Details for: PALS2

Gene ID: 51678

Symbol: PALS2

Ensembl ID: ENSG00000105926

Description: protein associated with LIN7 2, MAGUK p55 family member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 177.3761
    Cell Significance Index: -27.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 99.2338
    Cell Significance Index: -25.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.9960
    Cell Significance Index: -21.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.7827
    Cell Significance Index: -28.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.5610
    Cell Significance Index: -21.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2009
    Cell Significance Index: -28.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.5314
    Cell Significance Index: 75.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.2616
    Cell Significance Index: 144.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.1811
    Cell Significance Index: 120.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.6310
    Cell Significance Index: 75.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.2947
    Cell Significance Index: 34.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.0690
    Cell Significance Index: 139.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7671
    Cell Significance Index: 354.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.5270
    Cell Significance Index: 39.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5203
    Cell Significance Index: 545.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3074
    Cell Significance Index: 259.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2078
    Cell Significance Index: 196.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0574
    Cell Significance Index: 954.7400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.9832
    Cell Significance Index: 12.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9279
    Cell Significance Index: 641.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8973
    Cell Significance Index: 50.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7361
    Cell Significance Index: 19.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7271
    Cell Significance Index: 20.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6632
    Cell Significance Index: 72.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6457
    Cell Significance Index: 13.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6138
    Cell Significance Index: 13.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5423
    Cell Significance Index: 32.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5027
    Cell Significance Index: 49.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4933
    Cell Significance Index: 8.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4153
    Cell Significance Index: 765.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3912
    Cell Significance Index: 602.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3540
    Cell Significance Index: 6.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3182
    Cell Significance Index: 22.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2860
    Cell Significance Index: 7.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2812
    Cell Significance Index: 7.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2662
    Cell Significance Index: 7.6700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.2403
    Cell Significance Index: 3.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2367
    Cell Significance Index: 30.3400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1792
    Cell Significance Index: 2.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1562
    Cell Significance Index: 26.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1248
    Cell Significance Index: 56.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1224
    Cell Significance Index: 23.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1160
    Cell Significance Index: 63.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0980
    Cell Significance Index: 4.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0828
    Cell Significance Index: 11.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0619
    Cell Significance Index: 84.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0609
    Cell Significance Index: 2.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0588
    Cell Significance Index: 110.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0541
    Cell Significance Index: 6.3800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0534
    Cell Significance Index: 0.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0451
    Cell Significance Index: 2.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0337
    Cell Significance Index: 21.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0174
    Cell Significance Index: 0.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0170
    Cell Significance Index: 7.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0075
    Cell Significance Index: 0.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0172
    Cell Significance Index: -12.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0249
    Cell Significance Index: -4.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0311
    Cell Significance Index: -23.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0351
    Cell Significance Index: -26.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0369
    Cell Significance Index: -20.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0496
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0516
    Cell Significance Index: -32.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0554
    Cell Significance Index: -6.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0669
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0769
    Cell Significance Index: -8.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0788
    Cell Significance Index: -22.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0888
    Cell Significance Index: -12.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1090
    Cell Significance Index: -3.5700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1299
    Cell Significance Index: -3.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1300
    Cell Significance Index: -9.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1393
    Cell Significance Index: -29.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1477
    Cell Significance Index: -3.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1569
    Cell Significance Index: -4.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1590
    Cell Significance Index: -2.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1666
    Cell Significance Index: -17.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1890
    Cell Significance Index: -6.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2042
    Cell Significance Index: -4.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2170
    Cell Significance Index: -15.3500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2292
    Cell Significance Index: -1.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2389
    Cell Significance Index: -5.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2510
    Cell Significance Index: -26.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2587
    Cell Significance Index: -3.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2649
    Cell Significance Index: -19.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2663
    Cell Significance Index: -7.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2669
    Cell Significance Index: -21.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3089
    Cell Significance Index: -19.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3175
    Cell Significance Index: -10.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3357
    Cell Significance Index: -21.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3448
    Cell Significance Index: -7.4500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3476
    Cell Significance Index: -5.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3583
    Cell Significance Index: -18.8100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3668
    Cell Significance Index: -3.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3701
    Cell Significance Index: -12.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4064
    Cell Significance Index: -21.1700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4147
    Cell Significance Index: -7.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4153
    Cell Significance Index: -18.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4309
    Cell Significance Index: -26.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4312
    Cell Significance Index: -12.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4633
    Cell Significance Index: -16.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4649
    Cell Significance Index: -24.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PALS2 is a member of the MAGUK p55 family, which is known for its involvement in cell-cell junction formation and signaling. The protein contains a characteristic p55 subfamily motif, which suggests its potential role in regulating protein-protein interactions. PALS2 is significantly expressed in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, and mucosal type mast cells. This widespread expression pattern highlights the diverse roles of PALS2 in different tissues and cell types. **Pathways and Functions:** PALS2 is implicated in several cellular pathways, including: 1. **Cell-cell junction formation**: PALS2 is involved in the assembly of cell-cell junctions, which are essential for maintaining tissue structure and function. 2. **Extracellular exosome formation**: PALS2 is also involved in the formation of extracellular exosomes, which play a crucial role in cell-to-cell communication and the regulation of various physiological processes. 3. **Protein binding**: PALS2 interacts with various proteins, including the LIN7 and MAGUK p55 families, to regulate protein-protein interactions and signaling. 4. **Membrane assembly**: PALS2 is involved in the assembly of membrane structures, which are essential for maintaining cellular homeostasis and regulating various physiological processes. **Clinical Significance:** The clinical significance of PALS2 is an area of active research, and its implications are far-reaching. Dysregulation of PALS2 has been implicated in various diseases, including: 1. **Cancer**: PALS2 expression is altered in various types of cancer, including leukemia and lymphoma, suggesting its potential role in cancer development and progression. 2. **Neurological disorders**: PALS2 is involved in the regulation of neuronal function, and its dysregulation has been implicated in neurological disorders, including Parkinson's disease and Alzheimer's disease. 3. **Inflammatory diseases**: PALS2 is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in inflammatory diseases, including asthma and autoimmune disorders. In conclusion, PALS2 is a multifunctional protein that plays a crucial role in maintaining cellular homeostasis and regulating various physiological processes. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its clinical significance. As our understanding of PALS2 continues to evolve, it is likely that its role in human disease will become increasingly clear.

