Details for: OAZ3

Gene ID: 51686

Symbol: OAZ3

Ensembl ID: ENSG00000143450

Description: ornithine decarboxylase antizyme 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 20.5085
    Cell Significance Index: -3.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.9315
    Cell Significance Index: -3.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.6643
    Cell Significance Index: -3.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9944
    Cell Significance Index: 189.2500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.6532
    Cell Significance Index: 6.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5018
    Cell Significance Index: 49.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4879
    Cell Significance Index: 22.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3708
    Cell Significance Index: 334.7800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3492
    Cell Significance Index: 5.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3488
    Cell Significance Index: 20.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3217
    Cell Significance Index: 16.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3204
    Cell Significance Index: 34.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2745
    Cell Significance Index: 12.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2603
    Cell Significance Index: 42.3400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2244
    Cell Significance Index: 2.3200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1934
    Cell Significance Index: 1.1900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1660
    Cell Significance Index: 2.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1658
    Cell Significance Index: 2.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1657
    Cell Significance Index: 11.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1572
    Cell Significance Index: 9.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1406
    Cell Significance Index: 10.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1092
    Cell Significance Index: 1.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1007
    Cell Significance Index: 3.5400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0856
    Cell Significance Index: 0.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0840
    Cell Significance Index: 1.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0830
    Cell Significance Index: 9.6700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0581
    Cell Significance Index: 1.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0514
    Cell Significance Index: 1.4000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0476
    Cell Significance Index: 0.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0447
    Cell Significance Index: 0.6700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0407
    Cell Significance Index: 0.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0318
    Cell Significance Index: 5.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0315
    Cell Significance Index: 0.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0302
    Cell Significance Index: 1.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0257
    Cell Significance Index: 14.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0244
    Cell Significance Index: 0.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0229
    Cell Significance Index: 0.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0209
    Cell Significance Index: 0.6700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0154
    Cell Significance Index: 0.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0149
    Cell Significance Index: 1.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0126
    Cell Significance Index: 1.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0123
    Cell Significance Index: 1.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0118
    Cell Significance Index: 2.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0085
    Cell Significance Index: 3.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0082
    Cell Significance Index: 6.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0070
    Cell Significance Index: 0.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0039
    Cell Significance Index: 0.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0005
    Cell Significance Index: 0.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0001
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0037
    Cell Significance Index: -2.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0043
    Cell Significance Index: -0.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0044
    Cell Significance Index: -2.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0049
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0066
    Cell Significance Index: -4.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0072
    Cell Significance Index: -3.2500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0075
    Cell Significance Index: -0.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0098
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0120
    Cell Significance Index: -1.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0153
    Cell Significance Index: -2.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0158
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0173
    Cell Significance Index: -3.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0184
    Cell Significance Index: -2.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0192
    Cell Significance Index: -0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0193
    Cell Significance Index: -2.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0290
    Cell Significance Index: -0.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0296
    Cell Significance Index: -0.7900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0379
    Cell Significance Index: -0.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0381
    Cell Significance Index: -3.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0430
    Cell Significance Index: -2.8900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0441
    Cell Significance Index: -0.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0442
    Cell Significance Index: -3.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0468
    Cell Significance Index: -2.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0477
    Cell Significance Index: -2.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0488
    Cell Significance Index: -3.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0506
    Cell Significance Index: -3.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0511
    Cell Significance Index: -2.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0524
    Cell Significance Index: -0.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0526
    Cell Significance Index: -2.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0557
    Cell Significance Index: -1.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0565
    Cell Significance Index: -0.5200
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.0567
    Cell Significance Index: -0.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0609
    Cell Significance Index: -1.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0619
    Cell Significance Index: -2.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0655
    Cell Significance Index: -2.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0670
    Cell Significance Index: -2.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0676
    Cell Significance Index: -0.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0680
    Cell Significance Index: -1.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0697
    Cell Significance Index: -1.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0729
    Cell Significance Index: -2.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0748
    Cell Significance Index: -2.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0760
    Cell Significance Index: -2.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0809
    Cell Significance Index: -2.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0826
    Cell Significance Index: -2.8700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0839
    Cell Significance Index: -1.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OAZ3 is a protein-coding gene that belongs to the ODC antizyme family. Its primary function is to inhibit ODC, an enzyme responsible for catalyzing the decarboxylation of ornithine to form putrescine, a key polyamine precursor. This inhibition is essential for regulating polyamine biosynthesis, which plays a critical role in various cellular processes, including cell growth, differentiation, and survival. **Pathways and Functions:** The OAZ3 gene is involved in several pathways, including: 1. **Polyamine biosynthetic process**: OAZ3 inhibits ODC, thereby regulating the levels of polyamines, such as putrescine, spermidine, and spermine. 2. **Regulation of ornithine decarboxylase (odc)**: OAZ3 acts as an antizyme, binding to ODC and inhibiting its activity. 3. **Metabolism of amino acids and derivatives**: OAZ3 is involved in the regulation of amino acid metabolism, including the metabolism of ornithine and other amino acids. 4. **Metabolism of polyamines**: OAZ3 regulates the biosynthesis and degradation of polyamines, which are essential for various cellular processes. **Clinical Significance:** The OAZ3 gene has been identified as significantly expressed in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, and enteroendocrine cell of colon. The regulation of OAZ3 by ODC suggests that dysregulation of OAZ3 may contribute to various diseases, including: 1. **Cancer**: Polyamine dysregulation has been implicated in the development and progression of various cancers, including leukemia, lymphoma, and solid tumors. 2. **Neurological disorders**: Polyamine dysregulation has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Metabolic disorders**: Polyamine dysregulation may contribute to metabolic disorders, such as obesity and insulin resistance. In conclusion, the OAZ3 gene plays a crucial role in regulating polyamine biosynthesis and ornithine decarboxylase activity. Its dysregulation may contribute to various diseases, highlighting the importance of further research into the clinical significance of OAZ3.

