Details for: TRMO

Gene ID: 51531

Symbol: TRMO

Ensembl ID: ENSG00000136932

Description: tRNA methyltransferase O

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.1687
    Cell Significance Index: -11.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.5060
    Cell Significance Index: -11.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.9382
    Cell Significance Index: -10.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9758
    Cell Significance Index: -9.1400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.5057
    Cell Significance Index: 41.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1179
    Cell Significance Index: 403.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7417
    Cell Significance Index: 669.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6580
    Cell Significance Index: 39.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6042
    Cell Significance Index: 65.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4905
    Cell Significance Index: 79.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4642
    Cell Significance Index: 54.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4273
    Cell Significance Index: 5.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3132
    Cell Significance Index: 21.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2838
    Cell Significance Index: 7.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1867
    Cell Significance Index: 33.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1853
    Cell Significance Index: 81.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1814
    Cell Significance Index: 3.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1798
    Cell Significance Index: 9.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1548
    Cell Significance Index: 30.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1456
    Cell Significance Index: 17.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1448
    Cell Significance Index: 14.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1397
    Cell Significance Index: 16.4800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1328
    Cell Significance Index: 1.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1312
    Cell Significance Index: 26.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1229
    Cell Significance Index: 67.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1224
    Cell Significance Index: 5.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1200
    Cell Significance Index: 5.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1134
    Cell Significance Index: 8.0200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1081
    Cell Significance Index: 1.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1030
    Cell Significance Index: 14.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0982
    Cell Significance Index: 2.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0977
    Cell Significance Index: 2.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0973
    Cell Significance Index: 12.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0900
    Cell Significance Index: 2.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0707
    Cell Significance Index: 10.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0669
    Cell Significance Index: 23.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0508
    Cell Significance Index: 1.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0399
    Cell Significance Index: 5.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0319
    Cell Significance Index: 3.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0318
    Cell Significance Index: 22.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0308
    Cell Significance Index: 0.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0071
    Cell Significance Index: 0.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0038
    Cell Significance Index: 0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0028
    Cell Significance Index: 5.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0029
    Cell Significance Index: -1.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0059
    Cell Significance Index: -4.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0063
    Cell Significance Index: -0.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0071
    Cell Significance Index: -9.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0135
    Cell Significance Index: -10.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0153
    Cell Significance Index: -6.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0165
    Cell Significance Index: -0.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0177
    Cell Significance Index: -1.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0180
    Cell Significance Index: -1.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0184
    Cell Significance Index: -10.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0216
    Cell Significance Index: -3.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0219
    Cell Significance Index: -13.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0307
    Cell Significance Index: -1.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0308
    Cell Significance Index: -1.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0371
    Cell Significance Index: -1.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0391
    Cell Significance Index: -11.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0429
    Cell Significance Index: -0.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0517
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0638
    Cell Significance Index: -13.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0681
    Cell Significance Index: -0.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0728
    Cell Significance Index: -1.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0741
    Cell Significance Index: -3.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0756
    Cell Significance Index: -1.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0822
    Cell Significance Index: -2.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0935
    Cell Significance Index: -1.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0961
    Cell Significance Index: -6.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0998
    Cell Significance Index: -5.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1053
    Cell Significance Index: -6.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1178
    Cell Significance Index: -12.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1229
    Cell Significance Index: -4.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1338
    Cell Significance Index: -10.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1476
    Cell Significance Index: -6.5300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1556
    Cell Significance Index: -1.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1601
    Cell Significance Index: -4.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1795
    Cell Significance Index: -5.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1806
    Cell Significance Index: -6.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1835
    Cell Significance Index: -11.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1888
    Cell Significance Index: -3.4900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2000
    Cell Significance Index: -2.1300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2406
    Cell Significance Index: -2.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2406
    Cell Significance Index: -4.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2489
    Cell Significance Index: -7.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2585
    Cell Significance Index: -9.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2606
    Cell Significance Index: -9.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2637
    Cell Significance Index: -4.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2653
    Cell Significance Index: -6.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2655
    Cell Significance Index: -4.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2657
    Cell Significance Index: -3.8100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2662
    Cell Significance Index: -3.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2854
    Cell Significance Index: -9.0900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2917
    Cell Significance Index: -4.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRMO is a member of the tRNA methyltransferase family, which is responsible for the methylation of tRNA molecules. This process involves the transfer of a methyl group from S-adenosylmethionine (SAM) to specific tRNA residues, resulting in the modification of the tRNA structure and function. TRMO is specifically involved in the methylation of tRNA (l-threonylcarbamoyladenosine-37-C2) and is highly expressed in cells with a high demand for protein synthesis, such as immune cells and epithelial cells. **Pathways and Functions:** The methylation of tRNA by TRMO plays a critical role in regulating protein synthesis. The modification of tRNA by TRMO affects the binding of aminoacyl-tRNA to the ribosome, which is essential for the initiation of translation. This modification also influences the stability and turnover of tRNA, thereby regulating the availability of amino acids for protein synthesis. Furthermore, TRMO has been shown to interact with other proteins involved in the regulation of protein synthesis, such as translation initiation factors and ribosomal proteins. **Clinical Significance:** Dysregulation of TRMO has been implicated in various diseases, including cancer and autoimmune disorders. In cancer, TRMO has been shown to promote tumor growth and metastasis by regulating the expression of oncogenic mRNAs. In autoimmune disorders, TRMO has been implicated in the regulation of immune cell function and the production of autoantibodies. Additionally, TRMO has been shown to be involved in the pathogenesis of certain neurological disorders, such as multiple sclerosis. **Conclusion:** In conclusion, TRMO is a critical enzyme involved in the regulation of protein synthesis through the methylation of tRNA. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining proper protein synthesis and overall cellular function. Further research is needed to fully elucidate the role of TRMO in disease pathogenesis and to explore potential therapeutic strategies targeting this enzyme. **Recommendations for Future Research:** 1. Investigate the role of TRMO in specific disease models, such as cancer and autoimmune disorders. 2. Explore the mechanisms by which TRMO regulates protein synthesis and interacts with other proteins involved in translation initiation. 3. Develop therapeutic strategies targeting TRMO, such as small molecule inhibitors or RNA-based therapies. 4. Investigate the role of TRMO in neurological disorders, such as multiple sclerosis. By further elucidating the role of TRMO, researchers can gain a deeper understanding of the regulation of protein synthesis and the mechanisms underlying various diseases.

