Details for: RTEL1

Gene ID: 51750

Symbol: RTEL1

Ensembl ID: ENSG00000258366

Description: regulator of telomere elongation helicase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 31.8235
    Cell Significance Index: -4.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.5944
    Cell Significance Index: -4.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.0147
    Cell Significance Index: -4.9500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 2.0795
    Cell Significance Index: 29.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3180
    Cell Significance Index: 42.2200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.9257
    Cell Significance Index: 13.4400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.6680
    Cell Significance Index: 9.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5589
    Cell Significance Index: 112.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5525
    Cell Significance Index: 14.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5017
    Cell Significance Index: 22.1900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.4582
    Cell Significance Index: 5.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4513
    Cell Significance Index: 17.0900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4306
    Cell Significance Index: 9.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2700
    Cell Significance Index: 96.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1818
    Cell Significance Index: 9.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1478
    Cell Significance Index: 11.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1417
    Cell Significance Index: 8.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1235
    Cell Significance Index: 2.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1221
    Cell Significance Index: 22.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1069
    Cell Significance Index: 6.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0923
    Cell Significance Index: 5.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0867
    Cell Significance Index: 16.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0666
    Cell Significance Index: 1.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0580
    Cell Significance Index: 1.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0572
    Cell Significance Index: 1.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0559
    Cell Significance Index: 6.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0342
    Cell Significance Index: 0.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0305
    Cell Significance Index: 3.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0272
    Cell Significance Index: 0.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0259
    Cell Significance Index: 3.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0199
    Cell Significance Index: 0.1200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0083
    Cell Significance Index: 0.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0057
    Cell Significance Index: 0.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0057
    Cell Significance Index: 0.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0018
    Cell Significance Index: 0.0400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0007
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0025
    Cell Significance Index: -4.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0026
    Cell Significance Index: -1.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0039
    Cell Significance Index: -0.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0047
    Cell Significance Index: -2.6700
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.0057
    Cell Significance Index: -0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0068
    Cell Significance Index: -4.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0075
    Cell Significance Index: -4.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0084
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0089
    Cell Significance Index: -5.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0092
    Cell Significance Index: -5.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0103
    Cell Significance Index: -4.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0106
    Cell Significance Index: -4.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0113
    Cell Significance Index: -2.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0114
    Cell Significance Index: -3.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0118
    Cell Significance Index: -0.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0174
    Cell Significance Index: -2.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0187
    Cell Significance Index: -0.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0196
    Cell Significance Index: -1.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0198
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0214
    Cell Significance Index: -4.5100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0236
    Cell Significance Index: -0.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0274
    Cell Significance Index: -3.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0305
    Cell Significance Index: -1.0700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0321
    Cell Significance Index: -0.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0326
    Cell Significance Index: -3.3300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0327
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0330
    Cell Significance Index: -5.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0371
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0371
    Cell Significance Index: -4.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0403
    Cell Significance Index: -1.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0438
    Cell Significance Index: -1.1700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0457
    Cell Significance Index: -0.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0478
    Cell Significance Index: -4.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0499
    Cell Significance Index: -2.6000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0650
    Cell Significance Index: -0.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0677
    Cell Significance Index: -4.1500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0730
    Cell Significance Index: -0.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0745
    Cell Significance Index: -5.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0759
    Cell Significance Index: -1.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0764
    Cell Significance Index: -5.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0787
    Cell Significance Index: -2.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0803
    Cell Significance Index: -1.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0812
    Cell Significance Index: -5.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0914
    Cell Significance Index: -1.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0918
    Cell Significance Index: -4.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0919
    Cell Significance Index: -3.0100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0956
    Cell Significance Index: -1.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0961
    Cell Significance Index: -3.0600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0970
    Cell Significance Index: -2.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1076
    Cell Significance Index: -3.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1107
    Cell Significance Index: -5.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1133
    Cell Significance Index: -3.9700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1136
    Cell Significance Index: -2.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1138
    Cell Significance Index: -2.6300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1139
    Cell Significance Index: -1.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1145
    Cell Significance Index: -5.3400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1244
    Cell Significance Index: -2.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1277
    Cell Significance Index: -3.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1288
    Cell Significance Index: -3.4500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1311
    Cell Significance Index: -3.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1311
    Cell Significance Index: -3.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Telomere Elongation and Maintenance:** RTEL1 is specifically involved in the regulation of telomere elongation and maintenance, particularly through the homologous recombination and homology-directed repair pathways. 2. **High Expression in Proliferative Cells:** RTEL1 is highly expressed in cells with high proliferative rates, such as hematopoietic stem cells, progenitor cells, and neurons. 3. **Involvement in DNA Repair:** RTEL1 is also involved in the repair of DNA double-strand breaks through homologous recombination and homology-directed repair. 4. **Negative Regulation of DNA Recombination:** RTEL1 acts as a negative regulator of DNA recombination, preventing excessive DNA repair and maintaining genomic stability. **Pathways and Functions:** 1. **Homologous Recombination (HR) and Homology-Directed Repair (HDR):** RTEL1 is involved in the HR and HDR pathways, which are essential for the repair of DNA double-strand breaks and the maintenance of telomeres. 2. **Telomere Extension:** RTEL1 plays a crucial role in the extension of telomeres through the activation of telomerase and the deposition of telomeric repeats. 3. **DNA Repair:** RTEL1 is involved in the repair of DNA double-strand breaks through HR and HDR, maintaining genomic stability and preventing mutations. 4. **Negative Regulation of DNA Recombination:** RTEL1 acts as a negative regulator of DNA recombination, preventing excessive DNA repair and maintaining genomic stability. **Clinical Significance:** 1. **Cancer:** Dysregulation of RTEL1 has been implicated in various cancers, where it can contribute to genomic instability and telomere shortening. 2. **Aging and Age-Related Diseases:** RTEL1's dysregulation has been linked to aging and age-related diseases, such as telomere shortening and premature aging. 3. **Neurological Disorders:** RTEL1's dysregulation has been implicated in various neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Hematological Disorders:** RTEL1's dysregulation has been linked to various hematological disorders, such as leukemia and lymphoma. In conclusion, RTEL1 is a critical gene involved in the regulation of telomere elongation and maintenance, DNA repair, and negative regulation of DNA recombination. Its dysregulation has been implicated in various diseases, including cancer, aging, and neurological disorders, highlighting the importance of RTEL1 in maintaining genomic stability and preventing disease.

