Details for: STYXL1

Gene ID: 51657

Symbol: STYXL1

Ensembl ID: ENSG00000127952

Description: serine/threonine/tyrosine interacting like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 128.3228
    Cell Significance Index: -19.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.5428
    Cell Significance Index: -18.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.5315
    Cell Significance Index: -19.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.4973
    Cell Significance Index: -21.8600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.6651
    Cell Significance Index: -22.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.2253
    Cell Significance Index: -19.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.8619
    Cell Significance Index: -20.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.3277
    Cell Significance Index: -19.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3674
    Cell Significance Index: -21.1800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.9075
    Cell Significance Index: 64.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1332
    Cell Significance Index: 1023.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0963
    Cell Significance Index: 127.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8955
    Cell Significance Index: 53.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8817
    Cell Significance Index: 174.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8477
    Cell Significance Index: 170.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7260
    Cell Significance Index: 118.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6185
    Cell Significance Index: 32.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4313
    Cell Significance Index: 29.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4216
    Cell Significance Index: 19.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3659
    Cell Significance Index: 28.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3618
    Cell Significance Index: 16.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3603
    Cell Significance Index: 196.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3312
    Cell Significance Index: 12.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3088
    Cell Significance Index: 110.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3039
    Cell Significance Index: 57.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2593
    Cell Significance Index: 30.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2331
    Cell Significance Index: 15.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2289
    Cell Significance Index: 3.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2207
    Cell Significance Index: 39.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2166
    Cell Significance Index: 6.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2064
    Cell Significance Index: 20.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1937
    Cell Significance Index: 5.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1870
    Cell Significance Index: 5.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1852
    Cell Significance Index: 22.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1813
    Cell Significance Index: 8.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1696
    Cell Significance Index: 4.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1618
    Cell Significance Index: 10.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1482
    Cell Significance Index: 4.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1265
    Cell Significance Index: 7.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1028
    Cell Significance Index: 45.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1002
    Cell Significance Index: 13.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0749
    Cell Significance Index: 12.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0739
    Cell Significance Index: 1.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0644
    Cell Significance Index: 3.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0494
    Cell Significance Index: 1.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0384
    Cell Significance Index: 72.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0353
    Cell Significance Index: 24.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0261
    Cell Significance Index: 48.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0201
    Cell Significance Index: 30.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0167
    Cell Significance Index: 2.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0130
    Cell Significance Index: 0.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0081
    Cell Significance Index: 10.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0018
    Cell Significance Index: 0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0017
    Cell Significance Index: 1.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0013
    Cell Significance Index: -0.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0071
    Cell Significance Index: -0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0118
    Cell Significance Index: -8.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0123
    Cell Significance Index: -9.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0205
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0223
    Cell Significance Index: -16.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0296
    Cell Significance Index: -16.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0301
    Cell Significance Index: -0.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0343
    Cell Significance Index: -4.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0365
    Cell Significance Index: -22.8100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0368
    Cell Significance Index: -0.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0398
    Cell Significance Index: -0.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0400
    Cell Significance Index: -0.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0581
    Cell Significance Index: -1.8600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0582
    Cell Significance Index: -1.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0691
    Cell Significance Index: -4.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0717
    Cell Significance Index: -8.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0759
    Cell Significance Index: -21.8500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0947
    Cell Significance Index: -0.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0954
    Cell Significance Index: -6.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0962
    Cell Significance Index: -5.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1077
    Cell Significance Index: -22.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1085
    Cell Significance Index: -1.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1209
    Cell Significance Index: -4.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1412
    Cell Significance Index: -3.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1525
    Cell Significance Index: -3.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1765
    Cell Significance Index: -18.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2074
    Cell Significance Index: -2.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2080
    Cell Significance Index: -1.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2169
    Cell Significance Index: -3.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2239
    Cell Significance Index: -17.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2285
    Cell Significance Index: -7.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2333
    Cell Significance Index: -5.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2451
    Cell Significance Index: -4.5300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2541
    Cell Significance Index: -2.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2832
    Cell Significance Index: -17.3600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2917
    Cell Significance Index: -4.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3003
    Cell Significance Index: -3.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3617
    Cell Significance Index: -9.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3661
    Cell Significance Index: -19.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3733
    Cell Significance Index: -11.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3937
    Cell Significance Index: -12.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3981
    Cell Significance Index: -7.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3986
    Cell Significance Index: -11.7400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4026
    Cell Significance Index: -2.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STYXL1 is a serine/threonine/tyrosine interacting like 1 gene, with an Ensembl ID of ENSG00000127952. Its expression is significantly observed in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, mucosal type mast cell, peripheral blood mononuclear cell, ileal goblet cell, ciliated cell of the bronchus, orthochromatic erythroblast, CD8-alpha-beta-positive, alpha-beta intraepithelial T cell, stromal cell of bone marrow, and epithelial cell of pancreas. These diverse expression patterns suggest a multifaceted role of STYXL1 in cellular processes. **Pathways and Functions:** STYXL1 is implicated in various cellular pathways, including intracellular signal transduction, mitochondrial matrix, mitochondrialion, negative regulation of stress granule assembly, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of neuron projection development, protein binding, protein dephosphorylation, protein phosphatase binding, protein phosphatase inhibitor activity, pseudophosphatase activity, and regulation of intrinsic apoptotic signaling pathway. These pathways underscore the significance of STYXL1 in maintaining cellular homeostasis, regulating cellular processes, and modulating responses to stress. The protein-binding capabilities of STYXL1 suggest its involvement in protein-protein interactions, which are crucial for various cellular processes. The dephosphorylation activity of STYXL1 points to its potential role in regulating protein phosphorylation, a critical mechanism for signal transduction and cellular response. Furthermore, the pseudophosphatase activity of STYXL1 implies its capacity to regulate protein phosphatase activity, which is essential for maintaining cellular homeostasis. **Clinical Significance:** The clinical significance of STYXL1 is multifaceted. Its expression in hematopoietic cells suggests a potential role in hematopoiesis, a process critical for the development of blood cells. The involvement of STYXL1 in stress granule assembly and apoptotic signaling pathways implies its potential role in regulating cellular responses to stress and promoting apoptosis in aberrant cells. Moreover, the expression of STYXL1 in epithelial cells of the pancreas and bronchus suggests its potential role in maintaining epithelial homeostasis and regulating cellular processes in these tissues. The involvement of STYXL1 in neuron projection development implies its potential role in neurological development and function. In conclusion, STYXL1 is a serine/threonine/tyrosine interacting like 1 gene with diverse expression patterns and involvement in various cellular processes. Its clinical significance is multifaceted, with potential implications for hematopoiesis, epithelial homeostasis, and neurological development. Further research is required to fully elucidate the functions of STYXL1 and its clinical significance. **Recommendations:** 1. Further studies are required to elucidate the precise mechanisms of STYXL1 in regulating cellular processes. 2. The clinical significance of STYXL1 should be further explored, particularly in the context of hematopoiesis, epithelial homeostasis, and neurological development. 3. The potential therapeutic applications of STYXL1 should be investigated, with a focus on its role in regulating cellular processes and promoting apoptosis in aberrant cells. By continuing to investigate the intricacies of STYXL1, researchers can gain a deeper understanding of the complex interplay between this gene and various cellular processes, ultimately shedding light on its clinical significance and potential therapeutic applications.

