Details for: AIG1

Gene ID: 51390

Symbol: AIG1

Ensembl ID: ENSG00000146416

Description: androgen induced 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 442.0579
    Cell Significance Index: -68.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 270.3008
    Cell Significance Index: -68.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 159.8747
    Cell Significance Index: -65.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 151.7932
    Cell Significance Index: -71.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 141.7821
    Cell Significance Index: -57.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 131.4190
    Cell Significance Index: -67.6000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 107.0084
    Cell Significance Index: -71.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.3304
    Cell Significance Index: -57.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.3638
    Cell Significance Index: -71.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.0517
    Cell Significance Index: -67.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.4328
    Cell Significance Index: -65.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.3399
    Cell Significance Index: -72.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.9066
    Cell Significance Index: -23.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.5515
    Cell Significance Index: 76.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.6608
    Cell Significance Index: 190.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.1747
    Cell Significance Index: 29.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.0586
    Cell Significance Index: 1097.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9054
    Cell Significance Index: 576.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6874
    Cell Significance Index: 539.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3877
    Cell Significance Index: 183.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0500
    Cell Significance Index: 238.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8545
    Cell Significance Index: 1012.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6650
    Cell Significance Index: 300.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5011
    Cell Significance Index: 192.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.4792
    Cell Significance Index: 25.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.4618
    Cell Significance Index: 1011.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2769
    Cell Significance Index: 36.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1206
    Cell Significance Index: 75.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1192
    Cell Significance Index: 137.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0323
    Cell Significance Index: 63.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0139
    Cell Significance Index: 21.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0085
    Cell Significance Index: 75.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8730
    Cell Significance Index: 60.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7951
    Cell Significance Index: 21.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6894
    Cell Significance Index: 38.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4975
    Cell Significance Index: 80.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4908
    Cell Significance Index: 13.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3678
    Cell Significance Index: 19.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3536
    Cell Significance Index: 48.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3500
    Cell Significance Index: 9.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2958
    Cell Significance Index: 7.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2954
    Cell Significance Index: 56.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2945
    Cell Significance Index: 13.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2777
    Cell Significance Index: 522.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2111
    Cell Significance Index: 20.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2026
    Cell Significance Index: 9.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1606
    Cell Significance Index: 247.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1400
    Cell Significance Index: 88.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1387
    Cell Significance Index: 188.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1380
    Cell Significance Index: 17.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1249
    Cell Significance Index: 21.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1084
    Cell Significance Index: 199.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0789
    Cell Significance Index: 35.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0558
    Cell Significance Index: 1.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0539
    Cell Significance Index: 23.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0337
    Cell Significance Index: 24.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0265
    Cell Significance Index: -2.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0295
    Cell Significance Index: -21.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0531
    Cell Significance Index: -40.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0627
    Cell Significance Index: -39.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0716
    Cell Significance Index: -40.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0863
    Cell Significance Index: -8.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1115
    Cell Significance Index: -5.8100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1199
    Cell Significance Index: -1.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1350
    Cell Significance Index: -5.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1468
    Cell Significance Index: -5.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1666
    Cell Significance Index: -2.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1704
    Cell Significance Index: -8.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1730
    Cell Significance Index: -36.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2009
    Cell Significance Index: -23.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2090
