Details for: HOOK1

Gene ID: 51361

Symbol: HOOK1

Ensembl ID: ENSG00000134709

Description: hook microtubule tethering protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 156.2247
    Cell Significance Index: -24.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 102.4273
    Cell Significance Index: -25.9800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.0452
    Cell Significance Index: -21.5500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.4622
    Cell Significance Index: -26.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.5087
    Cell Significance Index: -21.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.3106
    Cell Significance Index: -26.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7232
    Cell Significance Index: -26.5300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 6.3169
    Cell Significance Index: 48.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.6096
    Cell Significance Index: -7.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.4697
    Cell Significance Index: 29.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.0033
    Cell Significance Index: 126.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9533
    Cell Significance Index: 212.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7729
    Cell Significance Index: 80.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4785
    Cell Significance Index: 296.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4207
    Cell Significance Index: 1282.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3531
    Cell Significance Index: 20.2800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2550
    Cell Significance Index: 10.0200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.1438
    Cell Significance Index: 19.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0678
    Cell Significance Index: 30.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0325
    Cell Significance Index: 39.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.0199
    Cell Significance Index: 12.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0144
    Cell Significance Index: 44.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9375
    Cell Significance Index: 20.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9106
    Cell Significance Index: 326.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.8641
    Cell Significance Index: 125.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8111
    Cell Significance Index: 56.0900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.7651
    Cell Significance Index: 6.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7407
    Cell Significance Index: 38.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7385
    Cell Significance Index: 403.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7095
    Cell Significance Index: 47.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.6833
    Cell Significance Index: 426.7100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.6609
    Cell Significance Index: 1.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6508
    Cell Significance Index: 129.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6005
    Cell Significance Index: 28.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5968
    Cell Significance Index: 16.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5693
    Cell Significance Index: 15.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5406
    Cell Significance Index: 373.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4871
    Cell Significance Index: 13.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4262
    Cell Significance Index: 22.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4186
    Cell Significance Index: 68.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3911
    Cell Significance Index: 8.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3722
    Cell Significance Index: 63.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3617
    Cell Significance Index: 68.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2852
    Cell Significance Index: 35.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2837
    Cell Significance Index: 51.1500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.2673
    Cell Significance Index: 3.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2603
    Cell Significance Index: 19.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2584
    Cell Significance Index: 5.9700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2150
    Cell Significance Index: 3.0600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.2123
    Cell Significance Index: 1.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2101
    Cell Significance Index: 20.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1834
    Cell Significance Index: 6.4500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1429
    Cell Significance Index: 3.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1426
    Cell Significance Index: 63.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1043
    Cell Significance Index: 13.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1032
    Cell Significance Index: 4.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0708
    Cell Significance Index: 133.2300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0654
    Cell Significance Index: 0.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0450
    Cell Significance Index: 28.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0444
    Cell Significance Index: 32.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0138
    Cell Significance Index: 21.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0076
    Cell Significance Index: 14.0400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0065
    Cell Significance Index: 0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0010
    Cell Significance Index: 1.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0120
    Cell Significance Index: -9.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0127
    Cell Significance Index: -0.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0188
    Cell Significance Index: -1.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0259
    Cell Significance Index: -14.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0295
    Cell Significance Index: -6.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0377
    Cell Significance Index: -2.3200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0389
    Cell Significance Index: -0.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0420
    Cell Significance Index: -0.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0487
    Cell Significance Index: -22.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0660
    Cell Significance Index: -0.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0693
    Cell Significance Index: -2.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0693
    Cell Significance Index: -5.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0727
    Cell Significance Index: -20.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0771
    Cell Significance Index: -7.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0940
    Cell Significance Index: -10.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0985
    Cell Significance Index: -11.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1079
    Cell Significance Index: -13.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1305
    Cell Significance Index: -15.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1370
    Cell Significance Index: -18.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1614
    Cell Significance Index: -12.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1776
    Cell Significance Index: -4.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1814
    Cell Significance Index: -1.6700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1910
    Cell Significance Index: -1.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1972
    Cell Significance Index: -23.2600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2202
    Cell Significance Index: -2.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2239
    Cell Significance Index: -5.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2242
    Cell Significance Index: -12.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2290
    Cell Significance Index: -4.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2322
    Cell Significance Index: -13.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2391
    Cell Significance Index: -24.9000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3001
    Cell Significance Index: -4.3000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3004
    Cell Significance Index: -6.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3293
    Cell Significance Index: -8.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3309
    Cell Significance Index: -10.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HOOK1 is a microtubule-binding protein that localizes to the perinuclear region of the cytoplasm, where it interacts with microtubules and other cytoskeletal components. This protein exhibits homodimerization activity, forming dimers that can bind to microtubules, thereby stabilizing their structure and facilitating their transport within the cytoplasm. HOOK1's ability to interact with the Hops complex, a motor protein that regulates microtubule dynamics, further underscores its role in modulating microtubule-dependent processes. **Pathways and Functions** HOOK1's primary functions are rooted in its ability to regulate microtubule organization and dynamics. This is achieved through its interaction with microtubules, facilitating their stabilization and transport within the cytoplasm. HOOK1's involvement in various cellular processes, including: 1. **Cytoskeleton-dependent intracellular transport**: HOOK1's interaction with microtubules enables the transport of cellular cargoes, such as vesicles and organelles, between different compartments within the cell. 2. **Endosome organization and transport**: HOOK1's binding to microtubules enables the formation and movement of endosomes, which are essential for receptor-mediated endocytosis and exocytosis. 3. **Lysosome organization and transport**: HOOK1's interaction with microtubules facilitates the movement of lysosomes, which are involved in degradation and recycling of cellular waste and proteins. **Clinical Significance** The dysregulation of HOOK1's functions has been implicated in various diseases, including: 1. **Hematological malignancies**: Mutations in HOOK1 have been associated with hematopoietic cancers, such as acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). 2. **Neurological disorders**: Altered expression of HOOK1 has been linked to neurodegenerative diseases, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 3. **Immunological disorders**: HOOK1's involvement in the regulation of immune cell function and trafficking highlights its potential role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, HOOK1 is a critical gene involved in the regulation of microtubule organization and dynamics, with implications for various cellular processes, including cytoskeleton-dependent transport, endosome organization, and lysosome movement. Further research into the functions and dysregulation of HOOK1 is necessary to fully elucidate its role in human disease and to develop targeted therapeutic strategies.

