Details for: ASB4

Gene ID: 51666

Symbol: ASB4

Ensembl ID: ENSG00000005981

Description: ankyrin repeat and SOCS box containing 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.8549
    Cell Significance Index: 183.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.0723
    Cell Significance Index: 596.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.5946
    Cell Significance Index: 97.7700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3954
    Cell Significance Index: 33.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4804
    Cell Significance Index: 91.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2918
    Cell Significance Index: 28.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2516
    Cell Significance Index: 227.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2482
    Cell Significance Index: 6.3800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.2407
    Cell Significance Index: 3.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1796
    Cell Significance Index: 19.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1652
    Cell Significance Index: 9.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1577
    Cell Significance Index: 25.6500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.1345
    Cell Significance Index: 2.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1246
    Cell Significance Index: 3.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0938
    Cell Significance Index: 6.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0849
    Cell Significance Index: 1.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0813
    Cell Significance Index: 16.1300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0758
    Cell Significance Index: 1.2800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0697
    Cell Significance Index: 1.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0618
    Cell Significance Index: 4.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0607
    Cell Significance Index: 1.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0576
    Cell Significance Index: 2.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0458
    Cell Significance Index: 0.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0437
    Cell Significance Index: 0.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0280
    Cell Significance Index: 0.5800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0087
    Cell Significance Index: 0.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0086
    Cell Significance Index: 0.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0051
    Cell Significance Index: 0.1800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0041
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0004
    Cell Significance Index: 0.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0008
    Cell Significance Index: -0.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0009
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0011
    Cell Significance Index: -0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0016
    Cell Significance Index: -0.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0034
    Cell Significance Index: -2.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0045
    Cell Significance Index: -2.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0051
    Cell Significance Index: -1.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0056
    Cell Significance Index: -2.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0056
    Cell Significance Index: -0.0800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0062
    Cell Significance Index: -0.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0064
    Cell Significance Index: -0.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0073
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0073
    Cell Significance Index: -1.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0079
    Cell Significance Index: -1.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0097
    Cell Significance Index: -0.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0121
    Cell Significance Index: -0.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0137
    Cell Significance Index: -0.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0143
    Cell Significance Index: -1.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0153
    Cell Significance Index: -2.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0163
    Cell Significance Index: -1.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0168
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0173
    Cell Significance Index: -1.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0184
    Cell Significance Index: -2.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0207
    Cell Significance Index: -2.6800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0223
    Cell Significance Index: -0.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0224
    Cell Significance Index: -0.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0251
    Cell Significance Index: -1.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0269
    Cell Significance Index: -2.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0333
    Cell Significance Index: -1.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0354
    Cell Significance Index: -0.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0355
    Cell Significance Index: -2.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0397
    Cell Significance Index: -2.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0402
    Cell Significance Index: -1.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0433
    Cell Significance Index: -1.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0441
    Cell Significance Index: -0.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0444
    Cell Significance Index: -2.4900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0445
    Cell Significance Index: -0.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0465
    Cell Significance Index: -2.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0473
    Cell Significance Index: -2.9100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0487
    Cell Significance Index: -0.7100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0540
    Cell Significance Index: -0.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0547
    Cell Significance Index: -2.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0579
    Cell Significance Index: -2.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0592
    Cell Significance Index: -3.1100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0634
    Cell Significance Index: -1.2900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0643
    Cell Significance Index: -1.0200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0651
    Cell Significance Index: -0.9000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0676
    Cell Significance Index: -1.2500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0682
    Cell Significance Index: -0.7800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0723
    Cell Significance Index: -0.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0742
    Cell Significance Index: -2.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0766
    Cell Significance Index: -2.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0774
    Cell Significance Index: -2.8400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0786
    Cell Significance Index: -1.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0833
    Cell Significance Index: -0.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0876
    Cell Significance Index: -1.7100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0909
    Cell Significance Index: -1.7900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0919
    Cell Significance Index: -1.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0921
    Cell Significance Index: -2.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0952
    Cell Significance Index: -2.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0954
    Cell Significance Index: -2.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0964
    Cell Significance Index: -2.7500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0964
    Cell Significance Index: -1.3000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1013
    Cell Significance Index: -1.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ASB4, encoded by the ENSG00000005981 gene, exhibits the following key characteristics: 1. **Ankyrin repeats**: ASB4 contains multiple ankyrin repeat domains, which are involved in protein-protein interactions and are essential for the protein's stability and function. 2. **SOCS box domain**: The SOCS box domain is a regulatory motif that is involved in the protein's interaction with other molecules and its ability to modulate protein activity. 3. **Ubiquitination and proteasome degradation**: ASB4 is involved in the regulation of protein degradation through ubiquitination and proteasome degradation, which is critical for the adaptive immune response. 4. **Expression in various tissues**: ASB4 is expressed in a range of tissues, including the adrenal gland, nervous system, and immune cells, suggesting its involvement in multiple biological processes. **Pathways and Functions:** ASB4 is involved in several biological pathways, including: 1. **Adaptive immune system**: ASB4 plays a crucial role in regulating the adaptive immune response through the modulation of protein degradation and ubiquitination. 2. **Antigen processing: ubiquitination & proteasome degradation**: ASB4 is involved in the regulation of antigen processing and presentation through the ubiquitination and proteasome degradation of proteins. 3. **Class I MHC mediated antigen processing & presentation**: ASB4 is also involved in the regulation of class I MHC-mediated antigen processing and presentation. 4. **Cytosol**: ASB4 is involved in the regulation of protein activity in the cytosol through its interaction with other molecules. 5. **Intracellular signal transduction**: ASB4 is involved in the regulation of intracellular signal transduction pathways, which are critical for the immune response. **Clinical Significance:** ASB4 has been identified in various disease contexts, including: 1. **Autoimmune diseases**: ASB4 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, through its role in regulating protein degradation and ubiquitination. 2. **Cancer**: ASB4 has been identified as a tumor suppressor gene in certain types of cancer, including breast cancer and lung cancer. 3. **Neurological disorders**: ASB4 has been implicated in the pathogenesis of neurological disorders, such as Parkinson's disease and Alzheimer's disease, through its role in regulating protein degradation and ubiquitination. In conclusion, ASB4 is a multifunctional protein that plays a critical role in regulating protein modification, particularly in the context of ubiquitination and proteasome degradation, which is essential for the adaptive immune response. Its involvement in various disease contexts highlights its clinical significance and underscores the need for further research into its role in human disease.