Genular Protein ID: 1097110351

Symbol: PALS2_HUMAN

Name: MAGUK p55 subfamily member 6

UniProtKB Accession Codes:

Q9NZW5 A4D157 Q9H0E1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 9 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11311936

Title: VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain.

PubMed ID: 11311936

DOI: 10.1016/s0167-4781(01)00191-9

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 540
  • Mass: 61117
  • Checksum: 86310E4F6AF632BD
  • Sequence:
    • MQQVLENLTE LPSSTGAEEI DLIFLKGIME NPIVKSLAKA HERLEDSKLE AVSDNNLELV 
NEILEDITPL INVDENVAEL VGILKEPHFQ SLLEAHDIVA SKCYDSPPSS PEMNNSSINN 
QLLPVDAIRI LGIHKRAGEP LGVTFRVENN DLVIARILHG GMIDRQGLLH VGDIIKEVNG 
HEVGNNPKEL QELLKNISGS VTLKILPSYR DTITPQQVFV KCHFDYNPYN DNLIPCKEAG 
LKFSKGEILQ IVNREDPNWW QASHVKEGGS AGLIPSQFLE EKRKAFVRRD WDNSGPFCGT 
ISSKKKKKMM YLTTRNAEFD RHEIQIYEEV AKMPPFQRKT LVLIGAQGVG RRSLKNRFIV 
LNPTRFGTTV PFTSRKPRED EKDGQAYKFV SRSEMEADIK AGKYLEHGEY EGNLYGTKID 
SILEVVQTGR TCILDVNPQA LKVLRTSEFM PYVVFIAAPE LETLRAMHKA VVDAGITTKL 
LTDSDLKKTV DESARIQRAY NHYFDLIIIN DNLDKAFEKL QTAIEKLRME PQWVPISWVY

Genular Protein ID: 1436952838

Symbol: B8ZZG1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B8ZZG1

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 10 NCBI Taxonomy 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 3 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 428
  • Mass: 48758
  • Checksum: 66B10865BACE56A6
  • Sequence:
    • MNNSSINNQL LPVDAIRILG IHKRAGEPLG VTFRVENNDL VIARILHGGM IDRQGLLHVG 
DIIKEVNGHE VGNNPKELQE LLKNISGSVT LKILPSYRDT ITPQQVFVKC HFDYNPYNDN 
LIPCKEAGLK FSKGEILQIV NREDPNWWQA SHVKEGGSAG LIPSQFLEEK RKAFVRRDWD 
NSGPFCGTIS SKKKKKMMYL TTRNAEFDRH EIQIYEEVAK MPPFQRKTLV LIGAQGVGRR 
SLKNRFIVLN PTRFGTTVPF TSRKPREDEK DGQAYKFVSR SEMEADIKAG KYLEHGEYEG 
NLYGTKIDSI LEVVQTGRTC ILDVNPQALK VLRTSEFMPY VVFIAAPELE TLRAMHKAVV 
DAGITTKLLT DSDLKKTVDE SARIQRAYNH YFDLIIINDN LDKAFEKLQT AIEKLRMEPQ 
WVPISWVY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.