Details for: ASB2

Gene ID: 51676

Symbol: ASB2

Ensembl ID: ENSG00000100628

Description: ankyrin repeat and SOCS box containing 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 37.9954
    Cell Significance Index: -5.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.2216
    Cell Significance Index: -5.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 13.9321
    Cell Significance Index: -5.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 11.5436
    Cell Significance Index: -5.4500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 8.2263
    Cell Significance Index: -5.5200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 6.8422
    Cell Significance Index: 110.4000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 6.4793
    Cell Significance Index: 158.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.9702
    Cell Significance Index: -5.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.7934
    Cell Significance Index: -5.9100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.9285
    Cell Significance Index: 15.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.9452
    Cell Significance Index: 50.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6818
    Cell Significance Index: 36.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5716
    Cell Significance Index: 120.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5382
    Cell Significance Index: 69.7200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.4075
    Cell Significance Index: 20.7800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.2500
    Cell Significance Index: 19.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1094
    Cell Significance Index: 211.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9599
    Cell Significance Index: 94.9600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.8839
    Cell Significance Index: 10.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7287
    Cell Significance Index: 657.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.7228
    Cell Significance Index: -2.2200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.6125
    Cell Significance Index: 9.2300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6107
    Cell Significance Index: 5.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4832
    Cell Significance Index: 14.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4529
    Cell Significance Index: 73.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3951
    Cell Significance Index: 42.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3937
    Cell Significance Index: 10.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3692
    Cell Significance Index: 43.5400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.3649
    Cell Significance Index: 3.8100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.3083
    Cell Significance Index: 3.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2760
    Cell Significance Index: 1.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2101
    Cell Significance Index: 4.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1916
    Cell Significance Index: 13.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1894
    Cell Significance Index: 38.0000
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.1230
    Cell Significance Index: 0.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1052
    Cell Significance Index: 57.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0876
    Cell Significance Index: 5.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0557
    Cell Significance Index: 0.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0469
    Cell Significance Index: 21.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0198
    Cell Significance Index: 37.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0195
    Cell Significance Index: 1.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0013
    Cell Significance Index: 0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0040
    Cell Significance Index: -6.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0046
    Cell Significance Index: -6.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0062
    Cell Significance Index: -0.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0063
    Cell Significance Index: -0.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0064
    Cell Significance Index: -4.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0077
    Cell Significance Index: -2.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0085
    Cell Significance Index: -5.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0093
    Cell Significance Index: -6.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0104
    Cell Significance Index: -0.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0109
    Cell Significance Index: -6.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0111
    Cell Significance Index: -6.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0165
    Cell Significance Index: -0.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0184
    Cell Significance Index: -5.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0206
    Cell Significance Index: -3.7100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0234
    Cell Significance Index: -0.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0244
    Cell Significance Index: -0.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0251
    Cell Significance Index: -0.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0253
    Cell Significance Index: -5.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0282
    Cell Significance Index: -1.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0308
    Cell Significance Index: -0.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0323
    Cell Significance Index: -4.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0331
    Cell Significance Index: -6.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0336
    Cell Significance Index: -3.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0365
    Cell Significance Index: -6.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0366
    Cell Significance Index: -4.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0386
    Cell Significance Index: -4.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0398
    Cell Significance Index: -5.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0463
    Cell Significance Index: -5.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0463
    Cell Significance Index: -0.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0489
    Cell Significance Index: -2.4700
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0496
    Cell Significance Index: -0.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0513
    Cell Significance Index: -5.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0651
    Cell Significance Index: -3.4200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0667
    Cell Significance Index: -2.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0670
    Cell Significance Index: -1.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0766
    Cell Significance Index: -3.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0777
    Cell Significance Index: -3.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0791
    Cell Significance Index: -5.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0825
    Cell Significance Index: -3.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0831
    Cell Significance Index: -1.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0895
    Cell Significance Index: -6.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0922
    Cell Significance Index: -3.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0941
    Cell Significance Index: -1.3400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1012
    Cell Significance Index: -1.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1033
    Cell Significance Index: -5.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1065
    Cell Significance Index: -1.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1067
    Cell Significance Index: -2.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1067
    Cell Significance Index: -5.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1070
    Cell Significance Index: -2.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1187
    Cell Significance Index: -2.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1242
    Cell Significance Index: -4.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1250
    Cell Significance Index: -5.8300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1361
    Cell Significance Index: -3.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1460
    Cell Significance Index: -4.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1470
    Cell Significance Index: -6.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1575
    Cell Significance Index: -5.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ankyrin repeat domains**: These domains are involved in protein-protein interactions and play a crucial role in the regulation of signaling pathways. 2. **SOCS box**: This domain is a conserved motif found in various proteins, including ASB2, and is involved in the regulation of protein ubiquitination and proteasome-mediated degradation. 3. **Ubiquitination and proteasome-mediated degradation**: ASB2 is a ubiquitin ligase, which means it can tag proteins for degradation by the proteasome, thereby regulating protein levels and cellular signaling. 4. **Multiple expression patterns**: ASB2 is expressed in various cell types, including hematopoietic cells, smooth muscle fibers, and cardiac muscle cells, indicating its broad functional roles. **Pathways and Functions:** The ASB2 gene is involved in several key signaling pathways, including: 1. **Adaptive immune system**: ASB2 regulates immune responses by modulating the activity of immune cells, such as dendritic cells and T cells. 2. **Antigen processing and presentation**: ASB2 is involved in the regulation of antigen processing and presentation by Class I MHC molecules, which is essential for the activation of T cells. 3. **Cardiac muscle cell development and differentiation**: ASB2 plays a role in the regulation of cardiac muscle cell development and differentiation, which is critical for heart function. 4. **Signal transduction**: ASB2 is involved in the regulation of various signal transduction pathways, including those involved in cellular differentiation, growth, and survival. **Clinical Significance:** Dysregulation of ASB2 has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: Mutations in the ASB2 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cardiac disorders**: ASB2 dysfunction has been linked to cardiac disorders, including cardiac muscle cell differentiation and heart development abnormalities. 3. **Cancer**: ASB2 has been implicated in cancer development and progression, particularly in hematological malignancies. In conclusion, the ASB2 gene is a critical regulator of various cellular processes, including immune responses, cellular differentiation, and signal transduction. Its dysregulation has been implicated in various diseases, highlighting the importance of ASB2 in maintaining cellular homeostasis and overall health.

