance Index: -4.5400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7191
    Cell Significance Index: 27.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4621
    Cell Significance Index: 144.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7539
    Cell Significance Index: 34.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6018
    Cell Significance Index: 543.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5938
    Cell Significance Index: 35.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5933
    Cell Significance Index: 16.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5564
    Cell Significance Index: 60.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5231
    Cell Significance Index: 104.9300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5013
    Cell Significance Index: 5.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4705
    Cell Significance Index: 76.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4371
    Cell Significance Index: 9.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3827
    Cell Significance Index: 75.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3779
    Cell Significance Index: 19.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3353
    Cell Significance Index: 46.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2835
    Cell Significance Index: 17.8700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2819
    Cell Significance Index: 3.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2817
    Cell Significance Index: 101.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2739
    Cell Significance Index: 18.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2046
    Cell Significance Index: 5.4800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1941
    Cell Significance Index: 3.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1895
    Cell Significance Index: 36.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1800
    Cell Significance Index: 79.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1722
    Cell Significance Index: 2.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1599
    Cell Significance Index: 5.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1567
    Cell Significance Index: 4.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1508
    Cell Significance Index: 9.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1335
    Cell Significance Index: 2.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1281
    Cell Significance Index: 88.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1192
    Cell Significance Index: 65.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1096
    Cell Significance Index: 14.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1056
    Cell Significance Index: 2.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1048
    Cell Significance Index: 2.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1021
    Cell Significance Index: 18.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0974
    Cell Significance Index: 4.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0973
    Cell Significance Index: 3.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0767
    Cell Significance Index: 9.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0730
    Cell Significance Index: 1.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0692
    Cell Significance Index: 1.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0669
    Cell Significance Index: 4.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0617
    Cell Significance Index: 1.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0545
    Cell Significance Index: 2.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0468
    Cell Significance Index: 6.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0376
    Cell Significance Index: 4.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0271
    Cell Significance Index: 1.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0222
    Cell Significance Index: 1.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0160
    Cell Significance Index: 1.2300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0155
    Cell Significance Index: 0.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0141
    Cell Significance Index: 0.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0017
    Cell Significance Index: 3.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0022
    Cell Significance Index: -1.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0078
    Cell Significance Index: -4.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0087
    Cell Significance Index: -11.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0098
    Cell Significance Index: -7.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0141
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0183
    Cell Significance Index: -13.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0187
    Cell Significance Index: -8.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0211
    Cell Significance Index: -0.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0213
    Cell Significance Index: -0.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0215
    Cell Significance Index: -0.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0225
    Cell Significance Index: -12.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0266
    Cell Significance Index: -16.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0289
    Cell Significance Index: -0.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0298
    Cell Significance Index: -0.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0328
    Cell Significance Index: -9.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0413
    Cell Significance Index: -2.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0443
    Cell Significance Index: -4.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0460
    Cell Significance Index: -3.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0486
    Cell Significance Index: -5.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0507
    Cell Significance Index: -7.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0685
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0713
    Cell Significance Index: -8.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0761
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0778
    Cell Significance Index: -16.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1027
    Cell Significance Index: -2.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1239
    Cell Significance Index: -9.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1296
    Cell Significance Index: -13.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1426
    Cell Significance Index: -7.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1528
    Cell Significance Index: -4.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1543
    Cell Significance Index: -9.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1701
    Cell Significance Index: -4.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1738
    Cell Significance Index: -4.6500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1741
    Cell Significance Index: -3.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1981
    Cell Significance Index: -5.0600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2530
    Cell Significance Index: -2.1500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2573
    Cell Significance Index: -5.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2594
    Cell Significance Index: -8.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2608
    Cell Significance Index: -3.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2618
    Cell Significance Index: -8.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2706
    Cell Significance Index: -9.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2739
    Cell Significance Index: -6.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional regulation**: ZNF771 acts as a transcription factor, regulating the expression of specific genes by binding to DNA sequences. 2. **DNA binding**: The protein binds to double-stranded DNA sequences, demonstrating its specificity in targeting particular genes for transcriptional activation or repression. 3. **Zinc finger domain**: ZNF771 contains a zinc finger domain, which is essential for its DNA binding activity and transcriptional regulation functions. 4. **Cell-type specificity**: The expression of ZNF771 is highly specific to certain cell types, including hematopoietic cells, immune cells, and cells of the epithelium. **Pathways and Functions** 1. **Generic transcription pathway**: ZNF771 participates in the generic transcription pathway, regulating the expression of a wide range of genes involved in cellular processes such as cell growth, differentiation, and survival. 2. **RNA polymerase II-specific**: As a transcription factor, ZNF771 interacts with RNA polymerase II, a key enzyme responsible for transcribing DNA into RNA. 3. **Metal ion binding**: The zinc finger domain of ZNF771 is essential for its metal ion binding activity, which is necessary for the protein's DNA binding function. 4. **Nucleus and nucleolus**: ZNF771 is primarily localized to the nucleus, with some expression detected in the nucleolus, where it may regulate gene expression in specific contexts. **Clinical Significance** 1. **Hematological disorders**: Mutations or alterations in the expression of ZNF771 may contribute to hematological disorders, such as leukemia or lymphoma, highlighting the protein's importance in maintaining hematopoietic cell function and regulation. 2. **Immune system dysregulation**: Abnormal expression or function of ZNF771 in immune cells may lead to immune system dysregulation, contributing to autoimmune diseases or impaired immune responses. 3. **Cancer research**: The identification of ZNF771 as a transcription factor in cancer cells may provide insights into the molecular mechanisms underlying cancer development and progression. 4. **Gene therapy and targeted therapies**: Further research on ZNF771 may lead to the development of gene therapies or targeted therapies that modulate its expression or activity to treat diseases associated with its dysregulation. In conclusion, ZNF771 is a transcription factor protein that plays a critical role in regulating gene expression in hematopoietic cells and immune cells. Its dysregulation has been implicated in various diseases, including hematological disorders and immune system dysregulation. Further research on ZNF771 may lead to the development of novel therapeutic strategies targeting this protein.

