Details for: MTFP1

Gene ID: 51537

Symbol: MTFP1

Ensembl ID: ENSG00000242114

Description: mitochondrial fission process 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 61.5255
    Cell Significance Index: -9.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.5150
    Cell Significance Index: -10.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6216
    Cell Significance Index: -10.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1137
    Cell Significance Index: -11.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7724
    Cell Significance Index: -10.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2582
    Cell Significance Index: 75.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0962
    Cell Significance Index: 23.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0930
    Cell Significance Index: 32.1000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.0362
    Cell Significance Index: 10.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7514
    Cell Significance Index: 87.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6366
    Cell Significance Index: 69.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4637
    Cell Significance Index: 4.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4248
    Cell Significance Index: 80.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2927
    Cell Significance Index: 20.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2796
    Cell Significance Index: 32.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2657
    Cell Significance Index: 7.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2481
    Cell Significance Index: 30.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2400
    Cell Significance Index: 39.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2218
    Cell Significance Index: 39.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2029
    Cell Significance Index: 20.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1937
    Cell Significance Index: 2.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1747
    Cell Significance Index: 157.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1377
    Cell Significance Index: 6.2400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1341
    Cell Significance Index: 1.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1290
    Cell Significance Index: 8.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1174
    Cell Significance Index: 2.9400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1023
    Cell Significance Index: 1.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0844
    Cell Significance Index: 1.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0617
    Cell Significance Index: 38.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0592
    Cell Significance Index: 4.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0451
    Cell Significance Index: 24.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0360
    Cell Significance Index: 0.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0335
    Cell Significance Index: 14.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0303
    Cell Significance Index: 0.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0273
    Cell Significance Index: 18.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0232
    Cell Significance Index: 1.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0177
    Cell Significance Index: 5.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0146
    Cell Significance Index: 1.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0146
    Cell Significance Index: 0.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0067
    Cell Significance Index: 1.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0064
    Cell Significance Index: 4.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0017
    Cell Significance Index: 1.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0013
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0045
    Cell Significance Index: -0.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0050
    Cell Significance Index: -9.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0058
    Cell Significance Index: -2.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0069
    Cell Significance Index: -12.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0083
    Cell Significance Index: -12.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0090
    Cell Significance Index: -5.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0104
    Cell Significance Index: -14.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0117
    Cell Significance Index: -0.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0123
    Cell Significance Index: -2.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0140
    Cell Significance Index: -10.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0163
    Cell Significance Index: -0.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0180
    Cell Significance Index: -1.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0197
    Cell Significance Index: -12.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0199
    Cell Significance Index: -0.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0216
    Cell Significance Index: -2.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0274
    Cell Significance Index: -12.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0277
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0288
    Cell Significance Index: -6.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0304
    Cell Significance Index: -4.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0327
    Cell Significance Index: -3.7300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0368
    Cell Significance Index: -0.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0447
    Cell Significance Index: -2.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0456
    Cell Significance Index: -1.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0491
    Cell Significance Index: -9.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0507
    Cell Significance Index: -2.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0538
    Cell Significance Index: -4.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0575
    Cell Significance Index: -4.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0625
    Cell Significance Index: -3.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0741
    Cell Significance Index: -1.2400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0806
    Cell Significance Index: -0.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0824
    Cell Significance Index: -3.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0845
    Cell Significance Index: -12.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0888
    Cell Significance Index: -2.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0955