Genular Protein ID: 1264779687

Symbol: ASB2_HUMAN

Name: Ankyrin repeat and SOCS box protein 2

UniProtKB Accession Codes:

Q96Q27 B2RDP9 B4E166 Q9NSU5 Q9Y567

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 4 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11566180

Title: ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells.

PubMed ID: 11566180

DOI: 10.1016/s0014-5793(01)02829-0

PubMed ID: 11682484

Title: ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells.

PubMed ID: 11682484

DOI: 10.1074/jbc.m108476200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11111040

Title: Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.

PubMed ID: 11111040

DOI: 10.1016/s0378-1119(00)00402-9

PubMed ID: 16325183

Title: ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.

PubMed ID: 16325183

DOI: 10.1016/j.febslet.2005.11.016

PubMed ID: 15590664

Title: ASB2 is an elongin BC-interacting protein that can assemble with cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex.

PubMed ID: 15590664

DOI: 10.1074/jbc.m413040200

PubMed ID: 19300455

Title: The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation.

PubMed ID: 19300455

DOI: 10.1038/cdd.2009.27

PubMed ID: 21119685

Title: Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.

PubMed ID: 21119685

DOI: 10.1038/cr.2010.165

PubMed ID: 21737450

Title: Functional and structural insights into ASB2alpha, a novel regulator of integrin-dependent adhesion of hematopoietic cells.

PubMed ID: 21737450

DOI: 10.1074/jbc.m111.220921

PubMed ID: 22382022

Title: The ASB2beta Ubiquitin-interacting motif is involved in its monoubiquitination.

PubMed ID: 22382022

DOI: 10.1016/j.bbrc.2012.02.070

PubMed ID: 22916308

Title: Filamins but not Janus kinases are substrates of the ASB2alpha cullin-ring E3 ubiquitin ligase in hematopoietic cells.

PubMed ID: 22916308

DOI: 10.1371/journal.pone.0043798

PubMed ID: 24044920

Title: Phosphorylation of serine 323 of ASB2alpha is pivotal for the targeting of filamin A to degradation.

PubMed ID: 24044920

DOI: 10.1016/j.cellsig.2013.09.011

PubMed ID: 24052262

Title: ASB2alpha, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain.

PubMed ID: 24052262

DOI: 10.1074/jbc.m113.496604

PubMed ID: 29955039

Title: High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2.

PubMed ID: 29955039

DOI: 10.1038/s41419-018-0769-5

PubMed ID: 32179481

Title: Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle.

PubMed ID: 32179481

DOI: 10.1016/j.isci.2020.100959

Sequence Information:

  • Length: 635
  • Mass: 70212
  • Checksum: B91E4EB394531076
  • Sequence:
    • MATQISTRGS QCTIGQEEYS LYSSLSEDEL VQMAIEQSLA DKTRGPTTAE ATASACTNRQ 
PAHFYPWTRS TAPPESSPAR APMGLFQGVM QKYSSSLFKT SQLAPADPLI KAIKDGDEEA 
LKTMIKEGKN LAEPNKEGWL PLHEAAYYGQ VGCLKVLQRA YPGTIDQRTL QEETAVYLAT 
CRGHLDCLLS LLQAGAEPDI SNKSRETPLY KACERKNAEA VKILVQHNAD TNHRCNRGWT 
ALHESVSRND LEVMQILVSG GAKVESKNAY GITPLFVAAQ SGQLEALRFL AKYGADINTQ 
ASDNASALYE ACKNEHEEVV EFLLSQGADA NKTNKDGLLP LHIASKKGNY RIVQMLLPVT 
SRTRIRRSGV SPLHLAAERN HDEVLEALLS ARFDVNTPLA PERARLYEDR RSSALYFAVV 
NNNVYATELL LQHGADPNRD VISPLLVAIR HGCLRTMQLL LDHGANIDAY IATHPTAFPA 
TIMFAMKCLS LLKFLMDLGC DGEPCFSCLY GNGPHPPAPQ PSSRFNDAPA ADKEPSVVQF 
CEFVSAPEVS RWAGPIIDVL LDYVGNVQLC SRLKEHIDSF EDWAVIKEKA EPPRPLAHLC 
RLRVRKAIGK YRIKLLDTLP LPGRLIRYLK YENTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.