Genular Protein ID: 1975721510

Symbol: RTEL1_HUMAN

Name: Novel helicase-like

UniProtKB Accession Codes:

Q9NZ71 A2A397 A2A398 B4DRM5 B4DYM3 B4E3N6 E1P5J4 E1P5J5 Q5JTV3 Q5JTV4 Q9BW37 Q9H402 Q9H4X6 Q9NX25 Q9NZ73 Q9UPR4 Q9Y4R6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 3 CTD 1 ChEBI 10 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 5 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 6 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 Rhea 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10655513

Title: Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.

PubMed ID: 10655513

DOI: 10.1073/pnas.97.3.1230

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18957201

Title: RTEL1 maintains genomic stability by suppressing homologous recombination.

PubMed ID: 18957201

DOI: 10.1016/j.cell.2008.08.016

PubMed ID: 22678361

Title: MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.

PubMed ID: 22678361

DOI: 10.1126/science.1219664

PubMed ID: 23453664

Title: Constitutional mutations in RTEL1 cause severe dyskeratosis congenita.

PubMed ID: 23453664

DOI: 10.1016/j.ajhg.2013.02.001

PubMed ID: 23585563

Title: IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.

PubMed ID: 23585563

DOI: 10.1074/jbc.m112.416602

PubMed ID: 23959892

Title: Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome.

PubMed ID: 23959892

DOI: 10.1073/pnas.1300600110

PubMed ID: 25848748

Title: Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening.

PubMed ID: 25848748

DOI: 10.1038/ng.3278

PubMed ID: 23329068

Title: Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in dyskeratosis congenita.

PubMed ID: 23329068

DOI: 10.1007/s00439-013-1265-8

PubMed ID: 23591994

Title: Human RTEL1 deficiency causes Hoyeraal-Hreidarsson syndrome with short telomeres and genome instability.

PubMed ID: 23591994

DOI: 10.1093/hmg/ddt178

PubMed ID: 24009516

Title: A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome.

PubMed ID: 24009516

DOI: 10.1371/journal.pgen.1003695

Sequence Information:

  • Length: 1219
  • Mass: 133683
  • Checksum: 28DFCFCC48BC0055
  • Sequence:
    • MPKIVLNGVT VDFPFQPYKC QQEYMTKVLE CLQQKVNGIL ESPTGTGKTL CLLCTTLAWR 
EHLRDGISAR KIAERAQGEL FPDRALSSWG NAAAAAGDPI ACYTDIPKII YASRTHSQLT 
QVINELRNTS YRPKVCVLGS REQLCIHPEV KKQESNHLQI HLCRKKVASR SCHFYNNVEE 
KSLEQELASP ILDIEDLVKS GSKHRVCPYY LSRNLKQQAD IIFMPYNYLL DAKSRRAHNI 
DLKGTVVIFD EAHNVEKMCE ESASFDLTPH DLASGLDVID QVLEEQTKAA QQGEPHPEFS 
ADSPSPGLNM ELEDIAKLKM ILLRLEGAID AVELPGDDSG VTKPGSYIFE LFAEAQITFQ 
TKGCILDSLD QIIQHLAGRA GVFTNTAGLQ KLADIIQIVF SVDPSEGSPG SPAGLGALQS 
YKVHIHPDAG HRRTAQRSDA WSTTAARKRG KVLSYWCFSP GHSMHELVRQ GVRSLILTSG 
TLAPVSSFAL EMQIPFPVCL ENPHIIDKHQ IWVGVVPRGP DGAQLSSAFD RRFSEECLSS 
LGKALGNIAR VVPYGLLIFF PSYPVMEKSL EFWRARDLAR KMEALKPLFV EPRSKGSFSE 
TISAYYARVA APGSTGATFL AVCRGKASEG LDFSDTNGRG VIVTGLPYPP RMDPRVVLKM 
QFLDEMKGQG GAGGQFLSGQ EWYRQQASRA VNQAIGRVIR HRQDYGAVFL CDHRFAFADA 
RAQLPSWVRP HVRVYDNFGH VIRDVAQFFR VAERTMPAPA PRATAPSVRG EDAVSEAKSP 
GPFFSTRKAK SLDLHVPSLK QRSSGSPAAG DPESSLCVEY EQEPVPARQR PRGLLAALEH 
SEQRAGSPGE EQAHSCSTLS LLSEKRPAEE PRGGRKKIRL VSHPEEPVAG AQTDRAKLFM 
VAVKQELSQA NFATFTQALQ DYKGSDDFAA LAACLGPLFA EDPKKHNLLQ GFYQFVRPHH 
KQQFEEVCIQ LTGRGCGYRP EHSIPRRQRA QPVLDPTGRT APDPKLTVST AAAQQLDPQE 
HLNQGRPHLS PRPPPTGDPG SQPQWGSGVP RAGKQGQHAV SAYLADARRA LGSAGCSQLL 
AALTAYKQDD DLDKVLAVLA ALTTAKPEDF PLLHRFSMFV RPHHKQRFSQ TCTDLTGRPY 
PGMEPPGPQE ERLAVPPVLT HRAPQPGPSR SEKTGKTQSK ISSFLRQRPA GTVGAGGEDA 
GPSQSSGPPH GPAASEWGL

