Details for: RNF138

Gene ID: 51444

Symbol: RNF138

Ensembl ID: ENSG00000134758

Description: ring finger protein 138

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 141.3094
    Cell Significance Index: -21.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 94.4239
    Cell Significance Index: -23.9500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 74.0507
    Cell Significance Index: -30.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 67.2727
    Cell Significance Index: -27.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.3123
    Cell Significance Index: -30.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.8140
    Cell Significance Index: -27.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.8394
    Cell Significance Index: -28.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9595
    Cell Significance Index: -26.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.3674
    Cell Significance Index: -25.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4099
    Cell Significance Index: -29.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5926
    Cell Significance Index: -12.2400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.8601
    Cell Significance Index: 14.0500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.3534
    Cell Significance Index: 14.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1290
    Cell Significance Index: 226.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1226
    Cell Significance Index: 1013.6700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.9904
    Cell Significance Index: 15.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9885
    Cell Significance Index: 107.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9023
    Cell Significance Index: 50.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8832
    Cell Significance Index: 12.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6168
    Cell Significance Index: 122.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5486
    Cell Significance Index: 196.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5263
    Cell Significance Index: 18.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4641
    Cell Significance Index: 45.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4620
    Cell Significance Index: 29.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4417
    Cell Significance Index: 84.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4262
    Cell Significance Index: 50.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3633
    Cell Significance Index: 7.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3519
    Cell Significance Index: 18.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3495
    Cell Significance Index: 241.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3252
    Cell Significance Index: 14.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3138
    Cell Significance Index: 171.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3024
    Cell Significance Index: 8.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2971
    Cell Significance Index: 18.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2747
    Cell Significance Index: 21.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2159
    Cell Significance Index: 95.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1981
    Cell Significance Index: 13.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1918
    Cell Significance Index: 5.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1768
    Cell Significance Index: 21.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1650
    Cell Significance Index: 3.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1546
    Cell Significance Index: 21.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1331
    Cell Significance Index: 3.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1287
    Cell Significance Index: 6.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1130
    Cell Significance Index: 14.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1011
    Cell Significance Index: 18.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0719
    Cell Significance Index: 12.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0612
    Cell Significance Index: 2.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0512
    Cell Significance Index: 1.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0378
    Cell Significance Index: 4.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0290
    Cell Significance Index: 54.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0139
    Cell Significance Index: 0.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0114
    Cell Significance Index: 7.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0078
    Cell Significance Index: 0.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0035
    Cell Significance Index: 0.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0026
    Cell Significance Index: 3.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0029
    Cell Significance Index: -3.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0101
    Cell Significance Index: -6.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0142
    Cell Significance Index: -6.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0178
    Cell Significance Index: -0.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0242
    Cell Significance Index: -1.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0288
    Cell Significance Index: -0.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0296
    Cell Significance Index: -22.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0337
    Cell Significance Index: -24.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0341
    Cell Significance Index: -19.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0370
    Cell Significance Index: -5.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0599
    Cell Significance Index: -4.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0644
    Cell Significance Index: -6.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0793
    Cell Significance Index: -5.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0814
    Cell Significance Index: -17.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0837
    Cell Significance Index: -1.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0872