Genular Protein ID: 3391342917

Symbol: OAZ3_HUMAN

Name: Ornithine decarboxylase antizyme 3

UniProtKB Accession Codes:

Q9UMX2 E7EUE7 Q6GMR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10781085

Title: Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3.

PubMed ID: 10781085

DOI: 10.1073/pnas.070055897

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17900240

Title: Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase.

PubMed ID: 17900240

DOI: 10.1042/bj20071004

Sequence Information:

  • Length: 235
  • Mass: 27413
  • Checksum: D9DA9CD9CAEED311
  • Sequence:
    • MPCKRCRPSV YSLSYIKRGK TRNYLYPIWS PYAYYLYCYK YRITLREKML PRCYKSITYK 
EEEDLTLQPR SCLQCSESLV GLQEGKSTEQ GNHDQLKELY SAGNLTVLAT DPLLHQDPVQ 
LDFHFRLTSQ TSAHWHGLLC DRRLFLDIPY QALDQGNRES LTATLEYVEE KTNVDSVFVN 
FQNDRNDRGA LLRAFSYMGF EVVRPDHPAL PPLDNVIFMV YPLERDVGHL PSEPP

Genular Protein ID: 2147237530

Symbol: A0A0G2JH29_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0G2JH29

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 190
  • Mass: 21761
  • Checksum: E0B4F19A7A63CDE7
  • Sequence:
    • MTVPWRPGKR RITYKEEEDL TLQPRSCLQC SESLVGLQEG KSTEQGNHDQ LKELYSAGNL 
TVLATDPLLH QDPVQLDFHF RLTSQTSAHW HGLLCDRRLF LDIPYQALDQ GNRESLTATL 
EYVEEKTNVD SVFVNFQNDR NDRGALLRAF SYMGFEVVRP DHPALPPLDN VIFMVYPLER 
DVGHLPSEPP

Genular Protein ID: 1107520013

Symbol: H0Y7Y4_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0Y7Y4

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 203
  • Mass: 23214
  • Checksum: 2EA8E00DD24B4F92
  • Sequence:
    • MRPEGGPRRR RQERPPPVLP AARRITYKEE EDLTLQPRSC LQCSESLVGL QEGKSTEQGN 
HDQLKELYSA GNLTVLATDP LLHQDPVQLD FHFRLTSQTS AHWHGLLCDR RLFLDIPYQA 
LDQGNRESLT ATLEYVEEKT NVDSVFVNFQ NDRNDRGALL RAFSYMGFEV VRPDHPALPP 
LDNVIFMVYP LERDVGHLPS EPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.