Genular Protein ID: 45696087

Symbol: STYL1_HUMAN

Name: Serine/threonine/tyrosine-interacting-like protein 1

UniProtKB Accession Codes:

Q9Y6J8 Q9UBP1 Q9UK06 Q9UK07 Q9UKG2 Q9UKG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 5 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 RefSeq 7 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9757831

Title: Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains.

PubMed ID: 9757831

DOI: 10.1016/s0968-0004(98)01241-9

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20180778

Title: The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation.

PubMed ID: 20180778

DOI: 10.1042/bj20091383

PubMed ID: 21262771

Title: MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis.

PubMed ID: 21262771

DOI: 10.1128/mcb.00788-10

PubMed ID: 23163895

Title: The pseudophosphatase MK-STYX inhibits stress granule assembly independently of Ser149 phosphorylation of G3BP-1.

PubMed ID: 23163895

DOI: 10.1111/febs.12068

PubMed ID: 24709986

Title: The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1.

PubMed ID: 24709986

DOI: 10.1371/journal.pone.0093896

PubMed ID: 29250526

Title: MK-STYX Alters the Morphology of Primary Neurons, and Outgrowths in MK-STYX Overexpressing PC-12 Cells Develop a Neuronal Phenotype.

PubMed ID: 29250526

DOI: 10.3389/fmolb.2017.00076

Sequence Information:

  • Length: 313
  • Mass: 35818
  • Checksum: 5EDB25AB4EB60419
  • Sequence:
    • MPGLLLCEPT ELYNILNQAT KLSRLTDPNY LCLLDVRSKW EYDESHVITA LRVKKKNNEY 
LLPESVDLEC VKYCVVYDNN SSTLEILLKD DDDDSDSDGD GKDLVPQAAI EYGRILTRLT 
HHPVYILKGG YERFSGTYHF LRTQKIIWMP QELDAFQPYP IEIVPGKVFV GNFSQACDPK 
IQKDLKIKAH VNVSMDTGPF FAGDADKLLH IRIEDSPEAQ ILPFLRHMCH FIEIHHHLGS 
VILIFSTQGI SRSCAAIIAY LMHSNEQTLQ RSWAYVKKCK NNMCPNRGLV SQLLEWEKTI 
LGDSITNIMD PLY

Genular Protein ID: 3964701354

Symbol: Q7Z3H6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z3H6

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 3 SMART 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 217
  • Mass: 24676
  • Checksum: 50FD7964AFC0E7CD
  • Sequence:
    • MPGLLLCEPT ELYNILNQAT KLSRLTDPNS LCLLDVRSKW EYDESHVITA LRVKKELDAF 
QPYPIEIVPG KVFVGNFSQA CDPKIQKDLK IKAHVNVSMD TGPFFAGDAD KLLHIRIEDS 
PEAQILPFLR HMCHFIEIHH HLGSVILIFS TQGISRSCAA IIAYLMHSNE QTLQRSWAYV 
KKCKNNMCPN RGLVSQLLEW EKTILGDSIT NIMDPLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.