    Cell Significance Index: -2.6700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1038
    Cell Significance Index: -1.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1057
    Cell Significance Index: -11.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1142
    Cell Significance Index: -3.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1150
    Cell Significance Index: -1.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1187
    Cell Significance Index: -7.2800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1264
    Cell Significance Index: -0.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1362
    Cell Significance Index: -3.5000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1377
    Cell Significance Index: -1.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1611
    Cell Significance Index: -12.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1637
    Cell Significance Index: -10.0600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1754
    Cell Significance Index: -1.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1757
    Cell Significance Index: -11.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1780
    Cell Significance Index: -11.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1786
    Cell Significance Index: -4.8600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1851
    Cell Significance Index: -3.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2085
    Cell Significance Index: -4.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2091
    Cell Significance Index: -3.0000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2153
    Cell Significance Index: -4.3800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.2200
    Cell Significance Index: -1.0700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2326
    Cell Significance Index: -3.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2481
    Cell Significance Index: -8.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2498
    Cell Significance Index: -11.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2509
    Cell Significance Index: -9.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MTFP1 is a protein localized to the mitochondrial outer membrane, where it is involved in the regulation of mitochondrial fission. The protein interacts with other mitochondrial proteins to facilitate the process of mitochondrial division. MTFP1 has been shown to be highly expressed in cells undergoing rapid proliferation and differentiation, such as hematopoietic cells. The protein's expression is also observed in various immune cell types, including T cells and stromal cells, suggesting its potential role in immune cell function and regulation. **Pathways and Functions:** MTFP1 is involved in the regulation of mitochondrial dynamics, a process critical for maintaining cellular homeostasis. Mitochondrial fission is the process by which mitochondria divide into two daughter mitochondria, a process that is essential for regulating cellular responses to stress. MTFP1 interacts with other mitochondrial proteins to facilitate the process of mitochondrial fission, including the protein Drp1 (dynamin-related protein 1), which is a key regulator of mitochondrial fission. The protein's interaction with Drp1 is essential for the regulation of mitochondrial dynamics and the maintenance of cellular homeostasis. **Clinical Significance:** The expression of MTFP1 in various immune cell types, including T cells and stromal cells, highlights its potential involvement in immune cell function and regulation. Dysregulation of mitochondrial dynamics, including mitochondrial fission, has been implicated in various diseases, including cancer and autoimmune disorders. Therefore, further studies are warranted to elucidate the role of MTFP1 in immune cell function and regulation, with a view to understanding its potential involvement in disease pathology. **Implications for Immune Cell Function:** The expression of MTFP1 in immune cells, such as T cells and stromal cells, suggests its potential role in immune cell function and regulation. MTFP1's interaction with other mitochondrial proteins, including Drp1, highlights its importance in the regulation of mitochondrial dynamics. Dysregulation of mitochondrial dynamics, including mitochondrial fission, has been implicated in various immune-related diseases, including autoimmune disorders and cancer. Therefore, further studies are warranted to elucidate the role of MTFP1 in immune cell function and regulation, with a view to understanding its potential involvement in disease pathology. **Implications for Disease:** The dysregulation of mitochondrial dynamics, including mitochondrial fission, has been implicated in various diseases, including cancer and autoimmune disorders. The expression of MTFP1 in immune cells, such as T cells and stromal cells, highlights its potential involvement in immune cell function and regulation. Therefore, further studies are warranted to elucidate the role of MTFP1 in disease pathology, with a view to developing new therapeutic strategies to regulate mitochondrial dynamics and prevent disease. **Future Directions:** Further studies are warranted to elucidate the role of MTFP1 in immune cell function and regulation, with a view to understanding its potential involvement in disease pathology. The expression of MTFP1 in various immune cell types, including T cells and stromal cells, highlights its potential role in immune cell function and regulation. The interaction of MTFP1 with other mitochondrial proteins, including Drp1, highlights its importance in the regulation of mitochondrial dynamics. The dysregulation of mitochondrial dynamics, including mitochondrial fission, has been implicated in various diseases, including cancer and autoimmune disorders. Therefore, further studies are warranted to elucidate the role of MTFP1 in disease pathology, with a view to developing new therapeutic strategies to regulate mitochondrial dynamics and prevent disease.

Genular Protein ID: 4258628839

Symbol: MTFP1_HUMAN

Name: Mitochondrial fission process protein 1

UniProtKB Accession Codes:

Q9UDX5 A6NFQ5 Q9H3K1 Q9P0N6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15155745

Title: Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis.

PubMed ID: 15155745

DOI: 10.1074/jbc.m404704200

PubMed ID: 15985469

Title: The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells.

PubMed ID: 15985469

DOI: 10.1242/jcs.02415

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 166
  • Mass: 18010
  • Checksum: 447D3BA5CC1ACA2D
  • Sequence:
    • MSEPQPRGAE RDLYRDTWVR YLGYANEVGE AFRSLVPAAV VWLSYGVASS YVLADAIDKG 
KKAGEVPSPE AGRSARVTVA VVDTFVWQAL ASVAIPGFTI NRVCAASLYV LGTATRWPLA 
VRKWTTTALG LLTIPIIIHP IDRSVDFLLD SSLRKLYPTV GKPSSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.