Genular Protein ID: 3392327811

Symbol: ZN771_HUMAN

Name: Zinc finger protein 771

UniProtKB Accession Codes:

Q7L3S4 Q8TAQ7 Q9NYI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 317
  • Mass: 35702
  • Checksum: BF752DE568010B88
  • Sequence:
    • MPGEQQAEEE EEEEMQEEMV LLVKGEEDEG EEKYEVVKLK IPMDNKEVPG EAPAPSADPA 
RPHACPDCGR AFARRSTLAK HARTHTGERP FGCTECGRRF SQKSALTKHG RTHTGERPYE 
CPECDKRFSA ASNLRQHRRR HTGEKPYACA HCGRRFAQSS NYAQHLRVHT GEKPYACPDC 
GRAFGGSSCL ARHRRTHTGE RPYACADCGT RFAQSSALAK HRRVHTGEKP HRCAVCGRRF 
GHRSNLAEHA RTHTGERPYP CAECGRRFRL SSHFIRHRRA HMRRRLYICA GCGRDFKLPP 
GATAATATER CPECEGS

Genular Protein ID: 3407343900

Symbol: B2R9V3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R9V3

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 275
  • Mass: 30782
  • Checksum: 52BF7D7DD0BE466D
  • Sequence:
    • MDNKEVPGEA PAPSADPARP HACPDCGRAF ARRSTLAKHA RTHTGERPFG CTECGRRFSQ 
KSALTKHGRT HTGERPYECP ECDKRFSAAS NLRQHRRRHT GEKPYACAHC GRRFAQSSNY 
AQHLRVHTGE KPYACPDCGR AFGGSSCLAR HRRTHTGERP YACADCGTRF AQSSALAKHR 
RVHTGEKPHR CAVCGRRFGH RSNLAEHART HTGERPYPCA ECGRRFRLSS HFIRHRRAHM 
RRRLYICAGC GRDFKLPPGA TAATATERCP ECEGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.