Genular Protein ID: 258756343

Symbol: R4IXY3_HUMAN

Name: N/A

UniProtKB Accession Codes:

R4IXY3

Database IDs:

ARBA 12 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 9 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 12 Gene3D 2 HAMAP 1 HAMAP-Rule 1 InterPro 9 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 1300
  • Mass: 142376
  • Checksum: E2A1C8EB33211C74
  • Sequence:
    • MPKIVLNGVT VDFPFQPYKC QQEYMTKVLE CLQQKVNGIL ESPTGTGKTL CLLCTTLAWR 
EHLRDGISAR KIAERAQGEL FPDRALSSWG NAAAAAGDPI ACYTDIPKII YASRTHSQLT 
QVINELRNTS YRPKVCVLGS REQLCIHPEV KKQESNHLQI HLCRKKVASR SCHFYNNVEE 
KSLEQELASP ILDIEDLVKS GSKHRVCPYY LSRNLKQQAD IIFMPYNYLL DAKSRRAHNI 
DLKGTVVIFD EAHNVEKMCE ESASFDLTPH DLASGLDVID QVLEEQTKAA QQGEPHPEFS 
ADSPSPGLNM ELEDIAKLKM ILLRLEGAID AVELPGDDSG VTKPGSYIFE LFAEAQITFQ 
TKGCILDSLD QIIQHLAGRA GVFTNTAGLQ KLADIIQIVF SVDPSEGSPG SPAGLGALQS 
YKVHIHPDAG HRRTAQRSDA WSTTAARKRG KVLSYWCFSP GHSMHELVRQ GVRSLILTSG 
TLAPVSSFAL EMQIPFPVCL ENPHIIDKHQ IWVGVVPRGP DGAQLSSAFD RRFSEECLSS 
LGKALGNIAR VVPYGLLIFF PSYPVMEKSL EFWRARDLAR KMEALKPLFV EPRSKGSFSE 
TISAYYARVA APGSTGATFL AVCRGKASEG LDFSDTNGRG VIVTGLPYPP RMDPRVVLKM 
QFLDEMKGQG GAGGQFLSGQ EWYRQQASRA VNQAIGRVIR HRQDYGAVFL CDHRFAFADA 
RAQLPSWVRP HVRVYDNFGH VIRDVAQFFR VAERTMPAPA PRATAPSVRG EDAVSEAKSP 
GPFFSTRKAK SLDLHVPSLK QRSSGSPAAG DPESSLCVEY EQEPVPARQR PRGLLAALEH 
SEQRAGSPGE EQAHSCSTLS LLSEKRPAEE PRGGRKKIRL VSHPEEPVAG AQTDRAKLFM 
VAVKQELSQA NFATFTQALQ DYKGSDDFAA LAACLGPLFA EDPKKHNLLQ GFYQFVRPHH 
KQQFEEVCIQ LTGRGCGYRP EHSIPRRQRA QPVLDPTGRT APDPKLTVST AAAQQLDPQE 
HLNQGRPHLS PRPPPTGDPG SHPQWGSGVP RAGKQGQHAV SAYLADARRA LGSAGCSQLL 
AALTAYKQDD DLDKVLAVLA ALTTAKPEDF PLLHRFSMFV RPHHKQRFSQ TCTDLTGRPY 
PGMEPPGPQE ERLAVPPVLT HRAPQPGPSR SEKTGKTQSK ISSFLRQRPA GTVGAGGEDA 
GPSQSSGPPH GPAASEWGEP HGRDIAGQQA TGAPGGPLSA GCVCQGCGAE DVVPFQCPAC 
DFQRCQACWQ RHLQASRMCP ACHTASRKQS VMQVFWPEPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.