Genular Protein ID: 189493817

Symbol: ASB4_HUMAN

Name: Ankyrin repeat and SOCS box protein 4

UniProtKB Accession Codes:

Q9Y574 A4D1H6 O14586 Q14D68 Q8TBT2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11111040

Title: Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.

PubMed ID: 11111040

DOI: 10.1016/s0378-1119(00)00402-9

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 426
  • Mass: 48195
  • Checksum: 4027F109A6C264A5
  • Sequence:
    • MDGTTAPVTK SGAAKLVKRN FLEALKSNDF GKLKAILIQR QIDVDTVFEV EDENMVLASY 
KQGYWLPSYK LKSSWATGLH LSVLFGHVEC LLVLLDHNAT INCRPNGKTP LHVACEMANV 
DCVKILCDRG AKLNCYSLSG HTALHFCTTP SSILCAKQLV WRGANVNMKT NNQDEETPLH 
TAAHFGLSEL VAFYVEHGAI VDSVNAHMET PLAIAAYWAL RFKEQEYSTE HHLVCRMLLD 
YKAEVNARDD DFKSPLHKAA WNCDHVLMHM MLEAGAEANL MDINGCAAIQ YVLKVTSVRP 
AAQPEICYQL LLNHGAARIY PPQFHKVIQA CHSCPKAIEV VVNAYEHIRW NTKWRRAIPD 
DDLEKYWDFY HSLFTVCCNS PRTLMHLSRC AIRRTLHNRC HRAIPLLSLP LSLKKYLLLE 
PEGIIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.