Genular Protein ID: 3295714169

Symbol: HOOK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UJC3 A8K8E9 A8MU44 B4DX15 O60561 Q5TG44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9927460

Title: Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila.

PubMed ID: 9927460

DOI: 10.1093/genetics/151.2.675

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11238449

Title: The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins.

PubMed ID: 11238449

DOI: 10.1083/jcb.152.5.923

PubMed ID: 15471887

Title: Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway.

PubMed ID: 15471887

DOI: 10.1093/hmg/ddh321

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18799622

Title: An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.

PubMed ID: 18799622

DOI: 10.1091/mbc.e08-05-0473

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32073997

Title: The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.

PubMed ID: 32073997

DOI: 10.1091/mbc.e19-11-0658

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 26528954

Title: DNAJC6 mutations associated with early-onset Parkinson's disease.

PubMed ID: 26528954

DOI: 10.1002/ana.24553

Sequence Information:

  • Length: 728
  • Mass: 84648
  • Checksum: E35CA91F2BB89B3E
  • Sequence:
    • MEETQPPPQP KLPLCDSLMI WLQTFNTASP CQDVKQLTSG VAMAQVLHQI DAAWFNESWL 
SRIKEDVGDN WRIKASNVKK VLQGIMSYYH EFLGQQISEA LIPDLNQITE CSDPVELGRL 
LQLILGCAIN CEKKQEHIQN IMTLEESVQH VVMTAIQELM SKEILSSPPN DAVGELEQQL 
KRALEELQEA LAEKEELRQR CEELDMQVTT LQDEKNSLVS ENEMMNEKLD QLDGSFDDPN 
TVVAKKYFHA QLQLEQLQEE NFRLEAAKDD YRVHCEELEK QLIEFQHRND ELTSLAEETR 
ALKDEIDVLR ATSDKANKLE STVEIYRQKL QDLNDLRKQV KTLQETNMMY MHNTVSLEEE 
LKKANAARTQ LETYKRQVQD LHVKLSSESK RADTLAFEMK RLEEKHEALL KEKERLIEQR 
DTLKETNEEL RCSQVQQDHL NQTDASATKS YENLAAEIMP VEYREVFIRL QHENKMLRLQ 
QEGSENERIE ELQEQLEQKH RKMNELETEQ RLSKERIREL QQQIEDLQKS LQEQGSKSEG 
ESSSKLKQKL EAHMEKLTEV HEELQKKQEL IEDLQPDINQ NVQKINELEA ALQKKDEDMK 
AMEERYKMYL EKARNVIKTL DPKLNPASAE IMLLRKQLAE KERRIEILES ECKVAKFRDY 
EEKLIVSAWY NKSLAFQKLG MESRLVSGGG ACSDTGACTP ARSFLAQQRH ITNTRRNLSV 
KVPATTSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.