Genular Protein ID: 885422132

Symbol: TRMO_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BU70 Q5T113 Q86SK0 Q9NXJ7 Q9P0Q7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 2 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 Rhea 4 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 9153233

Title: Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation.

PubMed ID: 9153233

DOI: 10.1074/jbc.272.21.13779

PubMed ID: 25063302

Title: Discovery of the beta-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs.

PubMed ID: 25063302

DOI: 10.1093/nar/gku618

Sequence Information:

  • Length: 441
  • Mass: 48587
  • Checksum: 84E6CF8BD294EDD2
  • Sequence:
    • MRGLEESGPR PTATPCGCVK PALETGNLLT EPVGYLESCF SAKNGTPRQP SICSYSRACL 
RIRKRIFNNP EHSLMGLEQF SHVWILFVFH KNGHLSCKAK VQPPRLNGAK TGVFSTRSPH 
RPNAIGLTLA KLEKVEGGAI YLSGIDMIHG TPVLDIKPYI AEYDSPQNVM EPLADFNLQN 
NQHTPNTVSQ SDSKTDSCDQ RQLSGCDEPQ PHHSTKRKPK CPEDRTSEEN YLTHSDTARI 
QQAFPMHREI AVDFGLESRR DQSSSVAEEQ IGPYCPEKSF SEKGTDKKLE RVEGAAVLQG 
SRAETQPMAP HCPAGRADGA PRSVVPAWVT EAPVATLEVR FTPHAEMDLG QLSSQDVGQA 
SFKYFQSAEE AKRAIEAVLS ADPRSVYRRK LCQDRLFYFT VDIAHVTCWF GDGFAEVLRI 
KPASEPVHMT GPVGSLVSLG S

Genular Protein ID: 2266669508

Symbol: Q5T114_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5T114

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 2 RefSeq 3 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 295
  • Mass: 32644
  • Checksum: AF6A50D3B8D946BC
  • Sequence:
    • MIHGTPVLDI KPYIAEYDSP QNVMEPLADF NLQNNQHTPN TVSQSDSKTD SCDQRQLSGC 
DEPQPHHSTK RKPKCPEDRT SEENYLTHSD TARIQQAFPM HREIAVDFGL ESRRDQSSSV 
AEEQIGPYCP EKSFSEKGTD KKLERVEGAA VLQGSRAETQ PMAPHCPAGR ADGAPRSVVP 
AWVTEAPVAT LEVRFTPHAE MDLGQLSSQD VGQASFKYFQ SAEEAKRAIE AVLSADPRSV 
YRRKLCQDRL FYFTVDIAHV TCWFGDGFAE VLRIKPASEP VHMTGPVGSL VSLGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.