    Cell Significance Index: -30.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2162
    Cell Significance Index: -62.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2241
    Cell Significance Index: -25.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2921
    Cell Significance Index: -18.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4086
    Cell Significance Index: -24.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4087
    Cell Significance Index: -8.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4744
    Cell Significance Index: -49.4000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4922
    Cell Significance Index: -5.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4937
    Cell Significance Index: -34.9200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5595
    Cell Significance Index: -63.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5750
    Cell Significance Index: -19.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6178
    Cell Significance Index: -15.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7255
    Cell Significance Index: -57.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7359
    Cell Significance Index: -10.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7765
    Cell Significance Index: -16.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8068
    Cell Significance Index: -18.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8184
    Cell Significance Index: -17.9200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8613
    Cell Significance Index: -17.0300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.8705
    Cell Significance Index: -6.9500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9060
    Cell Significance Index: -18.1900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.9068
    Cell Significance Index: -11.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9296
    Cell Significance Index: -27.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9317
    Cell Significance Index: -9.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9630
    Cell Significance Index: -20.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9865
    Cell Significance Index: -11.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9877
    Cell Significance Index: -31.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0012
    Cell Significance Index: -61.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0328
    Cell Significance Index: -17.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.0377
    Cell Significance Index: -66.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0434
    Cell Significance Index: -33.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** AIG1 is widely expressed in various cell types, including hematopoietic oligopotent progenitor cells, embryonic stem cells, smooth muscle fibers, and immune cells such as peripheral blood mononuclear cells and CD8-alpha-beta-positive, alpha-beta intraepithelial T cells. 2. **Androgen-Induced Expression:** The expression of AIG1 is significantly regulated by androgens, suggesting a potential role in hormonal influences on cellular behavior. 3. **Multifunctional Protein:** AIG1 is involved in multiple cellular processes, including membrane trafficking, protein binding, and fatty acid metabolism. **Pathways and Functions:** 1. **Endomembrane System:** AIG1 is involved in regulating membrane trafficking and endomembrane organization, which is essential for maintaining cellular homeostasis. 2. **Hydrolase Activity:** AIG1 is associated with hydrolase activity, which is involved in breaking down lipids and fatty acids, thereby regulating lipid metabolism. 3. **Long-Chain Fatty Acid Catabolic Process:** AIG1 plays a role in regulating the catabolic process of long-chain fatty acids, which is essential for energy production and lipid metabolism. 4. **Protein Binding:** AIG1 is involved in protein binding, which is essential for regulating protein-protein interactions and cellular signaling pathways. **Clinical Significance:** The study of AIG1 has significant implications for our understanding of cellular processes and their regulation. The androgen-dependent expression of AIG1 suggests a potential link to hormonal influences on cellular behavior, which is essential for maintaining tissue homeostasis and regulating immune responses. In the context of immune disorders, AIG1 may play a role in regulating immune cell function and development. For example, AIG1 expression in hematopoietic progenitor cells may influence the development of immune cells, such as T cells and B cells. Additionally, AIG1 expression in smooth muscle fibers may influence vascular tone and blood pressure regulation. Furthermore, the study of AIG1 may provide insights into the development of therapies targeting androgen-dependent cellular processes. For example, AIG1 inhibitors may be developed to treat conditions such as androgen-sensitive cancers or immune disorders. In conclusion, AIG1 is a multifaceted gene that plays a crucial role in regulating cellular processes, including membrane trafficking, protein binding, and fatty acid metabolism. Its androgen-dependent expression suggests a potential link to hormonal influences on cellular behavior, which has significant implications for our understanding of immune disorders and the development of novel therapies.

Genular Protein ID: 1840625364

Symbol: AIG1_HUMAN

Name: Androgen-induced gene 1 protein

UniProtKB Accession Codes:

Q9NVV5 B4DPX2 C9J569 Q5T2H2 Q6N047 Q7Z378 Q8TB14 Q9Y3A9 Q9Y5B4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChEBI 60 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 4 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 4 Rhea 24 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11266118

Title: Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells.

PubMed ID: 11266118

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27018888

Title: AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.

PubMed ID: 27018888

DOI: 10.1038/nchembio.2051

Sequence Information:

  • Length: 238
  • Mass: 27458
  • Checksum: DF5D5B8FC41A2C95
  • Sequence:
    • MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ AVFFGICVLT 
DLSSLLTRGS GNQEQERQLK KLISLRDWML AVLAFPVGVF VVAVFWIIYA YDREMIYPKL 
LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH QYPSRSSGLT AICTFSVGYI LWVCWVHHVT 
GMWVYPFLEH IGPGARIIFF GSTTILMNFL YLLGEVLNNY IWDTQKSMEE EKEKPKLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.