    Cell Significance Index: -25.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0963
    Cell Significance Index: -2.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1034
    Cell Significance Index: -12.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1188
    Cell Significance Index: -3.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1251
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1481
    Cell Significance Index: -16.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1559
    Cell Significance Index: -3.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1605
    Cell Significance Index: -0.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1922
    Cell Significance Index: -4.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2101
    Cell Significance Index: -6.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2115
    Cell Significance Index: -24.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2339
    Cell Significance Index: -14.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2351
    Cell Significance Index: -6.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2522
    Cell Significance Index: -26.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2538
    Cell Significance Index: -4.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2881
    Cell Significance Index: -15.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2929
    Cell Significance Index: -5.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3506
    Cell Significance Index: -9.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3612
    Cell Significance Index: -28.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4065
    Cell Significance Index: -8.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4204
    Cell Significance Index: -8.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4213
    Cell Significance Index: -25.8300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4417
    Cell Significance Index: -7.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4727
    Cell Significance Index: -12.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4735
    Cell Significance Index: -15.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5009
    Cell Significance Index: -16.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5089
    Cell Significance Index: -12.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5121
    Cell Significance Index: -6.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5458
    Cell Significance Index: -12.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNF138 is a member of the RING finger protein family, characterized by the presence of a RING domain, which is essential for its E3 ubiquitin ligase activity. The gene is highly expressed in various hematopoietic cells, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and peripheral blood mononuclear cells. RNF138 is also found in non-hematopoietic cells, such as ciliated cells of the bronchus and stromal cells of the bone marrow. **Pathways and Functions:** RNF138 is involved in several key pathways, including: 1. **Adaptive immune system**: RNF138 regulates the processing and presentation of antigens via MHC class I, which is essential for the activation of CD8+ T cells. 2. **Antigen processing: ubiquitination & proteasome degradation**: RNF138 is involved in the ubiquitination and degradation of antigens, which is a crucial step in the processing of antigens for presentation to the immune system. 3. **DNA double-strand break repair**: RNF138 is involved in the repair of DNA double-strand breaks via single-strand annealing and homologous recombination pathways. 4. **Wnt signaling pathway**: RNF138 interacts with proteins involved in the Wnt signaling pathway, which is essential for the regulation of cell proliferation, differentiation, and survival. **Clinical Significance:** RNF138 has been implicated in several immune-related disorders, including: 1. **Autoimmune diseases**: RNF138 has been shown to regulate the processing and presentation of antigens, which can contribute to the development of autoimmune diseases such as multiple sclerosis and type 1 diabetes. 2. **Cancer**: RNF138 has been implicated in the regulation of cell proliferation and survival in various types of cancer, including leukemia and lymphoma. 3. **Infectious diseases**: RNF138 has been shown to regulate the processing and presentation of antigens in response to infections, which can contribute to the development of immune responses. In conclusion, RNF138 is a multifaceted protein with a wide range of functions in immune regulation and cellular homeostasis. Further studies are needed to fully elucidate the role of RNF138 in immune-related disorders and to explore its potential as a therapeutic target. **Recommendations:** 1. **Further research**: Additional studies are needed to fully elucidate the role of RNF138 in immune-related disorders and to explore its potential as a therapeutic target. 2. **Immunotherapy**: RNF138 may be a potential target for immunotherapy in autoimmune diseases and cancer. 3. **Diagnostic biomarkers**: RNF138 may be a useful biomarker for the diagnosis of immune-related disorders. **References:** [Insert references to relevant studies] Note: The references should be updated to reflect the latest research on RNF138.

Genular Protein ID: 20076247

Symbol: RN138_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WVD3 B2RE17 Q9H8K2 Q9UF87 Q9UKI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16714285

Title: NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).

PubMed ID: 16714285

DOI: 10.1074/jbc.m602089200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26502055

Title: The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice.

PubMed ID: 26502055

DOI: 10.1038/ncb3259

PubMed ID: 26502057

Title: Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.

PubMed ID: 26502057

DOI: 10.1038/ncb3260

Sequence Information:

  • Length: 245
  • Mass: 28193
  • Checksum: 807EE4500BE0919C
  • Sequence:
    • MAEDLSAATS YTEDDFYCPV CQEVLKTPVR TTACQHVFCR KCFLTAMRES GAHCPLCRGN 
VTRRERACPE RALDLENIMR KFSGSCRCCA KQIKFYRMRH HYKSCKKYQD EYGVSSIIPN 
FQISQDSVGN SNRSETSTSD NTETYQENTS SSGHPTFKCP LCQESNFTRQ RLLDHCNSNH 
LFQIVPVTCP ICVSLPWGDP SQITRNFVSH LNQRHQFDYG EFVNLQLDEE TQYQTAVEES 
FQVNI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.